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https://www.readbyqxmd.com/read/27913545/what-have-we-learned-from-large-population-studies-of-von-willebrand-disease
#1
Robert R Montgomery, Veronica H Flood
Von Willebrand factor (VWF) is a critical regulator of hemostatic processes, including collagen binding, platelet adhesion, and platelet aggregation. It also serves as a carrier protein to normalize plasma factor VIII synthesis, release, and survival. While VWF protein measurements by immunoassay are reasonably comparable between institutions, the measurement of VWF ristocetin cofactor activity (VWF:RCo) has significant variability. Other tests of VWF function, including collagen binding or platelet glycoprotein IIb-IIIa binding, are not universally available, yet these functional defects may cause major bleeding even with normal VWF antigen (VWF:Ag) and VWF:RCo assays...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27911140/effect-of-secondary-preventive-therapy-on-recurrence-of-tuberculosis-in-hiv-infected-individuals-a-systematic-review
#2
Wassilis Sc Bruins, Frank van Leth
Human immunodeficiency virus (HIV)-infected individuals successfully treated for tuberculosis (TB) remain at risk of recurrence of the disease, especially in high TB incidence settings. We performed a systematic review, investigating whether secondary preventive therapy (sPT) with anti-TB drugs (preventive therapy in former TB patients with treatment success) is an effective strategy to prevent recurrence of TB in this patient group. We searched the databases PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar using the keywords HIV-infections, HIV, human immunodeficiency virus, AIDS, isoniazid, isoniazid preventive therapy (IPT), tuberculosis, TB, recurrence and recurrent disease, resulting in 253 potential publications...
December 2, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27910820/4d-bioprinting-the-next-generation-technology-for-biofabrication-enabled-by-stimuli-responsive-materials
#3
Yi-Chen Li, Yu Shrike Zhang, Ali Akpek, Su Ryon Shin, Ali Khademhosseini
Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, 4D bioprinting aims to create dynamic 3D patterned biological structures that can transform their shapes or behavior under various stimuli. In this review, we highlight the potential use of various stimuli-responsive materials for 4D printing and their extension into biofabrication...
December 2, 2016: Biofabrication
https://www.readbyqxmd.com/read/27906011/prevalence-of-hiv-and-hepatitis-b-coinfection-in-ghana-a-systematic-review-and-meta-analysis
#4
REVIEW
Akosua Adom Agyeman, Richard Ofori-Asenso
BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection has been associated with higher morbidity and mortality and may impact significantly on healthcare resource utilization. However, in Ghana, accurate estimates of the prevalence of HIV/HBV coinfection needed to inform policy decisions and the design of public health interventions are currently lacking. In this study, our aim was to determine the HIV/HBV coinfection prevalence rate in Ghana. METHODS: Primary studies reporting prevalence of HIV/HBV coinfection in Ghana were retrieved through searches conducted in PubMed, science direct, Google scholar and Africa journals online (AJOL) databases...
May 17, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27902580/the-dynamic-mix-of-art-and-science-in-interdisciplinary-team-care-for-community-dwelling-older-adults-with-dementia
#5
Nancy Oliva, Betty Wexler
No abstract text is available yet for this article.
January 2017: Professional Case Management
https://www.readbyqxmd.com/read/27899505/an-interview-with-david-mcclay
#6
Aidan Maartens
David McClay is the Arthur S. Pearse Professor of Biology at Trinity College of Arts and Sciences, Duke University, North Carolina. His lab works on the transcriptional control of morphogenesis in the sea urchin embryo. We caught up with David at the 2016 Society for Developmental Biology - International Society of Differentiation joint meeting in Boston, where he received the Lifetime Achievement Award.
December 1, 2016: Development
https://www.readbyqxmd.com/read/27898679/patient-reported-barriers-to-adherence-to-antiretroviral-therapy-a-systematic-review-and-meta-analysis
#7
Zara Shubber, Edward J Mills, Jean B Nachega, Rachel Vreeman, Marcelo Freitas, Peter Bock, Sabin Nsanzimana, Martina Penazzato, Tsitsi Appolo, Meg Doherty, Nathan Ford
BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the targeting of different interventions and future research priorities. METHODS AND FINDINGS: We searched MEDLINE via PubMed, Embase, Web of Science, and PsychINFO from 01 January 1997 to 31 March 2016 for studies reporting barriers to adherence to ART...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27897223/fast-and-simple-decycling-and-dismantling-of-networks
#8
Lenka Zdeborová, Pan Zhang, Hai-Jun Zhou
Decycling and dismantling of complex networks are underlying many important applications in network science. Recently these two closely related problems were tackled by several heuristic algorithms, simple and considerably sub-optimal, on the one hand, and involved and accurate message-passing ones that evaluate single-node marginal probabilities, on the other hand. In this paper we propose a simple and extremely fast algorithm, CoreHD, which recursively removes nodes of the highest degree from the 2-core of the network...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893575/variations-in-burn-excision-and-grafting-a-survey-of-the-american-burn-association
#9
Jacqueline S Israel, David G Greenhalgh, Angela L Gibson
It is unknown whether variations in burn care affect outcomes or affect the success of emerging therapeutics. The purpose of this study was to assess burn surgeons' preferences in excision and grafting to determine if surgical technique affects outcomes. A 71-item survey evaluating skin grafting techniques was emailed to members of the American Burn Association in July and August 2015. The survey was anonymous and voluntary. Relationships between variables were evaluated using Fisher's exact test. A P-value of ≤...
November 15, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27892230/clinical-academic-careers-embracing-the-art-and-science-of-nursing
#10
Abigail Masterson, Liz Robb
Clinical academics make a unique contribution to health research and scholarship by undertaking practice-focused research that offers direct benefits to patient care. The Florence Nightingale Foundation supports the development of research skills in nursing and midwifery through its scholarships and by establishing a network of chairs in clinical nursing practice research. The Florence Nightingale Foundation also provides leadership scholarships to deans and aspiring deans of university faculties of health...
November 23, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27890495/critical-care-guidelines-more-science-less-art
#11
EDITORIAL
The Lancet Respiratory Medicine
No abstract text is available yet for this article.
December 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27889875/development-of-an-educational-program-integrating-concepts-of-genetic-risk-and-preventive-strategies-for-children-with-a-family-history-of-melanoma
#12
Yelena P Wu, Lisa G Aspinwall, Elizabeth Nagelhout, Wendy Kohlmann, Kimberly A Kaphingst, Sheila Homburger, Ryan D Perkins, Douglas Grossman, Garrett Harding, Pamela Cassidy, Sancy A Leachman
Efforts to prevent melanoma, especially for those at elevated risk for the disease, should ideally begin during childhood. However, there are few preventive interventions targeting children who are at higher risk for melanoma due to a family history of the disease. Further, there are no educational interventions that aim to help these at-risk children understand their risk for melanoma and the ways in which preventive behaviors, such as sun protection, can mitigate their risk. The current paper describes a multidisciplinary team's process for creating a developmentally appropriate educational intervention about melanoma risk and prevention for children ages 8-17 years who have a family history of melanoma...
November 26, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27889536/compact-integration-of-multi-network-topology-for-functional-analysis-of-genes
#13
Hyunghoon Cho, Bonnie Berger, Jian Peng
The topological landscape of molecular or functional interaction networks provides a rich source of information for inferring functional patterns of genes or proteins. However, a pressing yet-unsolved challenge is how to combine multiple heterogeneous networks, each having different connectivity patterns, to achieve more accurate inference. Here, we describe the Mashup framework for scalable and robust network integration. In Mashup, the diffusion in each network is first analyzed to characterize the topological context of each node...
November 22, 2016: Cell Systems
https://www.readbyqxmd.com/read/27889442/current-perspectives-in-the-interpretation-of-gunshot-residues-in-forensic-science-a-review
#14
REVIEW
M Maitre, K P Kirkbride, M Horder, C Roux, A Beavis
The traces produced when a firearm is discharged can provide important information in cases when questions regarding a possible association of the firearm with a person of interest (POI), time since discharge or shooting distance are raised. With advances in technology, the forensic challenges presented by these traces, known as gunshot residues (GSR), are moving from the analytical domain to the interpretation of the analytical results. Different interpretation frameworks are currently competing. Formal classification of particles, using standards such as that produced by ASTM, focusses only on evaluation of evidence at the sub-source level...
September 22, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27882306/personalized-proteomics-the-future-of-precision-medicine
#15
Trevor T Duarte, Charles T Spencer
Medical diagnostics and treatment has advanced from a one size fits all science to treatment of the patient as a unique individual. Currently, this is limited solely to genetic analysis. However, epigenetic, transcriptional, proteomic, posttranslational modifications, metabolic, and environmental factors influence a patient's response to disease and treatment. As more analytical and diagnostic techniques are incorporated into medical practice, the personalized medicine initiative transitions to precision medicine giving a holistic view of the patient's condition...
2016: Proteomes
https://www.readbyqxmd.com/read/27879115/preface
#16
Avner Friedman, Mirosław Lachowicz, Urszula Ledzewicz, Monika Joanna Piotrowska, Zuzanna Szymanska
This volume was inspired by the topics presented at the international conference "Micro and Macro Systems in Life Sciences" which was held on Jun 8-12, 2015 in Będlewo, Poland. System biology is an approach which tries to understand how micro systems, at the molecular and cellular levels, affect macro systems such as organs, tissue and populations. Thus it is not surprising that a major theme of this volume evolves around cancer and its treatment. Articles on this topic include models for tumor induced angiogenesis, without and with delays, metastatic niche of the bone marrow, drug resistance and metronomic chemotherapy, and virotherapy of glioma...
February 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27876134/geniuses-of-medical-science-friendly-open-and-responsible-not-mad
#17
Maitane Oscoz-Irurozqui, Felipe Ortuño
Recent studies based on biography analysis provide support for the notion that the prevalence of mental illness in the creative geniuses of art, literature and science is higher than it is in more ordinary folk. However, this relationship between madness and genius, which was also addressed by the classical philosophers, has been generalized to all branches of professional endeavour. Whilst it may hold true for illustrious personalities of the fine arts, we found that the relationship proves inappropriate to the biographies of ten individuals renowned in history for their innovative contributions to medical science...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27874140/carbon-nanotube-fibers-and-films-synthesis-applications-and-perspectives-of-the-direct-spinning-method
#18
REVIEW
Dawid Janas, Krzysztof K Koziol
The direct-spinning method of creation of CNT macroassemblies has received a lot of attention because of its simplicity to produce high-performance material without apparent limits to its size. CNT fibers or films have shown unparalleled properties and opened new areas of research and commercial development. The process designed more than a decade ago has already given interesting information about the basic science of nanomaterials, which in parallel led to the creation of the first prototypes with high potential of implementation in everyday life...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27871944/predictors-of-food-decision-making-a-systematic-interdisciplinary-mapping-sim-review
#19
Claudia Symmank, Robert Mai, Stefan Hoffmann, F Marijn Stok, Britta Renner, Nanna Lien, Harald Rohm
The number of publications on consumer food decision making and its predictors and correlates has been steadily increasing over the last three decades. Given that different scientific disciplines illuminate this topic from different perspectives, it is necessary to develop an interdisciplinary overview. The aim of this study is to conduct a systematic interdisciplinary mapping (SIM) review by using rapid review techniques to explore the state-of-the-art, and to identify hot topics and research gaps in this field...
November 18, 2016: Appetite
https://www.readbyqxmd.com/read/27870940/blood-based-biomarkers-in-alzheimer-disease-current-state-of-the-science-and-a-novel-collaborative-paradigm-for-advancing-from-discovery-to-clinic
#20
Sid E O'Bryant, Michelle M Mielke, Robert A Rissman, Simone Lista, Hugo Vanderstichele, Henrik Zetterberg, Piotr Lewczuk, Holly Posner, James Hall, Leigh Johnson, Yiu-Lian Fong, Johan Luthman, Andreas Jeromin, Richard Batrla-Utermann, Alcibiades Villarreal, Gabrielle Britton, Peter J Snyder, Kim Henriksen, Paula Grammas, Veer Gupta, Ralph Martins, Harald Hampel
The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art...
November 18, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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