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https://www.readbyqxmd.com/read/29773065/copper-catalyzed-azide-alkyne-cycloaddition-cuaac-mediated-macrocylization-of-peptides-impact-on-conformation-and-biological-activity
#1
Chiara Testa, Anna Maria Papini, Michael Chorev, Paolo Rovero
The long lasting impetus to design novel modes of macrocyclization, and their implementation into a wide range of bioactive peptides, originates from their contributions to the restriction of conformational space and the stabilization of preferential bioactive conformations that support higher efficacy and binding affinity to cognate macromolecular targets, improved specificity and lowering susceptibility to enzymatic degradation processes. Introducing CuI-catalyzed azide-alkyne cycloadditon (CuAAC), a prototypical click reaction, to the field of peptide sciences as a bio-orthogonal reaction that generates a disubstituted-[1,2,3]triazol-1-yl moiety as a pseudopeptidic bond that is peptidomimetic in nature, paved the way to its wide spread application as a new and promising mode of macrocyclization...
May 17, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29768674/social-science-and-sozialwissenschaft-categorical-and-institutional-boundaries-of-knowledge
#2
Gerhard Sonnert
This article explores how linguistic categories affect boundary work in scholarly knowledge production. Whereas the German language knows the unified concept of Wissenschaft for all branches of scholarship represented at universities, the English language separates science from the arts or humanities and does not commonly engage an overarching concept. This has had consequences for American social science, which are traced both in the discourse shaping its development and in the deployment and distribution of institutional resources...
May 16, 2018: Journal of the History of the Behavioral Sciences
https://www.readbyqxmd.com/read/29763397/-memento-mori-and-photographic-perspective-of-roadside-trauma
#3
David B Nance, Sara Scarlet, Elizabeth B Dreesen
David Nance's photographs invite us to cross the liminal space between road and roadside and to consider the experience that trauma surgeons share with injured patients and the families of the injured and the dead. Just as trauma surgeons use the tools of science and surgery to make order out of the chaos of "the scene," so patients' families use art, found objects, and grief to transform anonymous roadsides into specific, personal remembrances. Bound together by the uncertainties of trauma, we can all stand at the side of the road bearing witness to both the inevitability and unpredictability of death...
May 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29761363/scientific-iconoclasm-and-active-imagination-synthetic-cells-as-techno-scientific-mandalas
#4
Hub Zwart
Metaphors allow us to come to terms with abstract and complex information, by comparing it to something which is structured, familiar and concrete. Although modern science is "iconoclastic", as Gaston Bachelard phrases it (i.e. bent on replacing living entities by symbolic data: e.g. biochemical and mathematical symbols and codes), scientists are at the same time prolific producers of metaphoric images themselves. Synthetic biology is an outstanding example of a technoscientific discourse replete with metaphors, including textual metaphors such as the "Morse code" of life, the "barcode" of life and the "book" of life...
May 14, 2018: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/29760254/learning-narrative-based-medicine-skills-narrative-based-medicine-3
#5
REVIEW
George Zaharias
OBJECTIVE: To raise awareness of narrative-based medicine (NBM) as a valuable approach to the consultation, which, if practised more widely by GPs, would convey considerable benefits to both patient and doctor. SOURCES OF INFORMATION: While this article draws on the perspectives of 2 of NBM's key proponents, Rita Charon and John Launer, it also presents the author's perspective on the usefulness of the arts. MAIN MESSAGE: This article presents some practical ways in which GPs can start using the skills of NBM and methods for developing those skills further...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29756991/the-immune-landscape-of-non-small-cell-lung-cancer-utility-of-cytologic-and-histologic-samples-obtained-through-minimally-invasive-pulmonary-procedures
#6
Jason Beattie, Lonny Yarmus, Momen Wahidi, M Patricia Rivera, Christopher Gilbert, Fabien Maldonado, Kasia Czarnecka, Angela Argento, Alexander Chen, Felix Herth, Daniel H Sterman
The success of immune checkpoint inhibitors and the discovery of useful biomarkers to predict response to these agents has shifted much of the focus of personalized care for advanced non-small cell lung cancer towards harnessing the immune response. With further advancement, more effective immunotherapy options will emerge along with more useful biomarkers. For patients with advanced disease, minimally invasive techniques will remain most appropriate for acquisition of tissue. This is in contrast to default gold-standard large tissue specimens obtained through surgical resection...
May 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29752493/review-of-mental-health-promotion-interventions-in-schools
#7
REVIEW
Michelle O'Reilly, Nadzeya Svirydzenka, Sarah Adams, Nisha Dogra
PURPOSE: The prevalence of mental disorders amongst children and adolescents is an increasing global problem. Schools have been positioned at the forefront of promoting positive mental health and well-being through implementing evidence-based interventions. The aim of this paper is to review current evidence-based research of mental health promotion interventions in schools and examine the reported effectiveness to identify those interventions that can support current policy and ensure that limited resources are appropriately used...
May 11, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29751126/radiological-follow-up-after-implanting-cervical-disc-prosthesis-in-anterior-discectomy-a-systematic-review
#8
REVIEW
Xiaoyu Yang, Tessa Janssen, Mark P Arts, Wilco C Peul, Carmen L A Vleggeert-Lankamp
Objective The objective of this study was to review current literature on comparison of radiological outcome of cervical arthroplasty with fusion after anterior discectomy for radiculopathy. Methods A literature search was performed in PubMed, Embase, Web of Science, COCHRANE, CENTRAL and CINAHL using a sensitive search string combination. Studies were selected by predefined selection criteria (a.o. patients exclusively suffering from cervical radiculopathy) and risk of bias was assessed using a validated Cochrane Checklist adjusted for this purpose...
May 8, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29750795/multiclass-classification-for-skin-cancer-profiling-based-on-the-integration-of-heterogeneous-gene-expression-series
#9
Juan Manuel Gálvez, Daniel Castillo, Luis Javier Herrera, Belén San Román, Olga Valenzuela, Francisco Manuel Ortuño, Ignacio Rojas
Most of the research studies developed applying microarray technology to the characterization of different pathological states of any disease may fail in reaching statistically significant results. This is largely due to the small repertoire of analysed samples, and to the limitation in the number of states or pathologies usually addressed. Moreover, the influence of potential deviations on the gene expression quantification is usually disregarded. In spite of the continuous changes in omic sciences, reflected for instance in the emergence of new Next-Generation Sequencing-related technologies, the existing availability of a vast amount of gene expression microarray datasets should be properly exploited...
2018: PloS One
https://www.readbyqxmd.com/read/29748817/the-role-of-the-microbiome-for-human-health-from-basic-science-to-clinical-applications
#10
M Hasan Mohajeri, Robert J M Brummer, Robert A Rastall, Rinse K Weersma, Hermie J M Harmsen, Marijke Faas, Manfred Eggersdorfer
The 2017 annual symposium organized by the University Medical Center Groningen in The Netherlands focused on the role of the gut microbiome in human health and disease. Experts from academia and industry examined interactions of prebiotics, probiotics, or vitamins with the gut microbiome in health and disease, the development of the microbiome in early-life and the role of the microbiome on the gut-brain axis. The gut microbiota changes dramatically during pregnancy and intrinsic factors (such as stress), in addition to extrinsic factors (such as diet, and drugs) influence the composition and activity of the gut microbiome throughout life...
May 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29748684/recent-advances-in-merging-photonic-crystals-and-plasmonics-for-bioanalytical-applications
#11
Bing Liu, Hosein Monshat, Zhongze Gu, Meng Lu, Xiangwei Zhao
Photonic crystals (PhCs) and plasmonic nanostructures offer the unprecedented capability to control the interaction of light and biomolecules at the nanoscale. Based on PhC and plasmonic phenomena, a variety of analytical techniques have been demonstrated and successfully implemented in many fields, such as biological sciences, clinical diagnosis, drug discovery, and environmental monitoring. During the past decades, PhC and plasmonic technologies have progressed in parallel with their pros and cons. The merging of photonic crystals with plasmonics will significantly improve biosensor performances and enlarge the linear detection range of analytical targets...
May 11, 2018: Analyst
https://www.readbyqxmd.com/read/29745321/selected-applications-for-current-polymers-in-prosthetic-dentistry-state-of-the-art
#12
Maciej Kawala, Joanna Smardz, Lukasz Adamczyk, Natalia Grychowska, Mieszko Wieckiewicz
BACKGROUND: Polymers are widely applied in medicine, including dentistry, i.e. in prosthodontics. AIM: The following paper is aimed at demonstrating the applications of selected modern polymers in prosthetic dentistry based on the reported literature. MATERIAL AND METHODS: The study was conducted using the PubMed, SCOPUS and CINAHL databases in relation to documents published during 1999-2017. The following keywords were used: polymers with: prosthetic dentistry, impression materials, denture base materials, bite registration materials, denture soft liners, occlusal splint materials and 3D printing...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29741985/accuracy-of-human-motion-capture-systems-for-sport-applications-state-of-the-art-review
#13
Eline van der Kruk, Marco M Reijne
OBJECTIVE: Sport research often requires human motion capture of an athlete. It can, however, be labour-intensive and difficult to select the right system, while manufacturers report on specifications which are determined in set-ups that largely differ from sport research in terms of volume, environment and motion. The aim of this review is to assist researchers in the selection of a suitable motion capture system for their experimental set-up for sport applications. An open online platform is initiated, to support (sport)researchers in the selection of a system and to enable them to contribute and update the overview...
May 9, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29740927/are-singleton-pregnancies-after-assisted-reproduction-technology-art-associated-with-a-higher-risk-of-placental-anomalies-compared-with-non-art-singleton-pregnancies-a-systematic-review-and-meta-analysis
#14
REVIEW
B G Vermey, A Buchanan, G M Chambers, E M Kolibianakis, J Bosdou, M G Chapman, C A Venetis
BACKGROUND: Placental anomalies (placenta praevia, placental abruption, morbidly adherent placenta and cord insertion anomalies) are associated with maternal and fetal morbidity and mortality. It has been suggested these might be more prevalent in pregnancies after assisted reproduction technology (ART). OBJECTIVES: To determine whether ART singleton pregnancies are associated with an increased risk of placental anomalies compared with non-ART singleton pregnancies...
May 8, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29736568/emerging-concepts-in-treating-cartilage-osteochondral-defects-and-osteoarthritis-of-the-knee-and-ankle
#15
Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, Pedro L Ripoll, João Espregueira-Mendes, J Miguel Oliveira, Rui L Reis, C Niek van Dijk
The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736508/the-growing-role-of-structural-mass-spectrometry-in-the-discovery-and-development-of-therapeutic-antibodies
#16
REVIEW
Yuwei Tian, Brandon T Ruotolo
The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Mass spectrometry has evolved into a rapid and sensitive tool for assessing the structures, stabilities, and dynamics of such proteins. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics. We conclude by discussing the future of structural mass spectrometry, and its role in enabling the biopharmaceutical pipeline...
May 8, 2018: Analyst
https://www.readbyqxmd.com/read/29734340/art-in-science-competition-invites-artworks-to-the-annual-exhibition-on-ismb-2018-in-chicago
#17
Milana Frenkel-Morgenstern, Lonnie Welch, Bruno Gaeta, Diane E Kovats
No abstract text is available yet for this article.
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#18
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29722952/a-nursing-student-s-reflective-account-of-decision-making-in-a-school-nursing-setting
#19
Bethaney Squirrell, Jane Hunt
Reflection is integral to professional revalidation and enhancing nursing practice; it is an art and a science to be learned. Learning the art of reflection begins as a student in clinical placement settings. Drawing on a reflective model, this article presents an account of one second-year children's nursing student's experiences in a community-based placement with a school nursing team. A school nurse appointment was reflected on where advice was offered to a 13-year-old student with sleep difficulties, low affect and lethargy, which included avoiding caffeinated drinks, reducing use of a laptop and mobile phone before going to sleep, and establishing a regular bedtime routine...
May 3, 2018: Nursing Children and Young People
https://www.readbyqxmd.com/read/29717654/professional-voice-sataloff-robert-t-professional-voice-the-science-and-art-of-clinical-care-4th-ed-san-diego-plural-publishing-inc-2017-hard-cover-illustrated-2224-pages-795
#20
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