Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, Dominic Dordai, Ru Wang, Gregg L Semenza
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and methylation at target genes. Here, we demonstrate that hypoxia-inducible gene expression in estrogen receptor (ER)-positive MCF7 and ER-negative SUM159 human breast cancer cells requires the histone H2A/H2B chaperone facilitates chromatin transcription (FACT) and the H2B ubiquitin ligase RING finger protein 20/40 (RNF20/40)...
March 21, 2024: Cell Reports