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https://www.readbyqxmd.com/read/27915075/building-the-case-for-a-novel-teleost-model-of-non-breeding-aggression-and-its-neuroendocrine-control
#1
Laura Quintana, Lucía Zubizarreta, Cecilia Jalabert, Gervasio Batista, Rossana Perrone, Ana Silva
In vertebrates, aggression has been traditionally associated with high levels of circulating androgens in breeding males. Nevertheless, the centrality of androgens as primary modulators of aggression is being reconsidered in at least in two particular cases: 1) territorial aggression outside the breeding season, and 2) aggression by females. We are developing the weakly electric fish, Gymnotus omarorum, as a novel, advantageous model system to address these two alternative forms of aggression. This species displays a short, escalated contest, after which a clear hierarchical status emerges...
November 30, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27903677/combined-inhibition-of-both-p110%C3%AE-and-p110%C3%AE-isoforms-of-phosphatidylinositol-3-kinase-is-required-for-sustained-therapeutic-effect-in-pten-deficient-er-breast-cancer
#2
Sarah R Hosford, Lloye M Dillon, Stephanie J Bouley, Rachele Rosati, Wei Yang, Vivian S Chen, Eugene Demidenko, Rocco P Morra, Todd W Miller
PURPOSE: Determine the roles of the phosphatidylinositol 3-kinase (PI3K) isoforms p110α and p110β in PTEN-deficient, estrogen receptor α (ER)-positive breast cancer, and the therapeutic potential of isoform-selective inhibitors. EXPERIMENTAL DESIGN: Anti-estrogen-sensitive and -resistant PTEN-deficient, ER+ human breast cancer cell lines, and mice bearing anti-estrogen-resistant xenografts were treated with the anti-estrogen fulvestrant, the p110α inhibitor BYL719, the p110β inhibitor GSK2636771, or combinations...
November 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27876127/in-silico-prediction-of-specific-pathways-that-regulate-mesangial-cell-proliferation-in-iga-nephropathy
#3
Elham Sadat Mirfazeli, Sayed-Amir Marashi, Shiva Kalantari
IgA nephropathy is one of the most common forms of primary glomerulonephritis worldwide leading to end-stage renal disease. Proliferation of mesangial cells, i.e., the multifunctional cells located in the intracapillary region of glomeruli, after IgA- dominant immune deposition is the major histologic feature in IgA nephropathy. In spite of several studies on molecular basis of proliferation in these cells, specific pathways responsible for regulation of proliferation are still to be discovered. In this study, we predicted a specific signaling pathway started from transferrin receptor (TFRC), a specific IgA1 receptor on mesangial cells, toward a set of proliferation-related proteins...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27867016/vasohibin-2-promotes-epithelial-mesenchymal-transition-in-human-breast-cancer-via-activation-of-transforming-growth-factor-%C3%AE-1-and-hypoxia-dependent-repression-of-gata-binding-factor-3
#4
Min Tu, Zhanjun Li, Xian Liu, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Guoxin Song, Jianmin Chen, Feng Guo, Kuirong Jiang, Shui Wang, Wentao Gao, Yi Miao
Vasohibin 2 (VASH2) is identified as an angiogenic factor, and has been implicated in tumor angiogenesis, proliferation and epithelial-mesenchymal transition (EMT). To investigate the EMT role of VASH2 in breast cancer, we overexpressed or knocked down expression of VASH2 in human breast cancer cell lines. We observed that VASH2 induced EMT in vitro and in vivo. The transforming growth factor β1 (TGFβ1) pathway was activated by VASH2, and expression of a dominant negative TGFβ type II receptor could block VASH2-mediated EMT...
November 17, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27801669/fen1-gene-variants-confer-reduced-risk-of-breast-cancer-in-chinese-women-a-case-control-study
#5
Shuai Lin, Meng Wang, Xinghan Liu, Ye Lu, Zhuoqing Gong, Yan Guo, Pengtao Yang, Tian Tian, Cong Dai, Yi Zheng, Peng Xu, Shanli Li, Yuyao Zhu, Zhijun Dai
This study aimed to assess the associations of two common Flap endonuclease 1 (FEN1) polymorphisms (rs4246215 and rs174538) with breast cancer risk in northwest Chinese women. We conducted a case-control study with 560 breast cancer patients and 583 age-matched healthy controls from Northwest China. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations. We found a significantly reduced risk of breast cancer associated with T allele of rs4246215 (allele model: OR 0.81, 95% CI 0...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27781410/expression-profile-of-e-cadherin-estrogen-receptors-and-p53-in-early-onset-gastric-cancers
#6
Fan Zhou, Yuanyuan Xu, Jiong Shi, Xing Lan, Xiaoping Zou, Lei Wang, Qin Huang
Early-onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E-cadherin, estrogen receptor α (ERα), estrogen receptor β (ERβ), and p53 in EOGC remains unclear, which was the focus of this study, to assess clinical significance of their expression in EOGC. The expression of E-cadherin, ERα, ERβ, and p53 in tumors and normal tissues from surgically resected EOGCs was assessed by immunohistochemistry (n = 139) and Western blot (n = 7) methods, respectively...
October 25, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27759456/morphological-characteristics-of-endometrium-in-patients-of-reproductive-age-with-viral-hepatitis-type-c
#7
T V Lisovskaya, G B Mal'gina, T A Perepletina, M A Chistyakov, I V Dan'kova, O A Melkozerova
AIM: The purpose of the study was to investigate the morphological features of endometrium in patients with viral hepatitis type C. MATERIALS AND METHODS: A morphological survey was conducted involving endometrium sections stained with hematoxylin and eosin and Van Gieson's picrofuchsin collected from 140 women of reproductive age, among them 70 patients were diagnosed with chronic hepatitis type C (CHC) infection with minimal (40 patients) and moderate activity (30 patients), and 70 women suffered from endometrial proliferative diseases without viral hepatitis (comparison group)...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27752129/exceptional-endocrine-profiles-characterise-the-meerkat-sex-status-and-reproductive-patterns
#8
Charli S Davies, Kendra N Smyth, Lydia K Greene, Debbie A Walsh, Jessica Mitchell, Tim Clutton-Brock, Christine M Drea
In vertebrates, reproductive endocrine concentrations are strongly differentiated by sex, with androgen biases typifying males and estrogen biases typifying females. These sex differences can be reduced in female-dominant species; however, even the most masculinised of females have less testosterone (T) than do conspecific males. To test if aggressively dominant, female meerkats (Suricata suricatta) may be hormonally masculinised, we measured serum androstenedione (A4), T and estradiol (E2) in both sexes and social classes, during both 'baseline' and reproductive events...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27739238/combinatory-estrogenic-effects-between-the-isoflavone-genistein-and-the-mycotoxins-zearalenone-and-alternariol-in-vitro
#9
Katharina Vejdovszky, Verena Schmidt, Benedikt Warth, Doris Marko
SCOPE: The isoflavone genistein, present in soy-based food and dietary supplements, is known for its estrogenic potential. In addition to phytoestrogens, food may also contain mycotoxins with estrogenic properties like zearalenone or alternariol, raising the question on potential combinatory effects of these xenoestrogens. METHODS AND RESULTS: Combinatory estrogenic effects of genistein with zeralenone or alternariol were studied in the human endometrial adenocarcinoma cell line Ishikawa as expression of alkaline phosphatase (AlP) activity...
October 14, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27721125/occurrence-distribution-and-risk-assessment-of-suspected-endocrine-disrupting-chemicals-in-surface-water-and-suspended-particulate-matter-of-yangtze-river-nanjing-section
#10
Yan-Hua Liu, Sheng-Hu Zhang, Gui-Xiang Ji, Sheng-Min Wu, Rui-Xin Guo, Jie Cheng, Zheng-Yu Yan, Jian-Qiu Chen
The occurrence and distribution of eight selected endocrine-disrupting chemicals were investigated in samples of surface water and suspended particulate matter (SPM) in Nanjing section of Yangtze River over a year (the flow period, the wet period and the dry period). All target compounds were detected at least once in surface water with 4-tert-butylphenol (4-TBP), nonyphenol (NP) and bisphenol A (BPA) as the dominant compounds, with concentrations in the range of 225-1121ng/L, 1.4-858ng/L and 1.7-563ng/L, respectively...
October 6, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27701872/does-hepatitis-b-virus-infection-cause-breast-cancer
#11
Vishnu Prasad Adhikari, Lin-Jie Lu, Ling-Quan Kong
Lifestyle and family history are two of the most important risk factors for breast cancer (BC). However, these risk factors cannot explain the differences in the incidence and early BC onset among Chinese females compared to their western counterparts. We propose in this hypothesis the potential mechanism of indirect oncogenesis of hepatitis B virus (HBV) in causing BC through its persistence as occult infection and continuous replication with long term subtle liver damage. Estrogen is mainly deactivated in the liver and long term necro-inflammatory damage to liver may result in persistent high level of estrogen, which is a dominant risk factor for BC...
September 12, 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27701432/influence-of-endogenous-and-exogenous-estrogenic-endocrine-on-intestinal-microbiota-in-zebrafish
#12
Yukun Liu, Yayun Yao, Huan Li, Fang Qiao, Junlin Wu, Zhen-Yu Du, Meiling Zhang
Gender is one of the factors influencing the intestinal microbial composition in mammals, but whether fish also have gender-specific intestinal microbial patterns remains unknown. In this decade, endocrine disrupting chemicals in surface and ground water of many areas and increasing observation of freshwater male fish displaying female sexual characteristics have been reported. Here we identified the difference in intestinal microbiota between male and female zebrafish, and revealed the influence of endocrine disrupting chemicals on zebrafish intestinal microbiota by using high-throughput sequencing...
2016: PloS One
https://www.readbyqxmd.com/read/27698617/unraveling-the-dynamics-of-the-human-vaginal-microbiome
#13
Kenetta L Nunn, Larry J Forney
Four Lactobacillus species, namely L. crispatus , L. iners, L. gasseri, and L. jensenii, commonly dominate the vaginal communities of most reproductive-age women. It is unclear why these particular species, and not others, are so prevalent. Historically, estrogen-induced glycogen production by the vaginal epithelium has been proffered as being key to supporting the proliferation of vaginal lactobacilli. However, the 'fly in the ointment' (that has been largely ignored) is that the species of Lactobacillus commonly found in the human vagina cannot directly metabolize glycogen...
September 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27692342/per-and-polyfluoroalkyl-substances-pfass-new-endocrine-disruptors-in-polar-bears-ursus-maritimus
#14
Kathrine Eggers Pedersen, Robert J Letcher, Christian Sonne, Rune Dietz, Bjarne Styrishave
Per- and polyfluoroalkyl substances (PFASs) are emerging in the Arctic and accumulate in brain tissues of East Greenland (EG) polar bears. In vitro studies have shown that PFASs might possess endocrine disrupting abilities and therefore the present study was conducted to investigate potential PFAS induced alterations in brain steroid concentrations. The concentrations of eleven steroid hormones were determined in eight brain regions from ten EG polar bears. Pregnenolone (PRE), the dominant progestagen, was found in mean concentrations of 5-47ng/g (ww) depending on brain region...
September 27, 2016: Environment International
https://www.readbyqxmd.com/read/27619945/winning-agonistic-encounters-increases-testosterone-and-androgen-receptor-expression-in-syrian-hamsters
#15
Catherine T Clinard, Abigail K Barnes, Samuel G Adler, Matthew A Cooper
Winning aggressive disputes is one of several experiences that can alter responses to future stressful events. We have previously tested dominant and subordinate male Syrian hamsters in a conditioned defeat model and found that dominant individuals show less change in behavior following social defeat stress compared to subordinates and controls, indicating a reduced conditioned defeat response. Resistance to the effects of social defeat in dominants is experience-dependent and requires the maintenance of dominance relationships for 14days...
September 9, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27614836/changes-in-fibroblast-growth-factor-9-mrna-in-granulosa-and-theca-cells-during-ovarian-follicular-growth-in-dairy-cattle
#16
L F Schütz, N B Schreiber, J N Gilliam, C Cortinovis, M L Totty, F Caloni, J R Evans, L J Spicer
Fibroblast growth factor 9 (FGF9) has been suggested to act as an antidifferentiation factor in cattle by reducing steroidogenesis and increasing cell proliferation in granulosa (GC) and theca (TC) cells. The objective of this study was to characterize FGF9 mRNA abundance in GC and TC during development of dominant follicles in dairy cattle. Estrous cycles of nonlactating dairy cattle were synchronized, and ovaries were collected on either d 3 to 4 (n = 8) or 5 to 6 (n = 8) postovulation for GC and TC RNA extraction from small (1-5 mm), medium (5...
September 7, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27580847/cell-type-and-region-specific-enhancement-of-adult-hippocampal-neurogenesis-by-daidzein-in-middle-aged-female-mice
#17
Jun Yamada, Jun Hatabe, Kaori Tankyo, Shozo Jinno
Adult hippocampal neurogenesis is associated with various brain functions, such as learning, memory, and emotion. Intriguingly, reduction in new cell production in the hippocampus in middle age may underlie some of the cognitive deficits. Among several factors that may affect adult hippocampal neurogenesis, estrogens have been suggested to be critically involved in the cognitive impairment of postmenopausal women. Phytoestrogens, such as daidzein and genistein, are expected to work as estrogen substitutes. In this study, we aimed to clarify the effects of daidzein on adult hippocampal neurogenesis using middle-aged (12-month-old) female mice...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27530666/gc-tof-ms-based-metabolomic-strategy-for-combined-toxicity-effects-of-deoxynivalenol-and-zearalenone-on-murine-macrophage-ana-1-cells
#18
Jian Ji, Pei Zhu, Fuwei Pi, Chao Sun, Hui Jiang, Jiadi Sun, Xiumei Wang, Yinzhi Zhang, Xiulan Sun
The actual health risk from exposure to combined mycotoxins is unknown, and few studies have focused on changes to cellular biological systems (e.g., metabolomics) caused by combined mycotoxic effects. To evaluate the combined mycotoxic effects of deoxynivalenol (DON) and zearalenone (ZEN) on the level of cellular biological systems, gas chromatographic, time-of-flight mass spectroscopy (GC-TOF/MS) of the complete murine macrophage ANA-1 cell metabolome was implemented in this study. Using optimized chromatography and mass spectrometry parameters, the metabolites detected by GC-TOF/MS were identified and processed using multivariate statistical analysis, including principal component analysis (PCA) and orthogonal projection on latent-structures discriminant analysis (OPLS-DA)...
September 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27457764/local-radiotherapy-alone-following-neoadjuvant-chemotherapy-and-surgery-in-combined-clinical-stage-ii-and-iii-breast-cancer
#19
Rohen White, Tamara Dinneen, Andreas Makris
PURPOSE: The outcomes and recurrence patterns for patients with combined clinical stage II and III breast cancer treated with local but not regional radiotherapy after neoadjuvant chemotherapy (NAC) and surgery are poorly documented. METHODS: We performed a retrospective review of a prospectively collected database comprised of breast cancer patients who received NAC at our institution. 172 patients met the specified criteria of receiving NAC, surgery inclusive of axillary nodal dissection and post-operative local (but not regional) radiotherapy...
July 26, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27451320/menopause-and-the-vaginal-microbiome
#20
REVIEW
Alicia L Muhleisen, Melissa M Herbst-Kralovetz
For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect on vulvovaginal atrophy, vaginal dryness, sexual health and overall quality of life. As molecular-based techniques have evolved, our understanding of the diversity and complexity of this bacterial community has expanded...
September 2016: Maturitas
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