keyword
https://read.qxmd.com/read/38118415/needle-biopsy-accelerates-pro-metastatic-changes-and-systemic-dissemination-in-breast-cancer-implications-for-mortality-by-surgery-delay
#21
JOURNAL ARTICLE
Hiroyasu Kameyama, Priya Dondapati, Reese Simmons, Macall Leslie, John F Langenheim, Yunguang Sun, Misung Yi, Aubrey Rottschaefer, Rashmi Pathak, Shreya Nuguri, Kar-Ming Fung, Shirng-Wern Tsaih, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka
Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis...
December 19, 2023: Cell reports medicine
https://read.qxmd.com/read/38107829/er-status-conversion-and-subsequent-treatment-an-assessment-of-negative-er-expression-detected-by-18f-fes-pet-in-metastatic-breast-cancer-patients-with-er-positive-primary-tumors
#22
JOURNAL ARTICLE
Shuhui You, Yizhao Xie, Mengjing Ji, Cheng Liu, Yannan Zhao, Chengcheng Gong, Shihui Hu, Yumeng Li, Zhongyi Yang, Biyun Wang
BACKGROUND: The 18F-fluoroestradiol positron emission tomography/computed tomography (18F-FES PET/CT) technique provides a convenient method to evaluate the overall estrogen receptor (ER) expression in metastatic breast cancer (MBC) patients. There are long debates on the characteristics and treatment strategy of patients with positive primary ER lesions but negative ER expression in metastatic disease. 18F-FES PET offers an opportunity to answer this question. OBJECTIVES: This study aimed to characterize the primary ER-positive patients with advanced-stage FES negativity and investigate the real-world treatment decisions made by physicians subsequently, and compare the efficacy between different regimens...
2023: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38078344/association-of-catechol-o-methyl-transferase-and-estrogen-receptors-polymorphism-with-severity-of-temporomandibular-disorder-in-iranian-patients
#23
JOURNAL ARTICLE
Hassan Roudgari, Shamsoulmolouk Najafi, Sheyda Khalilian, Zahra Ghafarzadeh, Aida Hahakzadeh, Sheida Behazin, Nafiseh Sheykhbahaei
BACKGROUND: There are many studies which strongly suggest that the pathophysiology of Temporomandibular joint Disorder (TMD) may also be influenced by genetic conditions. The current study was aimed to evaluate the hypothesis that the polymorphism of estrogen receptor genes, estrogen receptor 1 and 2 ( ESR1 and ESR2 ), and the gene Catechol-O-Methyl-Transferase ( COMT ) could be Predisposing factor for TMD. METHODS: In this case-control study, blood sample were taken from 100 TMD diagnosed patients based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 103 healthy individuals as the control group...
2023: Avicenna Journal of Medical Biotechnology
https://read.qxmd.com/read/38075258/stem-cells-implanted-with-nanofibrous-mats-for-injured-endometrial-regeneration-and-immune-microenvironment-remodeling
#24
JOURNAL ARTICLE
Lina Zhou, Hao Wang, Danpeng Shen, Jiangdong Xiang, Na Yu, Xiaoying He, Weiguang Zhao, Renjie Wang, Hongwei Wang, Hongliang Yu, Xueying Ding, Zhihong Liu, Yinyan He
Severe endometrial injury caused by invasive uterine operation and/or endometritis often results in intrauterine adhesions (IUAs), which are named Asherman's syndrome (AS), further leading to menstrual disorders, infertility and severe complications during pregnancy and delivery. IUAs or AS has been a challenging medical problem. Stem cells are a promising therapeutic modality for endometrial regeneration in patients with refractory AS. Here, we developed a new system of adipose-derived mesenchymal stem cells (ADMSCs) implantation on silk fibroin/polycaprolactone (SF/PCL) electrospun nanofibers (ADMSCs-SF/PCL) and used it in the damaged endometrium of a rat model...
December 2023: Materials today. Bio
https://read.qxmd.com/read/38045369/a-cellular-atlas-of-the-human-fallopian-tube-reveals-the-metamorphosis-of-secretory-epithelial-cells-during-the-menstrual-cycle-and-menopause
#25
M Weigert, Y Li, L Zhu, H Eckart, P Bajwa, R Krishnan, S Ackroyd, R R Lastra, A Bilecz, A Basu, E Lengyel, M Chen
UNLABELLED: The fallopian tube, connecting the uterus with the ovary, is a dynamic organ that undergoes cyclical changes and is the site of several diseases, including serous cancer. Here, we use single-cell technologies to construct a comprehensive cell map of healthy pre-menopausal fallopian tubes, capturing the impact of the menstrual cycle and menopause on different fallopian tube cells at the molecular level. The comparative analysis between pre- and post-menopausal fallopian tubes reveals substantial shifts in cellular abundance and gene expression patterns, highlighting the physiological changes associated with menopause...
November 23, 2023: medRxiv
https://read.qxmd.com/read/38044551/stratification-of-atherosclerosis-based-on-plasma-metabolic-states
#26
JOURNAL ARTICLE
Yuval Menaker, Inge van den Munckhof, Alice Scarpa, Katarzyna Placek, Rachel Brandes-Leibovitz, Yossef Glantzspiegel, Leo A B Joosten, Joost H W Rutten, Mihai G Netea, Irit Gat-Viks, Niels P Riksen
CONTEXT: Atherosclerosis is a dominant cause of cardiovascular disease (CVD), including myocardial infarction and stroke. OBJECTIVE: To investigate metabolic states that are associated with the development of atherosclerosis. METHODS: Cross-sectional cohort study at a university hospital in the Netherlands. A total of 302 adult subjects with a body mass index (BMI) ≥ 27 kg/m2 were included. We integrated plasma metabolomics with clinical metadata to quantify the "atherogenic state" of each individual, providing a continuous spectrum of atherogenic states that ranges between nonatherogenic states to highly atherogenic states...
December 4, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38042915/clonal-heterogeneity-in-er-breast-cancer-reveals-the-proteasome-and-pkc-as-potential-therapeutic-targets
#27
JOURNAL ARTICLE
Lukas Beumers, Efstathios-Iason Vlachavas, Simone Borgoni, Luisa Schwarzmüller, Luca Penso-Dolfin, Birgitta E Michels, Emre Sofyali, Sara Burmester, Daniela Heiss, Heike Wilhelm, Yosef Yarden, Dominic Helm, Rainer Will, Angela Goncalves, Stefan Wiemann
Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies. By isolating single clones from the resistant cell pools and characterizing replicates of individual clones we observed inter- (between cell lines) and intra-tumor (between different clones from the same cell line) heterogeneity...
December 2, 2023: NPJ Breast Cancer
https://read.qxmd.com/read/37990081/genetic-evidence-for-differential-functions-of-figla-and-nobox-in-zebrafish-ovarian-differentiation-and-folliculogenesis
#28
JOURNAL ARTICLE
Kun Wu, Yue Zhai, Mingming Qin, Cheng Zhao, Nana Ai, Jianguo He, Wei Ge
FIGLA and NOBOX are important oocyte-specific transcription factors. Both figla-/- and nobox-/- mutants showed all-male phenotype in zebrafish due to increased dominance of the male-promoting pathway. The early diversion towards males in these mutants has precluded analysis of their roles in folliculogenesis. In this study, we attenuated the male-promoting pathway by deleting dmrt1, a key male-promoting gene, in figla-/- and nobox-/- fish, which allows a sufficient display of defects in folliculogenesis...
November 21, 2023: Communications Biology
https://read.qxmd.com/read/37986961/transcriptomic-profiling-reveals-claudin-18-2-as-a-diagnostic-biomarker-of-m%C3%A3-n%C3%A3-trier-s-disease-and-the-role-of-hedgehog-signaling-in-pathogenesis
#29
Miyoung Shin, Tryston Gabriel, Robert J Coffey, Won Jae Huh
Both Ménétrier's disease (MD) and juvenile polyposis syndrome (JPS) are rare premalignant conditions that can lead to gastric cancer development. MD is an acquired disease without known causative mutations. MD patients are characterized by an increased expression of EGF receptor (EGFR) ligand and transforming growth factor alpha (TGF-α) in the stomach. JPS is inherited in an autosomal dominant pattern and is caused by BMPR1A or SMAD4 mutations. It is characterized by multiple polyps throughout the gastrointestinal tract along with certain SMAD4 mutations that can result in gastric polyposis...
November 6, 2023: bioRxiv
https://read.qxmd.com/read/37984148/polyfluoroalkyl-phosphate-esters-paps-as-pfas-substitutes-and-precursors-an-overview
#30
REVIEW
Junjie Ao, Weifeng Tang, Xiaoning Liu, Yan Ao, Qianlong Zhang, Jun Zhang
Polyfluoroalkyl phosphate esters (PAPs) are emerging substitutes for legacy per- and polyfluoroalkyl substances (PFAS), which are widely applied in consumer products and closely related to people's daily lives. Increasing concern has been raised about the safety of PAPs due to their metabolism into perfluorooctanoic acid (PFOA) and other perfluorinated carboxylates (PFCAs) in vivo. This review summarizes the current knowledge on PAPs and highlights the knowledge gaps. PAPs dominated the PFAS profiles in wastewater, sludge, household dust, food-contact materials, paper products, paints, and cosmetics...
November 17, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/37956933/assessment-of-bioactive-chemicals-in-wastewater-effluents-and-surface-waters-using-in-vitro-bioassays-in-the-nakdong-river-basin-korea
#31
JOURNAL ARTICLE
Yegyun Choi, Chang-Dong Seo, Woorim Lee, Heejong Son, Yunho Lee
Organic micropollutants present in effluents of wastewater treatment plants (WWTPs) can negatively affect the quality of receiving waters or drinking water sources. The present work monitored the concentration of bioactive chemicals using a battery of in vitro bioassays in 14 WWTP effluents, 2 effluent-dominant streams, and 5 river waters in the Nakdong River basin, Korea, for a two-year period. The WWTP effluents showed AR/ERα/TRβ (androgen/estrogen/thyroid hormone) activities at a few to tens ng/L, PAH/PPARγ/p53 (polycyclic-aromatic-hydrocarbon/lipid metabolism/genotoxicity) activities at hundreds ng/L, and PXR/Nrf2 (xenobiotic metabolism/oxidative stress) activities at tens to hundreds μg/L as bioanalytical equivalent concentrations...
November 11, 2023: Chemosphere
https://read.qxmd.com/read/37942127/sex-steroid-modulators-and-the-development-of-buschke-lowenstein-tumor-a-case-report-of-an-immunocompetent-patient
#32
Paige Stratton, Vithal Vernenkar, Aeryn J Fulton, Varun Soti
Buschke-Lowenstein tumors (BLTs) are benign dermatologic manifestations of human papillomavirus (HPV). They originate from longstanding condylomata in individuals with compromised immune systems. In this case report, we present a 68-year-old immunocompetent female with HPV condylomata that had transitioned to a large, fungated BLT in her right groin. The patient's immunocompetency was determined by the absence of diabetes, corticosteroid therapy, organ transplant, cytotoxic therapy, or any known primary or other secondary immunodeficiencies...
November 2023: Curēus
https://read.qxmd.com/read/37921212/design-and-pharmacophore-study-of-triazole-analogues-as-aromatase-inhibitors
#33
JOURNAL ARTICLE
Laxmi Banjare
BACKGROUND: In the current scenario, breast cancer is measured as one of the most dangerous health issues. An effective therapeutic class of drugs known as aromatase inhibitors is dominant against estrogen receptor-positive breast cancer. However, there is an urgent need to create target-specific AIs with better anti-breast cancer profiles due to the increased toxicity and adverse effects related to currently existing anti-breast cancer drugs. OBJECTIVES: In the present study, we have designed 100 novel tiazole analogues as aromatase inhibitors and their pharmacophoric features are explored...
November 2, 2023: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/37880965/cribriform-morular-thyroid-carcinoma-a-rare-case-and-associated-uncommon-features
#34
JOURNAL ARTICLE
Ajit Sahu, Mohammed Shahin, Priyansh Jain, Mahesh Sultania, Pavithra Ayyanar
Cribriform morular thyroid carcinoma has been added under tumors of uncertain histogenesis. Its peculiar clinical, histomorphological pattern, and immunohistochemical profile have been proved different from papillary thyroid carcinoma. A 59-year-old female patient had a lesion in the left lobe of the thyroid. Fine needle aspiration cytology was reported as medullary thyroid carcinoma. The total thyroidectomy specimen showed a predominantly solid tumor of size 9.5 cm in the left lobe. Microscopy showed a mixed growth pattern with the dominant cribriform and solid morular area...
October 25, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/37866702/alzheimer-s-disease-the-role-of-proteins-in-formation-mechanisms-and-new-therapeutic-approaches
#35
REVIEW
Amirreza Gholami
Alzheimer's disease (AD) is a progressive neurological disorder that affects the central nervous system (CNS), leading to memory and cognitive decline. In AD, the brain experiences three main structural changes: a significant decrease in the quantity of neurons, the development of neurofibrillary tangles (NFT) composed of hyperphosphorylated tau protein, and the formation of amyloid beta (Aβ) or senile plaques, which are protein deposits found outside cells and surrounded by dystrophic neurites. Genetic studies have identified four genes associated with autosomal dominant or familial early-onset AD (FAD): amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2), and apolipoprotein E (ApoE)...
October 20, 2023: Neuroscience Letters
https://read.qxmd.com/read/37834026/resveratrol-and-3-3-diindolylmethane-differentially-regulate-aryl-hydrocarbon-receptor-and-estrogen-receptor-alpha-activity-through-multiple-transcriptomic-targets-in-mcf-7-human-breast-cancer-cells
#36
JOURNAL ARTICLE
Siddhartha Das, Venkata S Somisetty, Stine M Ulven, Jason Matthews
Inhibitory crosstalk between estrogen receptor alpha (ERα) and aryl hydrocarbon receptor (AHR) regulates 17β-estradiol (E2)-dependent breast cancer cell signaling. ERα and AHR are transcription factors activated by E2 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), respectively. Dietary ligands resveratrol (RES) and 3,3'diindolylmethane (DIM) also activate ERα while only DIM activates AHR and RES represses it. DIM and RES are reported to have anti-cancer and anti-inflammatory properties...
September 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37810650/dual-activation-of-peroxymonosulfate-using-mnfe-2-o-4-g-c-3-n-4-and-visible-light-for-the-efficient-degradation-of-steroid-hormones-performance-mechanisms-and-environmental-impacts
#37
JOURNAL ARTICLE
Kitipong Poomipuen, Chainarong Sakulthaew, Chanat Chokejaroenrat, Athaphon Angkaew, Kanidrawee Techauay, Thapanee Poompoung, Kanokwan Teingtham, Piyaporn Phansak, Piyangkun Lueangjaroenkit, Daniel D Snow
Single activation of peroxymonosulfate (PMS) in a homogeneous system is sometimes insufficient for producing reactive oxygen species (ROS) for water treatment applications. In this work, manganese spinel ferrite and graphitic carbon nitride (MnFe2 O4 /g-C3 N4 ; MnF) were successfully used as an activator for PMS under visible light irradiation to remove the four-most-detected-hormone-contaminated water under different environmental conditions. The incorporation of g-C3 N4 in the nanocomposites led to material enhancements, including increased crystallinity, reduced particle agglomeration, amplified magnetism, improved recyclability, and increased active surface area, thereby facilitating the PMS activation and electron transfer processes...
October 3, 2023: ACS Omega
https://read.qxmd.com/read/37808391/modest-effects-of-osteoclast-specific-er%C3%AE-deletion-after-skeletal-maturity
#38
JOURNAL ARTICLE
Madison L Doolittle, Brittany A Eckhardt, Stephanie J Vos, Sarah Grain, Jennifer L Rowsey, Ming Ruan, Dominik Saul, Joshua N Farr, Megan M Weivoda, Sundeep Khosla, David G Monroe
Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for skeletal estrogen action. Previous studies using either global or cell-specific ERα deletion provided important insights, but each of these approaches had limitations. Specifically, either high circulating sex steroid levels in global ERα knockout mice or the effects of deletion of ERα during growth and development in constitutive cell-specific knockout mice have made it difficult to clearly define the role of ERα in specific cell types in the adult skeleton...
October 2023: JBMR Plus
https://read.qxmd.com/read/37802008/socioeconomic-and-seasonal-effects-on-spatiotemporal-trends-in-estrogen-occurrence-and-ecological-risk-within-a-river-across-low-urbanized-and-high-husbandry-landscapes
#39
JOURNAL ARTICLE
Yun Li, Jing Wang, Chunye Lin, Aihua Wang, Mengchang He, Xitao Liu, Wei Ouyang
Estrogen pollution is a persistent issue in rivers. This study investigated the occurrence, spatiotemporal variation mechanisms, sources, and ecological risks of estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethinylestradiol (EE2), diethylstilbestrol (DES), and bisphenol-A (BPA) in the waters of the Zijiang River, a tributary of the middle Yangtze River. The results revealed elevated detection frequencies and estrogen concentrations in the dry season compared to the wet season, mainly due to the precipitation dilution effect...
October 2, 2023: Environment International
https://read.qxmd.com/read/37793149/emerging-evidence-on-the-role-of-breast-microbiota-on-the-development-of-breast-cancer-in-high-risk-patients
#40
JOURNAL ARTICLE
Silvia Actis, Massimiliano Cazzaniga, Valentina Elisabetta Bounous, Marta D'Alonzo, Roberta Rosso, Francesca Accomasso, Carola Minella, Nicoletta Biglia
Cancer is a multi-factorial disease, and the etiology of breast cancer is due to a combination of both genetic and environmental factors. Breast tissue shows a unique microbiota, Proteobacteria and Firmicutes are the most abundant bacteria in breast tissue, and several studies have shown that the microbiota of healthy breast differs from that of breast cancer. Breast microbiota appears to be correlated with different characteristics of the tumor, and prognostic clinicopathologic features. It also appears that there are subtle differences between the microbial profiles of the healthy control and high-risk patients...
October 4, 2023: Carcinogenesis
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