Tadayoshi Hashimoto, Yoshiaki Nakamura, Saori Mishima, Izuma Nakayama, Daisuke Kotani, Akihito Kawazoe, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Naoko Iida, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Michiko Nagamine, Naoya Sakamoto, Takeshi Kuwata, Takayuki Yoshino, Kohei Shitara
Advanced gastric and gastroesophageal junction cancers (GC/GEJCs) harbor diverse molecular signatures, highlighting the need for intricate evaluations to identify potential therapeutic targets. Although whole-transcriptome sequencing (WTS) has emerged as a useful tool for understanding these molecular intricacies, its clinical implications have yet to be fully elucidated. This study evaluated the correlation between immunohistochemistry (IHC) and WTS, compared their clinical significance, and identified potential therapeutic targets undetectable through IHC alone...
March 1, 2024: Cancer Science