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Silent reflux

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https://www.readbyqxmd.com/read/28433970/simultaneous-transient-global-amnesia-and-right-mca-stroke-after-valsalva-manoeuvre
#1
Ariel Fernando Mariaca, Jose Manuel Valdueza, Christian Gaebel, Manuel Gomez-Choco
A 61-year-old man suffered an episode of transient confusion and anterograde amnesia after a Valsalva-related manoeuvre. The MRI diffusion weighted imaging (DWI) sequences showed a left hippocampal and two right parietal lesions that were deemed as acute. The MR angiography disclosed a high-grade stenosis in the right middle cerebral artery as was described by a transcranial colour-coded ultrasound as well. Ultrasound investigation of the jugular veins showed a right jugular venous reflux after a Valsalva manoeuvre...
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28258461/gastroesophageal-reflux-and-idiopathic-pulmonary-fibrosis
#2
Marco E Allaix, Fabrizio Rebecchi, Mario Morino, Francisco Schlottmann, Marco G Patti
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown origin that affects about 40,000 new patients every year in the USA. Albeit the disease is labelled as idiopathic, it is thought that pathologic reflux, often silent, plays a role in its pathogenesis through a process of microaspiration of gastric contents. AIMS: The aim of this study was to review the available evidence linking reflux to IPF, and to study the effect of medical and surgical therapy on the natural history of this disease...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28151751/adam-eve-and-the-reflux-enigma-age-and-sex-differences-across-the-gastro-oesophageal-reflux-spectrum
#3
Christine Royston, Karna D Bardhan
INTRODUCTION: We present demographic differences across the gastro-oesophageal reflux disease (GORD) spectrum in a UK District General Hospital. PATIENTS AND METHODS: Data were prospectively collected over 37 years. At endoscopy patients were categorized as: erosive oesophagitis (EO), Barrett's oesophagus (BO) or nonerosive reflux disease (NER). Analysis 1: comparison of EO, BO and NER 1977-2001 when the database for GORD without BO closed. Analysis 2: demographic differences in oesophageal adenocarcinoma (OAC) in total BO population diagnosed 1977-2011...
February 1, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096521/decreased-esophageal-sensitivity-to-acid-in-morbidly-obese-patients-a-cause-for-concern
#4
Vicente Ortiz, Diego Alvarez-Sotomayor, Esteban Sáez-González, Francia Carolina Díaz-Jaime, Marisa Iborra, Julio Ponce, Vicente Garrigues
Background/Aims: To evaluate esophageal sensitivity to acid between morbidly obese (MO) patients and non-MO controls with abnormal esophageal acid exposure. Methods: We conducted a cross-sectional study of 58 patients: 30 MO (cases) and 28 non-MO (controls). Esophageal symptoms and esophageal sensitivity to 0.1 M hydrochloric acid solution (Bernstein test) were compared between MO and non-MO patients with a prior diagnosis of abnormal esophageal acid exposure. Results: MO patients were less symptomatic than non-MO controls (14% vs 96%; odds ratio [OR], 0...
January 20, 2017: Gut and Liver
https://www.readbyqxmd.com/read/27994270/esophageal-transit-scintigraphy-in-systemic-sclerosis
#5
REVIEW
Marek Chojnowski, Małgorzata Kobylecka, Marzena Olesińska
Systemic sclerosis is a rare connective tissue disease, distinctive features of which are fibrosis and microangiopathy. The esophagus is one of the most commonly involved internal organs. Most patients experience dysphagia, difficulties in swallowing and gastro-esophageal reflux. However, in up to one third of cases, the initial onset of esophageal disease may be clinically silent. There are several diagnostic modalities available for assessing both morphological and functional abnormalities of the esophagus...
2016: Reumatologia
https://www.readbyqxmd.com/read/27613994/ten-years-of-chronic-cough-in-a-64-year-old-man-with-multiple-pulmonary%C3%A2-nodules
#6
Whittney A Warren, Scott S Dalane, Bryce D Warren, Paul G Peterson, Rodney D Boyum, William Kelly
A 64-year-old male former smoker with a history of prostate cancer presented to our pulmonary clinic, complaining of nonproductive cough for 10 years. Prior evaluation included treatment for upper airway cough syndrome and gastroesophageal reflux, stopping angiotensin-converting enzyme inhibitor, and initiation of inhaled β-agonists. Esophageal pH monitoring indicated silent reflux, and proton pump inhibitor therapy was started. He continued to cough and complain of dyspnea. Physical examination produced unremarkable results, with no evidence of lymphadenopathy...
September 2016: Chest
https://www.readbyqxmd.com/read/27516725/clinical-utility-of-bronchoalveolar-lavage-pepsin-in-diagnosis-of-gastroesophageal-reflux-among-wheezy-infants
#7
Ahmed Fathi Abdallah, Tarek El-Desoky, Khalid Fathi, Wagdy Fawzi Elkashef, Ahmed Zaki
Background. There is no gold standard test for diagnosis of gastroesophageal reflux disease (GERD) associated infantile wheezing. Objectives. To evaluate the value of bronchoalveolar lavage (BAL) pepsin assay in diagnosis of GERD in wheezy infants. Methods. Fifty-two wheezy infants were evaluated for GERD using esophageal combined impedance-pH (MII-pH) monitoring, esophagogastroduodenoscopy with esophageal biopsies, and BAL pepsin. Tracheobronchial aspirates from 10 healthy infants planned for surgery without history of respiratory problems were examined for pepsin...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27110898/idiopathic-pulmonary-fibrosis-novel-concepts-of-proton-pump-inhibitors-as-antifibrotic-drugs
#8
Yohannes T Ghebre, Ganesh Raghu
The prevalence of abnormal acid gastroesophageal reflux (GER) is higher in patients with idiopathic pulmonary fibrosis (IPF) than in matched control subjects. Several studies demonstrated that more than one-third of patients with IPF have abnormal esophageal acid exposures. In addition, many of these studies indicate that the majority of patients with IPF have silent reflux with no symptoms of GER. Findings of abnormal reflux persist in a large proportion of patients with IPF placed on antacid therapy such as proton pump inhibitors (PPIs)...
June 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27050437/association-between-obstructive-sleep-apnea-and-community-acquired-pneumonia
#9
Eusebi Chiner, Mónica Llombart, Joan Valls, Esther Pastor, José N Sancho-Chust, Ada Luz Andreu, Manuel Sánchez-de-la-Torre, Ferran Barbé
BACKGROUND: We hypothesized that obstructive sleep apnea (OSA) can predispose individuals to lower airway infections and community-acquired pneumonia (CAP) due to upper airway microaspiration. This study evaluated the association between OSA and CAP. METHODS: We performed a case-control study that included 82 patients with CAP and 41 patients with other infections (control group). The controls were matched according to age, sex and body mass index (BMI). A respiratory polygraph (RP) was performed upon admission for patients in both groups...
2016: PloS One
https://www.readbyqxmd.com/read/26557556/prevalence-and-spectrum-of-gastro-esophageal-reflux-disease-in-bronchial-asthma
#10
Sahoo Rameschandra, Vishak Acharya, Kunal, Tantry Vishwanath, Anand Ramkrishna, Preetam Acharya
BACKGROUND: There exists a complex interplay between asthma and gastroesophageal reflux disease. Both these diseases are known to aggravate each other and amelioration of one is necessary for the control of the other. There is a paucity of studies in Indian population on this subject. AIM: To evaluate the clinical features and the endoscopic findings of the upper gastrointestinal tract in patients with bronchial asthma. MATERIALS AND METHODS: Study was conducted at KMC group of hospitals, Mangalore in the Department of chest medicine in association with Department of gastroenterology...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26362482/the-utility-of-bronchoalveolar-lavage-findings-in-the-diagnosis-of-eosinophilic-esophagitis-in-children
#11
Robert J Yawn, Mohammad Fazili, Gwen Provo-Bell, Christopher T Wootten
INTRODUCTION: Bronchoalveolar lavage (BAL)-nucleated cell counts and the lipid-laden alveolar macrophage index (LLMI) have been investigated in predicting chronic aspiration as well as reflux esophagitis with variable results. To date, BAL neutrophil percentages and the LLMI have not been described in patients with eosinophilic esophagitis (EoE). OBJECTIVES: To evaluate BAL neutrophil percentages and LLMI levels in patients with EoE and compare these levels in patients with aerodigestive concerns without biopsy-proven EoE...
November 2015: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/26238826/pepsin-a-silent-biomarker-for-reflux-aspiration-or-an-active-player-in-extra-esophageal-mucosal-injury
#12
EDITORIAL
Peter J Kahrilas, Leila Kia
No abstract text is available yet for this article.
August 2015: Chest
https://www.readbyqxmd.com/read/25988748/endoscopic-surveillance-for-congenital-diaphragmatic-hernia-unexpected-prevalence-of-silent-esophagitis
#13
Anna Morandi, Francesco Macchini, Andrea Zanini, Noemi Pasqua, Giorgio Farris, Lorena Canazza, Valerio Gentilino, Antonio Di Cesare, Ernesto Leva
Introduction Gastroesophageal reflux disease (GERD) is a frequent comorbidity after congenital diaphragmatic hernia (CDH) repair. Our aim was to evaluate the clinical and endoscopic prevalence of esophagitis in a long-term follow-up of CDH patients. Materials and Methods Patients operated on for posterolateral CDH and undergoing general anesthesia for concomitant pathologies between January and October 2013 were included in the study. GERD was investigated both clinically (Manterola questionnaire) and endoscopically...
June 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25768949/use-of-fully-covered-self-expandable-metal-stents-for-benign-esophageal-disorders-in-children
#14
Bettina Lange, Rainer Kubiak, Lucas M Wessel, Georg Kähler
PURPOSE: There is a lack of experience with fully covered self-expandable metal stents (SEMSs) for benign esophageal disorders in children. PATIENTS AND METHODS: Eleven children (six boys, five girls) with a median age of 30.5 months (range, 1 month-11 years) who underwent treatment with SEMSs for a benign esophageal condition between February 2006 and January 2014 were recruited to this retrospective study. Etiologies included esophageal atresia with postoperative stricture (n=4), recurrent fistula (n=1), and/or anastomotic leak (n=1), as well as iatrogenic perforation of the esophagus following endoscopy (n=4) or laparoscopic fundoplication (n=1)...
April 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/25711289/exposure-to-non-steroid-anti-inflammatory-drugs-nsaids-and-suppressing-hydrogen-sulfide-synthesis-leads-to-altered-structure-and-impaired-function-of-the-oesophagus-and-oesophagogastric-junction
#15
Oksana Zayachkivska, Nazar Bula, Dzvinka Khyrivska, Elena Gavrilyuk, John L Wallace
INTRODUCTION: The non-steroid anti-inflammatory drugs (NSAIDs) are among the drugs that can commonly cause injury in the esophagus, such as non-reflux oesophagitis, with important clinical consequences. This injury may be 'silent' and therefore often overlooked. Recently, we established that hydrogen sulfide (H2S) is a critical mediator of esophageal mucosal protection and repair. The aim of the study was to determine the effect of naproxen, the most commonly used NSAIDs, on the oesophagus and oesophagogastric junction and its relation with suppression or stimulation of endogenous H2S synthesis during naproxen-induced oesophageal injury...
June 2015: Inflammopharmacology
https://www.readbyqxmd.com/read/25458778/the-prevalence-of-oesophagitis-in-silent-gastro-oesophageal-reflux-disease-higher-than-expected
#16
COMMENT
Frank Zerbib
No abstract text is available yet for this article.
January 2015: Digestive and Liver Disease
https://www.readbyqxmd.com/read/25360300/prevalence-of-gastro-oesophageal-reflux-disease-with-upper-gastrointestinal-symptoms-without-heartburn-and-regurgitation
#17
Nimish Vakil, Börje Wernersson, Lis Ohlsson, John Dent
BACKGROUND: Symptomatically 'silent' gastro-oesophageal reflux disease (GORD) may be underdiagnosed. OBJECTIVE: To determine the prevalence of untreated GORD without heartburn and/or regurgitation in primary care. METHODS: Patients were included if they had frequent upper gastrointestinal symptoms and had not taken a proton pump inhibitor in the previous 2 months (Diamond study: NCT00291746). GORD was diagnosed based on the presence of reflux oesophagitis, pathological oesophageal acid exposure, and/or a positive symptom-acid association probability...
June 2014: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/25308612/predictive-factors-of-silent-reflux-in-subjects-with-erosive-esophagitis
#18
Wei-Yi Lei, Hao-Chun Yu, Shu-Hui Wen, Tso-Tsai Liu, Chih-Hsun Yi, Chia-Chi Wang, Ching-Sheng Hsu, Chien-Hwa Chen, Chien-Lin Chen, Fabio Pace
BACKGROUND: Asymptomatic erosive esophagitis by definition is a condition lacking any reflux symptom. AIMS: We aimed to investigate the prevalence of asymptomatic erosive esophagitis in a general population undergoing periodic health checkup. METHODS: Consecutive subjects undergoing a medical checkup were enrolled for evaluation of reflux disease with upper endoscopy and a validated reflux questionnaire. The presence and severity of erosive esophagitis were evaluated...
January 2015: Digestive and Liver Disease
https://www.readbyqxmd.com/read/24968886/prevalence-characteristics-and-outcome-of-non-cardiac-chest-pain-and-elevated-copeptin-levels
#19
RANDOMIZED CONTROLLED TRIAL
Fabio Stallone, Raphael Twerenbold, Karin Wildi, Tobias Reichlin, Maria Rubini Gimenez, Philip Haaf, Nicole Fuechslin, Petra Hillinger, Cedric Jaeger, Philipp Kreutzinger, Christian Puelacher, Milos Radosavac, Zoraida Moreno Weidmann, Berit Moehring, Ursina Honegger, Carmela Schumacher, Kris Denhaerynck, Christiane Arnold, Roland Bingisser, Jörn Ole Vollert, Stefan Osswald, Christian Mueller
OBJECTIVE: Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. METHODS: A total of 984 consecutive patients with non-cardiac chest pain were selected from a prospective multicentre study of acute chest pain patients presenting to the emergency department...
November 2014: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/24916018/epistaxis-caused-by-a-dural-av-fistula-at-the-cribriform-plate
#20
J Marc C van Dijk, Astrid G W Korsten-Meijer, Aryan Mazuri
OBJECTIVES/HYPOTHESIS: A dural arteriovenous fistula (DAVF) with cortical venous reflux (CVR) is a dangerous neurovascular entity. A DAVF at the cribriform plate is typically silent until its inevitable presentation with intracranial hemorrhage. CASE SUMMARY: A 67-year-old male presented with severe epistaxis. Following unsuccessful conventional measures and a surgical exploration, a catheter angiography showed a DAVF at the cribriform plate, with its nidus extending into the nasal cavity...
November 2014: Laryngoscope
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