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Silent reflux

Whittney A Warren, Scott S Dalane, Bryce D Warren, Paul G Peterson, Rodney D Boyum, William Kelly
A 64-year-old male former smoker with a history of prostate cancer presented to our pulmonary clinic, complaining of nonproductive cough for 10 years. Prior evaluation included treatment for upper airway cough syndrome and gastroesophageal reflux, stopping angiotensin-converting enzyme inhibitor, and initiation of inhaled β-agonists. Esophageal pH monitoring indicated silent reflux, and proton pump inhibitor therapy was started. He continued to cough and complain of dyspnea. Physical examination produced unremarkable results, with no evidence of lymphadenopathy...
September 2016: Chest
Ahmed Fathi Abdallah, Tarek El-Desoky, Khalid Fathi, Wagdy Fawzi Elkashef, Ahmed Zaki
Background. There is no gold standard test for diagnosis of gastroesophageal reflux disease (GERD) associated infantile wheezing. Objectives. To evaluate the value of bronchoalveolar lavage (BAL) pepsin assay in diagnosis of GERD in wheezy infants. Methods. Fifty-two wheezy infants were evaluated for GERD using esophageal combined impedance-pH (MII-pH) monitoring, esophagogastroduodenoscopy with esophageal biopsies, and BAL pepsin. Tracheobronchial aspirates from 10 healthy infants planned for surgery without history of respiratory problems were examined for pepsin...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Yohannes T Ghebre, Ganesh Raghu
The prevalence of abnormal acid gastroesophageal reflux (GER) is higher in patients with idiopathic pulmonary fibrosis (IPF) than in matched control subjects. Several studies demonstrated that more than one-third of patients with IPF have abnormal esophageal acid exposures. In addition, many of these studies indicate that the majority of patients with IPF have silent reflux with no symptoms of GER. Findings of abnormal reflux persist in a large proportion of patients with IPF placed on antacid therapy such as proton pump inhibitors (PPIs)...
June 15, 2016: American Journal of Respiratory and Critical Care Medicine
Eusebi Chiner, Mónica Llombart, Joan Valls, Esther Pastor, José N Sancho-Chust, Ada Luz Andreu, Manuel Sánchez-de-la-Torre, Ferran Barbé
BACKGROUND: We hypothesized that obstructive sleep apnea (OSA) can predispose individuals to lower airway infections and community-acquired pneumonia (CAP) due to upper airway microaspiration. This study evaluated the association between OSA and CAP. METHODS: We performed a case-control study that included 82 patients with CAP and 41 patients with other infections (control group). The controls were matched according to age, sex and body mass index (BMI). A respiratory polygraph (RP) was performed upon admission for patients in both groups...
2016: PloS One
Sahoo Rameschandra, Vishak Acharya, Kunal, Tantry Vishwanath, Anand Ramkrishna, Preetam Acharya
BACKGROUND: There exists a complex interplay between asthma and gastroesophageal reflux disease. Both these diseases are known to aggravate each other and amelioration of one is necessary for the control of the other. There is a paucity of studies in Indian population on this subject. AIM: To evaluate the clinical features and the endoscopic findings of the upper gastrointestinal tract in patients with bronchial asthma. MATERIALS AND METHODS: Study was conducted at KMC group of hospitals, Mangalore in the Department of chest medicine in association with Department of gastroenterology...
October 2015: Journal of Clinical and Diagnostic Research: JCDR
Robert J Yawn, Mohammad Fazili, Gwen Provo-Bell, Christopher T Wootten
INTRODUCTION: Bronchoalveolar lavage (BAL)-nucleated cell counts and the lipid-laden alveolar macrophage index (LLMI) have been investigated in predicting chronic aspiration as well as reflux esophagitis with variable results. To date, BAL neutrophil percentages and the LLMI have not been described in patients with eosinophilic esophagitis (EoE). OBJECTIVES: To evaluate BAL neutrophil percentages and LLMI levels in patients with EoE and compare these levels in patients with aerodigestive concerns without biopsy-proven EoE...
November 2015: International Journal of Pediatric Otorhinolaryngology
Peter J Kahrilas, Leila Kia
No abstract text is available yet for this article.
August 2015: Chest
Anna Morandi, Francesco Macchini, Andrea Zanini, Noemi Pasqua, Giorgio Farris, Lorena Canazza, Valerio Gentilino, Antonio Di Cesare, Ernesto Leva
Introduction Gastroesophageal reflux disease (GERD) is a frequent comorbidity after congenital diaphragmatic hernia (CDH) repair. Our aim was to evaluate the clinical and endoscopic prevalence of esophagitis in a long-term follow-up of CDH patients. Materials and Methods Patients operated on for posterolateral CDH and undergoing general anesthesia for concomitant pathologies between January and October 2013 were included in the study. GERD was investigated both clinically (Manterola questionnaire) and endoscopically...
June 2016: European Journal of Pediatric Surgery
Bettina Lange, Rainer Kubiak, Lucas M Wessel, Georg Kähler
PURPOSE: There is a lack of experience with fully covered self-expandable metal stents (SEMSs) for benign esophageal disorders in children. PATIENTS AND METHODS: Eleven children (six boys, five girls) with a median age of 30.5 months (range, 1 month-11 years) who underwent treatment with SEMSs for a benign esophageal condition between February 2006 and January 2014 were recruited to this retrospective study. Etiologies included esophageal atresia with postoperative stricture (n=4), recurrent fistula (n=1), and/or anastomotic leak (n=1), as well as iatrogenic perforation of the esophagus following endoscopy (n=4) or laparoscopic fundoplication (n=1)...
April 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Oksana Zayachkivska, Nazar Bula, Dzvinka Khyrivska, Elena Gavrilyuk, John L Wallace
INTRODUCTION: The non-steroid anti-inflammatory drugs (NSAIDs) are among the drugs that can commonly cause injury in the esophagus, such as non-reflux oesophagitis, with important clinical consequences. This injury may be 'silent' and therefore often overlooked. Recently, we established that hydrogen sulfide (H2S) is a critical mediator of esophageal mucosal protection and repair. The aim of the study was to determine the effect of naproxen, the most commonly used NSAIDs, on the oesophagus and oesophagogastric junction and its relation with suppression or stimulation of endogenous H2S synthesis during naproxen-induced oesophageal injury...
June 2015: Inflammopharmacology
Frank Zerbib
No abstract text is available yet for this article.
January 2015: Digestive and Liver Disease
Nimish Vakil, Börje Wernersson, Lis Ohlsson, John Dent
BACKGROUND: Symptomatically 'silent' gastro-oesophageal reflux disease (GORD) may be underdiagnosed. OBJECTIVE: To determine the prevalence of untreated GORD without heartburn and/or regurgitation in primary care. METHODS: Patients were included if they had frequent upper gastrointestinal symptoms and had not taken a proton pump inhibitor in the previous 2 months (Diamond study: NCT00291746). GORD was diagnosed based on the presence of reflux oesophagitis, pathological oesophageal acid exposure, and/or a positive symptom-acid association probability...
June 2014: United European Gastroenterology Journal
Wei-Yi Lei, Hao-Chun Yu, Shu-Hui Wen, Tso-Tsai Liu, Chih-Hsun Yi, Chia-Chi Wang, Ching-Sheng Hsu, Chien-Hwa Chen, Chien-Lin Chen, Fabio Pace
BACKGROUND: Asymptomatic erosive esophagitis by definition is a condition lacking any reflux symptom. AIMS: We aimed to investigate the prevalence of asymptomatic erosive esophagitis in a general population undergoing periodic health checkup. METHODS: Consecutive subjects undergoing a medical checkup were enrolled for evaluation of reflux disease with upper endoscopy and a validated reflux questionnaire. The presence and severity of erosive esophagitis were evaluated...
January 2015: Digestive and Liver Disease
Fabio Stallone, Raphael Twerenbold, Karin Wildi, Tobias Reichlin, Maria Rubini Gimenez, Philip Haaf, Nicole Fuechslin, Petra Hillinger, Cedric Jaeger, Philipp Kreutzinger, Christian Puelacher, Milos Radosavac, Zoraida Moreno Weidmann, Berit Moehring, Ursina Honegger, Carmela Schumacher, Kris Denhaerynck, Christiane Arnold, Roland Bingisser, Jörn Ole Vollert, Stefan Osswald, Christian Mueller
OBJECTIVE: Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. METHODS: A total of 984 consecutive patients with non-cardiac chest pain were selected from a prospective multicentre study of acute chest pain patients presenting to the emergency department...
November 2014: Heart: Official Journal of the British Cardiac Society
J Marc C van Dijk, Astrid G W Korsten-Meijer, Aryan Mazuri
OBJECTIVES/HYPOTHESIS: A dural arteriovenous fistula (DAVF) with cortical venous reflux (CVR) is a dangerous neurovascular entity. A DAVF at the cribriform plate is typically silent until its inevitable presentation with intracranial hemorrhage. CASE SUMMARY: A 67-year-old male presented with severe epistaxis. Following unsuccessful conventional measures and a surgical exploration, a catheter angiography showed a DAVF at the cribriform plate, with its nidus extending into the nasal cavity...
November 2014: Laryngoscope
Y Y Lee, K E L McColl
Obesity is a major reason for the recent increase in incidence of reflux disease and cancers at the distal esophagus and gastroesophageal junction (GOJ) and is mediated through a rise in the intra-abdominal pressure (IAP) but the exact mechanisms are unclear. Raised IAP from obesity and with application of waist belt produces mechanical distortion of the GOJ through formation of partial hiatus hernia. Even though there is no trans-sphincteric acid reflux, there is increased ingress of acid into the lower sphincter (intra-sphincteric reflux) as a consequence of raised IAP...
May 2015: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Annemarie L Lee, Brenda M Button, Linda Denehy, Stuart J Roberts, Tiffany L Bamford, Samantha J Ellis, Fi-Tjen Mu, Ralf G Heine, Robert G Stirling, John W Wilson
BACKGROUND AND OBJECTIVE: The aims of this observational study were (i) to examine the prevalence of symptomatic and clinically silent proximal and distal gastro-oesophageal reflux (GOR) in adults with chronic obstructive pulmonary disease (COPD) or bronchiectasis, (ii) the presence of gastric aspiration, and (iii) to explore the possible clinical significance of this comorbidity in these conditions. METHODS: Twenty-seven participants with COPD, 27 with bronchiectasis and 17 control subjects completed reflux symptom evaluation and dual-channel 24 h oesophageal pH monitoring...
February 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Marco E Allaix, Piero M Fisichella, Imre Noth, Fernando A Herbella, Bernardo Borraez Segura, Marco G Patti
BACKGROUND: Even though the pathogenesis of idiopathic pulmonary fibrosis (IPF) is unknown, there is mounting evidence that abnormal reflux (GERD) and aspiration of gastric contents may play a role in the pathogenesis of this disease. AIMS: The aims of this study were to determine in patients with GERD and IPF: (a) the clinical presentation, (b) the esophageal function, and (c) the reflux profile. METHODS: We compared the clinical presentation, the esophageal function (as defined by high-resolution manometry), and the reflux profile (by dual sensor pH monitoring) in 80 patients with GERD (group A) and in 22 patients with GERD and IPF (group B)...
January 2014: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
P Katsinelos, G Lazaraki, J Kountouras, G Chatzimavroudis, C Zavos, S Terzoudis, E Tsiaousi, S Gkagkalis, C Trakatelli, A Bellou, T Vasiliadis
BACKGROUND: Barrett's esophagus(BE) is a premalignant condition associated with chronic gastro-esophageal reflux disease (GERD). As only a small proportion of BE progresses to malignancy, it is important to study BE prevalence to prevent adenocarcinoma. MATERIALS AND METHODS: Between January 2007 and December 2010, all consecutive individuals who underwent routine upper endoscopy were prospectively recruited. Patients referred for GERD were excluded from the study...
January 2013: Hippokratia
N Asayama, N Nagata, T Shimbo, S Nishimura, T Igari, J Akiyama, N Ohmagari, Y Hamada, T Nishijima, H Yazaki, K Teruya, S Oka, N Uemura
Severe Candida esophagitis (CE) may lead to development of strictures, hemorrhage, esophagotracheal fistula, and a consequent decrease in quality of life. Although the severity of CE has been classified based on macroscopic findings on endoscopy, the clinical significance remains unknown. The aim of the study was to elucidate the predictive clinical factors for endoscopic severity of CE. Patients who underwent upper endoscopy and answered questionnaires were prospectively enrolled. Smoking, alcohol, human immunodeficiency virus (HIV) infection, diabetes mellitus, chronic renal failure, liver cirrhosis, systemic steroids use, proton pump inhibitor use, H2 blocker use, and gastrointestinal (GI) symptoms were assessed on the same day of endoscopy...
April 2014: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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