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https://www.readbyqxmd.com/read/28213308/simultaneous-estimation-of-detection-sensitivity-and-absolute-copy-number-from-digital-pcr-serial-dilution
#1
Xutao Deng, Brian S Custer, Michael P Busch, Sonia Bakkour, Tzong-Hae Lee
Digital polymerase chain reaction (dPCR) is a refinement of the conventional PCR approach to nucleic acid detection and absolute quantification. Digital PCR works by partitioning a sample of DNA or cDNA into many individual, parallel PCR reactions. Current quantification methods rely on the assumption that the PCR reactions are always able to detect single target molecules. When the assumption does not hold, the copy numbers will be severely underestimated. We developed a novel dPCR quantification method which determines whether the single copy assumption is violated or not by simultaneously estimating the assay sensitivity and the copy numbers using serial dilution data sets...
February 1, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28213032/applicability-of-a-colorimetric-method-for-evaluation-of-lactic-acid-bacteria-with-probiotic-properties
#2
Min Young Jung, Jina Lee, Boyeon Park, Hyelyeon Hwang, Sung-Oh Sohn, Se Hee Lee, Hyeong In Lim, Hae Woong Park, Jong-Hee Lee
Rapid colorimetric methods using various indicator reagents have been developed to monitor bacterial viability. Here, we examined the applicability of a method based on the reduction of resazurin or water-soluble tetrazolium salt-8 (WST-8) to screen lactic acid bacteria (LAB) for growth, tolerance against bile acid and low pH. The resazurin reduction test proved unsuitable for screening LAB such as Lactobacillus plantarum and Leuconostoc mesenteroides since it reacted with acid present in the cultures. LAB growth could be indirectly quantified by measuring WST-8 reduction...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28211818/comparison-of-the-effects-of-bilateral-and-unilateral-training-after-stroke-a-meta-analysis
#3
Yejin Lee, Moon Young Kim, Ji-Hyuk Park, Hae Yean Park
BACKGROUND: The differential effects of bilateral and unilateral training on upper extremity (UE) function remain unclear. OBJECTIVE: To compare the effectiveness of bilateral and unilateral training on UE function and activities of daily living (ADL) after stroke. METHODS: Randomized controlled trials (RCTs) were selected for inclusion by two reviewers after searching the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and KoreaMed...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211114/magnesium-lithospermate-b-from-salvia-miltiorrhiza-bunge-ameliorates-aging-induced-renal-inflammation-and-senescence-via-nadph-oxidase-mediated-reactive-oxygen-generation
#4
Chan Hum Park, Sung Ho Shin, Eun Kyeong Lee, Dae Hyun Kim, Min-Jo Kim, Seong-Soo Roh, Takako Yokozawa, Hae Young Chung
The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age-related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2- or 8-mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species...
February 16, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28210087/prognostic-significance-of-the-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-stage-iii-and-iv-colorectal-cancer
#5
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
AIM: To evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHODS: Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28210046/effects-of-diaphragm-breathing-exercise-and-feedback-breathing-exercise-on-pulmonary-function-in-healthy-adults
#6
Min-Sik Yong, Hae-Yong Lee, Yun-Seob Lee
[Purpose] The present study investigated effects of diaphragm breathing exercise and feedback breathing exercise on respiratory function. [Subjects and Methods] Thirty-one subjects were randomly assigned to two groups; the feedback breathing exercise group and the maneuver-diaphragm exercise group. The feedback breathing exercise group was asked to breathe with feedback breathing device, and the maneuver-diaphragm exercise group was asked to perform diaphragm respiration. Respiratory function was evaluated when a subject sat on a chair comfortably...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28208973/shear-wave-elastography-features-of-primary-non-hodgkin-s-lymphoma-of-the-breast-a-case-report-and-literature-review
#7
Youdong Kim, Kyung Hee Ko, Hae Kyoung Jung, Hyun Ju Lee
Lymphoma is a rare malignancy of the breast, comprising approximately 0.04 to 0.5% of breast malignancies. Because the clinical findings of breast lymphoma are nonspecific and similar to those of breast carcinoma, it is important to distinguish breast lymphoma from other breast disease on the basis of radiologic findings. Elastography is an interesting imaging tool that reflects the tissue stiffness, increasingly being used in the evaluation of breast tumours. However, only a limited number of studies have focused on the elastographic findings of breast lymphoma...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207189/effects-of-human-mesenchymal-stem-cells-co-culture-on-calcium-induced-differentiation-of-normal-human-keratinocytes
#8
Shyam Kishor Sah, Hae Young Kim, Ji Hae Lee, Seong-Wook Lee, Hyung-Sik Kim, Yeon-Soo Kim, Kyung-Sun Kang, Tae-Yoon Kim
The influence of mesenchymal stem cells (MSCs) on keratinocytes in altered microenvironments is poorly understood. Here, we co-cultured umbilical cord blood-derived MSCs with normal human epidermal keratinocytes (NHEK) to evaluate their paracrine effect in the presence of high extracellular calcium (Ca(2+) ) concentration. High Ca(2+) environment to keratinocytes can disrupt normal skin barrier function due to abnormal/premature differentiation of keratinocytes. Surprisingly, we found that MSCs suppress both proliferation and differentiation of keratinocytes under a high Ca(2+) environment in TGFβ1-dependent manner...
February 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28207063/optimizing-tubal-ligation-service-delivery-a-prospective-cohort-study-to-measure-the-task-sharing-experience-of-marie-stopes-international-ethiopia
#9
Olivia Nuccio, Birhanu Sendek, Min Hae Park, Tesfaye Mesele, Francis Ogojo Okello, Cristin Gordon-Maclean
No abstract text is available yet for this article.
March 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28205544/structural-environment-built-by-akap12-colon-mesenchymal-cells-drives-m2-macrophages-during-inflammation-recovery
#10
Jun-Mo Yang, Hye Shin Lee, Ji Hae Seo, Ji-Hyeon Park, Irwin H Gelman, Eng H Lo, Kyu-Won Kim
Macrophages exhibit phenotypic plasticity, as they have the ability to switch their functional phenotypes during inflammation and recovery. Simultaneously, the mechanical environment actively changes. However, how these dynamic alterations affect the macrophage phenotype is unknown. Here, we observed that the extracellular matrix (ECM) constructed by AKAP12+ colon mesenchymal cells (CMCs) generated M2 macrophages by regulating their shape during recovery. Notably, rounded macrophages were present in the linear and loose ECM of inflamed colons and polarized to the M1 phenotype...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205045/characteristics-of-brca1-2-mutations-carriers-including-large-genomic-rearrangements-in-high-risk-breast-cancer-patients
#11
Boyoung Park, Ji Yeon Sohn, Kyong-Ah Yoon, Keun Seok Lee, Eun Hae Cho, Myong Cheol Lim, Moon Jung Yang, Soo Jin Park, Moo Hyun Lee, See Youn Lee, Yoon Jung Chang, Dong Ock Lee, Sun-Young Kong, Eun Sook Lee
PURPOSE: We investigated the prevalence of BRCA1/2 small mutations and large genomic rearrangements in high risk breast cancer patients who attended a genetic counseling clinic. METHODS: In total 478 patients were assessed for BRCA1/2 mutations by direct sequencing, of whom, 306 were identified as non-carriers of BRCA1/2 mutation and assessed for large rearrangement mutations by multiplex ligation-dependent probe amplification. Family history and clinicopathological characteristics of patients were evaluated...
February 15, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28203554/the-13-year-experience-of-performing-pancreaticoduodenectomy-in-a-mid-volume-municipal-hospital
#12
Hongbeom Kim, Jung Kee Chung, Young Joon Ahn, Hae Won Lee, In Mok Jung
PURPOSE: Pancreaticoduodenectomy (PD) is a complex surgery associated with high morbidity, mortality, and cost. Municipal hospitals have their important role in the public health and welfare system. The purpose of this study was to identify the feasibility as well as the cost-effectiveness of performing PD in a mid-volume municipal hospital based on 13 years of experience with PD. METHODS: From March 2003 to November 2015, 183 patients underwent PD at Seoul Metropolitan Government - Seoul National University Boramae Medical Center...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28202404/recombinant-human-c1-esterase-inhibitor-to-treat-acute-hereditary-angioedema-attacks-in-adolescents
#13
James W Baker, Avner Reshef, Dumitru Moldovan, Joseph R Harper, Anurag Relan, Marc A Riedl
BACKGROUND: Recombinant human C1-esterase inhibitor (rhC1-INH) is efficacious and well tolerated for managing hereditary angioedema (HAE) attacks in adults. However, there are insufficient data on its efficacy and safety in adolescents. OBJECTIVE: To evaluate the efficacy and safety profiles of rhC1-INH for acute HAE attacks in adolescents. METHODS: Adolescents (aged 12-18 y) with HAE enrolled in 2 randomized controlled trials and 2 open-label extension trials were included and received intravenous rhC1-INH for acute attacks...
February 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28198651/burden-of-disease-attributable-to-smoking-in-korea
#14
Aqeela Zahra, Hae-Kwan Cheong, Jae-Hyun Park
Smoking is one of the major health threats and is highly prevalent in Korea. This study quantifies the burden of disease (BOD) resulting from smoking by using the most reliable national statistics of Korea. We followed Global Burden of Disease Study (GBD) 2013 methodology for estimating BOD attributable to smoking. Population attributable fraction was calculated for all diseases and multiplied by disability-adjusted life years (DALYs) to obtain BOD by each disease. Total burden of smoking in Korea was 1 368 072 DALYs (38 per 1000); 68% of the disease burden was in males and 32% in females...
January 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28196412/mapk3-at-the-autism-linked-human-16p11-2-locus-influences-precise-synaptic-target-selection-at-drosophila-larval-neuromuscular-junctions
#15
Sang Mee Park, Hae Ryoun Park, Ji Hye Lee
Proper synaptic function in neural circuits requires precise pairings between correct pre- and post-synaptic partners. Errors in this process may underlie development of neuropsychiatric disorders, such as autism spectrum disorder (ASD). Development of ASD can be influenced by genetic factors, including copy number variations (CNVs). In this study, we focused on a CNV occurring at the 16p11.2 locus in the human genome and investigated potential defects in synaptic connectivity caused by reduced activities of genes located in this region at Drosophila larval neuromuscular junctions, a well-established model synapse with stereotypic synaptic structures...
February 15, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28196151/estimation-of-years-lived-with-disability-due-to-noncommunicable-diseases-and-injuries-using-a-population-representative-survey
#16
Ji In Park, Hae Hyuk Jung
The Global Burden of Disease 2010 and the WHO Global Health Estimates of years lived with disability (YLDs) uses disability-weights obtained from lay health-state descriptions, which cannot fully reflect different disease manifestations, according to severity, treatment, and environment. The aim of this study was to provide population-representative YLDs of noncommunicable diseases and injuries using a prevalence-based approach, with the disability weight measured in subjects with specific diseases or injuries...
2017: PloS One
https://www.readbyqxmd.com/read/28194852/development-of-a-transformation-model-to-derive-general-population-based-utility-mapping-the-pruritus-visual-analog-scale-vas-to-the-eq-5d-utility
#17
Sun-Young Park, Eun-Ja Park, Hae Sun Suh, Dongmun Ha, Eui-Kyung Lee
RATIONALE, AIMS, AND OBJECTIVES: Although nonpreference-based disease-specific measures are widely used in clinical studies, they cannot generate utilities for economic evaluation. A solution to this problem is to estimate utilities from disease-specific instruments using the mapping function. This study aimed to develop a transformation model for mapping the pruritus-visual analog scale (VAS) to the EuroQol 5-Dimension 3-Level (EQ-5D-3L) utility index in pruritus. METHODS: A cross-sectional survey was conducted with a sample (n = 268) drawn from the general population of South Korea...
February 14, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28194776/mutational-spectrum-of-the-serping1-gene-in-swiss-patients-with-hereditary-angioedema
#18
Urs C Steiner, Melanie Keller, Pirmin Schmid, Sven Cichon, Walter A Wuillemin
Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease caused by mutations in the C1 inhibitor gene SERPING1. Phenotype and clinical features of the disease are very heterogeneous, varying even in the same family. Compared to HAE cohorts in other countries the genetic background of the Swiss HAE patients has not been elucidated yet. In the present study we investigated the mutational spectrum of the SERPING1 gene in nineteen patients of nine unrelated Swiss families...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28194368/statistical-notes-for-clinical-researchers-risk-difference-risk-ratio-and-odds-ratio
#19
Hae-Young Kim
No abstract text is available yet for this article.
February 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28194361/post-space-preparation-timing-of-root-canals-sealed-with-ah-plus-sealer
#20
Hae-Ri Kim, Young Kyung Kim, Tae-Yub Kwon
OBJECTIVES: To determine the optimal timing for post space preparation of root canals sealed with epoxy resin-based AH Plus sealer in terms of its polymerization and influence on apical leakage. MATERIALS AND METHODS: The epoxy polymerization of AH Plus (Dentsply DeTrey) as a function of time after mixing (8, 24, and 72 hours, and 1 week) was evaluated using Fourier transform infrared (FTIR) spectroscopy and microhardness measurements. The change in the glass transition temperature (Tg ) of the material with time was also investigated using differential scanning calorimetry (DSC)...
February 2017: Restorative Dentistry & Endodontics
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