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https://www.readbyqxmd.com/read/29351736/studying-medical-communication-with-video-vignettes-a-randomized-study-on-how-variations-in-video-vignette-introduction-format-and-camera-focus-influence-analogue-patients-engagement
#1
Leonie N C Visser, Nadine Bol, Marij A Hillen, Mathilde G E Verdam, Hanneke C J M de Haes, Julia C M van Weert, Ellen M A Smets
BACKGROUND: Video vignettes are used to test the effects of physicians' communication on patient outcomes. Methodological choices in video-vignette development may have far-stretching consequences for participants' engagement with the video, and thus the ecological validity of this design. To supplement the scant evidence in this field, this study tested how variations in video-vignette introduction format and camera focus influence participants' engagement with a video vignette showing a bad news consultation...
January 19, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29350788/reliability-and-validity-of-the-atopic-dermatitis-symptom-score
#2
Ji Young Lee, Minji Kim, Hea-Kyoung Yang, Hyun Mi Kim, Joongbum Cho, Young-Min Kim, In Seok Lim, Hae-Kwan Cheong, Hye Seung Kim, Insuk Sohn, Jihyun Kim, Kangmo Ahn
BACKGROUND: We have developed the Atopic Dermatitis Symptom Score (ADSS) by which patients or parents can easily assess and record AD symptoms on a daily basis in a smartphone application. The aim of the present study was to evaluate the reliability and validity of the ADSS. METHODS: We enrolled 307 children and adolescents with AD. Parents or caregivers were asked to record daily symptoms of the patients (itching, sleep disturbance, erythema, dryness, oozing, and oedema) using a scale of 0 to 4...
January 19, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29350515/rapid-one-pot-microwave-synthesis-of-mixed-linker-hybrid-zeolitic-imidazolate-framework-membranes-for-tunable-gas-separations
#3
Febrian Hillman, Jordan Brito, Hae-Kwon Jeong
The relatively slow and complex fabrication processes of polycrystalline metal-organic framework (MOF) membranes often times restrict their way to commercialization, despite their potential for molecular separation applications. Herein we report a rapid one-pot microwave synthesis of mixed linker hybrid zeolitic-imidazolate framework (ZIF) membranes consisting of 2-methylimidazolate (ZIF-8 linker) and benzimidazolate (ZIF-7 linker) linkers, termed ZIF-7-8 membranes. The fast-volumetric microwave heating in conjunction with unique counter diffusion of metal and linker solutions enabled unprecedented rapid synthesis of well-intergrown ZIF-7-8 membranes in ~ 90 s, the fastest MOF membrane preparation up to date...
January 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29349945/the-within-group-discrimination-ability-of-the-cancer-of-the-prostate-risk-assessment-score-for-men-with-intermediate-risk-prostate-cancer
#4
Ho Won Kang, Hae Do Jung, Joo Yong Lee, Jong Kyou Kwon, Seong Uk Jeh, Kang Su Cho, Won Sik Ham, Young Deuk Choi
BACKGROUND: Significant clinical heterogeneity within contemporary risk group is well known, particularly for those with intermediate-risk prostate cancer (IRPCa). Our study aimed to analyze the ability of the Cancer of the Prostate Risk Assessment (CAPRA) score to discern between favorable and non-favorable risk in patients with IRPCa. METHODS: We retrospectively reviewed the data of 203 IRPCa patients who underwent extraperitoneal robot-assisted radical prostatectomy (RARP) performed by a single surgeon...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29348728/systems-level-mechanisms-of-action-of-panax-ginseng-a-network-pharmacological-approach
#5
REVIEW
Sa-Yoon Park, Ji-Hun Park, Hyo-Su Kim, Choong-Yeol Lee, Hae-Jeung Lee, Ki Sung Kang, Chang-Eop Kim
Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348725/protective-effect-of-ginsenoside-rb1-against-tacrolimus-induced-apoptosis-in-renal-proximal-tubular-llc-pk1-cells
#6
Dahae Lee, Dong-Soo Lee, Kiwon Jung, Gwi Seo Hwang, Hye Lim Lee, Noriko Yamabe, Hae-Jeong Lee, Dae-Woon Eom, Ki Hyun Kim, Ki Sung Kang
Background: The aim of the present study was to evaluate the potential protective effects of six ginsenosides (Rb1, Rb2, Rc, Rd, Rg1, and Rg3) isolated from Panax ginseng against tacrolimus (FK506)-induced apoptosis in renal proximal tubular LLC-PK1 cells. Methods: LLC-PK1 cells were treated with FK506 and ginsenosides, and cell viability was measured. Protein expressions of mitogen-activated protein kinases, caspase-3, and kidney injury molecule-1 (KIM-1) were evaluated by Western blotting analyses...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348724/ginsenoside-rg3-promotes-inflammation-resolution-through-m2-macrophage-polarization
#7
Saeromi Kang, Soo-Jin Park, Ae-Yeon Lee, Jin Huang, Hae-Young Chung, Dong-Soon Im
Background: Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation. Methods: Mouse peritoneal macrophages were polarized into M1 or M2 phenotypes...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348471/three-dimensional-evaluation-of-posterior-pole-and-optic-nerve-head-in-tilted-disc
#8
Yong Chan Kim, Ji-Sun Moon, Hae-Young Lopilly Park, Chan Kee Park
For over a century, tilted disc syndrome (TDS) has been defined vaguely. The lack of consensus of the terminology arises from the lack of understanding of the pathogenesis of this condition. Also, myopic discs with temporal crescents or peripapillary atrophy (PPA) are histologically indistinguishable from TDS. Therefore, we examined the morphological background of the extreme ONH appearances such as the myopic tilted disc and the TDS by analyzing the posterior segment of the eye from a three-dimensional (3D) perspective...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348460/fyn-promotes-mesenchymal-phenotypes-of-basal-type-breast-cancer-cells-through-stat5-notch2-signaling-node
#9
Ga-Hang Lee, Ki-Chun Yoo, Yoojeong An, Hae-June Lee, Minyoung Lee, Nizam Uddin, Min-Jung Kim, In-Gyu Kim, Yongjoon Suh, Su-Jae Lee
Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cancer subtype. Importantly, FYN enhanced NOTCH2 activation in basal type breast cancer cells through STAT5-mediated upregulation of Jagged-1 and DLL4 NOTCH ligands, thereby contributed to mesenchymal phenotypes...
January 19, 2018: Oncogene
https://www.readbyqxmd.com/read/29348440/neural-predictors-of-cognitive-improvement-by-multi-strategic-memory-training-based-on-metamemory-in-older-adults-with-subjective-memory-complaints
#10
Soowon Park, Seung-Ho Ryu, Yongjoon Yoo, Jin-Ju Yang, Hunki Kwon, Jung-Hae Youn, Jong-Min Lee, Seong-Jin Cho, Jun-Young Lee
Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such memory trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important for maximizing the training efficacy of memory-training programs. The purpose of this study was to find the individual characteristics and brain morphological characteristics that predict cognitive improvement after a multi-strategic memory training based on metamemory concept...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348337/complete-genome-sequence-of-sphingorhabdus-sp-ygsmi21-exhibiting-high-enantioselective-epoxide-hydrolase-activity
#11
Hae-Seon Kim, Sun Ho Cha, Ho Young Suk, Nyun-Ho Park, Jung-Hee Woo
Sphingorhabdus sp. YGSMI21 is a novel strain exhibiting high enantioselective hydrolysis activity for styrene oxide. Here, we present its complete genome sequence, consisting of one circular chromosome (3.86 Mb) and one plasmid (0.196 Mb).
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29345142/mediating-role-of-career-coaching-on-job-search-behavior-of-older-generations
#12
Doo Hun Lim, Eunjung Oh, Boreum Ju, Hae Na Kim
This study focuses on career development processes and options for older workers in South Korea and explores how career coaching enhances their career development efforts and transition needs. The purpose of this study is to investigate the structural relationship between older employees' goal-setting, self-efficacy, and job-search behavior mediated by career coaching. A total of 249 participants were recruited in a metropolitan city in South Korea. Based on the literature review, hypotheses were developed and tested on the structural model and the following findings were revealed...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29343988/does-breast-density-measured-through-population-based-screening-independently-increase-breast-cancer-risk-in-asian-females
#13
Boyoung Park, Hye Mi Cho, Eun Hye Lee, Seunghoon Song, Mina Suh, Kui Son Choi, Bong Joo Kang, Kyungran Ko, Ann Yi, Hae Kyoung Jung, Joo Hee Cha, Jae Kwan Jun
Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case-control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29343716/expression-of-the-methionine-sulfoxide-reductase-lost-during-evolution-extends-drosophila-lifespan-in-a-methionine-dependent-manner
#14
Byung Cheon Lee, Hae Min Lee, Sorah Kim, Andrei S Avanesov, Aro Lee, Bok-Hwan Chun, Gerd Vorbruggen, Vadim N Gladyshev
Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342884/effect-of-the-extraction-process-on-the-biological-activity-of-lyophilized-apricot-extracts-recovered-from-apricot-pomace
#15
Dina Cheaib, Nada El Darra, Hiba N Rajha, Iman El-Ghazzawi, Richard G Maroun, Nicolas Louka
The preservation of polyphenols in fruits by lyophilization has gained great interest in the recent decades. The present study aims to assess the impact of the pre-treatment extraction methods heat-assisted extraction (HAE) and infrared (IR) on lyophilized apricot pomace extracts. Then to test the conservation of polyphenols quantities as well as their bioactivities (antiradical and antibacterial) in lyophilized extract. An aqueous extract was obtained through either heat-assisted extraction or infrared pre-treatments then lyophilized to obtain a dried form...
January 14, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29339659/fc%C3%AE-r-ros-ck2%C3%AE-is-the-key-inducer-of-nf-%C3%AE%C2%BAb-activation-in-a-murine-model-of-asthma
#16
June-Mo Kim, Hae-Kyoung Kim, Yoo-Na Im, Yun-Soo Bae, Suhn-Young Im, Hern-Ku Lee
BACKGROUND: The transcription factor nuclear factor (NF)-κB plays a pivotal role in the development of allergic airway inflammation. However, the mechanism of NF-κB activation in asthma remains to be elucidated. METHODS: CK2α activation was assessed by CK2α phosphorylation and protein expression. Airway levels of histamine and cytokines were determined by ELISA. We used 2 (active and passive) forms of allergic pulmonary inflammation models. In the active form, the animals were immunized with ovalbumin (OVA) intraperitoneally, followed by an airway challenge with OVA...
January 17, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29339079/diagnostic-usefulness-of-combination-of-diffusion-weighted-imaging-and-t2wi-including-apparent-diffusion-coefficient-in-breast-lesions-assessment-of-histologic-grade
#17
Keum Won Kim, Cherie M Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PURPOSE: This study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer. MATERIALS AND METHODS: This study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm2). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System...
January 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29338119/management-of-morning-hypertension-a-consensus-statement-of-an-asian-expert-panel
#18
REVIEW
Ji-Guang Wang, Kazuomi Kario, Chen-Huan Chen, Jeong-Bae Park, Satoshi Hoshide, Yong Huo, Hae-Young Lee, Yan Li, Masaki Mogi, Masanori Munakata, Sungha Park, Dingliang Zhu
Morning blood pressure (BP) surge is an important aspect of hypertension research. Morning BP monitoring could be a clinically relevant concept in the therapeutic management of hypertension and in the prevention of cardiovascular complications by defining and treating morning hypertension. Because antihypertensive medication is often taken in the morning, uncontrolled morning BP during the trough effect hours could be a hallmark of inadequate choice of antihypertensive regimen, such as the use of short- or intermediate-acting drugs, underdosing of drugs, or no use or underuse of combination therapy...
January 16, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29334604/breast-conservation-therapy-versus-mastectomy-in-patients-with-t1-2n1-triple-negative-breast-cancer-pooled-analysis-of-krog-14-18-and-14-23
#19
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Purpose: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) vs. mastectomy for patients with pT1-2N1 triple negative breast cancer (TNBC). Methods: Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334181/donor-variability-in-growth-kinetics-of-healthy-hmscs-using-manual-processing-considerations-for-manufacture-of-cell-therapies
#20
Giulia Detela, Owen W Bain, Hae-Won Kim, David J Williams, Chris Mason, Anthony Mathur, Ivan B Wall
Human mesenchymal stromal cells (hMSCs) are excellent candidates for cell therapy but their expansion to desired clinical quantities can be compromised by ex vivo processing, due to differences between donor material and process variation. The aim of this article was to characterize growth kinetics of healthy baseline "reference" hMSCs using typical manual processing. Bone-marrow derived hMSCs from ten donors were isolated based on plastic adherence, expanded and analyzed for their growth kinetics until passage 4...
January 15, 2018: Biotechnology Journal
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