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https://www.readbyqxmd.com/read/29792847/the-polymorphisms-of-atoh-7-et-1-and-ace-in-non-arteritic-anterior-ischemic-optic-neuropathy
#1
Ting Chen, Jin Ma, Guangliang Shan, Yong Zhong
Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in the elderly. The role of the genetic polymorphisms of Atonal Homolog 7 (ATOH7), Endothelin-1 (ET-1) and Angiotensin Converting Enzyme (ACE) in NAION and the combined effects of the gene-gene and gene-medical comorbidities on NAION were not clear. We conducted a perspective, case-control study. 71 NAION patients and 142 age and sex-matched healthy controls were enrolled. Single nucleotide polymorphisms of ATOH7 (rs1900004), ET-1 (rs5370) and ACE (rs1799752) were identified by polymerase chain reaction (PCR) method and all PCR products were screened with Sanger sequencing...
May 21, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29791960/ultrasound-of-the-brachial-plexus
#2
James F Griffith
Examination of the brachial plexus with ultrasound is efficient because it allows many parts of the brachial plexus as well as the surrounding soft tissues to be assessed with high spatial resolution. The key to performing good ultrasound of the brachial plexus is being familiar with the anatomy and the common variants. That makes it possible to concentrate solely on the ultrasound appearances free of simultaneously wondering about the anatomy. Ultrasound of the brachial plexus is particularly good for assessing nerve sheath tumor, perineural fibrosis, metastases, some inflammatory neuropathies, neuralgic amyotrophy, and posttraumatic sequalae...
July 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29791950/global-health-neurology-hiv-aids
#3
Payal B Patel, Serena S Spudich
With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majority of studies have focused on individuals residing in the developed world, while the impact of HIV disproportionately affects people living in developing countries. This review focuses on recent domestic and international studies regarding neurologic complications related to HIV, including opportunistic infections, peripheral neuropathy, cerebrovascular disease, and HIV-associated neurocognitive disorders, in light of the growing population affected by these conditions...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791761/nerve-action-potential-amplitudes-a-robust-marker-of-diabetic-peripheral-neuropathy
#4
Marie Monlun, Marie Hugo, Laurence Blanco, Kamel Mohammedi, Ahdab Rechdi, Laure Alexandre, Stéphane Poirot-Mazeres, Kalina Rajaobelina, Vincent Rigalleau
We were interested in the recent publication of Peterson et al. (1) who reported a progressive reduction of sural nerve amplitudes from 10.9μV to 7.0μV, during a ten year follow-up of 87 people with varying degrees of glucose intolerance. This reduction was more pronounced for people whose glucose tolerance deteriorated during the follow-up period, and paralleled their increasing HbA1c. In contrast, nerve conduction velocities only decreased from 47.6 to 45.8 m/s, without any significant relation to HbA1c This article is protected by copyright...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29791638/assessment-of-ulceration-risk-in-diabetic-individuals
#5
Luz Marina Alfonso Dutra, Maria Rita Carvalho Garbi Novaes, Manuela Costa Melo, Danyelle Lorrane Carneiro Veloso, Dayane Leticia Faustino, Leila Maria Sales Sousa
OBJECTIVE: To identify the risk factors for foot ulceration through the tracing of diabetic peripheral neuropathy and peripheral arterial disease in individuals with type I and II diabetes, who were assisted in reference centers of the Federal District, Brazil. METHOD: a cross-sectional and analytical study, with the assessment of 117 individuals in outpatient clinics of the Federal District. Continuous variables were compared through Mann-Whitney test, and categorized variables, through Chi-square test for univariate analysis and Logistics regression test for multivariate analysis...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791033/diabetes-related-lower-extremity-complications-are-a-leading-cause-of-the-global-burden-of-disability
#6
P A Lazzarini, R E Pacella, D G Armstrong, J J van Netten
Globally ~435 million people have diabetes [1], and an estimated 19-34% (~83-148 million people) of those will be expected to develop foot ulcers in their lifetime [2]. Foot ulcers are typically precipitated by other diabetes-related lower-extremity complications, (DRLECs) including peripheral neuropathy and peripheral vascular disease [2,3]. Collectively, DRLECs are a leading cause of infection, hospitalization and amputation outcomes [2-5], yet, these outcomes are readily preventable with evidence-based care [6,7]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790285/peripapillary-vessel-density-changes-in-leber-s-hereditary-optic-neuropathy-a-new-biomarker
#7
Nicole Balducci, Maria Lucia Cascavilla, Antonio Ciardella, Chiara La Morgia, Giacinto Triolo, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
IMPORTANCE: The contribution of the microvascular supply to the pathogenesis of Leber's Hereditary Optic Neuropathy (LHON) is poorly understood. BACKGROUND: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON. DESIGN: Prospective, cross-sectional, multicenter, observational study. PARTICIPANTS: Twenty-two LHON patients divided in 4 groups: unaffected mutation carriers (LHON-u); early subacute stage (LHON-e); late subacute stage (LHON-l); chronic stage (LHON-ch)...
May 22, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29790137/-diabetic-foot-neuropathy-and-related-factors-in-patients-with-type-2-diabetes-mellitus
#8
Tzu-Yu Chen, Chia-Huei Lin, Yue-Cune Chang, Chih-Hsin Wang, Yi-Jen Hung, Wen-Chii Tzeng
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) face a higher risk of diabetic foot neuropathy, which increases the risk of death. The early detection of factors that influence diabetic neuropathy reduces the risk of foot lesions, including foot ulcerations, lower extremity amputation, and mortality. PURPOSE: To explore the demographic, disease-characteristic, health-literacy, and foot-self-care-behavior factors that affect diabetic foot neuropathy in patients with T2DM...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789529/inhibiting-p38-mapk-alpha-rescues-axonal-retrograde-transport-defects-in-a-mouse-model-of-als
#9
Katherine L Gibbs, Bernadett Kalmar, Elena R Rhymes, Alexander D Fellows, Mahmood Ahmed, Paul Whiting, Ceri H Davies, Linda Greensmith, Giampietro Schiavo
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal transport have been observed pre-symptomatically in the SOD1G93A mouse model of ALS, and have been proposed to play a role in motor neuron degeneration as well as in other pathologies of the nervous system, such as Alzheimer's disease and hereditary neuropathies. In this study, we screen a library of small-molecule kinase inhibitors towards the identification of pharmacological enhancers of the axonal retrograde transport of signalling endosomes, which might be used to normalise the rate of this process in diseased neurons...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789229/cryoglobulinemic-vasculitis-and-psoriatic-arthritis-case-report-of-an-unusual-association
#10
Lizeth Yamile Urrea-Pineda, Sebastián Gómez-Jiménez, Daniel Jaramillo-Arroyave, Carlos Horacio Muñoz-Vahos, Adriana Lucía Vanegas-García, Gloria Vasquéz, Mauricio Restrepo-Escobar, Luis Alonso González-Naranjo
We report the case of a 47-year-old man with a 9-year history of psoriatic arthritis (PsA) in whom we detected renal involvement, hypocomplementemia, peripheral neuropathy, acral necrotic lesions and positive cryoglobulins. The results of the diagnosis led us to conclude that the clinical picture corresponded to cryoglobulinemic vasculitis concomitant with PsA. In addition, we present a review of the literature on the presence of these two diseases in a single patient.
May 19, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29789193/deoxysphingolipid-precursors-indicate-abnormal-sphingolipid-metabolism-in-individuals-with-primary-and-secondary-disturbances-of-serine-availability
#11
C R Ferreira, S M I Goorden, A Soldatos, H M Byers, J M M Ghauharali-van der Vlugt, F S Beers-Stet, C Groden, C D van Karnebeek, W A Gahl, F M Vaz, X Jiang, H J Vernon
Patients with primary serine biosynthetic defects manifest with intellectual disability, microcephaly, ichthyosis, seizures and peripheral neuropathy. The underlying pathogenesis of peripheral neuropathy in these patients has not been elucidated, but could be related to a decrease in the availability of certain classical sphingolipids, or to an increase in atypical sphingolipids. Here, we show that patients with primary serine deficiency have a statistically significant elevation in specific atypical sphingolipids, namely deoxydihydroceramides of 18-22 carbons in acyl length...
May 7, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29787766/structure-and-functional-characterization-of-human-histidine-triad-nucleotide-binding-protein-1-mutations-associated-with-inherited-axonal-neuropathy-with-neuromyotonia
#12
Rachit M Shah, Kimberly M Maize, Harrison T West, Alexander M Strom, Barry C Finzel, Carston R Wagner
Inherited peripheral neuropathies are a group of neurodegenerative disorders that clinically affect 1 in 2500 individuals. Recently, genetic mutations in Human Histidine Nucleotide Binding Protein 1 (hHint1) have been strongly and most frequently associated with patients suffering from axonal neuropathy with neuromyotonia. However, the correlation between the impact of these mutations on the hHint1 structure, enzymatic activity and in vivo function has remained ambiguous. Here, we provide detailed biochemical characterization of a set of these hHint1 mutations...
May 19, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29787402/a-pilot-study-of-a-novel-automated-somatosensory-evoked-potential-ssep-monitoring-device-for-detection-and-prevention-of-intraoperative-peripheral-nerve-injury-in-total-shoulder-arthroplasty-surgery
#13
Jason Chui, John M Murkin, Darren Drosdowech
INTRODUCTION: Peripheral nerve injury is a potentially devastating complication after total shoulder arthroplasty (TSA) surgery. This pilot study aimed to assess the feasibility of using an automated somatosensory evoked potential (SSEP) device to provide a timely alert/intervention to minimize intraoperative nerve insults during TSA surgery. METHODS: A prospective, single-arm, observational study was conducted in a single university hospital. The attending anesthesiologist monitored the study participants using the EPAD automated SSEP device and an intervention was made if there was an alert during TSA surgery...
May 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29787347/stp-position-paper-recommended-best-practices-for-sampling-processing-and-analysis-of-the-peripheral-nervous-system-nerves-and-somatic-and-autonomic-ganglia-during-nonclinical-toxicity-studies
#14
Brad Bolon, Georg Krinke, Mark T Butt, Deepa B Rao, Ingrid D Pardo, Bernard S Jortner, Robert H Garman, Karl Jensen, Lydia Andrews-Jones, James P Morrison, Alok K Sharma, Michael S Thibodeau
Peripheral nervous system (PNS) toxicity is surveyed inconsistently in nonclinical general toxicity studies. These Society of Toxicologic Pathology "best practice" recommendations are designed to ensure consistent, efficient, and effective sampling, processing, and evaluation of PNS tissues for four different situations encountered during nonclinical general toxicity (screening) and dedicated neurotoxicity studies. For toxicity studies where neurotoxicity is unknown or not anticipated (situation 1), PNS evaluation may be limited to one sensorimotor spinal nerve...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29786012/navigation-guided-optic-canal-decompression-for-traumatic-optic-neuropathy-two-case-reports
#15
Kasturi Bhattacharjee, Samir Serasiya, Deepika Kapoor, Harsha Bhattacharjee
Two cases of traumatic optic neuropathy presented with profound loss of vision. Both cases received a course of intravenous corticosteroids elsewhere but did not improve. They underwent Navigation guided optic canal decompression via external transcaruncular approach, following which both cases showed visual improvement. Postoperative Visual Evoked Potential and optical coherence technology of Retinal nerve fibre layer showed improvement. These case reports emphasize on the role of stereotactic navigation technology for optic canal decompression in cases of traumatic optic neuropathy...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29784239/paraneoplastic-syndromes-in-ophthalmology
#16
REVIEW
A Bussat, S Langner-Lemercier, A Salmon, F Mouriaux
Paraneoplastic syndromes involving the visual system are a heterogeneous group of disorders occurring in the setting of systemic malignancy. They are unrelated to local tumor invasion or metastasis and unexplained by nutritional, metabolic, infectious or iatrogenic causes. The presence of antibodies may aid in the diagnosis of a paraneoplastic syndrome, although this is not an absolute requirement. Chorioretinal involvement is seen in CAR (cancer-associated retinopathy) syndrome, MAR (melanoma-associated retinopathy) syndrome, paraneoplastic vitelliform maculopathy, and bilateral diffuse uveal melanocytic proliferation...
May 18, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29784175/late-onset-leber-hereditary-optic-neuropathy-presenting-after-intraocular-surgery
#17
Panagiotis I Sergouniotis, Anne Fiona Spencer, Mandagere Vishwanath, Fion Bremner, Alec Ansons
No abstract text is available yet for this article.
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29784095/pseudohemangioma-in-nonarteritic-anterior-ischemic-optic-neuropathy
#18
Elizabeth Fortin, Eric D Gaier
No abstract text is available yet for this article.
June 2018: Ophthalmology
https://www.readbyqxmd.com/read/29782936/stratification-of-type-2-diabetes-based-on-routine-clinical-markers
#19
Narges Safai, Ashfaq Ali, Peter Rossing, Martin Ridderstråle
AIMS: We hypothesized that patients with dysregulated type 2 diabetes may be stratified based on routine clinical markers. METHODS: In this retrospective cohort study, diabetes related clinical measures including age at onset, diabetes duration, HbA1c , BMI, HOMA2-β, HOMA2-IR and GAD65 autoantibodies, were used for sub-grouping patients by K-means clustering and for adjusting. Probability of diabetes complications (95% confidence interval), were calculated using logistic regression...
May 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29782495/molecular-immunological-and-neurophysiological-evaluations-for-early-diagnosis-of-neural-impairment-in-seropositive-leprosy-household-contacts
#20
Diogo Fernandes Dos Santos, Matheus Rocha Mendonça, Douglas Eulálio Antunes, Elaine Fávaro Pípi Sabino, Raquel Campos Pereira, Luiz Ricardo Goulart, Isabela Maria Bernardes Goulart
BACKGROUND: Household contacts constitute the highest risk group for leprosy development, and despite significant progress in the disease control, early diagnosis remains the primary goals for leprosy management programs. METHODS: We have recruited 175 seropositive and 35 seronegative household contacts from 2014 to 2016, who were subjected to an extensive protocol that included clinical, molecular (peripheral blood qPCR, slit-skin smear qPCR, skin biopsy qPCR) and electroneuromyographic evaluations...
May 21, 2018: PLoS Neglected Tropical Diseases
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