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https://www.readbyqxmd.com/read/28095959/general-aviation-pilots-over-70-years-old
#1
Alpo Vuorio, Saryani Asmayawati, Bruce Budowle, Robin Griffiths, Timo Strandberg, Jaana Kuoppala, Antti Sajantila
BACKGROUND: Currently it is not unusual for general aviation pilots in the United States to continue to fly beyond the age of 70, even into their 80s and 90s. Pilots have regular examinations according to protocols which do not specify special or additional requirements for pilots over 70 yr of age. Additionally, the third class medical reforms passed by the U.S. Senate on 15 July 2016 could potentially result in even less stringent medical certification requirements for general aviation pilots...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28081486/front-line-treatment-of-cll-in-the-era-of-novel-agents
#2
REVIEW
Tadeusz Robak, Stephan Stilgenbauer, Alessandra Tedeschi
Although chemoimmunotherapy prolongs survival and as such, is the standard of care for treatment-naïve patients, its effectiveness may be reduced by associated toxicity and dose reductions. In addition, it has been associated with the development of myelosuppression and secondary neoplasms; treatments are hence needed which offer greater survival and lowered toxicity. A range of new targeted agents, ibrutinib, idelalisib and venetoclax, have demonstrated such a balance in a second-line setting, offering CLL patients durable remissions and a modest toxicity profile...
December 30, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28077671/impact-of-long-term-care-facility-residence-on-the-antibiotic-resistance-of-urinary-tract-escherichia-coli-and-klebsiella
#3
Alicia Rosello, Andrew C Hayward, Susan Hopkins, Carolyne Horner, Dean Ironmonger, Peter M Hawkey, Sarah R Deeny
BACKGROUND: Long-term care facilities (LTCFs) are thought to be important reservoirs of antimicrobial-resistant (AMR) bacteria; however, there is no routine surveillance of resistance in LTCF residents, or large population-based studies comparing AMR in LTCFs with the community, so the relative burden of AMR in LTCFs remains unknown. OBJECTIVES: To compare the frequency of antibiotic resistance of urinary tract bacteria from residents of LTCFs for the elderly and adults aged 70 years or older living in the community...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28076422/monoclonal-antibody-against-g-glycoprotein-increases-respiratory-syncytial-virus-clearance-in-vivo-and-prevents-vaccine-enhanced-diseases
#4
Hyo-Jeong Lee, Jeong-Yoon Lee, Min-Hee Park, Joo-Young Kim, Jun Chang
Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract illness in infants, young children, and the elderly. The G glycoprotein plays a role in host cell attachment and also modulates the host immune response, thereby inducing disease pathogenesis. We generated two monoclonal antibodies (mAbs; 5H6 and 3A5) against G protein core fragment (Gcf), which consisted of amino acid residues 131 to 230 from RSV A2 G protein. Epitope mapping study revealed that 5H6 specifically binds to the G/164-176 peptide that includes conserved sequences shared by both RSV A and B subtypes, and 3A5 binds to the G/190-204 peptide...
2017: PloS One
https://www.readbyqxmd.com/read/28069848/aco-affiliated-hospitals-reduced-rehospitalizations-from-skilled-nursing-facilities-faster-than-other-hospitals
#5
Ulrika Winblad, Vincent Mor, John P McHugh, Momotazur Rahman
Medicare's more than 420 accountable care organizations (ACOs) provide care for a considerable percentage of the elderly in the United States. One goal of ACOs is to improve care coordination and thereby decrease rates of rehospitalization. We examined whether ACO-affiliated hospitals were more effective than other hospitals in reducing rehospitalizations from skilled nursing facilities. We found a general reduction in rehospitalizations from 2007 to 2013, which suggests that all hospitals made efforts to reduce rehospitalizations...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28063651/recent-highlights-in-psoriasis-research
#6
REVIEW
Samuel T Hwang, Tamar Nijsten, James T Elder
This article highlights recent advances in the immunology, epidemiology, and genetics/genomics of psoriasis from 2015 through 2016. Advances sometimes generate more questions, and this article makes an attempt to point out where controversies might exist in the literature. Many of the articles mentioned were published in the Journal of Investigative Dermatology, but many articles from the broader scientific literature are also cited, to provide context and to add further validity for some of these key findings...
January 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28062482/dysregulated-nox4-ubiquitination-contributes-to-redox-imbalance-and-age-related-severity-of-acute-lung-injury
#7
Sunmi Palumbo, Yoon-Joo Shin, Kareem Ahmad, Ankit A Desai, Hector Quijada, Mohamed Mohamed, Adam Knox, Saad Sammani, Brett A Colson, Ting Wang, Joe G N Garcia, Louise Hecker
Acute respiratory distress syndrome (ARDS) is a devastating critical illness disproportionately affecting the elderly population(higher incidence and mortality). The integrity of the lung endothelial cell (EC) monolayer is critical for preservation of lung function. However, mechanisms mediating EC barrier regulation in aging remain unclear. We assessed the severity of acute lung injury (ALI) in young (2 months) and aged (18 months) mice using a two-hit pre-clinical model. Compared to young cohorts, aged mice exhibited increased ALI severity, with greater vascular permeability characterized by elevated albumin influx, levels of bronchoalveolar lavage (BAL) cells (neutrophils) and protein...
January 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28062255/differential-effects-of-bihemispheric-and-unihemispheric-transcranial-direct-current-stimulation-in-young-and-elderly-adults-in-verbal-learning
#8
Valentina Fiori, Michael Nitsche, Luigi Iasevoli, Gabriella Cucuzza, Carlo Caltagirone, Paola Marangolo
For the past few years, the potential of transcranial direct current stimulation (tDCS) for the treatment of several pathologies has been investigated. In the language domain, several studies, in healthy and brain-damaged populations, have already shown that tDCS is effective in enhancing naming, repetition and semantic word generation. In those studies, different tDCS electrode configurations have been tested, however, a direct comparison between different montages in verbal learning has never been conducted...
January 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28048103/su-g-brc-11-impact-of-dose-calculation-algorithms-on-lung-sbrt-treatments
#9
J Rosenfield, X Yang, X Dong, E Elder, K Higgins, A Dhabaan
PURPOSE: To investigate potential dosimetrical differences between the Acuros XB (AXB) and AAA dose calculation algorithms, with a specific focus on lung SBRT treatments involving inherently high degrees of anatomical heterogeneity, small field sizes, and varying tumor locations relative to critical structures. METHODS: A cohort of 20 SBRT patients treated in our clinic was selected to include varying lung tumor locations. For each patient, the Eclipse treatment planning system was employed to generate a lung SBRT plan using the AXB dose calculation algorithm, in addition to the AAA plan previously calculated for clinical use...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047069/su-f-t-446-improving-craniospinal-irradiation-technique-using-volumetric-modulated-arc-therapy-vmat-planning-and-its-dosimetric-verification
#10
X Yang, M Tejani, X Jiang, E Elder, A Dhabaan
PURPOSE: The purpose of this study is to investigate a volumetric modulated arc therapy (VMAT) treatment planning technique for supine craniospinal irradiation (CSI). Evaluate the suitability of VMAT for CSI with dosimetric measurements and compare it to 3D conformal planning using specific plan metrics such as dose conformity, homogeneity, and dose of organs at risk (OAR). METHODS: Ten CSI patients treated with conventional 3D technique were re-planned with VMAT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047061/su-f-r-07-radiomics-of-ct-features-and-associations-and-correlation-with-outcomes-following-lung-sbrt
#11
E Schreibmann, A Iwinski Sutter, D Whitaker, J Switchenko, E Elder, K Higgins, P Patel
OBJECTIVE: To investigate the prognostic significance of image gradients and in predicting clinical outcomes in a patients with non-small cell lung cancer treated with stereotactic body radiotherapy (SBRT) on 71 patients with 83 treated lesions. METHODS: The records of patients treated with lung SBRT were retrospectively reviewed. When applicable, SBRT target volumes were modified to exclude any overlap with pleura, chestwall, or mediastinum. The ITK software package was utilized to generate quantitative measures of image intensity, inhomogeneity, shape morphology and first and second-order CT textures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031705/earlier-nephrology-consultation-may-not-be-associated-with-improved-short-term-survival-of-acute-kidney-injury-in-very-elderly-men
#12
Qinglin Li, Meng Zhao, Jing Du, Xiaodan Wang
OBJECTIVES: A delayed nephrology consultation (NC) may be associated with a poor prognosis in acute kidney injury (AKI) patients. The aims of this study were to compare the clinical and laboratory characteristics of elderly AKI patients evaluated and not evaluated by nephrologists and to generate a hypothesis regarding the relationship between the timing of the NC and 90-day outcomes. METHODS: From 2007 to 2015, this study explored associations among the presence and timing of NC with the non-intensive care unit stay and 90-day mortality in elderly AKI patients at the Geriatric Department of the Chinese People's Liberation Army General Hospital...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28028953/opinions-of-old-age-according-to-residents-of-polish-public-nursing-homes-and-members-of-the-universities-of-the-third-age
#13
Mateusz Cybulski, Elżbieta Krajewska-Kułak, Jacek Jamiołkowski
BACKGROUND: Statistical data from the turn of the 21st century shows a significant increase in the average human life span and, what follows, an extension of old age. OBJECTIVES: The aim of this study was to become familiar with the opinions submitted by respondents regarding aging and old age, health problems connected with aging and preferred health behaviors. MATERIAL AND METHODS: The research was conducted between January 3rd 2013 and February 15th 2014 on a group of 200 residents of public nursing homes and 200 members of the University of the Third Age using a questionnaire created by the authors...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28025490/a-model-of-health-for-family-caregivers-of-elders
#14
Florence M Weierbach, Yan Cao
: Family members who provide care to their loved ones experience changes in their own health. The caregiver health model (CGHM) is a new model that identifies health holistically and identifies four determinant(s) that contribute to the health status of the family caregiver. The purpose is to introduce the CGHM: Hypothesis 1: the determinants of health in the CGHM contribute to the health of the Caregiver, Hypothesis 2: the determinants of health contribute to changes in the caregivers' health at 8 and 16 weeks, and Hypothesis 3: a change in health occurs from baseline to 8 and 16 weeks...
December 22, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28025116/perceived-timing-of-a-postural-perturbation
#15
Julian Lupo, Michael Barnett-Cowan
Falling down is a common event that threatens the survival of an organism. Simple, yet sophisticated neural mechanisms allow for rapid detection of a fall as well as the generation of compensatory reflexes designed to prevent a fall. Fall awareness and preventative alerting devices could potentially mitigate the likelihood of a fall, however, relatively little is known about the perceived timing of a fall. Common anecdotal reports suggest that humans often describe distortions in their perception of time with very little recollection of what occurred during the fall...
December 24, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28024862/perceived-urban-neighborhood-environment-for-physical-activity-of-older-adults-in-seoul-korea-a-multimethod-qualitative-study
#16
Seunghyun Yoo, Dong Ha Kim
This study assessed the attributes of a perceived urban neighborhood environment for the physical activity (PA) of older adults by applying a qualitative multimethod approach to collect both descriptive and spatial information. Conducted in a northern community of Seoul, Korea, from April 2014 to November 2015, data collection methods included 90 walking tours by researchers, 46 face-to-face, semi-structured interviews combined with qualitative mapping with senior residents aged 65+, 19 guided tours with the interviewees, and 3 focus groups with 12 community service providers...
December 24, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/28002517/correlations-between-etiological-factors-and-lesion-severity-in-carotid-artery-atheromatosis
#17
Cristian Constantin, Dana Maria Albulescu, Valeria Carmen Albu, Aniela Raluca Danciu, Andrei Constantin Deaconu
Occurrence of atheromatous plaques on the internal wall of large and medium sized arteries represents a widely spread disease. It is especially found in the elderly, but also in individuals belonging to the 4th-6th decade of life with an increasing incidence. Correlating the main etiological factors with morphological change severity, in conjunction with settling the importance of each factor on its own in generating and developing arterial plaques, has an important predictive role in the evolution of atherosclerotic pathology...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28000268/implants-for-elderly-patients
#18
REVIEW
Martin Schimmel, Frauke Müller, Valérie Suter, Daniel Buser
In the developed world, the large birth cohorts of the so-called baby boomer generation have arrived in medical and dental practices. Often, elderly patients are 'young-old' baby boomers in whom partial edentulism is the predominant indication for implant therapy. However, the generation 85+ years of age represents a new challenge for the dental profession, as their lives are frequently dominated by dependency, multimorbidity and frailty. In geriatric implant dentistry, treatment planning is highly individualized, as interindividual differences become more pronounced with age...
February 2017: Periodontology 2000
https://www.readbyqxmd.com/read/27997292/intergenerational-care-perceptions-of-older-women-and-middle-adolescents-in-a-resource-constrained-community-in-south-africa
#19
Vera Roos, Sonia Oosthuizen, Tonette De Jager
This study describes intergenerational care perceptions in a resource-challenged community. Ten women (aged 60+) and eight middle adolescents (3 boys and 5 girls) participated in the Mmogo-method®, a visual data-collection method. Textual data were analyzed thematically and visual data by applying steps proposed by Roos and Redelinghuys (2016). Findings confirmed that both groups provided physical and instrumental care to the other. Older women also cared for adolescents by teaching and disciplining them, while the adolescents cared for older people by obtaining an education and by showing respect...
December 20, 2016: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/27993249/-prevalence-of-mood-and-anxiety-disorders-on-people-with-chronic-conditions-results-from-the-national-mental-health-survey-in-colombia-2015
#20
Nathalie Tamayo Martínez, Carlos Gómez-Restrepo, Sandra Ramírez, María Nelcy Rodríguez
INTRODUCTION: The study of mental disorders in people with chronic conditions recognises the importance of actively seeking and treating both, since chronic conditions have a higher prevalence than mental disorders and their comorbidity generates greater burden than if each one was considered separately. OBJECTIVES: To measure the prevalence of mood disorders and anxiety in a Colombian population of 12 years and older and with and without different chronic conditions...
December 2016: Revista Colombiana de Psiquiatría
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