keyword
MENU ▼
Read by QxMD icon Read
search

Elderly + generation

keyword
https://www.readbyqxmd.com/read/29153116/community-guide-cardiovascular-disease-economic-reviews-tailoring-methods-to-ensure-utility-of-findings
#1
Sajal K Chattopadhyay, Verughese Jacob, Shawna L Mercer, David P Hopkins, Randy W Elder, Christopher D Jones
The Community Preventive Services Task Force recommended five interventions for cardiovascular disease prevention between 2012 and 2015. Systematic economic reviews of these interventions faced challenges that made it difficult to generate meaningful policy and programmatic conclusions. This paper describes the methods used to assess, synthesize, and evaluate the economic evidence to generate reliable and useful economic conclusions and address the comparability of economic findings across interventions. Specifically, steps were taken to assess completeness of data and identify the components and drivers of cost and benefit...
December 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29151982/the-effect-of-low-magnitude-low-frequency-vibrations-lmlf-on-osteogenic-differentiation-potential-of-human-adipose-derived-mesenchymal-stem-cells
#2
Monika Marędziak, Daniel Lewandowski, Krzysztof A Tomaszewski, Krzysztof Kubiak, Krzsztof Marycz
Introduction: In the current study, we investigated the effect of low magnitude, low frequency (LMLF) mechanical vibrations on the osteogenic differentiation potential of human adipose derived mesenchymal stem cells (hASC), taken from elderly patients. Methods: During 21 days in osteogenic culture medium, cells were periodically exposed to three different frequencies (25, 35 and 45 Hz) of continuous sinusoidal oscillation, using a vibration generator. We measured cell proliferation, cell morphology, calcium and phosphorus deposition using Almar Blue assay, fluorescence microscopy, scanning electron microscopy, and a EDX detector, respectively...
2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29148534/genetic-testing-of-complement-and-coagulation-pathways-in-patients-with-severe-hypertension-and-renal-microangiopathy
#3
Christopher P Larsen, Jon D Wilson, Alejandro Best-Rocha, Marjorie L Beggs, Randolph A Hennigar
A diagnosis of thrombotic microangiopathy on kidney biopsy in a patient presenting with hypertensive emergency has historically elicited the diagnosis of malignant hypertension-associated thrombotic microangiopathy. Recent studies, however, have raised awareness that a number of these patients may actually represent atypical hemolytic uremic syndrome. To further investigate this premise, we performed next-generation sequencing to interrogate the coding regions of 29 complement and coagulation cascade genes associated with atypical hemolytic uremic syndrome in 100 non-elderly patients presenting with severe hypertension, renal failure and a kidney biopsy showing microangiopathic changes limited to the classic accelerated hypertension-associated lesion of arterial intimal edema ('mucoid intimal hyperplasia') in isolation and without accompanying glomerular microthrombi...
November 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29147805/can-clinical-practice-indicator-relating-to-long-acting-benzodiazepine-use-in-the-elderly-be-easily-generated-in-a-hospital-setting
#4
Badria Kadri, Antonio Teixeira, Christelle Duteil, Annabelle Tan, Hélène Barreteau, Christophe Segouin, Pénélope Troude
BACKGROUND: To improve the appropriate use of long-acting benzodiazepine (la.bzd) prescriptions in the elderly, the Haute Autorité de Santé (HAS) has developed clinical practice indicators (CPI). The alert indicator (AI) evaluates the prevalence of la.bzd prescription among older people. The mastering indicator (MI) corresponds to the prevalence of elderly with a justified, i.e., appropriate, la.bzd prescription among all the elderly with la.bzd prescriptions. OBJECTIVE: The objective of this study was to test the feasibility of routine generation of CPI regarding la...
November 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29146523/factors-that-contribute-to-differences-in-survival-of-black-vs-white-patients-with-colorectal-cancer
#5
Helmneh M Sineshaw, Kimmie Ng, W Dana Flanders, Otis W Brawley, Ahmedin Jemal
BACKGROUND & AIMS: Previous studies reported that black vs white disparities in survival among elderly patients with colorectal cancer (CRC) were due to differences in tumor characteristics (tumor stage, grade, nodal status, and comorbidity) rather than differences in treatment. We sought to determine the sequential contribution of differences in insurance, comorbidity, tumor characteristics, and treatment receipt to the black-white survival disparity among patients with CRC in 18-64 years old...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29140858/computerized-cognitive-testing-in-primary-care-a-qualitative-study
#6
Geneva Millett, Gary Naglie, Ross Upshur, Liisa Jaakkimainen, Jocelyn Charles, Mary C Tierney
Computerized cognitive assessment tools may facilitate early identification of dementia in the primary care setting. We investigated primary care physicians' (PCPs') views on advantages and disadvantages of computerized testing based on their experience with the Computer Assessment of Mild Cognitive Impairment (CAMCI). Over a 2-month period, 259 patients, 65 years and older, from the family practice of 13 PCPs completed the CAMCI. Twelve PCPs participated in an individual interview. Generally, PCPs felt that the relationship between them and their patients helped facilitate cognitive testing; however, they thought available paper tests were time consuming and not sufficiently informative...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29121710/effects-of-living-alone-versus-with-others-and-of-housemate-type-on-smoking-drinking-dietary-habits-and-physical-activity-among-elderly-people
#7
Seungmin Jeong, Sung Il Cho
OBJECTIVES: This study examined differences in health behaviors between elderly people living alone and with others; it also investigated whether the effect of living with others differs according to housemate type, namely a spouse and/or younger generations. METHODS: Gender-stratified data from the 2013 Korea Community Health Survey for individuals aged 60 to 74 living in Seoul were analyzed. Logistic regression modeling was conducted to obtain odds ratios (ORs) and 95% confidence intervals (CIs) of the outcome variables (smoking, drinking, eating salty foods, inactive lifestyle) for the variables of interest (living alone/with others, housemate type)...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29121085/biomechanical-simulation-of-vocal-fold-dynamics-in-adults-based-on-laryngeal-high-speed-videoendoscopy
#8
Michael Döllinger, Pablo Gómez, Rita R Patel, Christoph Alexiou, Christopher Bohr, Anne Schützenberger
MOTIVATION: Human voice is generated in the larynx by the two oscillating vocal folds. Owing to the limited space and accessibility of the larynx, endoscopic investigation of the actual phonatory process in detail is challenging. Hence the biomechanics of the human phonatory process are still not yet fully understood. Therefore, we adapt a mathematical model of the vocal folds towards vocal fold oscillations to quantify gender and age related differences expressed by computed biomechanical model parameters...
2017: PloS One
https://www.readbyqxmd.com/read/29119468/clinical-decision-support-and-optional-point-of-care-testing-of-renal-function-for-safe-use-of-antibiotics-in-elderly-patients-a-retrospective-study-in-community-pharmacy-practice
#9
Mette Heringa, Annemieke Floor-Schreudering, Peter A G M De Smet, Marcel L Bouvy
OBJECTIVE: The aim was to investigate the management of drug therapy alerts on safe use of antibiotics in elderly patients with (potential) renal impairment and the contribution of optional creatinine point of care testing (PoCT) in community pharmacy practice. METHODS: Community pharmacists used a clinical decision support system (CDSS) for seven antibiotics. Alerts were generated during prescription processing in the case of previously registered renal impairment and when no information on renal function was available for patients aged 70 and over...
November 8, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29118202/bayesian-optimal-adaptation-explains-age-related-human-sensorimotor-changes
#10
Faisal Karmali, Gregory T Whitman, Richard F Lewis
The brain uses information from different sensory systems to guide motor behavior, and aging is associated with a simultaneous decline in the quality of sensory information provided to the brain and a deterioration in motor control. Correlations between age-dependent decline in sensory anatomical structures and behavior have been demonstrated, and it has recently been suggested that a Bayesian framework could explain these relationships. Here we show that age-dependent changes in a human sensorimotor reflex, the vestibulo-ocular reflex, are explained by a Bayesian optimal adaptation in the brain occurring in response to death of motion-sensing hair cells...
November 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29117183/capacity-of-ttreg-generation-is-not-impaired-in-the-atrophied-thymus
#11
Jiyoung Oh, Weikan Wang, Rachel Thomas, Dong-Ming Su
Postnatal thymic epithelial cell (TEC) homeostatic defect- or natural aging-induced thymic atrophy results in a decline in central T-cell tolerance establishment, which is constituted by thymocyte negative selection and cluster of differentiation (CD) 4+ thymic regulatory T (tTreg) cell generation. Emerging evidence shows this decline mainly results from defects in negative selection, but there is insufficient evidence regarding whether tTreg cell generation is also impaired. We mechanistically studied tTreg cell generation in the atrophied thymus by utilizing both postnatal TEC-defective (resulting from FoxN1-floxed conditional knockout [cKO]) and naturally aged mouse models...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29102999/prospective-cohort-study-to-investigate-the-burden-and-transmission-of-acute-gastroenteritis-in-care-homes-a-study-protocol
#12
Thomas Inns, Anna Pulawska-Czub, John P Harris, Roberto Vivancos, Jonathan M Read, Nicholas J Beeching, David J Allen, Miren Iturriza-Gomara, Sarah J O'Brien
INTRODUCTION: Noroviruses are the leading cause of acute gastroenteritis in all age groups, but illness is more severe and causes excess mortality in the elderly, particularly those in long-term care. The total burden of norovirus disease in the elderly in the UK is poorly defined; no current surveillance programmes systematically or accurately quantify norovirus infection in those living in care homes. The aim of this study is to evaluate an enhanced surveillance system for acute gastroenteritis among the elderly in care homes...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29099504/atypical-fibroxanthoma-and-pleomorphic-dermal-sarcoma-harbor-frequent-notch1-2-and-fat1-mutations-and-similar-dna-copy-number-alteration-profiles
#13
Klaus G Griewank, Thomas Wiesner, Rajmohan Murali, Carina Pischler, Hansgeorg Müller, Christian Koelsche, Inga Möller, Cindy Franklin, Ioana Cosgarea, Antje Sucker, Dirk Schadendorf, Jörg Schaller, Susanne Horn, Thomas Brenn, Thomas Mentzel
Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invasion. To investigate the as-yet poorly understood genetics of these tumors, 41 atypical fibroxanthomas and 40 pleomorphic dermal sarcomas were subjected to targeted next-generation sequencing approaches as well as DNA copy number analysis by comparative genomic hybridization...
November 3, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29099037/quantification-of-age-related-lung-tissue-mechanics-under-mechanical-ventilation
#14
JongWon Kim, Rebecca L Heise, Angela M Reynolds, Ramana M Pidaparti
Elderly patients with obstructive lung diseases often receive mechanical ventilation to support their breathing and restore respiratory function. However, mechanical ventilation is known to increase the severity of ventilator-induced lung injury (VILI) in the elderly. Therefore, it is important to investigate the effects of aging to better understand the lung tissue mechanics to estimate the severity of ventilator-induced lung injuries. Two age-related geometric models involving human bronchioles from generation G10 to G23 and alveolar sacs were developed...
September 29, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29091724/impact-of-age-and-pre-existing-influenza-immune-responses-in-humans-receiving-split-inactivated-influenza-vaccine-on-the-induction-of-the-breadth-of-antibodies-to-influenza-a-strains
#15
Ivette A Nuñez, Michael A Carlock, James D Allen, Simon O Owino, Krissy K Moehling, Patricia Nowalk, Michael Susick, Kensington Diagle, Kristen Sweeney, Sophia Mundle, Thorsten U Vogel, Simon Delagrave, Moti Ramgopal, Richard K Zimmerman, Harry Kleanthous, Ted M Ross
Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18-85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The impact of repeated vaccination on breadth and durability of antibodies was assessed as a result of vaccine strain changes. Total IgG anti-hemagglutinin (HA) binding antibodies and hemagglutination-inhibition (HAI) activity increased in all age groups against both influenza A HA components in the vaccine post-vaccination (day 21)...
2017: PloS One
https://www.readbyqxmd.com/read/29079958/fukushima-triple-disaster-and-the-road-to-recovery-a-qualitative-exploration-of-resilience-in-internally-displaced-residents
#16
Claire L Mann, Christina N Gillezeau, Alessandro Massazza, Daniel J Lyons, Kanata Tanaka, Kazuma Yonekura, Hideharu Sekine, Robert Yanagisawa, Craig L Katz
Six years after the March 2011 Triple Disaster, over 35,000 Japanese individuals remain in temporary housing. Evacuated residents, many of who are elderly, face mental health challenges. This study evaluates the well being of individuals living in temporary housing within Fukushima. Reactions to relocation were explored using Photovoice, a community-based participatory research method, in which a set of research questions are examined qualitatively through photographs and interviews. Seven participants (average age = 69...
October 27, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29076416/novel-treatment-and-new-drugs-in-epilepsy-treatment
#17
Elissavet Eskioglou, M P Perrenoud, Phiilippe Ryvlin, Jan Novy
We now get benefit from more than 20 antiepileptic drugs (AEDs) in the care of people with epilepsy. Newer generation of AED is associated with a more favourable tolerability profile than older generation AEDs which makes them easier to use, despite similar efficacy. In order to define the place of newer generation AEDs in the therapy, we review here the main current guidelines about their use for a special issue concerning antiepileptic drugs in neurosurgical practice. We also discuss how to tailor the treatment with newer generation AEDs according to the patient's needs and comorbid conditions...
October 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29076415/antiepileptic-drugs-for-preventing-seizures-in-patients-with-chronic-subdural-hematoma
#18
Pedro Moura Branco, Bernardo Oliveira Ratilal, João Costa, Cristina Sampaio
Chronic subdural hematoma (CSH) is an accumulation of blood within the intracranial subdural space. It is associated with minor traumatic events and affects mostly the elderly. CSH can be effectively treated surgically with good outcomes, although the recurrence rate is high. Epileptic seizures are one of the major complications associated with CSH, either in the pre or postoperative period. The incidence rate of new onset seizures after CSH diagnosis ranges between 3% and 23%. However, the benefit of using prophylactic antiepileptic drugs in these patients is controversial with significant variations in clinical practice...
October 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29075186/age-related-changes-in-sensorimotor-temporal-binding
#19
Tiziana Vercillo, Carlos Carrasco, Fang Jiang
The causal relationship between a voluntary movement and a sensory event is crucial for experiencing agency. Sensory events must occur within a certain delay from a voluntary movement to be perceived as self-generated. Therefore, temporal sensitivity, i.e., the ability to discriminate temporal asynchronies between motor and sensory events, is important for sensorimotor binding. Moreover, differences in the physical propagation of external stimuli can sometimes challenge sensorimotor binding, generating illusory asynchrony...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29070646/amyloid-pet-burden-and-regional-distribution-in-cerebral-amyloid-angiopathy-a-systematic-review-and-meta-analysis-of-biomarker-performance
#20
Andreas Charidimou, Karim Farid, Hsin-Hsi Tsai, Li-Kai Tsai, Rouh-Fang Yen, Jean-Claude Baron
INTRODUCTION: We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA). METHODS: In a PubMed systematic search, we identified case-control studies with extractable data on global and occipital-to-global amyloid-PET uptake in symptomatic patients with CAA (per Boston criteria) versus control groups (healthy participants or patients with non-CAA deep intracerebral haemorrhage) and patients with Alzheimer's disease...
October 25, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
keyword
keyword
60505
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"