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https://www.readbyqxmd.com/read/29775620/a-monoclonal-antibody-sandwich-elisa-for-vitamin-d-binding-protein-vdbp-is-unaffected-by-gc-globulin-phenotype-peptides-and-actin-and-demonstrates-reduced-levels-in-sepsis-and-non-sepsis-intensive-care-patients
#1
Katrina Hong, Christopher M Florkowski, Matthew P Doogue, Peter A Elder, John G Lewis
The measurement of vitamin D-binding protein (VDBP) by immunoassay has been confounded by variable antibody recognition of the Gc1s, Gc1F and Gc2 phenotypes. This has led to spurious conclusions regarding vitamin D status in different ethnic groups. In order to overcome these problems there is a requirement for VDBP antibodies that are unaffected by phenotype status. Here we report the generation and testing of three monoclonal antibodies to VDBP which recognise linear epitopes and are unaffected by vast molar excesses of synthetic peptides spanning these phenotypic domains...
May 15, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29769054/factors-associated-with-social-participation-amongst-elders-in-rural-sri-lanka-a-cross-sectional-mixed-methods-analysis
#2
Celeste Marsh, Paul A Agius, Gamini Jayakody, Roshan Shajehan, Chandima Abeywickrema, Kelly Durrant, Stanley Luchters, Wendy Holmes
BACKGROUND: Populations of low and middle-income countries are ageing rapidly; there is a need for policies that support an increase in the duration of old age lived in good health. There is growing evidence that social participation protects against morbidity and mortality, but few studies explore patterns of social participation. Analysis of baseline quantitative and qualitative data from a trial of the impact of Elders' Clubs on health and well-being in the hill country of Sri Lanka provided an opportunity to better understand the extent of, and influences on, social participation among elders...
May 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29765209/using-the-frailty-assessment-for-care-planning-tool-fact-to-screen-elderly-chronic-kidney-disease-patients-for-frailty-the-nurse-experience
#3
Heather Moffatt, Paige Moorhouse, Laurie Mallery, David Landry, Karthik Tennankore
Purpose: Recent evidence supports the prognostic significance of frailty for functional decline and poor health outcomes in patients with chronic kidney disease. Yet, despite the development of clinical tools to screen for frailty, little is known about the experiential impact of screening for frailty in this setting. The Frailty Assessment for Care Planning Tool (FACT) evaluates frailty across 4 domains: mobility, function, social circumstances, and cognition. The purpose of this qualitative study was as follows: 1) explore the nurse experience of screening for frailty using the FACT tool in a specialized outpatient renal clinic; 2) determine how, if at all, provider perceptions of frailty changed after implementation of the frailty screening tool; and 3) determine the perceived factors that influence uptake and administration of the FACT screening tool in a specialized clinical setting...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29762312/the-influence-of-occupation-on-wellbeing-as-experienced-by-the-elderly-a-systematic-review
#4
Christina Jessen-Winge, Mille Nyboe Petersen, Anne-Le Morville
OBJECTIVE: The objective of this review was to synthesize knowledge regarding which types of occupations the elderly perceive as important to and supporting their overall wellbeing. INTRODUCTION: Being active is an important part of managing the daily challenges of advanced old age. Occupational therapy and occupational science are based on the premise that a person's occupations are intertwined with their health and are thus needed for them to experience a meaningful life and improve their wellbeing...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761543/influence-of-backrest-angle-on-swallowing-musculature-activity-and-physical-strain-during-the-head-lift-exercise-in-elderly-women-compared-with-young-women
#5
Naomi Koshi, Hiromi Matsumoto, Tetsuya Hiramatsu, Yoko Shimizu, Hiroshi Hagino
BACKGROUND: The head lift exercise (HLE) is the most common exercise for strengthening the swallowing musculature in clinical situations. OBJECTIVE: The present study investigated whether a change in the backrest angle of a bed influences swallowing musculature activity and physical strain during the HLE and whether it can generate an appropriate exercise load for swallowing musculature activity for older women compared with younger women. METHODS: Participants were 10 elderly women and 10 young women, each of whom performed the HLE with a backrest randomly angled at 0°, 15°, 30°, or 45°...
May 14, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29760253/deprescribing-benzodiazepine-receptor-agonists-evidence-based-clinical-practice-guideline
#6
Kevin Pottie, Wade Thompson, Simon Davies, Jean Grenier, Cheryl A Sadowski, Vivian Welch, Anne Holbrook, Cynthia Boyd, Robert Swenson, Andy Ma, Barbara Farrell
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop benzodiazepine receptor agonists (BZRAs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. METHODS: The overall team comprised 8 clinicians (1 family physician, 2 psychiatrists, 1 clinical psychologist, 1 clinical pharmacologist, 2 clinical pharmacists, and 1 geriatrician) and a methodologist; members disclosed conflicts of interest...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29759150/comprehensive-characterization-of-circulating-and-bone-marrow-derived-multiple-myeloma-cells-at-minimal-residual-disease
#7
REVIEW
Johannes M Waldschmidt, Praveen Anand, Birgit Knoechel, Jens G Lohr
The presence or absence of minimal residual disease (MRD) in patients with multiple myeloma (MM) has emerged as a useful marker to determine the depth of remission. MRD negativity as an endpoint has been shown to be associated with improved progression-free survival in many studies. MRD detection is therefore part of numerous clinical trial protocols for MM. At the present time, two methodologies are most widely accepted for MRD detection: (1) multicolor flow cytometry and (2) next-generation sequencing-based clonotype detection...
January 2018: Seminars in Hematology
https://www.readbyqxmd.com/read/29757095/death-preparation-of-chinese-rural-elders
#8
Yanping Liu, Gertina J van Schalkwyk
In this qualitative study, we explored how Chinese rural elders narrate death-related issues and death preparation. Adopting a phenomenological approach, we interviewed 14 participants regarding the particular actions they employ to prepare for death. The findings revealed a death preparation system for rural Chinese elders that is instrumental in how they converse about death, wish for a good death, make objects and symbols, and anticipate an afterlife as a worshiped ancestor rather than a wandering ghost...
May 14, 2018: Death Studies
https://www.readbyqxmd.com/read/29755342/mitochondria-estrogen-and-female-brain-aging
#9
REVIEW
Imane Lejri, Amandine Grimm, Anne Eckert
Mitochondria play an essential role in the generation of steroid hormones including the female sex hormones. These hormones are, in turn, able to modulate mitochondrial activities. Mitochondria possess crucial roles in cell maintenance, survival and well-being, because they are the main source of energy as well as of reactive oxygen species (ROS) within the cell. The impairment of these important organelles is one of the central features of aging. In women's health, estrogen plays an important role during adulthood not only in the estrous cycle, but also in the brain via neuroprotective, neurotrophic and antioxidant modes of action...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29754781/social-engagement-and-the-elderly-in-rural-indonesia
#10
Ariane Utomo, Peter Mcdonald, Iwu Utomo, Nur Cahyadi, Robert Sparrow
Rural areas in Indonesia are older relative to urban areas. This paper questions how levels of social engagement vary across among the elderly in rural Indonesia. A sample of 2750 respondents aged 60 and over was drawn from 10 purposely-selected relatively "old" villages. Our three measures of social engagement are: participation in income-generating activities, in communal activities, and in care work. While there are notable village-level differences in patterns of social engagement, the majority of our respondents are actively engaged in productive activities in their old age until they can no longer be so...
May 8, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29754071/aging-increases-susceptibility-to-ovarian-cancer-metastasis-in-murine-allograft-models-and-alters-immune-composition-of-peritoneal-adipose-tissue
#11
Elizabeth A Loughran, Annemarie K Leonard, Tyvette S Hilliard, Ryan C Phan, Madeleine G Yemc, Elizabeth Harper, Emma Sheedy, Yuliya Klymenko, Marwa Asem, Yueying Liu, Jing Yang, Jeff Johnson, Laura Tarwater, Zonggao Shi, Matthew Leevy, Matthew J Ravosa, M Sharon Stack
Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis...
May 10, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29750409/implications-of-the-propensity-score-matching-paradox-in-pharmacoepidemiology
#12
John E Ripollone, Krista F Huybrechts, Kenneth J Rothman, Ryan E Ferguson, Jessica M Franklin
Recent work demonstrated that propensity score matching may lead to increased covariate imbalance, even with the corresponding decrease in propensity score distance between matched units. The extent to which this paradoxical phenomenon might harm causal inference in real epidemiologic studies has not been explored. We evaluated the effect of this phenomenon using insurance claims data from the Pharmaceutical Assistance Contract for the Elderly (1999-2002) and Medicaid Analytic eXtract (2000-2007) databases...
May 10, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29747709/polimedication-applicability-of-a-computer-tool-to-reduce-polypharmacy-in-nursing-homes
#13
Tomás M García-Caballero, Juan Lojo, Carlos Menéndez, Roberto Fernández-Álvarez, Raimundo Mateos, Alejandro Garcia-Caballero
ABSTRACTBackground:The risks of polypharmacy can be far greater than the benefits, especially in the elderly. Comorbidity makes polypharmacy very prevalent in this population; thus, increasing the occurrence of adverse effects. To solve this problem, the most common strategy is to use lists of potentially inappropriate medications. However, this strategy is time consuming. METHODS: In order to minimize the expenditure of time, our group devised a pilot computer tool (Polimedication) that automatically processes lists of medication providing the corresponding Screening Tool of Older Persons' potentially inappropriate Prescriptions alerts and facilitating standardized reports...
May 11, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29744824/usefulness-of-personalized-three-dimensional-printed-model-on-the-satisfaction-of-preoperative-education-for-patients-undergoing-robot-assisted-partial-nephrectomy-and-their-families
#14
Jun Teishima, Yukihiro Takayama, Shogo Iwaguro, Tetsutaro Hayashi, Shogo Inoue, Keisuke Hieda, Shunsuke Shinmei, Ryoji Kato, Koji Mita, Akio Matsubara
OBJECTIVE: To clarify the usefulness of a personalized three-dimensional (3D) printed model of the kidney for preoperative education among patients who underwent robot-assisted partial nephrectomy (RAPN). METHODS: Twenty-nine cases of patients who planned to undergo RAPN and 19 of their families participated in this study. A three-dimensional model consisting of the kidney, tumors, ureter, inferior vena cava, and abdominal aorta in each case was generated using a Z Printer 450 based on the findings of preoperative enhanced CT...
May 9, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29741689/cryoballoon-ablation-in-the-elderly-one-year-outcome-and-safety-of-the-second-generation-28mm-cryoballoon-in-patients-over-75-years-old
#15
Verena Tscholl, Tina Lin, Abdullah Khaled-A Lsharaf, Barbara Bellmann, Patrick Nagel, Klaus Lenz, Ulf Landmesser, Mattias Roser, Andreas Rillig
Aims: The efficacy of the second-generation cryoballoon (CB) ablation in patients with atrial fibrillation (AF) has been demonstrated previously. Data on the efficacy of CB ablation in elderly patients is missing. The aim of this study was to evaluate the long-term success rate of pulmonary vein isolation (PVI) in patients ≥75 years vs. <75 years using the second-generation 28mm CB. Methods and results: Eighty patients [n = 40 ≥75 years (Group 1); n = 40 <75 years (Group 2)] with paroxysmal [n = 37 (46%) or persistent (n = 43 (54%)] AF were included...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29739336/circular-rna-expression-and-regulatory-network-prediction-in-posterior-cingulate-astrocytes-in-elderly-subjects
#16
Shobana Sekar, Lori Cuyugan, Jonathan Adkins, Philipp Geiger, Winnie S Liang
BACKGROUND: Circular RNAs (circRNAs) are a novel class of endogenous, non-coding RNAs that form covalently closed continuous loops and that are both highly conserved and abundant in the mammalian brain. A role for circRNAs in sponging microRNAs (miRNAs) has been proposed, but the circRNA-miRNA-mRNA interaction networks in human brain cells have not been defined. Therefore, we identified circRNAs in RNA sequencing data previously generated from astrocytes microdissected from the posterior cingulate (PC) of Alzheimer's disease (AD) patients (N = 10) and healthy elderly controls (N = 10) using four circRNA prediction algorithms - CIRI, CIRCexplorer, find_circ and KNIFE...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29736891/children-and-the-elderly-wealth-inequality-among-america-s-dependents
#17
Christina M Gibson-Davis, Christine Percheski
Life cycle theory predicts that elderly households have higher levels of wealth than households with children, but these wealth gaps are likely dynamic, responding to changes in labor market conditions, patterns of debt accumulation, and the overall economic context. Using Survey of Consumer Finances data from 1989 through 2013, we compare wealth levels between and within the two groups that make up America's dependents: the elderly and child households (households with a resident child aged 18 or younger)...
May 7, 2018: Demography
https://www.readbyqxmd.com/read/29736270/fiv-vaccine-with-receptor-epitopes-results-in-neutralizing-antibodies-but-does-not-confer-resistance-to-challenge
#18
Craig Miller, Mauren Emanuelli, Elizabeth Fink, Esther Musselman, Ryan Mackie, Ryan Troyer, John Elder, Sue VandeWoude
Feline immunodeficiency virus (FIV) is the feline analogue to human immunodeficiency virus (HIV) and utilizes parallel modes of receptor-mediated entry. The FIV surface glycoprotein (SU) is an important target for induction of neutralizing antibodies, and autoantibodies to the FIV binding receptor (CD134) block infection ex vivo; thus highlighting the potential for immunotherapies which utilize anti-receptor antibodies to block viral infection. To determine whether vaccination with CD134-SU complexes could induce protection against FIV infection, cats ( n  = 5 per group) were immunized with soluble CD134, recombinant FIV-SU protein, and/or CD134+SU complexes...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29735208/rethinking-musicality-in-dementia-as-embodied-and-relational
#19
Pia Kontos, Alisa Grigorovich
With the biomedicalisation and the pharmaceuticalisation of dementia, music programs, as with other arts- and leisure-based programs, have primarily been implemented as non-pharmacological means to generate social and behavioural changes. We argue that understanding and fully supporting the musicality of persons living with dementia requires engagement with citizenship discourse. Specifically we draw on a model of relational citizenship that recognizes that corporeality is a fundamental source of self-expression, interdependence, and reciprocal engagement...
June 2018: Journal of Aging Studies
https://www.readbyqxmd.com/read/29733807/fractal-regulation-and-incident-alzheimer-s-disease-in-elderly-individuals
#20
Peng Li, Lei Yu, Andrew S P Lim, Aron S Buchman, Frank A J L Scheer, Steven A Shea, Julie A Schneider, David A Bennett, Kun Hu
INTRODUCTION: Healthy physiological systems exhibit fractal regulation (FR), generating similar fluctuation patterns in physiological outputs across different time scales. FR in motor activity is degraded in dementia, and the degradation correlates to cognitive decline. We tested whether degraded FR predicts Alzheimer's disease dementia. METHODS: FR in motor activity was assessed in 1097 nondemented older adults at baseline. Cognition was assessed annually for up to 11 years...
May 4, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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