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https://www.readbyqxmd.com/read/28403645/classification-the-key-to-understanding-facial-pain
#1
Peter Svensson, Arne May
It is indisputable that the global scientific advances in headache research, be it bench or bedside, have benefited enormously from the operational diagnostic criteria published in 1988. Today, this classification system is indispensable. The reason for this success is a low inter-rater variability. In general, orofacial pain conditions are less well characterised - with the noticeable exemption of temporomandibular disorder pain. Tremendous work has been put into changing this, and significant progress has been achieved - in particular, in terms of the clinical implications and overriding conceptual models for oro-facial pain...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28356319/fast-acting-insulin-aspart-improves-glycemic-control-in-basal-bolus-treatment-for-type-1-diabetes-results-of-a-26-week-multicenter-active-controlled-treat-to-target-randomized-parallel-group-trial-onset-1
#2
David Russell-Jones, Bruce W Bode, Christophe De Block, Edward Franek, Simon R Heller, Chantal Mathieu, Athena Philis-Tsimikas, Ludger Rose, Vincent C Woo, Anne Birk Østerskov, Tina Graungaard, Richard M Bergenstal
OBJECTIVE: This multicenter, treat-to-target, phase 3 trial evaluated the efficacy and safety of fast-acting insulin aspart (faster aspart) versus conventional insulin aspart (IAsp) in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: The primary end point was change from baseline in HbA1c after 26 weeks. After an 8-week run-in, subjects were randomized (1:1:1) to double-blind mealtime faster aspart (n = 381), IAsp (n = 380), or open-label postmeal faster aspart (n = 382)-each with insulin detemir...
March 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28317446/news-announcements-and-iasp
#3
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Crisis
https://www.readbyqxmd.com/read/28256166/news-announcements-and-iasp
#4
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Crisis
https://www.readbyqxmd.com/read/28205039/a-pooled-analysis-of-clinical-pharmacology-trials-investigating-the-pharmacokinetic-and-pharmacodynamic-characteristics-of-fast-acting-insulin-aspart-in-adults-with-type-1-diabetes
#5
Tim Heise, Thomas R Pieber, Thomas Danne, Lars Erichsen, Hanne Haahr
BACKGROUND: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation aiming to mimic the fast endogenous prandial insulin release more closely than currently available insulin products. In a post hoc analysis of pooled data from six clinical pharmacology trials, the pharmacological characteristics of faster aspart and IAsp were compared. METHODS: The analysis included 218 adult subjects with type 1 diabetes from six randomised, double-blind, crossover trials in the faster aspart clinical development programme...
May 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28165180/faster-acting-insulin-aspart-provides-faster-onset-and-greater-early-exposure-vs-insulin-aspart-in-children-and-adolescents-with-type-1-diabetes-mellitus
#6
Maryam Fath, Thomas Danne, Torben Biester, Lars Erichsen, Olga Kordonouri, Hanne Haahr
BACKGROUND: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM: This randomized, double-blind, 2-period crossover trial investigated the pharmacological properties of faster aspart vs IAsp in 12 children (6-11 years), 13 adolescents (12-17 years), and 15 adults (18-64 years) with type 1 diabetes mellitus...
February 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28055230/improved-postprandial-glycemic-control-with-faster-acting-insulin-aspart-in-patients-with-type-1-diabetes-using-continuous-subcutaneous-insulin-infusion
#7
Bruce W Bode, Joseph A Johnson, Liselotte Hyveled, Søren C Tamer, Marek Demissie
BACKGROUND: Faster aspart is insulin aspart (IAsp) in a new formulation, which in continuous subcutaneous insulin infusion (CSII) in subjects with type 1 diabetes has shown a faster onset and offset of glucose-lowering effect than IAsp. METHODS: This double-blind, randomized, crossover active-controlled trial compared 2-h postprandial plasma glucose (PPG) response, following 2 weeks of CSII with faster aspart or IAsp. Primary endpoint: mean change in PPG 2 h after a standardized meal test (ΔPGav,0-2h)...
January 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28033251/multicenter-study-on-the-asymmetry-of-skin-temperature-in-complex-regional-pain-syndrome-an-examination-of-temperature-distribution-and-symptom-duration
#8
MULTICENTER STUDY
Chan Woo Cho, Francis Sahngun Nahm, Eunjoo Choi, Pyung-Bok Lee, In-Ki Jang, Chul Joong Lee, Yong Chul Kim, Sang Chul Lee
According to the International Association for the Study of Pain (IASP) and American Medical Association (AMA), the diagnostic criteria for complex regional pain syndrome (CRPS) require the presence of skin temperature asymmetry. In CRPS, it is generally accepted that the temperature of skin of affected limbs changes from warm to cold; however, in our clinical practice, we have experienced many cases with different thermographic characteristics. Therefore, we conducted a retrospective multicenter study that examined the distribution of skin temperature in patients with CRPS and skin temperature asymmetry versus symptom duration...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030974/news-announcements-iasp-and-reviewers
#9
Mark J Goldblatt, Mark Schechter, Elsa Ronningstam, Benjamin Herbstman
No abstract text is available yet for this article.
November 2016: Crisis
https://www.readbyqxmd.com/read/28030972/news-announcements-iasp-and-reviewers
#10
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Crisis
https://www.readbyqxmd.com/read/28011806/nationwide-cross-sectional-study-of-the-impact-of-chronic-pain-on-an-individual-s-employment-relationship-with-the-family-and-the-social-support
#11
Helena de Sola, Alejandro Salazar, María Dueñas, Begoña Ojeda, Inmaculada Failde
OBJECTIVES: To determine the prevalence and the factors related to sick leave and job loss among individuals suffering from chronic pain (CP), and to analyse specifically the effect of family and social support on the individual's employment. DESIGN: Observational cross-sectional study. SETTING: Data were collected using structured computer-assisted telephone interviews between February and June 2011. PARTICIPANTS: A nationwide study of 1543 Spanish adults of working age (<65), 213 of whom suffered from CP (pain suffered at least 4 or 5 days a week during the past 3 months, according to the criteria of the International Association for the Study of Pain (IASP))...
December 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27873152/a-comparison-of-pharmacokinetic-and-pharmacodynamic-properties-between-faster-acting-insulin-aspart-and-insulin-aspart-in-elderly-subjects-with-type-1-diabetes-mellitus
#12
Tim Heise, Ulrike Hövelmann, Eric Zijlstra, Kirstine Stender-Petersen, Jacob Bonde Jacobsen, Hanne Haahr
BACKGROUND: Due to population aging, an increasing number of elderly patients with diabetes use insulin. It is therefore important to investigate the characteristics of new insulins in this population. Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with faster absorption. This study investigated the pharmacological properties of faster aspart in elderly subjects with type 1 diabetes mellitus (T1DM). METHODS: In a randomised, double-blind, two-period crossover trial, 30 elderly (≥65 years) and 37 younger adults (18-35 years) with T1DM received single subcutaneous faster aspart or IAsp dosing (0...
January 2017: Drugs & Aging
https://www.readbyqxmd.com/read/27868446/news-announcements-and-iasp
#13
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Crisis
https://www.readbyqxmd.com/read/27853981/intensification-of-idegasp-twice-daily-adding-insulin-aspart-vs-switching-to-basal-bolus-exploratory-randomized-trial-in-type-2-diabetes
#14
Wan Mohamaed Wan Bebakar, Louis Chaykin, Malene Lundgren Hersløv, Søren Rasmussen
INTRODUCTION: In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intensifying IDegAsp BID treatment in these patients by either adding a once-daily (OD) bolus injection of insulin aspart (IAsp) or by switching to a basal-bolus regimen of insulin degludec (IDeg) plus IAsp taken three times a day (TID)...
February 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27809590/news-announcements-and-iasp
#15
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Crisis
https://www.readbyqxmd.com/read/27709762/pharmacological-properties-of-faster-acting-insulin-aspart-vs-insulin-aspart-in-patients-with-type-1-diabetes-receiving-continuous-subcutaneous-insulin-infusion-a-randomized-double-blind-crossover-trial
#16
Tim Heise, Eric Zijlstra, Leszek Nosek, Tord Rikte, Hanne Haahr
AIM: To evaluate the pharmacological characteristics of faster-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp) during continuous subcutaneous insulin infusion (CSII). METHODS: In this randomized, double-blind, crossover trial, 48 men and women aged 18 to 64 years with type 1 diabetes mellitus (T1DM) received faster aspart and IAsp as a 0.15 U/kg bolus dose via CSII, on top of a basal rate (0.02 U/kg/h), in a glucose clamp setting (target 5...
February 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27696221/a-review-of-insulin-degludec-insulin-aspart-pharmacokinetic-and-pharmacodynamic-properties-and-their-implications-in-clinical-use
#17
REVIEW
Hanne Haahr, Edmond G Fita, Tim Heise
Insulin degludec/insulin aspart (IDegAsp; 70 % IDeg and 30 % IAsp) is a soluble combination of two individual insulin analogues in one product, designed to provide mealtime glycaemic control due to the IAsp component and basal glucose-lowering effect from the IDeg component. The pharmacokinetic and pharmacodynamic characteristics of IDegAsp have been investigated in a series of clinical pharmacology studies with generally comparable designs, methodologies and patient inclusion/exclusion criteria. The glucose-lowering effect profile of IDegAsp during once-daily dosing at steady state shows distinct and clearly separated action from the prandial and basal components of IDegAsp...
April 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27635092/opioid-prescribing-habits-of-physicians-in-kwara-state-nigeria
#18
Zakari A Suleiman, Kolawole W Wahab, Israel K Kolawole
OBJECTIVE: Although opioid analgesics are effective in the treatment of moderate to severe acute, cancer and chronic non-malignant pains, they are under-prescribed in Nigeria. The objective of this study was to assess the prescription pattern of opioids among physicians in a north central State, Nigeria.. DESIGN: This was a descriptive cross sectional study. SETTING: The study was conducted at the International Association for the Study of Pain (IASP)-sponsored workshops on pain and palliative care at the University of Ilorin Teaching Hospital, Ilorin, Nigeria...
June 2016: Ghana Medical Journal
https://www.readbyqxmd.com/read/27626009/the-relation-between-reflex-sympathetic-dystrophy-syndrome-and-trauma-severity-in-patients-with-distal-tibia-fracture
#19
Reza Bahador, Ahmadreza Mirbolook, Sara Arbab, Pooya Derakhshan, Amirmohammad Gholizadeh, Sadegh Abedi
BACKGROUND: Reflex sympathetic dystrophy (RSD) syndrome is a multifactorial disorder with clinical features of neurogenic inflammation that causes hypersensitivity to pain or severe allodynia as well as blood flow problems, swelling, skin discoloration and maladaptive neuroplasticity due to vasomotor disorders. Patients with major trauma are prone to homeostasis leading to inflammatory response syndrome and multiple organ distress syndrome. Several studies have investigated the etiology of this condition, but the cause remains unknown...
May 2016: Trauma Monthly
https://www.readbyqxmd.com/read/27600385/development-of-insulin-detemir-insulin-aspart-cross-reacting-antibodies-following-treatment-with-insulin-detemir-104-week-study-in-children-and-adolescents-with-type-1-diabetes-aged-2-16%C3%A2-years
#20
Nandu Thalange, Abdullah Bereket, Lisbeth Bjerring Jensen, Line Conradsen Hiort, Valentina Peterkova
BACKGROUND: To study the long-term development (104 weeks) of insulin antibodies during treatment with insulin detemir (IDet) and insulin aspart (IAsp) in children with type 1 diabetes aged 2-16 years. METHODS: A 52-week, two-arm, randomized trial comparing IDet and neutral protamine Hagedorn insulin, both in combination with IAsp, was followed by a one-arm, 52-week extension trial of the IDet + IAsp arm. The present analysis was conducted in children who completed the randomized trial and entered into the extension trial...
December 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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