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https://www.readbyqxmd.com/read/29661030/diagnostic-accuracy-of-an-identification-tool-for-localized-neuropathic-pain-based-on-the-iasp-criteria
#1
Víctor Mayoral, Concepción Pérez-Hernández, Inmaculada Muro, Ana Leal, Jesús Villoria, Ana Esquivias
OBJECTIVE: Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS: A case-control study was performed in 19 pain clinics within Spain. A pain clinician used the experimental screening tool (the index test, IT) to assign the descriptions of non-neuropathic (nNP), non-localized neuropathic (nLNP) and localized neuropathic (LNP) to the patients' pain conditions...
April 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29565943/an-update-of-the-systematic-appraisal-of-the-accuracy-and-utility-of-discography-in-chronic-spinal-pain
#2
Laxmaiah Manchikanti, Amol Soin, Ramsin M Benyamin, Vijay Singh, Frank Je Falco, Aaron K Calodney, Vahid Grami, Joshua A Hirsch
BACKGROUND: The intervertebral disc has been implicated as a major cause of chronic spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients, and in 16% to 53% of patients with pain in the cervical spine...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29499419/a-soluble-activin-type-iia-receptor-mitigates-the-loss-of-femoral-neck-bone-strength-and-cancellous-bone-mass-in-a-mouse-model-of-disuse-osteopenia
#3
Andreas Lodberg, Marco Eijken, Bram C J van der Eerden, Mette Wendelboe Okkels, Jesper Skovhus Thomsen, Annemarie Brüel
Disuse causes a rapid and substantial bone loss distinct in its pathophysiology from the bone loss associated with cancers, age, and menopause. While inhibitors of the activin-receptor signaling pathway (IASPs) have been shown to prevent ovariectomy- and cancer-induced bone loss, their application in a model of disuse osteopenia remains to be tested. Here, we show that a soluble activin type IIA receptor (ActRIIA-mFc) increases diaphyseal bone strength and cancellous bone mass, and mitigates the loss of femoral neck bone strength in the Botulinum Toxin A (BTX)-model of disuse osteopenia in female C57BL/6J mice...
February 27, 2018: Bone
https://www.readbyqxmd.com/read/29493118/greater-early-postprandial-suppression-of-endogenous-glucose-production-and-higher-initial-glucose-disappearance-is-achieved-with-fast-acting-insulin-aspart-compared-to-insulin-aspart
#4
Ananda Basu, Thomas R Pieber, Ann Kathrine Hansen, Stefanie Sach-Friedl, Lars Erichsen, Rita Basu, Hanne Haahr
AIMS: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with accelerated initial absorption after subcutaneous administration, leading to improved postprandial glucose control versus IAsp. We investigated the mechanisms behind the reduced postprandial glucose with faster aspart versus IAsp. MATERIALS AND METHODS: In a randomised, double-blind, crossover trial, 41 subjects with type 1 diabetes received identical subcutaneous single faster aspart and IAsp doses (individualised for each subject) together with a standardised mixed meal (including 75 g carbohydrate labelled with [1-13 C] glucose)...
March 1, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29451706/insulin-degludec-insulin-aspart-lowers-fasting-plasma-glucose-and-rates-of-confirmed-and-nocturnal-hypoglycaemia-independent-of-baseline-hba-1c-levels-disease-duration-or-bmi-a-pooled-meta-analysis-of-phase-3-studies-in-patients-with-type-2-diabetes
#5
Martin Haluzík, Greg Fulcher, Thomas R Pieber, Lars Bardtrum, Deniz Tutkunkardas, Helena W Rodbard
AIMS: Previous studies demonstrated the co-formulation of insulin degludec (IDeg)/insulin aspart (IAsp) 'IDegAsp' offers lower rates of hypoglycaemia with smaller changes in weight compared with basal-bolus (IDeg once daily [OD] + IAsp [2-4 injections]) and premix insulin (BIAsp 30 twice daily [BID]) comparators. This study aimed to investigate whether the benefits of IDegAsp, given twice daily, extend across a wide spectrum of patients with diabetes. MATERIALS AND METHODS: This was a post hoc pooled analysis of five phase 3 randomised, 26-week, open-label, BID, treat-to-target trials comparing IDegAsp BID (n = 1111) with one of two 'comparators' - BIAsp 30 BID (n = 561) or IDeg OD + IAsp (n = 136)...
February 16, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29436056/assessing-neuropathic-pain-in-patients-with-low-back-related-leg-pain-comparing-the-paindetect-questionnaire-with-the-2016-neupsig-grading-system
#6
Eivind Hasvik, Anne Julsrud Haugen, Johannes Gjerstad, Lars Grøvle
BACKGROUND: Low back-related leg pain with nerve root involvement is conceptually regarded as a neuropathic condition. However, it is uncertain to what extent patients with this condition can be formally classified with neuropathic pain. METHOD: First, we used the 2016 revision of the IASP Special Interest Group on Neuropathic Pain (NeuPSIG) grading system for neuropathic pain to grade patients suffering from low back-related leg pain and a corresponding disc herniation with either unlikely, possible, probable or definite neuropathic pain...
February 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29430563/abstracts-from-proceedings-cork-crps-2017-iasp-special-interest-group-in-complex-regional-pain-syndrome-crps
#7
Dominic Hegarty
No abstract text is available yet for this article.
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29427812/chronic-pain-and-its-association-with-obesity-among-older-adults-in-china
#8
Jie Li, Jian Chen, Qirong Qin, Dongdong Zhao, Bao Dong, Qiongqiong Ren, Dandan Yu, Peng Bi, Yehuan Sun
OBJECTIVES: There is a paucity of epidemiological data on chronic pain and obesity among older adults. This study attempted to present the characterization of chronic pain and its association with obesity among the Chinese elderly. METHODS: A cross-sectional survey was undertaken among 6524 elderly individuals aged ≥60 years in China. Chronic pain was identified by self-reports based on the definition from the International Association for the Study of Pain (IASP)...
February 6, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29392219/-are-perioperative-opioids-obsolete-proceedings-of-an-iasp-acute-pain-special-interest-group-satellite-symposium-september-25-2016-yokohama-japan
#9
Daniel B Carr, Robert I Cohen
This IASP Satellite Symposium surveyed opioid adverse effects upon patients and society, current and future drug and nondrug alternatives, and strategies to optimize postoperative outcomes through quality improvement.
July 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29316130/efficacy-and-safety-of-fast-acting-insulin-aspart-in-comparison-with-insulin-aspart-in-type-1-diabetes-onset-1-a-52-week-randomized-treat-to-target-phase-iii-trial
#10
Chantal Mathieu, Bruce W Bode, Edward Franek, Athena Philis-Tsimikas, Ludger Rose, Tina Graungaard, Anne Birk Østerskov, David Russell-Jones
AIMS: To compare the safety and efficacy of fast-acting insulin aspart (faster aspart) with conventional insulin aspart (IAsp) in adults with type 1 diabetes (T1D). MATERIALS AND METHODS: onset 1 was a randomized, multicentre, treat-to-target, phase III, 52-week (initial 26 weeks + additional 26 weeks) trial conducted at 165 sites across 9 countries. Adults with T1D were randomly allocated to double-blind mealtime faster aspart or IAsp, each with once- or twice-daily insulin detemir...
January 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29305766/a-novel-lips-assay-for-insulin-autoantibodies
#11
Daniela Liberati, Rebecca C Wyatt, Cristina Brigatti, Ilaria Marzinotto, Maurizio Ferrari, Elena Bazzigaluppi, Emanuele Bosi, Ben T Gillard, Kathleen M Gillespie, Frans Gorus, Ilse Weets, Eric Balti, Lorenzo Piemonti, Peter Achenbach, Alistair J K Williams, Vito Lampasona
AIMS: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. METHODS: We developed (pro)insulin antigens with alternative placements of a NanoLuc™ luciferase reporter (NLuc)...
March 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29096274/attachment-of-coxiella-burnetii-to-the-zona-pellucida-of-in%C3%A2-vitro-produced-goat-embryos
#12
J L Pellerin, A Alsaleh, P Mermillod, J M G Souza-Fabjan, A Rodolakis, E Rousset, L Dubreil, J F Bruyas, C Roux, F Fieni
Previous work demonstrated that after infection of in vivo derived caprine embryos, Coxiella burnetti (C. burnetii) showed a strong tendency to adhere to the zona pellicida (ZP). To investigate the risk of C. burnetii transmission via embryo transfer of in vitro-produced goat embryos the aim of this study was, (i) to evaluate the ability of C. burnetii to adhere to the intact zona pellicida of in vitro-produced goat embryos and to determine by confocal microscopy the location of the bacteria, (ii) to test the efficacy of IETS recommended rules for the washing of bovine embryos to eliminate C...
October 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/29051187/in-vivo-magnetofection-a-novel-approach-for-targeted-topical-delivery-of-nucleic-acids-for-rectoanal-motility-disorders
#13
Jagmohan Singh, Ipsita Mohanty, Satish Rattan
In these studies, we developed a novel approach of in vivo magnetofection for localized delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target Rho kinase2) to the circular smooth muscle layer of the internal anal sphincter (IAS). The IAS tone is known to play a major role in the rectoanal continence via activation of RhoA-associated kinase (RhoA/ROCK2). These studies established an optimized protocol for efficient gene delivery using an assembly of equal volumes of in vivo PolyMag and miR139-5p or anti-miR-139-5p (100 nM each) injected in the circular smooth muscle layer in the pinpointed areas of the rat perianal region and then incubated for 20 min under magnetic field...
January 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29017373/clinical-considerations-for-use-of-insulin-degludec-insulin-aspart-in-japanese-patients
#14
REVIEW
Takahisa Hirose, Takuya Awata, Yuiko Yamamoto, Mads Peter Hemmingsen
Co-formulation of basal and bolus insulin components provides a simpler regimen for patients with type 2 diabetes than separate basal-bolus treatment. However, conventional premixed insulin products include a suboptimal protaminated basal component that requires resuspension prior to injection. Insulin degludec/insulin aspart (IDegAsp) is the first soluble co-formulation of a basal insulin with an ultra-long duration of action (IDeg) and a rapid-acting bolus insulin (IAsp) in a single injection. Areas covered: In this review, the authors summarize findings from pre-clinical studies and the clinical trial program and provide guidance for the initiating and switching of IDegAsp in different patient populations...
January 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28947243/hand-lesion-after-arthroscopic-rotator-cuff-repair-association-with-complex-regional-pain-syndrome
#15
Ryo Tanesue, Masafumi Gotoh, Yasuhiro Mitsui, Hidehiro Nakamura, Hirokazu Honda, Hiroki Ohzono, Hisao Shimokobe, Tsuyoshi Tokunaga, Takaki Imai, Takahiro Okawa, Naoto Shiba
BACKGROUND: It is known that complex regional pain syndrome (CRPS) occurs after arthroscopic rotator cuff repair (ARCR); however, few studies have investigated this complication. Therefore, the purpose of the present study was to evaluate CRPS after ARCR. METHODS: A total of 182 patients who underwent ARCR were enrolled in this study. The average age of patients was 62.8 ± 10.0 years, with an average follow-up period of 21.5 ± 38.1 months. CRPS criteria outlined by the Ministry of Health, Labor, and Welfare study team for CRPS in Japan (MHLWJ) and International Association for the Study of Pain (IASP 2005) were utilized for diagnosis...
January 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28940145/pharmacological-properties-of-faster-acting-insulin-aspart
#16
REVIEW
Torben Biester, Olga Kordonouri, Thomas Danne
PURPOSE OF REVIEW: Faster aspart is a new formulation of insulin aspart (IAsp) produced by adding the excipients niacinamide and L-arginine. As this new, "ultra-rapid insulin" is available in the EU-market and Canada, the pharmacokinetic and pharmacodynamics data is summarized. RECENT FINDINGS: Faster aspart shows an earlier onset of appearance of insulin in the bloodstream after subcutaneous administration and an earlier onset of glucose-lowering action and a higher glycemic effect within the first 30 min...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28653798/spinal-cord-injury-pain-instrument-and-paindetect-questionnaire-convergent-construct-validity-in-individuals-with-spinal-cord-injury
#17
S Franz, C Schuld, E P Wilder-Smith, L Heutehaus, S Lang, S Gantz, S Schuh-Hofer, R-D Treede, T N Bryce, H Wang, N Weidner
BACKGROUND: Neuropathic pain (NeuP) is a frequent sequel of spinal cord injury (SCI). The SCI Pain Instrument (SCIPI) was developed as a SCI-specific NeuP screening tool. A preliminary validation reported encouraging results requiring further evaluation in terms of psychometric properties. The painDETECT questionnaire (PDQ), a commonly applied NeuP assessment tool, was primarily validated in German, but not specifically developed for SCI and not yet validated according to current diagnostic guidelines...
June 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28649203/trps-in-pain-sensation
#18
REVIEW
Isaac Jardín, José J López, Raquel Diez, José Sánchez-Collado, Carlos Cantonero, Letizia Albarrán, Geoffrey E Woodard, Pedro C Redondo, Ginés M Salido, Tarik Smani, Juan A Rosado
According to the International Association for the Study of Pain (IASP) pain is characterized as an "unpleasant sensory and emotional experience associated with actual or potential tissue damage". The TRP super-family, compressing up to 28 isoforms in mammals, mediates a myriad of physiological and pathophysiological processes, pain among them. TRP channel might be constituted by similar or different TRP subunits, which will result in the formation of homomeric or heteromeric channels with distinct properties and functions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28556616/fast-acting-insulin-aspart-in-japanese-patients-with-type-1-diabetes-faster-onset-higher-early-exposure-and-greater-early-glucose-lowering-effect-relative-to-insulin-aspart
#19
Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen, Hanne Haahr
INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing. The present study compared the pharmacokinetic/pharmacodynamic characteristics of faster aspart vs IAsp in Japanese patients with type 1 diabetes. MATERIALS AND METHODS: In a randomized, double-blind, cross-over design, 43 participants were given faster aspart and IAsp (0...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28551736/back-pain-with-leg-pain
#20
REVIEW
Simon Vulfsons, Negev Bar, Elon Eisenberg
PURPOSE OF REVIEW: The clinical diagnostic dilemma of low back pain that is associated with lower limb pain is very common. In relation to back pain that radiates to the leg, the International Association for the Study of Pain (IASP) states: "Pain in the lower limb should be described specifically as either referred pain or radicular pain. In cases of doubt no implication should be made and the pain should be described as pain in the lower limb." RECENT FINDINGS: Bogduks' editorial in the journal PAIN (2009) helps us to differentiate and define the terms somatic referred pain, radicular pain, and radiculopathy...
July 2017: Current Pain and Headache Reports
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