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Marina M Finnern, Dieter Kleinböhl, Herta Flor, Justus Benrath, Rupert Hölzl
BACKGROUND AND AIMS: Evaluating the degree to which pain has become chronic beyond mere duration poses several problems. The IASP Pain Taxonomy Axis IV employs intensity and duration combined to nine ordered categories. The Chronic Pain Grade links intensity and disability, but only the latter contributes to higher grades. The Mainz Pain Staging System includes temporal and spatial aspects, medication and health care utilization. Their interrelations, scale properties and construct validity are not always known or debatable...
June 5, 2018: Scandinavian Journal of Pain
Hyungtae Kim, Cheol-Hyeong Lee, Sung-Hun Kim, Yeon-Dong Kim
Chronic regional pain syndrome (CRPS) is an inflammatory and neuropathic pain disorder characterized by the involvement of the autonomic nervous system with sensory, autonomic, motor, skin, and bone changes. At present, universally accepted consensus criteria for CRPS are not yet established, despite the diagnostic criteria proposed by the International Association for the Study of Pain (IASP). Various hypotheses for the pathophysiology of CRPS have been proposed; as a result, current therapeutic modalities are varied...
2018: PloS One
Kristen Bodner, Salvatore D'Amico, Man Luo, Elizabeth Sommers, Laura Goldstein, Caitlin Neri, Paula Gardiner
PURPOSE: This project assesses the prevalence of integrative medicine (IM) in pediatric pain clinics (PPCs) across the United States. METHODS: PPCs were identified through the American Pain Society and cross referenced through the International Association for the Study of Pain (IASP). A cross-sectional review using each PPC's website was then utilized for further information. We collected data regarding each program's target population, non-profit status (where non-profits were designated as hospitals that do not operate for-profit purpose, and private as institutions receiving private funding), location, services provided and participating providers...
June 2018: Complementary Therapies in Medicine
Sanjay Kalra, Stephen Atkin, Antonio Cervera, Ashok Kumar Das, Orgur Demir, Tevfik Demir, Md Fariduddin, Khoa Tuan Vo, Bon Jeong Ku, Ajay Kumar, Zafar A Latif, Rachid Malek, Bien J Matawaran, Roopa Mehta, Nam Quang Tran, Araceli Panelo, Sundeep Ruder, Joel Rodriquez Saldana, Khalid A Shaikh, Amit Shakya, Dina Shrestha, A G Unnikrishnan
Insulin degludec/aspart (IDegAsp) is the first soluble insulin co-formulation, combining a long-acting insulin degludec (IDeg) and rapid-acting insulin aspart (IAsp). In type 2 diabetes patients with oral antidiabetes agent (OAD) inadequacy, insulin initiation with IDegAsp once daily provides superior long-term glycemic control compared to insulin glargine, with similar fasting plasma glucose (FPG) and insulin doses, and numerically lower rates of overall and nocturnal hypoglycemia. Furthermore, in patients with uncontrolled type 2 diabetes previously treated with insulins, IDegAsp twice daily effectively improves glycated hemoglobin and FPG, with fewer hypoglycemic episodes versus premix insulins and basal bolus therapy...
May 23, 2018: Advances in Therapy
Julia M Hush, Michael Nicholas, Catherine M Dean
Supplemental Digital Content is Available in the Text. This article describes the process and evaluation of embedding the IASP Pain Curriculum for Physical Therapy into a 3-year Doctor of Physiotherapy Program in Australia.
March 2018: Pain Reports (Baltimore, Md.)
Rolf-Detlef Treede
Milton Cohen, John Quintner, and Simon van Rysewyk proposed a revision of the IASP definition of pain of 1979. This commentary summarizes, why this proposal is useful for guiding assessment of pain, but not its definition.
March 2018: Pain Reports (Baltimore, Md.)
Mike Osborn
Milton Cohen et al. proposed a revision of the IASP definition of pain of 1979. This commentary summarizes, why this redefinition is necessary, appropriate, and timely.
March 2018: Pain Reports (Baltimore, Md.)
Milton Cohen, John Quintner, Simon van Rysewyk
Introduction: The definition of pain promulgated by the International Association for the Study of Pain (IASP) is widely accepted as a pragmatic characterisation of that human experience. Although the Notes that accompany it characterise pain as "always subjective," the IASP definition itself fails to sufficiently integrate phenomenological aspects of pain. Methods: This essay reviews the historical development of the IASP definition, and the commentaries and suggested modifications to it over almost 40 years...
March 2018: Pain Reports (Baltimore, Md.)
Víctor Mayoral, Concepción Pérez-Hernández, Inmaculada Muro, Ana Leal, Jesús Villoria, Ana Esquivias
OBJECTIVE: Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS: A case-control study was performed in 19 pain clinics within Spain. A pain clinician used the experimental screening tool (the index test, IT) to assign the descriptions of non-neuropathic (nNP), non-localized neuropathic (nLNP), and localized neuropathic (LNP) to the patients' pain conditions...
April 27, 2018: Current Medical Research and Opinion
Laxmaiah Manchikanti, Amol Soin, Ramsin M Benyamin, Vijay Singh, Frank Je Falco, Aaron K Calodney, Vahid Grami, Joshua A Hirsch
BACKGROUND: The intervertebral disc has been implicated as a major cause of chronic spinal pain based on clinical, basic science, and epidemiological research. There is, however, a lack of consensus regarding the diagnosis and treatment of intervertebral disc disorders. Based on controlled evaluations, lumbar intervertebral discs have been shown to be the source of chronic back pain without disc herniation in 26% to 39% of patients, and in 16% to 53% of patients with pain in the cervical spine...
March 2018: Pain Physician
Andreas Lodberg, Marco Eijken, Bram C J van der Eerden, Mette Wendelboe Okkels, Jesper Skovhus Thomsen, Annemarie Brüel
Disuse causes a rapid and substantial bone loss distinct in its pathophysiology from the bone loss associated with cancers, age, and menopause. While inhibitors of the activin-receptor signaling pathway (IASPs) have been shown to prevent ovariectomy- and cancer-induced bone loss, their application in a model of disuse osteopenia remains to be tested. Here, we show that a soluble activin type IIA receptor (ActRIIA-mFc) increases diaphyseal bone strength and cancellous bone mass, and mitigates the loss of femoral neck bone strength in the Botulinum Toxin A (BTX)-model of disuse osteopenia in female C57BL/6J mice...
May 2018: Bone
Ananda Basu, Thomas R Pieber, Ann K Hansen, Stefanie Sach-Friedl, Lars Erichsen, Rita Basu, Hanne Haahr
AIM: To investigate the mechanisms behind the lower postprandial glucose (PPG) concentrations achieved with fast-acting insulin aspart (faster aspart) than with insulin aspart (IAsp). MATERIALS AND METHODS: In a randomized, double-blind, crossover trial, 41 people with type 1 diabetes received identical subcutaneous single faster aspart and IAsp doses (individualized for each participant), together with a standardized mixed meal (including 75 g carbohydrate labelled with [1-13 C] glucose)...
March 1, 2018: Diabetes, Obesity & Metabolism
Martin Haluzík, Greg Fulcher, Thomas R Pieber, Lars Bardtrum, Deniz Tutkunkardas, Helena W Rodbard
AIMS: To investigate whether the proven benefits of insulin degludec (IDeg) combined with insulin aspart (IAsp), known as IDegAsp, given twice daily, extend across a wide spectrum of patients with diabetes. MATERIALS AND METHODS: This was a post hoc pooled analysis of 5 phase III randomized, 26-week, open-label, treat-to-target trials comparing IDegAsp twice daily (n = 1111) with one of two comparators: premixed insulin (biphasic insulin aspart 30 [BIAsp 30]) twice daily (n = 561) or IDeg once daily + IAsp (n = 136)...
February 16, 2018: Diabetes, Obesity & Metabolism
E Hasvik, A J Haugen, J Gjerstad, L Grøvle
BACKGROUND: Low back-related leg pain with nerve root involvement is conceptually regarded as a neuropathic condition. However, it is uncertain to what extent patients with this condition can be formally classified with neuropathic pain. METHOD: First, we used the 2016 revision of the IASP Special Interest Group on Neuropathic Pain (NeuPSIG) grading system for neuropathic pain to grade patients suffering from low back-related leg pain and a corresponding disc herniation with either unlikely, possible, probable or definite neuropathic pain...
February 13, 2018: European Journal of Pain: EJP
Dominic Hegarty
No abstract text is available yet for this article.
January 2018: Pain Reports (Baltimore, Md.)
Jie Li, Jian Chen, Qirong Qin, Dongdong Zhao, Bao Dong, Qiongqiong Ren, Dandan Yu, Peng Bi, Yehuan Sun
OBJECTIVES: There is a paucity of epidemiological data on chronic pain and obesity among older adults. This study attempted to present the characterization of chronic pain and its association with obesity among the Chinese elderly. METHODS: A cross-sectional survey was undertaken among 6524 elderly individuals aged ≥60 years in China. Chronic pain was identified by self-reports based on the definition from the International Association for the Study of Pain (IASP)...
May 2018: Archives of Gerontology and Geriatrics
Daniel B Carr, Robert I Cohen
This IASP Satellite Symposium surveyed opioid adverse effects upon patients and society, current and future drug and nondrug alternatives, and strategies to optimize postoperative outcomes through quality improvement.
July 2017: Pain Reports (Baltimore, Md.)
Chantal Mathieu, Bruce W Bode, Edward Franek, Athena Philis-Tsimikas, Ludger Rose, Tina Graungaard, Anne Birk Østerskov, David Russell-Jones
AIMS: To compare the safety and efficacy of fast-acting insulin aspart (faster aspart) with conventional insulin aspart (IAsp) in adults with type 1 diabetes (T1D). MATERIALS AND METHODS: onset 1 was a randomized, multicentre, treat-to-target, phase III, 52-week (initial 26 weeks + additional 26 weeks) trial conducted at 165 sites across 9 countries. Adults with T1D were randomly allocated to double-blind mealtime faster aspart or IAsp, each with once- or twice-daily insulin detemir...
May 2018: Diabetes, Obesity & Metabolism
Daniela Liberati, Rebecca C Wyatt, Cristina Brigatti, Ilaria Marzinotto, Maurizio Ferrari, Elena Bazzigaluppi, Emanuele Bosi, Ben T Gillard, Kathleen M Gillespie, Frans Gorus, Ilse Weets, Eric Balti, Lorenzo Piemonti, Peter Achenbach, Alistair J K Williams, Vito Lampasona
AIMS: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. METHODS: We developed (pro)insulin antigens with alternative placements of a NanoLuc™ luciferase reporter (NLuc)...
March 2018: Acta Diabetologica
J L Pellerin, A Alsaleh, P Mermillod, J M G Souza-Fabjan, A Rodolakis, E Rousset, L Dubreil, J F Bruyas, C Roux, F Fieni
Previous work demonstrated that after infection of in vivo derived caprine embryos, Coxiella burnetti (C. burnetii) showed a strong tendency to adhere to the zona pellicida (ZP). To investigate the risk of C. burnetii transmission via embryo transfer of in vitro-produced goat embryos the aim of this study was, (i) to evaluate the ability of C. burnetii to adhere to the intact zona pellicida of in vitro-produced goat embryos and to determine by confocal microscopy the location of the bacteria, (ii) to test the efficacy of IETS recommended rules for the washing of bovine embryos to eliminate C...
October 26, 2017: Theriogenology
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