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https://www.readbyqxmd.com/read/29763604/attenuation-of-macrophage-accumulation-and-polarisation-in-obese-diabetic-mice-by-a-small-molecule-significantly-improved-insulin-sensitivity
#1
Sandip Mukherjee, Snehasis Das, Dipanjan Chattopadhyay, Shuvasree Sarkar, Subhendu Kumar Chatterjee, Dhrubajyoti Talukdar, Sutapa Mukherjee, Subeer S Majumder, Satinath Mukhopadhyay, Mihir K Chaudhuri, Samir Bhattacharya
Accumulation and polarization of anti-inflammatory M2 to proinflammatory M1 macrophage in the adipose tissue of obese diabetic mice is an important pathogenic signature. It worsens lipid induced inflammation and insulin resistance. Here we demonstrate that a small molecule, a peroxyvanadate compound i.e. DmpzH [VO(O2 )2 (dmpz)] or dmp, could robustly decrease macrophage infiltration, accumulation and their polarization in high fat diet (HFD) induced obese diabetic mice. In searching the underlying mechanism it was revealed that SIRT1 level was strikingly low in the inflamed adipose tissue of HFD mice as compared to mice fed with standard diet (SD)...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29734035/magnetic-multiwalled-carbon-nanotubes-as-nanocarrier-tags-for-sensitive-determination-of-fetuin-in-saliva
#2
Esther Sánchez-Tirado, Araceli González-Cortés, Paloma Yáñez-Sedeño, José M Pingarrón
This paper reports the development and performance of an electrochemical immunosensor using magnetic multiwalled carbon nanotubes (m-MWCNTs) as nanocarrier tags for the determination of human fetuin A (HFA), a relevant biomarker of obesity, insulin resistance, and type-2 diabetes as well as for pancreatic and liver cancers and inflammatory processes. Screen-printed carbon electrodes were grafted with p-aminobezoic acid and streptavidin was covalently immobilized on the electrode surface. A biotinylated capture antibody was immobilized through streptavidin-biotin interaction and a sandwich assay configuration was implemented using m-MWCNTs conjugated with HRP and anti-HFA antibodies as the detection label...
April 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29696296/a-heterogeneous-response-of-liver-and-skeletal-muscle-fat-to-the-combination-of-a-paleolithic-diet-and-exercise-in-obese-individuals-with-type-2-diabetes-a-randomised-controlled-trial
#3
Julia Otten, Andreas Stomby, Maria Waling, Andreas Isaksson, Ingegerd Söderström, Mats Ryberg, Michael Svensson, Jón Hauksson, Tommy Olsson
AIMS/HYPOTHESIS: The aim of the study was to investigate ectopic fat deposition and insulin sensitivity, in a parallel single-blinded randomised controlled trial, comparing Paleolithic diet alone with the combination of Paleolithic diet and exercise in individuals with type 2 diabetes. METHODS: Thirty-two individuals with type 2 diabetes with BMI 25-40 kg/m2 and 30-70 years of age followed a Paleolithic diet ad libitum for 12 weeks. In addition, study participants were randomised by computer program to either supervised combined exercise training (PD-EX group) or standard care exercise recommendations (PD group)...
April 26, 2018: Diabetologia
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#4
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#5
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29619113/analysis-of-circulating-angiopoietin-like-protein-3-and-genetic-variants-in-lipid-metabolism-and-liver-health-the-diogenes-study
#6
Anne Lundby Hess, Jérôme Carayol, Trine Blædel, Jörg Hager, Alessandro Di Cara, Arne Astrup, Wim H M Saris, Lesli Hingstrup Larsen, Armand Valsesia
Background: Angiopoietin-like protein 3 (ANGPTL3), a liver-derived protein, plays an important role in the lipid and lipoprotein metabolism. Using data available from the DiOGenes study, we assessed the link with clinical improvements (weight, plasma lipid, and insulin levels) and changes in liver markers, alanine aminotransferase, aspartate aminotransferase (AST), adiponectin, fetuin A and B, and cytokeratin 18 (CK-18), upon low-calorie diet (LCD) intervention. We also examined the role of genetic variation in determining the level of circulating ANGPTL3 and the relation between the identified genetic markers and markers of hepatic steatosis...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29607540/melatonin-improves-insulin-resistance-and-hepatic-steatosis-through-attenuation-of-alpha-2-hs-glycoprotein
#7
Jee-In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner...
April 1, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29582352/correlation-analysis-of-monocyte-subsets-and-insulin-resistance-considering-fetuin-a-involvement-in-patients-with-type-2-diabetes
#8
Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto
BACKGROUND: Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A-induced proinflammatory polarization and migration of macrophages plays a crucial role, it remains obscure whether monocyte subsets in circulation could simulate characteristics of macrophages in adipose tissues. This study aims to investigate the correlation between monocyte subsets with fetuin-A and its relevant insulin resistance...
March 27, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29562796/first-trimester-irisin-and-fetuin-a-concentration-in-predicting-macrosomia
#9
Monika Zbucka-Kretowska, Mariusz Kuzmicki, Beata Telejko, Joanna Goscik, Michal Ciborowski, Danuta Lipinska, Justyna Hryniewicka, Anna Citko, Slawomir Lawicki, Slawomir Wolczynski
OBJECTIVE: We investigated the diagnostic value of first-trimester adipokines and placental markers in predicting macrosomia. METHODS: Out of 328 women recruited during the prenatal diagnosis between 11th and 13th week of pregnancy and subjected to follow up until delivery, we selected 26 women who gave birth to macrosomic babies and 34 women who gave birth to normal weight neonates for the evaluation of first trimester serum levels of pregnancy associated plasma protein-A, free β-human chorionic gonadotropin, placental growth factor (PIGF), and selected adipokines...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29523632/circulating-fetuin-a-and-risk-of-type-2-diabetes-a-mendelian-randomization-analysis
#10
Janine Kröger, Karina Meidtner, Norbert Stefan, Marcela Guevara, Nicola D Kerrison, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Paul W Franks, Heinz Freisling, Marc J Gunter, José María Huerta, Rudolf Kaaks, Timothy J Key, Kay Tee Khaw, Vittorio Krogh, Tilman Kühn, Francesca Romana Mancini, Amalia Mattiello, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Núria Sala, Elena Salamanca-Fernández, Ivonne Sluijs, Annemieke Mw Spijkerman, Anne Tjonneland, Konstantinos K Tsilidis, Rosario Tumino, Yvonne T van der Schouw, Nita G Forouhi, Stephen J Sharp, Claudia Langenberg, Elio Riboli, Matthias B Schulze, Nicholas J Wareham
Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian Randomization study with SNPs located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the prospective EPIC-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 cases...
March 9, 2018: Diabetes
https://www.readbyqxmd.com/read/29511793/calcifying-nanoparticles-induce-cytotoxicity-mediated-by-ros-jnk-signaling-pathways
#11
Jihua Wu, Zhiwei Tao, Yaoliang Deng, Quan Liu, Yunlong Liu, Xiaofeng Guan, Xiang Wang
Calcifying nanoparticles (CNPs) play an important role in kidney stone formation, but the mechanism(s) are unclear. CNPs were isolated and cultured from midstream urine of patients with kidney stones. CNP morphology and characteristics were examined by electron microscopy and electrophoresis analysis. Chemical composition was analyzed using energy-dispersive X-ray microanalysis and Western blotting. Human renal proximal convoluted tubule cell (HK-2) cultures were exposed to CNPs for 0, 12 and 72 h, and production of reactive oxygen species (ROS), mitochondrial membrane potential and apoptosis levels were evaluated...
March 6, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29508692/cross-sectional-association-between-sugar-sweetened-beverage-intake-and-cardiometabolic-biomarkers-in-us-women
#12
Zhi Yu, Sylvia H Ley, Qi Sun, Frank B Hu, Vasanti S Malik
Few studies have evaluated the relationships between intake of sugar-sweetened beverages (SSB) and intermediate biomarkers of cardiometabolic risk. Associations between artificially sweetened beverages (ASB) and fruit juice with cardiometabolic biomarkers are also unclear. We investigated habitual SSB, ASB and fruit juice intake in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glucose metabolism. We analysed cross-sectional data from 8492 participants in the Nurses' Health Study who were free of diabetes and CVD...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29505020/low-serum-fetuin-a-as-a-biomarker-to-predict-pneumococcal-necrotizing-pneumonia-and-hemolytic-uremic-syndrome-in-children-erratum
#13
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29475832/hepatic-f-box-protein-fbxw7-maintains-glucose-homeostasis-through-degradation-of-fetuin-a
#14
Jiejie Zhao, Xuelian Xiong, Yao Li, Xing Liu, Tao Wang, Hong Zhang, Yang Jiao, Jingjing Jiang, Huijie Zhang, Qiqun Tang, Xin Gao, Xuejun Li, Yan Lu, Bin Liu, Cheng Hu, Xiaoying Li
Type 2 diabetes mellitus (T2DM) has become one of the most serious and long-term threats to human health. However, the molecular mechanism that links obesity to insulin resistance remains largely unknown. Here, we show that F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase, is markedly downregulated in the liver of two obese mouse models and obese human subjects. We further identify a functional low-frequency human FBXW7 coding variant (p.Ala204Thr) in the Chinese population, which is associated with elevated blood glucose and T2DM risk...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29462898/do-nonalcoholic-fatty-liver-disease-and-fetuin-a-play-different-roles-in-symptomatic-coronary-artery-disease-and-peripheral-arterial-disease
#15
Fabio Nascimbeni, Dante Romagnoli, Stefano Ballestri, Enrica Baldelli, Simonetta Lugari, Valentina Sirotti, Valentina Giampaoli, Amedeo Lonardo
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is strongly associated with both atherosclerotic cardiovascular disease (CVD) and Fetuin-A. However, the association of Fetuin-A with atherosclerosis is more controversial. We hypothesized that the pathogenic interplay of NAFLD, Fetuin-A and atherosclerosis varies based on arterial site. Accordingly, we aimed to assess NAFLD prevalence, Fetuin-A values and their relationship with symptomatic atherosclerosis occurring in different localizations: coronary artery disease (CAD) vs...
February 16, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29455027/electrochemical-detection-of-influenza-virus-h9n2-based-on-both-immunomagnetic-extraction-and-gold-catalysis-using-an-immobilization-free-screen-printed-carbon-microelectrode
#16
Maher Sayhi, Oussama Ouerghi, Kamel Belgacem, Marwa Arbi, Yudum Tepeli, Abdeljalil Ghram, Ülkü Anik, Lars Österlund, Dhafer Laouini, Mohamed Fethi Diouani
Influenza is a viral infectious disease considered as a source of many health problems and enormous socioeconomic disruptions. Conventional methods are inadequate for in-field detection of the virus and generally suffer from being laborious and time-consuming. Thus, studies aiming to develop effective alternatives to conventional methods are urgently needed. In this work, we developed an approach for the isolation and detection of influenza A virus subtype H9N2. For this aim, two specific influenza receptors were used...
June 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29441480/prognostic-value-of-cardiovascular-calcifications-in-hemodialysis-patients-a-longitudinal-study
#17
Nada Dimkovic, Georg Schlieper, Aleksandar Jankovic, Zivka Djuric, Marcus Ketteler, Tatjana Damjanovic, Petar Djuric, Jelena Marinkovic, Zoran Radojcic, Natasa Markovic, Jürgen Floege
PURPOSE: Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. METHODS: We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months)...
February 13, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29439057/association-of-fetuin-a-with-incident-type-2-diabetes-results-from-the-monica-kora-augsburg-study-and-a-systematic-meta-analysis
#18
Chaterina Sujana, Cornelia Huth, Astrid Zierer, Sophie Meesters, Julie Sudduth-Klinger, Wolfgang Koenig, Christian Herder, Annette Peters, Barbara Thorand
OBJECTIVE: We investigated the association of circulating fetuin-A with incident T2D particularly examining potential sex differences. Additionally, we determined whether putative associations were independent of subclinical inflammation, adiponectin and liver fat content. DESIGN: Case-cohort study plus systematic meta-analysis. METHODS: We investigated the association between baseline fetuin-A levels and incident T2D in the MONICA/KORA Augsburg study using Cox proportional hazards analyses...
April 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29407476/forensic-proteomics-for-the-evaluation-of-the-post-mortem-decay-in-bones
#19
Noemi Procopio, Anna Williams, Andrew T Chamberlain, Michael Buckley
Current methods for evaluation the of post-mortem interval (PMI) of skeletal remains suffer from poor accuracy due to the great number of variables that affect the diagenetic process and to the lack of specific guidelines to address this issue. During decomposition, proteins can undergo cumulative decay over the time, resulting in a decrease in the range and abundance of proteins present (i.e., the proteome) in different tissues as well as in an increase of post-translational modifications occurring in these proteins...
April 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29356547/exploring-biological-and-geological-age-related-changes-through-variations-in-intra-and-intertooth-proteomes-of-ancient-dentine
#20
Noemi Procopio, Andrew T Chamberlain, Michael Buckley
Proteomic analyses are becoming more widely used in archeology not only due to the greater preservation of proteins in ancient specimens than DNA but also because they can offer different information, particularly relating to compositional preservation and potentially a means to estimate biological and geological age. However, it remains unclear to what extent different burial environments impact these aspects of proteome decay. Teeth have to date been much less studied than bone but are ideal to explore how proteins decay with time due to the negligible turnover that occurs in dentine relative to bone...
March 2, 2018: Journal of Proteome Research
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