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fetuin-a

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https://www.readbyqxmd.com/read/28096437/phase-angle-predicts-arterial-stiffness-and-vascular-calcification-in-peritoneal-dialysis-patients
#1
Margarida Sarmento-Dias, Carla Santos-Araújo, Rui Poínhos, Bruno Oliveira, Maria Sousa, Liliana S Silva, Isabel S Silva, Flora Correia, Manuel Pestana
♦ Objectives: Fluid overload (FO) is frequently present in peritoneal dialysis (PD) patients and is associated with markers of malnutrition, inflammation, and atherosclerosis/calcification (MIAC) syndrome. We examined the relationships in stable PD patients between phase angle (PhA) and the spectrum of uremic vasculopathy including vascular calcification and arterial stiffness and between PhA and changes in serum fetuin-A levels. ♦ Methods: Sixty-one stable adult PD patients were evaluated in a cross-sectional study (ST1)...
January 17, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28094081/emerging-human-fetuin-a-assays-for-biomedical-diagnostics
#2
REVIEW
Sandeep Kumar Vashist, E Marion Schneider, A G Venkatesh, John H T Luong
Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathophysiological conditions with considerable biomedical significance; one example is the formation of calciprotein particles in osteoporosis and impaired calcium metabolisms. With impressive advances in in vitro diagnostic assays during the last decade, ELISAs have become a workhorse in routine clinical diagnostics. Recent diagnostic formats involve high-sensitivity immunoassay procedures, surface plasmon resonance, rapid immunoassay chemistries, signal enhancement, and smartphone detection...
January 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28052525/daily-variability-in-serum-levels-of-calciprotein-particles-and-their-association-with-mineral-metabolism-parameters-a-cross-sectional-pilot-study
#3
Hodaka Yamada, Makoto Kuro-O, San-E Ishikawa, Shunsuke Funazaki, Ikuyo Kusaka, Masafumi Kakei, Kazuo Hara
BACKGROUND: Calciprotein particles (CPPs), colloidal protein-mineral nanoparticles composed of solid-phase calcium phosphate and serum protein fetuin-A found in blood, are emerging as a novel component of chronic kidney disease-mineral and bone disorder (CKD-MBD). In this study, we examined daily variations in CPPs as well as their association with mineral metabolism parameters in normal individuals and early-stage CKD patients. METHODS: Twenty subjects (10 healthy adults, 10 diabetic patients) were enrolled...
January 4, 2017: Nephrology
https://www.readbyqxmd.com/read/28039046/bone-quality-assessment-as-measured-by-trabecular-bone-score-in-patients-with-end-stage-renal-disease-on-dialysis
#4
Maria P Yavropoulou, Vasilios Vaios, Maria Pikilidou, Ioannis Chryssogonidis, Melina Sachinidou, Symeon Tournis, Konstantinos Makris, Kalliopi Kotsa, Michalis Daniilidis, Afroditi Haritanti, Vassilios Liakopoulos
Patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) exhibit osteoporosis and increased fracture risk. Dual-energy X-ray absorptiometry scan measurements and calculation of fracture risk assessment toll score underestimate fracture risk in these patients and do not estimate bone quality. Trabecular bone score (TBS) has been recently proposed as an indirect measure of bone microarchitecture. In this study, we investigated alterations of bone quality in patients with ESRD on HD, using TBS...
December 27, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28001239/patients-with-dental-calculus-have-increased-saliva-and-gingival-crevicular-fluid-fetuin-a-levels-but-no-association-with-fetuin-a-polymorphisms
#5
Gülnihal Emrem Doğan, Turgut Demir, Esra Laloğlu, Ebru Sağlam, Hülya Aksoy, Abdulkadir Yildirim, Fatih Akçay
Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus...
December 22, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27998014/fetuin-a-serum-amyloid-a-and-tumor-necrosis-factor-alpha-levels-in-periodontal-health-and-disease
#6
Çiğdem Coşkun Türer, Umut Ballı, Berrak Güven
OBJECTIVES: The present study is evaluating fetuin-A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease. MATERIAL AND METHODS: Sixty patients were divided into three groups: Group 1 periodontal health (n=20), group 2 gingivitis (n=20) and group 3 chronic periodontitis (CP) (n=20). GCF and serum samples were evaluated using enzyme linked immunosorbent assay kit...
December 20, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27990439/effect-of-exogenous-fetuin-a-on-tgf-%C3%AE-smad-signaling-in-hepatic-stellate-cells
#7
Yulai Zhou, Shuang Yang, Pan Zhang
Objective. To explore the effects of low concentration of exogenous fetuin-A intervention on TGF-β1 induced LX2 cells through detection of the expression of mRNA and protein of Smad2, Smad3, and Smad7. Methods. MTT assay was used to detect the LX2 cells proliferation and the regression equation calculating software was applied to determine IC50 of fetuin-A. RT-PCR was used to determine the relative content of Smad2, Smad3, and Smad7 mRNA in LX2 cells. Western blot was used to detect the LX2 cells relative content of Smad2, Smad3, Smad7 protein expression, respectively...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27965111/sialylated-fetuin-a-as-a-candidate-predictive-biomarker-for-successful-grass-pollen-allergen-immunotherapy
#8
Noémie Caillot, Julien Bouley, Karine Jain, Sandrine Mariano, Sonia Luce, Stéphane Horiot, Sabi Airouche, Chloé Beuraud, Christian Beauvallet, Philippe Devillier, Sylvie Chollet-Martin, Christine Kellenberger, Laurent Mascarell, Henri Chabre, Thierry Batard, Emmanuel Nony, Vincent Lombardi, Véronique Baron-Bodo, Philippe Moingeon
BACKGROUND: Eligibility to immunotherapy is based on the determination of IgE reactivity to a specific allergen by skin prick or in vitro testing. Biomarkers predicting the likelihood of clinical improvement during immunotherapy would significantly improve patient selection. METHODS: Proteins were differentially assessed by 2D-DiGE and label-free mass spectrometry in pre-treatment sera obtained from clinical responders and non-responders within a cohort of 82 grass pollen allergic patients receiving sublingual immunotherapy or placebo...
December 10, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27928636/effects-of-lanthanum-carbonate-and-calcium-carbonate-on-fibroblast-growth-factor-23-and-hepcidin-levels-in-chronic-hemodialysis-patients
#9
Yu-Ming Chang, Shih-Ching Tsai, Chih-Chung Shiao, Hung-Hsiang Liou, Chuan-Lan Yang, Nai-Yu Tung, Kua-Sui Hsu, I-Ling Chen, Mei-Chyn Liu, Jsun-Liang Kao, Rong-Na Jhen, Ya-Ting Huang
BACKGROUND: Phosphate binders have an impact on fibroblast growth factor 23 (FGF23); however, the effect of phosphate binders on serum hepcidin has not been explored. We conducted a 24-week multicenter randomized controlled trial to investigate the effects of lanthanum carbonate or calcium carbonate monotherapy on serum phosphate, FGF23, and hepcidin levels in chronic hemodialysis patients. METHODS: Forty-six patients were recruited, and daily dietary phosphorus was controlled between 600-800 mg...
December 7, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27899247/association-of-plasma-fetuin-a-levels-with-peripheral-arterial-disease-and-lower-extremity-arterial-calcification-in-subjects-with-type-2-diabetes-mellitus
#10
Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Iordanis Mourouzis, Despoina Perrea, Nicholas Katsilambros, Petros P Sfikakis, Nikolaos Tentolouris
AIMS: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884680/caloric-restriction-ameliorates-cardiomyopathy-in-animal-model-of-diabetes
#11
Keren Cohen, Maayan Waldman, Nader G Abraham, Michal Laniado-Schwartzman, Danny Gurfield, Dan Aravot, Michael Arad, Edith Hochhauser
BACKGROUND: The db/db mouse is an animal model of diabetes in which leptin receptor activity is deficient resulting accelerated cardiomyopathy when exposed to angiotensin (AT). Toll-like receptors 4 and 2 (TLR4, TLR2) are pattern recognition receptors, that recognize pathogen-associated molecular patterns and exacerbate and release inflammatory cytokines. Fetuin A (Fet A) is a fatty acid carrier which affects inflammation and insulin resistance in obese humans and animals through TLRs...
January 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/27882696/fetuin-a-alpha-2hs-glycoprotein-modulates-growth-motility-invasion-and-senescence-in-high-grade-astrocytomas
#12
Gladys N Nangami, Amos M Sakwe, Michael G Izban, Tanu Rana, Philip E Lammers, Portia Thomas, Zhenbang Chen, Josiah Ochieng
Glioblastomas (high-grade astrocytomas) are highly aggressive brain tumors with poor prognosis and limited treatment options. In the present studies, we have defined the role of fetuin-A, a liver-derived multifunctional serum protein, in the growth of an established glioblastoma cell line, LN229. We hereby demonstrate that these cells synthesize ectopic fetuin-A which supports their growth in culture in the absence of serum. We have demonstrated that a panel of tissue microarray (TMA) of glioblastomas also express ectopic fetuin-A...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27882180/concentrations-of-fetuin-a-osteoprotegerin-and-%C3%AE-klotho-in-patients-with-alcoholic-liver-cirrhosis
#13
Andrzej Prystupa, Anna Dąbrowska, Jarosław Jerzy Sak, Jerzy Tarach, Anna Toruń-Jurkowska, Patrycja Lachowska-Kotowska, Grzegorz Dzida
The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 54 patients with alcoholic liver cirrhosis treated in various hospitals in the Lublin region of Poland were randomly enrolled. The control group consisted of 18 healthy individuals without liver disease, who did not drink alcohol...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27856445/fetuin-a-and-risk-of-diabetes-independent-of-liver-fat-content-the-multi-ethnic-study-of-atherosclerosis
#14
Sarah A Aroner, Kenneth J Mukamal, David E St-Jules, Matthew J Budoff, Ronit Katz, Michael H Criqui, Matthew A Allison, Ian H de Boer, David S Siscovick, Joachim H Ix, Majken K Jensen
Fetuin-A is a hepatic secretory protein and a novel risk factor for diabetes. However, it remains unclear whether the association between high levels of fetuin-A and diabetes can be attributed to nonalcoholic fatty liver disease. We conducted a case-cohort study among 1,957 subcohort members and 455 incident diabetes cases in the Multi-Ethnic Study of Atherosclerosis, a multicenter US study of Caucasian, African-American, Hispanic, and Chinese-American adults aged 45-84 years. Serum fetuin-A and computed tomography-determined liver fat content were measured from samples collected at baseline (2000-2002)...
January 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27831903/calciprotein-particles-as-potential-etiologic-agents-of-idiopathic-preterm-birth
#15
Lydia L Shook, Catalin S Buhimschi, Antonette T Dulay, Megan E McCarthy, John T Hardy, Christina M Duzyj Buniak, Guomao Zhao, Irina A Buhimschi
Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality and is often preceded by preterm premature rupture of the membranes (PPROM) without an identifiable cause. Pathological calcification, the deposition of hydroxyapatite (HA) in nonskeletal tissues, has been implicated in degenerative diseases including atherosclerosis and aneurism rupture. Among pathogenic mechanisms, the aberrant aggregation of HA into calciprotein particles (CPPs) and the HA-induced differentiation of mesenchymal cells into osteoblasts (ectopic osteogenesis) have been implicated...
November 9, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27799869/proteomic-profiling-of-retinoblastoma-by-high-resolution-mass-spectrometry
#16
Ravikanth Danda, Kalaivani Ganapathy, Gajanan Sathe, Anil K Madugundu, Sharavan Ramachandran, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, T S Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda, Sailaja V Elchuri
BACKGROUND: Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary retinoblastoma. High throughput analysis of retinoblastoma transcriptome is available however the proteomic landscape of retinoblastoma remains unexplored. In the present study we used high resolution mass spectrometry-based quantitative proteomics to identify proteins associated with pathogenesis of retinoblastoma...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27772733/corrigendum-to-fgf23-regulated-production-of-fetuin-a-ahsg-in-osteocytes-bone-83-2016-35-47
#17
D Mattinzoli, M P Rastaldi, M Ikehata, S Armelloni, C Pignatari, L A Giardino, M Li, C M Alfieri, A Regalia, D Riccardi, P Messa
No abstract text is available yet for this article.
December 2016: Bone
https://www.readbyqxmd.com/read/27768920/nano-lc-ms-ms-for-the-identification-of-proteins-trapped-in-sorbent-cartridges-used-for-coupled-plasma-filtration-adsorption-treatments-of-healthy-pigs
#18
Donatella Nardiello, Clelia Prattichizzo, Maria Teresa Rocchetti, Loreto Gesualdo, Diego Centonze
A dedicated proteomic approach based on nano-Liquid Chromatography coupled with tandem mass spectrometry in ion trap is proposed for the analysis of proteins trapped in sorbent resin cartridges used to remove inflammatory mediators from blood by coupled plasma filtration adsorption (CPFA). The final purpose of the proposed proteomic approach was to obtain a reference map of plasma proteins trapped in CPFA sorbents used for the extracorporeal blood purification of healthy pigs, with the potential impact to design new bio-filters able to control the inflammatory imbalance under pathological conditions, such as severe sepsis...
January 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27754964/investigation-of-the-inflammatory-biomarkers-of-metabolic-syndrome-in-adolescents
#19
Ummugulsum Can, Muammer Buyukinan, Asuman Guzelant, Ayse Ugur, Adnan Karaibrahimoglu, Sukrıye Yabancıun
BACKGROUND: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), α2-macroglobulin (α2-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and α1-acid glycoprotein (AGP) in an adolescent population with MetS...
November 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27748389/the-impact-of-insulin-resistance-on-the-kidney-and-vasculature
#20
REVIEW
Ferruh Artunc, Erwin Schleicher, Cora Weigert, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated pathways. The disorder is characterized by a reduced action of insulin despite increased insulin concentrations (hyperinsulinaemia). The effects of insulin on the kidney and vasculature differ in part from the effects on classical insulin target organs. Insulin causes vasodilation by enhancing endothelial nitric oxide production through activation of the phosphatidylinositol 3-kinase pathway. In insulin-resistant states, this pathway is impaired and the mitogen-activated protein kinase pathway stimulates vasoconstriction...
December 2016: Nature Reviews. Nephrology
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