keyword
MENU ▼
Read by QxMD icon Read
search

25(OH)D

keyword
https://www.readbyqxmd.com/read/28107527/effects-of-the-administration-of-25-oh-vitamin-d3-in-an-experimental-model-of-chronic-kidney-disease-in-animals-null-for-1-alpha-hydroxylase
#1
Noelia Torremadé, Milica Bozic, David Goltzman, Elvira Fernandez, José M Valdivielso
The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. This study evaluates the dose of 25(OH)D3 that restores parathyroid hormone (PTH) and calcium levels in a model of CKD in CYP27B1-/- mice. Furthermore, we compare the safety and efficacy of the same dose in CYP27B1+/+ animals...
2017: PloS One
https://www.readbyqxmd.com/read/28107277/suppressive-effect-of-1%C3%AE-25-dihydroxyvitamin-d3-on-th17-immune-responses-in-kidney-transplant-recipients-with-tacrolimus-based-immunosuppression
#2
Byung Ha Chung, Bo-Mi Kim, Kyoung Chan Doh, Ji-Won Min, Mi-La Cho, Kyoung Woon Kim, Chul Woo Yang
BACKGROUND: The aim of this study was to investigate whether 1α,25-dihydroxyvitamin D3 can regulate Th17-related-immune responses in kidney transplant recipients (KTRs) being treated with tacrolimus (Tac)-based immunosuppression. METHODS: First, we evaluated the effect of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on Th17-immune responses in an in vitro study using peripheral blood mononuclear cells (PBMCs) from healthy volunteers or KTRs. Next, we investigated mTOR/STAT3 signaling as a mechanism by which 1,25(OH)2D3 exerted its effect on T cells using the Jurkat cell line...
October 6, 2016: Transplantation
https://www.readbyqxmd.com/read/28106720/25-hydroxy-vitamin-d-concentration-is-not-affected-by-severe-or-non-severe-pneumonia-or-inflammation-in-young-children
#3
Johanne Haugen, Ram K Chandyo, Manjeswori Ulak, Maria Mathisen, Sudha Basnet, Karl A Brokstad, Palle Valentiner-Branth, Prakash S Shrestha, Tor A Strand
Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker for status. Our objectives were to measure whether 25(OH)D concentration was altered by an episode of acute lower respiratory tract infection and whether markers of inflammation predicted the 25(OH)D concentration...
January 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#4
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28104493/the-effect-of-parathyroid-hormone-on-the-uptake-and-retention-of-25-hydroxyvitamin-d-in-skeletal-muscle-cells
#5
REVIEW
M Abboud, M S Rybchyn, J Liu, Y Ning, C Gordon-Thomson, T C Brennan-Speranza, L Cole, H Greenfield, D R Fraser, R S Mason
Data from our studies, and those of others, support the proposal that there is a role for skeletal muscle in the maintenance of vitamin D status. We demonstrated that skeletal muscle is able to internalise extracellular vitamin D binding protein, which then binds to actin in the cytoplasm, to provide high affinity binding sites which accumulate 25-hydroxyvitamin D3 (25(OH)D3) [1]. This study investigated the concentration- and time-dependent effects of parathyroid hormone (PTH) on the capacity of muscle cells to take up and release (3)H-25(OH)D3...
January 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28104492/constitutively-active-ras-signaling-reduces-1-25-dihydroxyvitamin-d-mediated-gene-transcription-in-intestinal-epithelial-cells-by-reducing-vitamin-d-receptor-expression
#6
REVIEW
Marsha L DeSmet, James C Fleet
High vitamin D status is associated with reduced colon cancer risk but these studies ignore the diversity in the molecular etiology of colon cancer. RAS activating mutations are common in colon cancer and they activate pro-proliferative signaling pathways. We examined the impact of RAS activating mutations on 1,25 dihydroxyvitamin D (1,25(OH)2D)-mediated gene expression in cultured colon and intestinal cell lines. Transient transfection of Caco-2 cells with a constitutively active mutant K-RAS (G12 V) significantly reduced 1,25(OH)2D-induced activity of both a human 25-hydroxyvitamin D, 24 hydroxyase (CYP24A1) promoter-luciferase and an artificial 3X vitamin D response element (VDRE) promoter-luciferase reporter gene...
January 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28102718/vitamin-d-status-aeroallergen-sensitization-and-allergic-rhinitis-a-systematic-review-and-meta-analysis
#7
Zahra Aryan, Nima Rezaei, Carlos A Camargo
PURPOSE: The role of vitamin D status in the etiology of allergic diseases is uncertain. The aim of this study was to investigate the association of vitamin D status with risk of two main outcomes: aeroallergen sensitization and allergic rhinitis (AR). METHODS: We performed a systematic review of Medline, Scopus, Science Citation Index, and Google Scholar databases. Studies were included if they reported on prevalent or incident cases of aeroallergen sensitization or AR according to vitamin D status...
January 19, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28101343/effect-of-1-25-oh-2d3-on-transdifferentiation-of-rat-renal-tubular-epithelial-cells-induced-by-high-glucose
#8
Hongtao Hu, Shen Xu, Shuang Hu, Yue Gao, Hua Shui
Deficiency in vitamin D and its active metabolite is a characteristic of chronic kidney diseases (CKDs). Previous studies have reported that 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D, can attenuate renal interstitial fibrosis. The present study aimed to explore the effect of 1,25(OH)2D3 on the transdifferentiation of NRK-52E rat renal tubular epithelial cells (RTECs) induced by high glucose, as well as the expression of vitamin D receptor (VDR) and production of angiotensin (Ang) II...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28100331/-hmgb1-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-and-role-of-vitamin-d-in-asthmatic-mice
#9
Jun-Ying Qiao, Li Song, Yan-Li Zhang, Bin Luan
OBJECTIVE: To investigate the changes in the mRNA and protein expression of high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), and nuclear factor-kappa B (NF-κB) in lung tissues of asthmatic mice and the interventional effect of vitamin D. METHODS: A total of 48 BALB/c mice were randomly divided into control group, asthma group, and 1,25-(OH)2D3 intervention group, with 16 mice in each group. An animal model of asthma was established, and lung tissue samples were taken in each group at weeks 1 and 2 of ovalbumin challenging...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099554/no-correlation-was-observed-between-vitamin-d-levels-and-disability-of-patients-with-multiple-sclerosis-between-latitudes-18%C3%A2-and-30%C3%A2-south
#10
Yara Dadalti Fragoso, Tarso Adoni, Soniza Vieira Alves-Leon, Samira L Apostolos-Pereira, Walter Oleschko Arruda, Joseph B Bidin Brooks, Henrique S Rodrigues Cal, Carlos A Albuquerque Damasceno, Paulo Diniz Gama, Marcus V Magno Goncalves, Carlos A da Silva de Jesus, Suzana C Nunes Machado, Letícia Fezer Mansur, Andre P da Cunha Matta, Maria Fernanda Mendes, Rogerio Rizo Morales, Adaucto Wanderley da Nobrega-Jr, Monica K Fiuza Parolin, Mario Pietro Peres, Marlise de Castro Ribeiro, Heloisa Helena Ruocco, Simone Scherpenhuijzen, Fabio Siquinelli, Patrick N Stoney, Daniel Lima Varela, Audred Cristina Biondo Eboni, Caroline Vieira Spessotto, Elisa Teixeira da Rocha, Pamela Emanuele Lacerda
Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26...
January 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28099429/vitamin-d-insufficiency-in-neonatal-hypoxic-ischemic-encephalopathy
#11
Danielle W Lowe, Bruce W Hollis, Carol L Wagner, Thomas Bass, David A Kaufman, Michael J Horgan, Laurence M Givelichian, Koravangatta Sankaran, Jerome Y Yager, Lakshmi D Katikaneni, Don Wiest, Dorothea Jenkins
BACKGROUND: Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia. METHODS: We analyzed short term relationships between 25(OH) and 1,25(OH)2 vitamin D, vitamin D binding protein, and cytokines related to Th17 function in serum samples from a multicenter randomized controlled trial of hypothermia 33(0)C for 48h after HIE birth versus normothermia in 50 infants with moderate to severe HIE...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28096639/association-between-serum-25-hydroxyvitamin-d-levels-and-bone-mineral-density-in-normal-postmenopausal-women
#12
Vasundhara Kamineni, Akkenapally Prasanna Latha, K Ramathulasi
AIM: This study was conducted with the objective of assessing serum 25-hydroxyvitamin D (25(OH)D) in postmenopausal women (PMW), to detect osteopenia or osteoporosis in PMW and to establish a correlation between serum 25(OH)D levels and bone mineral density (BMD). MATERIALS AND METHODS: A total of 100 healthy PMW were selected, and a prospective observational study was conducted to correlate the BMD with serum 25(OH)D levels. Their laboratory investigations along with serum 25(OH)D levels were done...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28095099/efficacy-of-an-exercise-and-nutritional-supplement-program-on-physical-performance-and-nutritional-status-in-older-adults-with-mobility-limitations-residing-at-senior-living-facilities
#13
Michael P Corcoran, Miriam E Nelson, Jennifer M Sacheck, Kieran F Reid, Dylan Kirn, Roger A Fielding, Kenneth K H Chui, Sara C Folta
This cluster-randomized trial was designed to determine the efficacy of a 6-month exercise-nutritional supplement program (ENP) on physical function and nutritional status for older adults and the feasibility of implementing this program in a senior living setting. Twenty senior living facilities were randomized to either a three day per week group-based ENP led by a trained facility staff member or a health education program (SAP). Participants (N=121) completed a short physical performance battery, 400 meter walk, handgrip strength test, and mini-nutrition assessment...
January 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28095046/does-vitamin-d-metabolite-measurement-help-predict-25-oh-d-change-following-vitamin-d-supplementation
#14
Neil Binkley, Gretta Borchardt, Ellen Siglinsky, Diane Krueger
OBJECTIVE: Variability in 25(OH)D change following vitamin D supplementation exists. Vitamin D metabolite measurement might assist in predicting 25(OH)D response and also contribute to defining vitamin D adequacy. This study assessed utility of vitamin D metabolite measurements to predict 25(OH)D response and explored the relationship of a "vitamin D composite index" (comprised of the sum of serum 25(OH) D, vitamin D3 and 24,25(OH)2D) with PTH. METHODS: Sixty-two postmenopausal women were randomized to daily vitamin D3 1,800 IU or placebo for 4 months...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28095044/vitamin-d-binding-protein-and-25-hydroxyvitamin-d-levels-emerging-clinical-applications
#15
Navinder K Jassil, Anupa Sharma, Daniel Bikle, Xiangbing Wang
25-hydroxyvitamin D (25(OH)D), the precursor of the active form of vitamin D, is recognized as the optimal indicator of vitamin D status. Vitamin D3 undergoes conversion through a multitude of enzymatic reactions described within the paper and vitamin D levels are dependent on many factors, including the vitamin D binding protein (DBP). The free hormone hypothesis postulates that protein-bound hormones are not biologically available and that unbound hormones are biologically active. The majority of circulating 25(OH)D and 1,25-dihydroxyvitamin D is tightly bound to DBP and albumin, with less than 1% circulating in an unbound form...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28095043/serum-insulin-growth-factor-1-in-lebanese-schoolchildren-and-its-relation-to-vitamin-d-and-ferritin-levels
#16
Marie-Hélène Gannagé-Yared, Elise Chahine, Vanessa Farah, Tony Ibrahim, Nadia Asmar, Georges Halaby
OBJECTIVE: The aim of our study is to establish reference values for IGF-1 in Lebanese schoolchildren, and to evaluate the relationship between IGF-1 and age, gender, body mass index (BMI),vitamin D and ferritin. METHODS: In this cross-sectional study, 952 Lebanese schoolchildren (495 boys and 457 girls) aged 8-18 years, were included. Blood samples were taken from 10 schools of different socioeconomic status. Chemiluminescent immunoassays were used for IGF-1, 25(OH)D, testosterone and ferritin measurements...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28094599/plasma-25-hydroxyvitamin-d3-levels-in-colorectal-cancer-patients-and-associations-with-physical-activity
#17
Stephanie Skender, Jürgen Böhm, Petra Schrotz-King, Jenny Chang-Claude, Erin M Siegel, Karen Steindorf, Robert W Owen, Jennifer Ose, Michael Hoffmeister, Hermann Brenner, Cornelia M Ulrich
Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3 and PA in prospectively followed colorectal cancer patients in the ColoCare study. At 6, 12, and 24 mo after surgery, patients donated a blood sample, wore an accelerometer for 10 consecutive days, and completed a PA questionnaire. Plasma 25-hydroxyvitamin D3 (25(OH)D3) levels were measured by high-performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age, and body mass index...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094278/persistent-fibroblast-growth-factor-23-signalling-in-the-parathyroid-glands-for-secondary-hyperparathyroidism-in-mice-with-chronic-kidney-disease
#18
Kazuki Kawakami, Ai Takeshita, Kenryo Furushima, Masayasu Miyajima, Ikuji Hatamura, Makoto Kuro-O, Yasuhide Furuta, Kazushige Sakaguchi
Secondary hyperparathyroidism, in which parathyroid hormone (PTH) is excessively secreted in response to factors such as hyperphosphataemia, hypocalcaemia, and low 1,25-dihydroxyvitamin D (1,25(OH)2D) levels, is commonly observed in patients with chronic kidney disease (CKD), and is accompanied by high levels of fibroblast growth factor 23 (FGF23). However, the effect of FGF23 on the parathyroid glands (PG) remains controversial. To bind to FGF receptors, FGF23 requires αKlotho, which is highly expressed in the PG...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093353/vitamin-d-metabolites-in-captivity-should-we-measure-free-or-total-25-oh-d-to-assess-vitamin-d-status
#19
REVIEW
Daniel Bikle, Roger Bouillon, Ravi Thadhani, Inez Schoenmakers
There is general consensus that serum 25(OH)D is the best biochemical marker for nutritional vitamin D status. Whether free 25(OH)D would be a better marker than total 25(OH)D is so far unclear. Free 25(OH)D can either be calculated based on the measurement of the serum concentrations of total 25(OH)D, vitamin D-binding protein (DBP), albumin, and the affinity between 25(OH)D and its binding proteins in physiological situations. Free 25(OH)D can also be measured directly by equilibrium dialysis, ultrafitration or immunoassays...
January 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28093352/cyp24a1-loss-of-function-clinical-phenotype-of-monoallelic-and-biallelic-mutations
#20
REVIEW
Thomas O Carpenter
CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH)2D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite and storage form of the vitamin. CYP24A1 can be stimulated hormonally by 1,25-(OH)2D and by FGF23, whereas CYP27B1, encoding the vitamin D-1α-hydroxylase, is stimulated hormonally by parathyroid hormone (PTH) and downregulated by FGF23...
January 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
keyword
keyword
60500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"