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25(OH)D

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https://www.readbyqxmd.com/read/28549923/maintaining-vitamin-d-sufficiency-is-associated-with-improved-structural-and-symptomatic-outcomes-in-knee-osteoarthritis
#1
Shuang Zheng, Xingzhong Jin, Flavia Cicuttini, Xia Wang, Zhaohua Zhu, Anita Wluka, Weiyu Han, Tania Winzenberg, Benny Antony, Dawn Aitken, Leigh Blizzard, Graeme Jones, Changhai Ding
BACKGROUND: To describe whether maintaining sufficient serum vitamin D levels in people with knee osteoarthritis and baseline vitamin D insufficiency has an association with change in knee structures and symptoms over two years. METHODS: Participants (n=413, age 63.2) with symptomatic knee osteoarthritis and vitamin D insufficiency were enrolled in a clinical trial. 340 participants (82.3%) completed the study with 25-hydroxyvitamin D [25(OH)D] measurements at month 0, 3 and 24...
May 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28549637/maternal-obesity-25-hydroxy-vitamin-d-concentration-and-bone-density-in-breastfeeding-dyads
#2
Sarbattama Sen, Annie Penfield-Cyr, Bruce W Hollis, Carol L Wagner
OBJECTIVE: To examine the association between maternal body mass index (BMI) and serum 25-hydroxy vitamin D [25(OH)D] concentration and bone density in mother-infant pairs. STUDY DESIGN: The study was a secondary analysis of 234 exclusively breastfeeding dyads who were recruited in the first postpartum month for a randomized controlled trial of maternal vs infant vitamin D supplementation. Mean 25(OH)D concentrations and bone mineral density (BMD) were compared by BMI group...
May 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28549199/effect-of-1-25-oh2d3-on-the-proliferation-of-human-mesangial-cells-and-their-expression-of-ki67
#3
D Zhao, C-J Zhang, R Yang, J-P Chen, L Ma, G Liu, X-P Yang
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of cultured human mesangial cells and their expression of Ki67 in vitro, and to establish its mechanism of action. Cultured human mesangial cells were randomly divided into the following four groups: normal control (N group; administered Dulbecco's modified Eagle's medium containing 5% fetal bovine serum), proliferation [epidermal growth factor (EGF) group; administered 10 μg/L EGF], VD3 intervention [administered 10(-8) M 1,25(OH)2D3], and proliferation and intervention [EGF+VD3 group; administered 10 μg/L EGF and 10(-8) M 1,25(OH)2D3]...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549072/predictors-of-25-hydroxyvitamin-d-measured-at-multiple-time-points-in-a-multiethnic-population
#4
Julia A Knight, Jody Wong, David E C Cole, Tim K Lee, Esteban J Parra
The evidence for a relationship of vitamin D with non-skeletal health outcomes is inconsistent. The validity of single or predicted measurements of 25-hydroxyvitamin D (25(OH)D) is unknown as this biomarker is highly seasonally variable. We compared models of 25(OH)D at baseline, at multiple time points throughout the year, and averaged over the year in 309 individuals in Toronto, Canada (43˚ N), 2009-2013. Information and blood samples were collected every two months. Baseline and average concentrations were correlated (r = 0...
May 26, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28548312/vitamin-d-dependent-rickets-type-1b-25-hydroxylase-deficiency-a-rare-condition-or-a-misdiagnosed-condition
#5
Molin A, Wiedemann A, Demers N, Kaufmann M, Do Cao J, Mainard L, Dousset B, Journeau P, Abeguile G, Coudray N, Mittre H, Richard N, Weryha G, Sorlin A, Jones G, Kottler Ml, Feillet F
Vitamin D requires a two-step activation by hydroxylation: the first step is catalyzed by hepatic 25-hydroxylase (CYP2R1, 11p15.2), and the second one is catalyzed by renal 1α-hydroxylase (CYP27B1, 12q13.1), which produces the active hormonal form of 1,25-(OH)2 D. Mutations of CYP2R1 have been associated with Vitamin D-dependent rickets type 1B (VDDR1B), a very rare condition that has only been reported to affect 4 families to date. We describe 7 patients from two unrelated families who presented with homozygous loss-of-function mutations of CYP2R1...
May 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28547646/risk-factors-for-vitamin-d-deficiency-and-impact-of-repletion-in-a-tertiary-care-inflammatory-bowel-disease-population
#6
Samantha Zullow, Guruprasad Jambaulikar, Ankur Rustgi, Sandra Quezada, Raymond K Cross
INTRODUCTION: Many patients with inflammatory bowel disease (IBD) are vitamin D deficient. The purpose of our study was to identify risk factors for vitamin D deficiency in IBD and to assess the impact of vitamin D repletion on disease activity and quality of life (QOL). METHODS: Patients with at least one 25-OH vitamin D level measured between 2004 and 2011 were included. Patients with a level <30 ng/ml at baseline were followed until the time of repletion...
May 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28545772/plasma-vitamin-d-and-osteo-cartilaginous-markers-in-italian-males-affected-by-intervertebral-disc-degeneration-focus-on-seasonal-and-pathological-trend-of-type-ii-collagen-degradation
#7
Marco Brayda-Bruno, Marco Viganò, Sabina Cauci, Jacopo A Vitale, Laura de Girolamo, Paola De Luca, Giovanni Lombardi, Giuseppe Banfi, Alessandra Colombini
OBJECTIVE: To evaluate plasma vitamin D and cross-linked C-telopeptides of type I (CTx-I) and type II (CTx-II) collagen concentrations in males with lumbar intervertebral disc degeneration (IVD) compared to healthy controls. Improved knowledge might suggest to optimize the vitamin D status of IVD patients and contribute to clarify mechanisms of cartilage degradation. METHODS: 79 Italian males with lumbar IVD assessed by Magnetic Resonance Imaging (MRI) and 79 age, sex and BMI-matched healthy controls were enrolled...
May 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28542561/impaired-functional-capacity-of-fetal-endothelial-cells-in-preeclampsia
#8
Lars Brodowski, Jennifer Burlakov, Sarah Hass, Constantin von Kaisenberg, Frauke von Versen-Höynck
OBJECTIVES: Preeclampsia is one of the main contributers to maternal and fetal morbidity and mortality during pregnancy. A history of preeclampsia puts mother and offspring at an increased cardiovascular risk in later life. We hypothesized that at the time of birth functional impairments of fetal endothelial cells can be detected in pregnancies complicated by preeclampsia and that a therapeutic intervention using 1,25 (OH)2 vitamin D3 can reverse the adverse effects of preeclampsia on cell function...
2017: PloS One
https://www.readbyqxmd.com/read/28540270/fgf-23-klotho-and-vitamin-d-levels-in-scleroderma
#9
Ravan Ahmadi, Mehrzad Hajialilo, Amir Ghorbanihaghjo, Ali Mota, Sina Raeisi, Nasrin Bargahi, Mohammad Valilo, Farahnaz Askarian
BACKGROUND: Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interfere with calcium and phosphate metabolism. The purpose of this study was to evaluate serum Klotho, FGF-23, intact PTH (iPTH) and vitamin D levels in scleroderma patients compared with the healthy controls...
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28539530/active-form-of-vitamin-d-ameliorates-non-alcoholic-fatty-liver-disease-by-alleviating-oxidative-stress-in-a-high-fat-diet-rat-model
#10
Chong-Gui Zhu, Ya-Xin Liu, Hao Wang, Bao-Ping Wang, Hui-Qi Qu, Bao-Li Wang, Mei Zhu
The purpose of this study was to determine whether treatment using the active form of vitamin D (1,25(OH)2D3) could protect against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats and ameliorate oxidative stress. Male Sprague-Dawley rats were divided into three groups and treated with standard chow, HFD, or HFD plus intraperitoneal injection of 1,25(OH)2D3 (5 μg/kg body weight, twice per week), respectively, for 16 weeks. Serum lipid profiles, hepatic function, intrahepatic lipid, and calcium levels were determined...
May 23, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28539466/modeling-the-cellular-response-of-lung-cancer-to-radiation-therapy-for-a-broad-range-of-fractionation-schedules
#11
Jeho Jeong, Jung Hun Oh, Jan-Jakob Sonke, José S A Belderbos, Jeffrey D Bradley, Andrew N Fontanella, Shyam S Rao, Joe Deasy
To demonstrate that a mathematical model can be used to quantitatively understand tumor cellular dynamics during a course of radiotherapy, and to predict the likelihood of local control as a function of dose and treatment fractions.<br /><br />Experimental Design: We model outcomes for early-stage, localized non-small cell lung cancer (NSCLC), by fitting a mechanistic, cellular dynamics-based tumor control probability that assumes a constant local supply of oxygen and glucose. In addition to standard radiobiological effects such as repair of sub-lethal damage and the impact of hypoxia, we also accounted for proliferation as well as radiosensitivity variability within the cell cycle...
May 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28539415/vitamin-d-supplementation-trials-aimed-at-reducing-mortality-have-much-higher-power-when-focusing-on-people-with-low-serum-25-hydroxyvitamin-d-concentrations
#12
Hermann Brenner, Lina Jansen, Kai-Uwe Saum, Bernd Holleczek, Ben Schöttker
Background: Evidence of an inverse association between serum vitamin D and mortality from epidemiological studies has prompted efforts to reduce mortality by vitamin D supplementation, either in targeted interventions for people with vitamin D insufficiency or deficiency, or in untargeted interventions regardless of baseline vitamin D status.Objective: We aimed to assess the expected impact of the 2 different approaches on effect sizes and power of intervention studies.Methods: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured in 9579 participants aged 50-75 y in the German Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung (ESTHER) study who were followed for mortality for a median of 12...
May 24, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28538382/improvement-of-fatigue-after-vitamin-d-supplementation-in-kidney-transplant-recipients
#13
Bin Han, Xiao Wu, Yong Guo
Low serum levels of vitamin D have been associated with fatigue in both healthy and clinical populations. Our aim was to evaluate the effect of vitamin D supplementation on fatigue in kidney transplant recipients (KTRs). In total, 137 patients after kidney transplant and 119 age- and sex-matched healthy volunteers were recruited. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured by competitive protein-binding assay. Fatigue was assessed using the subscale fatigue of the Checklist Individual Strength (CIS)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28536085/interaction-between-the-effects-of-the-selective-estrogen-modulator-femarelle-and-a-vitamin-d-analog-in-human-umbilical-artery-vascular-smooth-muscle-cells
#14
Dalia Somjen, Esther Knoll, Orli Sharon, Ariel Many, Naftali Stern
To further investigate the interaction between vitamin D system and estrogen-mimetic compounds in the human vasculature we studied the effect of the "less- calcemic" analog of 1,25(OH)2D3 (1,25D); JK 1624F2-2 (JKF) in the presence of selective estrogen modulator femarelle (F), the phytoestrogen daidzein (D) and estradiol-17b (E2) on (3)[H] thymidine incorporation (DNA synthesis) and creatine kinase specific activity (CK) in human umbilical artery vascular smooth muscle cells (VSMC). F, D and E2, stimulated DNA synthesis at low concentrations, and inhibited it at high concentrations...
May 20, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28535609/synthesis-of-%C3%AE-galactooligosaccharide-using-bifidobacterial-%C3%AE-galactosidase-purified-from-recombinant-escherichia-coli
#15
So Young Oh, So Youn Youn, Myung Soo Park, Hyoung Geun Kim, Nam In Baek, Zhi Peng Li, Geun Eog Ji
Galactooligosaccharides (GOS) are known to be selectively utilized by Bifidobacterium, which can bring about healthy changes of the composition of intestinal microflora. In this study, β-GOS are synthesized using bifidobacterial β-galactosidase(G1) purified from recombinant E. coli with a high GOS yield and with high productivity and enhanced bifidogenic activity. The purified recombinant G1 showed maximum production of β-GOS at pH 8.5 and 45°C. A matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of the major peaks of the produced β-GOS showed MW of 527 and 689, indicating the synthesis of β-GOS at degrees of polymerization (DP) of 3 and DP4, respectively...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28533007/free-25-oh-d-concentrations-are-associated-with-atopy-and-lung-function-in-children-with-asthma
#16
Suzanne L Pollard, John J Lima, Edward Mougey, Karina Romero, Carla Tarazona-Meza, Katherine Tomaino, Gary Malpartida Guzmán, Nadia N Hansel, William Checkley
BACKGROUND: Evidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total concentrations; however, no studies have examined the relation between free 25(OH)D and respiratory or allergic disease. OBJECTIVE: To examine associations between total and free 25(OH)D concentrations and asthma outcomes. METHODS: We quantified total and free 25(OH)D concentrations in 137 Peruvian children with asthma and 152 children without asthma and examined associations with asthma outcomes...
May 19, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28532484/seasonal-variations-of-vitamin-d-and-its-relation-to-lipid-profile-in-iranian-children-and-adults
#17
Sakineh Nouri Saeidlou, Davoud Vahabzadeh, Fariba Babaei, Zakaria Vahabzadeh
BACKGROUND: Vitamin D has a multitude of functional properties and acts like a hormone in the body. Its effect on the lipid profile is one of the proposed mechanisms for its relationship with many disorders during its deficiency. But, this relationship is still conflicting and debatable, so this study was conducted to determine the association between serum level of vitamin D and lipid profiles, including serum concentrations of cholesterol, triglyceride (TG), HDL, and LDL in healthy subjects...
May 22, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28532201/vitamin-d-status-in-algerian-beh%C3%A3-et-s-disease-patients-an-immunomodulatory-effect-on-no-pathway
#18
Zineb Djeraba, Fatiha Benlabidi, Fatma Zohra Djaballah-Ider, Oussama Medjeber, Amina Arroul-Lammali, Houda Belguendouz, Fifi Otmani, Chafia Touil-Boukoffa
Behçet's disease (BD) is an inflammatory multisystemic disorder associated with orogenital ulcers, uveitis and skin lesions with unpredictable episodes of exacerbations and remissions. Even though several immunological and environmental factors contribute to BD progression, its ethiopathogenesis remains uncertain and elusive. Considered as one of the potent environmental factors that can increase prevalence of some autoimmune and inflammatory disorders, vitamin D deficiency has been linked to several diseases as BD...
May 22, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28531780/vitamin-d-status-and-the-effects-of-oral-vitamin-d-treatment-in-children-with-vitiligo-a-prospective-study
#19
Gülay Karagüzel, Nil P Sakarya, Sevgi Bahadır, Selçuk Yaman, Ayşenur Ökten
BACKGROUND & AIMS: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. METHODS: Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531358/vitamin-b1-deficiency-in-patients-with-postural-tachycardia-syndrome-pots
#20
Svetlana Blitshteyn
OBJECTIVE: POTS is a heterogeneous disorder of the autonomic nervous system that can result from multiple etiologies. An increased prevalence of vitamin B12, vitamin D 25-OH and iron deficiencies has been observed in patients with POTS. This study examined the prevalence of vitamin B1 deficiency and assessed response to vitamin B1 supplementation in the deficient POTS patients. METHODS AND RESULTS: Medical records of 65 consecutive patients with POTS evaluated at our clinic were reviewed...
May 21, 2017: Neurological Research
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