Peng Zhang, Yi Wan, Jinrong Ma, Jin Gong, Ziwei Zhong, Yuxin Cui, Hongli Zhang, Yanyan Da, Junpeng Ma, Chenxi Li, Lijuan Liu, Tian Gong, Youwen Tan, Chengsheng Zhang
Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various malignancies. However, the role of LDHB in modulating immune responses against hepatocellular carcinoma (HCC) remains largely unknown. Here, we found that down-regulation of lactate dehydrogenase B (LDHB) was coupled with the promoter hypermethylation and knocking down the DNA methyltransferase 3A (DNMT 3A) restored LDHB expression levels in HCC cell lines. Bioinformatics analysis of the HCC cohort from The Cancer Genome Atlas revealed a significant positive correlation between LDHB expression and immune regulatory signaling pathways and immune cell infiltrations...
May 13, 2024: Cancer Immunology, Immunotherapy: CII