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https://www.readbyqxmd.com/read/28239907/effects-of-oral-%C3%AE-lipoic-acid-administration-on-body-weight-in-overweight-or-obese-subjects-a-crossover-randomized-double-blind-placebo-controlled-trial
#1
Nong Li, Weili Yan, Xiaojuan Hu, Yongdi Huang, Fugang Wang, Weiguo Zhang, Qian Wang, Xiaoling Wang, Kehong Sun
OBJECTIVE: Alpha-lipoic acid (ALA) has shown beneficial properties on diabetes and obesity. The aim of this study was to examine the effects of oral ALA on body weight in subjects with overweight or obese. DESIGN: Single-centre, randomized, double-blind, crossover controlled study. PARTICIPANTS: A total of 166 subjects of Chinese Han ethnicity with a BMI ≥25 kg/m(2) were screened and 103 subjects fulfilled the study requirements, in terms of informed consent and participation to the study...
January 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28239879/nonparametric-comparison-of-survival-functions-based-on-interval-censored-data-with-unequal-censoring
#2
Yanqin Feng, Ran Duan, Jianguo Sun
Nonparametric comparison of survival functions is one of the most commonly required task in failure time studies such as clinical trials, and for this, many procedures have been developed under various situations. This paper considers a situation that often occurs in practice but has not been discussed much: the comparison based on interval-censored data in the presence of unequal censoring. That is, one observes only interval-censored data, and the distributions of or the mechanisms behind censoring variables may depend on treatments and thus be different for the subjects in different treatment groups...
February 27, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28239844/spectrum-and-clinical-variants-of-giant-cell-elastolytic-granuloma
#3
Wan-Ting Chen, Pa-Fan Hsiao, Yu-Hung Wu
BACKGROUND: Giant cell elastolytic granuloma, also known as annular elastolytic giant cell granuloma or actinic granuloma, is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas. OBJECTIVES: To clarify clinical characteristics based on case series observation. METHODS: We retrospectively reviewed patients who fulfilled the pathological diagnosis criteria for giant cell elastolytic granuloma seen at Mackay Memorial Hospital from 2000 to 2014...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28239828/the-relation-of-the-serum-aldosterone-level-and-central-serous-chorioretinopathy-a-pilot-study
#4
Q Gong, X-H Sun, S-T Yuan, Q-H Liu
OBJECTIVE: The aim of this study was to investigate the serum aldosterone level and abnormal levels of mineral corticoid in patients with the central serous chorioretinopathy (CSC). PATIENTS AND METHODS: All recruited patients with CSC received fundus fluorescein angiography (FFA), enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) and serum aldosterone assay. The patients were classified into spontaneously resolved group and unresolved group according to a 3-months follow-up of Optical Coherence Tomography (OCT) examination...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239824/long-non-coding-rna-cche1-overexpression-predicts-a-poor-prognosis-for-cervical-cancer
#5
Y Chen, C-X Wang, X-X Sun, C Wang, T-F Liu, D-J Wang
OBJECTIVE: Our study is intended to explore the correlation of long non-coding RNA CCHE1 (CCHE1) and clinicopathological factors of cervical cancer patients, and evaluate the impact of CCHE1 on the prognosis of cervical cancer. PATIENTS AND METHODS: The CCHE1 expression in cervical cancer tissues was examined by quantitative Real-time PCR (qRT-PCR) and its correlation with clinicopathological features was also analyzed. A Kaplan-Meier survival curve was generated following a log-rank test...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239820/long-non-coding-rna-neat1-acts-as-oncogene-in-nsclc-by-regulating-the-wnt-signaling-pathway
#6
S-J Sun, Q Lin, J-X Ma, W-W Shi, B Yang, F Li
OBJECTIVE: The present study aimed to explore the role of long non-coding RNA NEAT1 (NEAT1) in mediating non-small cell lung cancer (NSCLC) cell migration and invasion, as well as the underlying regulatory mechanisms. PATIENTS AND METHODS: The NEAT1 expression in NSCLC tissues and cell lines was measured using reverse transcription‑quantitative polymerase chain reaction (RT-qPCR). The relationships between NEAT1 expression and clinicopathological parameters were examined by chi-square test...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239815/correlation-between-gdf15-mmp7-and-gastric-cancer-and-its-prognosis
#7
L Lu, G-Q Ma, X-D Liu, R-R Sun, Q Wang, M Liu, P-Y Zhang
OBJECTIVE: To explore the correlation between GDF15, MMP7 and gastric cancer and its prognosis. PATIENTS AND METHODS: Thirty-six cases of gastric cancer admitted to our hospital from February 2014 to February 2015 were included in the observation group. Thirty-two healthy people were selected during the same period as the control group. The levels of MMP7 and GDF15 mRNA in the observation group before and after treatment and in the control group were detected by fluorescence quantitative PCR...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239754/neprilysin-facilitates-adipogenesis-through-potentiation-of-the-phosphatidylinositol-3-kinase-pi3k-signaling-pathway
#8
Juwan Kim, Dasol Han, Sung-Hyun Byun, Mookwang Kwon, Sun-Jung Cho, Young Ho Koh, Keejung Yoon
Neprilysin (NEP) is a zinc metallopeptidase that cleaves a number of small peptides into inactive forms. Despite the recent evidence of a significant correlation between the levels of NEP in plasma and the severity of obesity in humans, a cause-and-effect relationship or a functional role of NEP in obesity has remained uncertain. In this study, we show that NEP has a positive regulatory effect on fat cell formation from precursor cells. NEP increases the accumulation of cytoplasmic triglycerides in 3T3-L1 preadipocytes or the C3H10T1/2 mesenchymal stem cell line in differentiation conditions...
February 27, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28239711/interfacial-defects-induced-electronic-property-transformation-at-perovskite-srvo3-srtio3-and-lacro3-srtio3-heterointerfaces
#9
Junjie Li, Deqiang Yin, Qiang Li, Rong Sun, Sumei Huang, Fanzhi Meng
Unravelling the atomic structure and chemical species of interfacial defects is critical to understanding the origin of interfacial properties in many heterojunctions. Here, by combining advanced transmission electron microscopy, spectroscopy and first-principles calculations, we demonstrate interfacial Ti diffusion in SrVO3/SrTiO3 and LaCrO3/SrTiO3 heterointerfaces and uncover that the interfacial defects induce a significant change in electronic properties by showing an electronic transformation from the insulating state to metallic state at SrVO3/SrTiO3 heterointerfaces due to the hybridization of interfacial Ti d, O p and V d, and a metallic to insulating state transformation at LaCrO3/SrTiO3 because of Ti-Cr mixing induced charge redistribution in the interfacial layer...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28239702/antiferromagnetic-interlayer-coupling-and-thus-induced-distinct-spin-texture-for-the-lamno3-lacoo3-5-superlattices
#10
Jing Zhang, Hongrui Zhang, Xuejing Zhang, Xiangxiang Guan, Xi Shen, Deshun Hong, Hui Zhang, Banggui Liu, Richeng Yu, Baogen Shen, Jirong Sun
Artificial engineering of an interfacial spin structure of complex oxides with strongly coupled spin, orbital, charge and lattice degrees of freedom is crucially important for the exploration of novel effects associated with magnetic tunneling, exchange biasing, and spin injecting/manipulating, which are the central issues of spintronics. Here we demonstrate the presence of a distinct interlayer coupling between LaMnO3 (LMO) and LaCoO3 (LCO) and the resulting dramatic effect on the spin structure. We found that the LCO layer in (LMO/LCO)5 superlattices exhibits not only an antiferromagnetic coupling with a neighboring LMO layer but also a long-range magnetic order with substantially reduced magnetization...
February 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28239696/a-solvent-free-dense-energetic-metal-organic-framework-emof-to-improve-stability-and-energetic-performance-via-in-situ-microcalorimetry
#11
Yinli Zhang, Sheng Zhang, Lin Sun, Qi Yang, Jing Han, Qing Wei, Gang Xie, Sanping Chen, Shengli Gao
It is a tremendous challenge to prepare solvent-free dense energetic metal-organic frameworks (EMOFs), hence also to improve their stability and energetic performance. In this study, based on in situ microcalorimetry, an interpenetrating EMOF without solvent molecules, [Cu(tztr)]n (1, H2tztr = 3-(tetrazol-5-yl)triazole) was obtained, possessing high stability (Tdec = 360 °C) and outstanding energetic properties (ΔHdet = 7.53 kcal cm(-3), D = 8.429 km s(-1), P = 40.02 GPa).
February 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28239687/protein-phosphatase-5-contributes-to-the-overexpression-of-epigenetically-regulated-t-lymphocyte-genes-in-patients-with-lupus
#12
D Patel, G Gorelik, B Richardson
OBJECTIVE: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4(+) T cells, altering the expression of genes suppressed by this mechanism that convert normal "helper" cells into auto reactive cells which promote lupus flares...
December 2016: Lupus (Los Angel)
https://www.readbyqxmd.com/read/28239649/switching-harmful-visceral-fat-to-beneficial-energy-combustion-improves-metabolic-dysfunctions
#13
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh J Samani, Yun Zhang, Yihai Cao
Visceral fat is considered the genuine and harmful white adipose tissue (WAT) that is associated to development of metabolic disorders, cardiovascular disease, and cancer. Here, we present a new concept to turn the harmful visceral fat into a beneficial energy consumption depot, which is beneficial for improvement of metabolic dysfunctions in obese mice. We show that low temperature-dependent browning of visceral fat caused decreased adipose weight, total body weight, and body mass index, despite increased food intake...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239416/biodegradation-of-alkaline-lignin-by-bacillus-ligniniphilus-l1
#14
Daochen Zhu, Peipei Zhang, Changxiao Xie, Weimin Zhang, Jianzhong Sun, Wei-Jun Qian, Bin Yang
BACKGROUND: Lignin is the most abundant aromatic biopolymer in the biosphere and it comprises up to 30% of plant biomass. Although lignin is the most recalcitrant component of the plant cell wall, still there are microorganisms able to decompose it or degrade it. Fungi are recognized as the most widely used microbes for lignin degradation. However, bacteria have also been known to be able to utilize lignin as a carbon or energy source. Bacillus ligniniphilus L1 was selected in this study due to its capability to utilize alkaline lignin as a single carbon or energy source and its excellent ability to survive in extreme environments...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28239414/a-novel-small-rna-coar-regulates-coenzyme-a-biosynthesis-and-tolerance-of-synechocystis-sp-pcc6803-to-1-butanol-possibly-via-promoter-directed-transcriptional-silencing
#15
Tao Sun, Guangsheng Pei, Jiangxin Wang, Lei Chen, Weiwen Zhang
BACKGROUND: Microbial small RNAs (sRNAs) have been proposed as valuable regulatory elements for optimizing cellular metabolism for industrial purposes. However, little information is currently available on functional relevance of sRNAs to biofuels tolerance in cyanobacteria. RESULTS: Here, we described the identification and functional characterization of a novel 124 nt sRNA Ncl1460 involved in tolerance to biofuel 1-butanol in Synechocystis sp. PCC 6803. The expression of Ncl1460 was verified by blotting assay and its length was determined through 3' RACE...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28239406/erratum-to-suicidal-ideation-and-suicide-attempts-among-asthma
#16
Jae Ho Chung, Sun-Hyun Kim, Yong Won Lee
[This corrects the article DOI: 10.1186/s12991-016-0122-2.].
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28239316/15-hydroxyprostaglandin-dehydrogenase-as-a-marker-in-colon-carcinogenesis-analysis-of-the-prostaglandin-pathway-in-human-colonic-tissue
#17
Dong-Hoon Yang, Yeon-Mi Ryu, Sun-Mi Lee, Jin-Yong Jeong, Soon Man Yoon, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Seung-Jae Myung
BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2), 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and microsomal prostaglandin E synthase-1 (mPGEs-1) regulate prostaglandin E2 (PGE2) expression and are involved in colon carcinogenesis. We investigated the expression of PGE2 and its regulating genes in sporadic human colon tumors and matched normal tissues. METHODS: Twenty colonic adenomas and 27 colonic adenocarcinomas were evaluated. COX-2 and 15-PGDH expression was quantified by real-time polymerase chain reaction...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239313/second-korean-guidelines-for-the-management-of-ulcerative-colitis
#18
REVIEW
Chang Hwan Choi, Won Moon, You Sun Kim, Eun Soo Kim, Bo-In Lee, Yunho Jung, Yong Sik Yoon, Heeyoung Lee, Dong Il Park, Dong Soo Han
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during exacerbation of the disease. The incidence and prevalence of UC in Korea are still lower than those of Western countries, but have been rapidly increasing during the past decades. Various medical and surgical therapies, including biologics, are currently used for the management of UC...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239311/the-great-rise-of-intestinal-research-as-an-international-journal-3-years-after-its-language-change-to-english-as-evidenced-by-journal-metrics
#19
EDITORIAL
Geum Hee Jeong, Sun Huh
No abstract text is available yet for this article.
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239159/sarsasapogenin-aa13-inhibits-lps-induced-inflammatory-responses-in-macrophage-cells-in-vitro-and-relieves-dimethylbenzene-induced-ear-edema-in-mice
#20
Dong Dong, Nan-Nan Zhou, Rui-Xuan Liu, Jia-Wei Xiong, Hui Pan, Si-Qi Sun, Lei Ma, Rui Wang
Sarsasapogenin-AA13 (AA13) is a novel synthetic derivative of sarsasapogenin extracted from the Chinese herb Rhizoma Anemarrhenae. In this study we investigated the effects of AA13 on lipopolysaccharide (LPS)-induced production of inflammatory factors in macrophage cells and the anti-inflammatory activity of AA13 in an inflammatory model of dimethylbenzene-induced ear edema. Macrophage cells (RAW264.7 cells and mouse peritoneal macrophages) were exposed to LPS (1 μg/mL); pretreatment with AA13 (5-20 μmol/L) dose-dependently inhibited LPS-induced production of NO, TNF-α and PGE2, and LPS-stimulated expression levels of COX-2 and iNOS...
February 27, 2017: Acta Pharmacologica Sinica
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