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Xinyi Ding, Yuxiang Sun, Yanming Chen, Wanchuan Ding, Steven Emory, Tianhao Li, Zixing Xu, Ning Han, Jun Wang, Gang Ruan
Micellar nanocrystals (micelles with encapsulated nanocrystals) have become an emerging major class of nanobiomaterials. We describe a method of fabricating micellar nanocrystals based on combining top-down electrospray, bottom-up self-assembly, and solvent-based structure control. This method involves first using electrospray to generate uniform ultrafine liquid droplets, each of which functions as a micro-reactor in which self-assembly reaction occurs forming micellar nanocrystals, with the structures (micelle shape and nanocrystal encapsulation) controlled by the organic solvent used...
February 11, 2018: Journal of Visualized Experiments: JoVE
Ting Zhang, Hao Zhang, Liang He, Zhihong Wang, Wenwu Dong, Wei Sun, Ping Zhang
BACKGROUND Low levels of 1-25-dihydroxyvitamin D3 [1,25(OH)2D3] in serum may be a risk factor for several tumor types. Also, high cathelicidin antimicrobial peptide (CAMP) expression is regarded to be important against tumor progression. We evaluated the potential importance of 1,25(OH)2D3 in the diagnosis and treatment of papillary thyroid cancer (PTC). MATERIAL AND METHODS The preoperative serum level of 1,25(OH)2D3 was measured using a double-antibody sandwich enzyme-linked immunosorbent assay. Vitamin D3 receptor (VDR) expression was detected by streptavidin-peroxidase immunohistochemical staining in PTC specimens...
March 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Zhiyan Wang, Chaochao Lv, Xin Xu, Xiangdong Li, Yali Yao, Xiaojing Gao, Zhe Sun, Yuzhou Wang, Yujie Sun, Yan Xiao, Kegong Tian
Rotavirus A (RVA) G9 genotype is recognized as an emerging genotype which is spreading worldwide, however, our knowledge on pathogenicity of this virus is limited. In this study, porcine RVA strain HN03 was successfully isolated on MA-104 cells, and the isolate was propagated continuously for 7 passages after a virus cloning at passage 3. The virus titers from 4 to 10 passages ranged from 107.1 to 108.1 TCID50 /ml. The growth curve of HN03 strain in cell culture was determined, and the virus production dynamics was confirmed by immunoperoxidase monolayer assay (IPMA)...
March 16, 2018: Journal of Veterinary Medical Science
Hayley B Gershengorn, Carri W Chan, Yunchao Xu, Hanxi Sun, Ronni Levy, Mor Armony, Michelle N Gong
OBJECTIVE: To understand the impact of adding a medical step-down unit (SDU) on patient outcomes and throughput in a medical intensive care unit (ICU). DESIGN: Retrospective cohort study. SETTING: Two academic tertiary care hospitals within the same health-care system. PATIENTS: Adults admitted to the medical ICU at either the control or intervention hospital from October 2013 to March 2014 (preintervention) and October 2014 to March 2015 (postintervention)...
January 1, 2018: Journal of Intensive Care Medicine
Lei Zhang, Beiqi Sun, Qianyi Liu, Fanyang Mo
We describe here an operationally simple and straightforward synthesis method for a series of diverse 4,5-disubstituted 1,2,3-thiadiazoles via the nucleophilic addition of α-diazo carbonyl compounds to carbon disulfide. This method features using abundant and inexpensive carbon disulfide with mild reaction conditions.
March 19, 2018: Journal of Organic Chemistry
Yan-Ru Liu, Zhi-Shu Tang, Jin-Ao Duan, Xiao-Chun Sun, Zhong-Xing Song, Xin-Bo Shi, Yang Lv, Zhao Zhang, Da-Wei Qian
To explore the flavor and meridian tropism classification of Callianthemum taipaicum by principal components analysis(PCA) and partial least square analysis(PLS). Meanwhile,to establish a high performance liquid chromatography-tandem mass spectrometry(HPLC-ESI-MS) method for the simultaneous determination of 55 active components from 13 kinds of Ranunculaceae of Chinese traditional herbs. Samples were separated on HPLC system by Agilent 5 TC-C₁₈(2)(4.6 mm×250 mm,5 μm)column and eluted with acetonitrile and 0...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Wen-Wen Sun, Jin-Xia Dou, Lin Zhang, Li-Kui Qiao, Na Shen, Wen-Yuan Gao
To compare the therapeutic effects of different treatment methods on the nude mice bearing colon cancer HT29 cells. BalB/C nude mice colon cancer stem cell models were established and randomly divided into the following four groups, with 8 nude mice in each group: blank control group, DC-CIK group, Huaier group, and Huaier combined with DC-CIK group (combined treatment group). The mice in DC-CIK group and combined treatment group received 1×10⁶ DC-CIK cells treatment by tail vein injectionafter the tumor stem cells were inoculated for 4 days,2 times a week for three weeks...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xin-Yao Su, Chun-Li Jiang, Ya-Chun Xu, Meng-Chu Sun, Chen-Hao Huang, Jian-Ping Xue, Cai-Xia Wang
Residue of Mori Cortex was studied to optimize its enzymatic hydrolysis process, and explore its potential as a carbon source for biochemistry and biofuel production. The cellulose content of diluted acid pretreated (DAP) and non-pretreated from Mori Cortex were measured in this study, and the results showed that the cellulose content of DAP and non-pretreated from Mori Cortex were 52.5% and 47%, respectively. This higher cellulose content indicated that residue of Mori Cortex had the potential to act as a carbon source for biochemistry and biofuel production...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Kang-Yu Wang, Wei-Can Liu, Mei-Ping Zhang, Ming-Zhu Zhao, Yan-Fang Wang, Li Li, Chun-Yu Sun, Ke-Xin Hu, Yue-Yi Cong, Yi Wang
The relationship between saponin content of Panax quinquefolius in different parts of the organization and expression of ginsenoside biosynthesis related gene was obtained by the correlation analysis between saponin content and gene expression. The 14 tissue parts of P. quinquefolius were studied, six saponins in P. quinquefolius. Samples (ginsenoside Rg₁, Re, Rb₁, Rc, Rb₂ and Rd), group saponins and total saponins were determined by high performance liquid chromatography and vanillin-sulfuric acid colorimetric method...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Jia Yang, Peng Xiao, Jiaming Sun, Liang Guo
PURPOSE: Melanoma is an aggressive form of human cancer with limited treatment options currently available. The present study was aimed to evaluate the anticancer activity of kaempferol (KAM) against the human malignant melanoma A375 cell line along with evaluation of its effects on apoptosis, cell cycle, cell migration and m-TOR/PI3K/AKT pathway. METHODS: Effects on cell viability were assessed by MTT assay while clonogenic assay measured the effects of KAM on colony formation...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Chen Sun, Jianxia Li
PURPOSE: To investigate the expression of microRNA (miRNA-137) in oral squamous cell carcinoma (OSCC) and its effects on activity, invasion and proliferation of OSCC human squamous cell carcinoma cell lines 2 (HSC-2 cell line). METHODS: 158 cases of pathologically-confirmed OSCC tissues and corresponding para-cancerous tissues were collected. The tissue mRNA was extracted and miRNA-137 expression in tissues was detected using real-time polymerase chain reaction (RT-PCR)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Xiang-Wu Yang, Shai-Hong Zhu, Peng-Zhou Li, Wei-Zheng Li, Xu-Long Sun
PURPOSE: This study aimed to compare the short- and longterm outcomes of elderly and middle-aged patients with gastric cancer who underwent laparoscopic gastrectomy. METHODS: From January 2010 to February 2017, a total of 75 patients with gastric cancer aged ≥70 years (elderly group) underwent laparoscopic gastrectomy, and their short- and long-term outcomes were compared with those of 197 patients with gastric cancer aged 60-69 years (middleaged group) who underwent also laparoscopic gastrectomy during the same period...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jie Sun, Jingang Zhang
PURPOSE: To evaluate the value of sentinel lymph node (SLN) identification using carbon nanoparticles in abdominal lymph node metastasis in elderly (>60 years old) patients with colorectal cancer. METHODS: Eighty patients admitted at Weihai Second Municipal Hospital affiliated to Qingdao University from November 2014 to February 2017 were selected and divided into the control group (n=40) and the observation group (n=40) using the random number method. The control group was treated with surgery, while the observation group was administered carbon nanoparticle tracer for intraoperative dye detection and positioning; the first to four black-stained lymph nodes were marked as SLN, then radical surgery for colorectal cancer was performed...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Guangyuan Sun, Jun Xue, Yue Zhang, Xiaobin Gao, Fei Guo
PURPOSE: This study aimed to use propensity score matching (PSM) to compare the short- and long-term outcomes of laparoscopic surgery for the treatment of rectal cancer in elderly and middle-aged patients. METHODS: Data were retrospectively obtained from 588 patients aged ≥60 years when they underwent laparoscopic surgery for rectal cancer in our hospital between January 2009 and December 2016. The patients were divided into an elderly group (≥70 years) or a middle-aged group (60-69 years), and were subsequently matched 1:1 using PSM for sex, body mass index, Charlson comorbidity index (CCI), tumor location, clinical stage, and American Society of Anesthesiologists (ASA) score...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Shaohui Sun, Ruishu Yang, Xin Wang, Shaokang Yan
An attractive approach for the production of transportation fuels from renewable biomass resources is to convert oxygenates into alkanes. In this paper, C5 -C20 alkanes formed via the hydrogenation and hydrodeoxygenation of the oligomers of furfuryl alcohol(FA) can be used as gasoline, diesel and jet fuel fraction. The first step of the process is the oligomers of FA convert into hydrogenated products over Raney Ni catalyst in a batch reactor. The second step of the process converts hydrogenated products to alkanes via hydrodeoxygenation over different bi-functional catalysts include hydrogenation and acidic deoxidization active sites...
April 2018: Data in Brief
B Køster, J Søndergaard, J B Nielsen, A Olsen, J Bentzen
An important feature of questionnaire validation is reliability. To be able to measure a given concept by questionnaire validly, the reliability needs to be high. The objectives of this study were to examine reliability of attitude and knowledge and behavioral consistency of sunburn in a developed questionnaire for monitoring and evaluating population sun-related behavior. Sun related behavior, attitude and knowledge was measured weekly by a questionnaire in the summer of 2013 among 664 Danes. Reliability was tested in a test-retest design...
June 2018: Preventive Medicine Reports
Guomin Li, Qian Shen, Li Sun, Haimei Liu, Yu An, Hong Xu
Branchio-oto-renal (BOR) syndrome is a rare autosomal dominant disorder characterized by branchial cleft fistulae or cysts, preauricular pits, ear malformations, hearing loss, and renal anomalies. Mutations in the human homologue of the Drosophila eyes absent gene ( EYA1 ) are the most common cause of BOR syndrome. PCR and direct sequencing were used to investigate all of the exons and exon-intron boundaries in the EYA1 gene in a patient with BOR syndrome from China. The patient was a child who displayed clinical features of BOR syndrome...
February 2018: Intractable & Rare Diseases Research
Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo, Jianan Y Qu
Femtosecond laser microsurgery has become an advanced method for clinical procedures and biological research. The tissue treated by femtosecond laser can become highly fluorescent, indicating the formation of new fluorescent compounds that can naturally label the treated tissue site. We systematically characterized the fluorescence signals produced by femtosecond laser ablation in biological tissues in vivo . Our findings showed that they possess unique fluorescence properties and can be clearly differentiated from endogenous signals and major fluorescent proteins...
February 1, 2018: Biomedical Optics Express
Zhang Li, Fan Huang, Jiong Zhang, Behdad Dashtbozorg, Samaneh Abbasi-Sureshjani, Yue Sun, Xi Long, Qifeng Yu, Bart Ter Haar Romeny, Tao Tan
Multi-modal retinal image registration is often required to utilize the complementary information from different retinal imaging modalities. However, a robust and accurate registration is still a challenge due to the modality-varied resolution, contrast, and luminosity. In this paper, a two step registration method is proposed to address this problem. Descriptor matching on mean phase images is used to globally register images in the first step. Deformable registration based on modality independent neighbourhood descriptor (MIND) method is followed to locally refine the registration result in the second step...
February 1, 2018: Biomedical Optics Express
Chenxue Jiang, Shuiyun Han, Wucheng Chen, Xiaozhen Ying, He Wu, Yaoyao Zhu, Guodong Shi, Xiaojiang Sun, Yaping Xu
Background: and purpose: This retrospective study aimed to investigate the feasibility of shrinking field radiotherapy during chemoradiotherapy in non-small cell lung cancer (NSCLC). Patients and methods: Ninety-seven patients with stage III NSCLC who achieved a good response to chemoradiation were analyzed. Computed tomography was performed after 40-50 Gy dose radiation to evaluate curative effect. Patients in the shrinking field group underwent resimulation CT scans and shrinking field radiotherapy...
February 23, 2018: Oncotarget
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