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Polymorbidity

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https://www.readbyqxmd.com/read/28480974/comorbidities-and-medications-of-patients-with-chronic-hepatitis-c-under-specialist-care-in-the-uk
#1
Benjamin Hudson, Alex J Walker, William L Irving
Designing services with the capacity and expertise to meet the needs of the chronic hepatitis C (CHC) population in the era of direct acting antivirals (DAAs), and widening access to such treatments, requires detailed understanding of the characteristics and healthcare needs of the existing patient population. In this retrospective analysis of data from the National HCV Research UK Biobank between March 2012-October 2014 the characteristics of the CHC population currently under specialist care in the UK were evaluated - with specific focus upon use of medications, adverse lifestyle choices, and comorbidities...
May 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28452726/-nesfatin-1-activity-in-patients-with-essential-hypertension-and-prediabetes-type-2-diabetes
#2
O Kovalyova, T Ashcheulova, A Demydenko, M Vizir, O Kochubiei
Essential hypertension (EH) is one of the important problems and comorbidity negatively affects the prognosis of the disease. Substantial thing is investigation of metabolic substances that influence the carbohydrate profile. Aim - investigation of the nesfatin-1 activity in patients with Essential hypertension and prediabetes/type2 diabetes. 83 patients with EH were examined and divided into groups according to dysglicemia and abdominal obesity. Significant increasing of nesfatin-1 in patients with EH 7,81±0,26 ng/ml was found comparing to controls 4,54±0,13 ng/ml, p<0,05...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28386499/total-knee-arthroplasty-in-severe-valgus-osteoarthritis-excellent-early-results-in-a-90-year-old-patient-with-a-valgus-deformity-of-47%C3%A2
#3
Petros Ismailidis, Rolf Kernen, Sebastian Andreas Mueller
Grade III valgus deformity (tibiofemoral alignment > 20°) is present in only 0.5% of patients receiving total knee arthroplasty. Furthermore, cases with a valgus deformity exceeding 40° are even rarer. Since they mostly affect elderly, polymorbid patients, successful outcome means a great challenge. We report on a case of a 90-year-old patient with a valgus deformity of 47°. The patient was preoperatively restricted to a wheel chair, unable to walk, and only able to stand for a few seconds. The maximal knee flexion was 100°, and there was an extension deficit of 15°...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28382662/successful-targeted-treatment-of-mast-cell-activation-syndrome-with-tofacitinib
#4
Lawrence B Afrin, Roger W Fox, Susan L Zito, Leo Choe, Sarah C Glover
Mast cell (MC) activation syndrome (MCAS) is a collection of illnesses of inappropriate MC activation with little to no neoplastic MC proliferation, distinguishing it from mastocytosis. MCAS presents as chronic, generally inflammatory multisystem polymorbidity likely driven in most by heterogeneous patterns of constitutively activating mutations in MC regulatory elements, posing challenges for identifying optimal mutation-targeted treatment in individual patients. Targeting commonly affected downstream effectors may yield clinical benefit independent of upstream mutational profile...
April 6, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28270157/evidence-based-design-recommendations-for-prevalence-studies-on-multimorbidity-improving-comparability-of-estimates
#5
Barbara M Holzer, Klarissa Siebenhuener, Matthias Bopp, Christoph E Minder
BACKGROUND: In aging populations, multimorbidity causes a disease burden of growing importance and cost. However, estimates of the prevalence of multimorbidity (prevMM) vary widely across studies, impeding valid comparisons and interpretation of differences. With this study we pursued two research objectives: (1) to identify a set of study design and demographic factors related to prevMM, and (2) based on (1), to formulate design recommendations for future studies with improved comparability of prevalence estimates...
March 7, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28054112/-surgical-treatment-of-colorectal-carcinoma-in-the-elderly
#6
J Schuld, M Glanemann
Colorectal carcinoma is one of the most frequent tumor entities worldwide. The treatment of elderly and mostly polymorbid patients is an outstanding challenge in view of the demographic change with a continuously aging community. Due to the demographic changes the numbers of elderly (>65 years) and very old (≥80 years) patients are steadily increasing in surgical cohorts. This has resulted in higher morbidity and mortality rates in comparison to younger patients, with increased wound healing and cardiovascular complications but with comparable numbers of anastomotic insufficiency...
February 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28009313/character-and-frequency-of-the-variations-of-co-and-polymorbid-syntropic-extrahepatic-lesions-and-their-dependence-on-the-hepatopulmonary-syndrome-severity-degree-in-cirrhotic-patients
#7
O Abrahamovych, M Abrahamovych, S Tolopko, O Fayura, M Ferko
In this study, we comprehensively examined 93 patients with liver cirrhosis, selected in a randomized manner, with the preliminary stratification by the presence of hepatopulmonary syndrome with the aim to study the nature and frequency of extrahepatic syntropic lesions of organs and systems and their dependence on the severity of lung injury that is necessary for the appointment of the most effective individualized comprehensive treatment. The results of our calculations showed that with the increasing of the hepatopulmonary syndromeseverity degree, the nature and the frequency of the syntropic co- and polymorbid functional and organic extrahepatic lesions of the organs and body systems was significantly (p<0...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27982377/polypharmacy-and-polymorbidity-in-older-adults-in-brazil-a-public-health-challenge
#8
Luiz Roberto Ramos, Noemia Urruth Leão Tavares, Andréa Dâmaso Bertoldi, Mareni Rocha Farias, Maria Auxiliadora Oliveira, Vera Lucia Luiza, Tatiane da Silva Dal Pizzol, Paulo Sérgio Dourado Arrais, Sotero Serrate Mengue
OBJECTIVE: To analyze variations in the prevalence of chronic use of medicines by older adults in Brazil according to its possible association with the most prevalent chronic diseases and demographic and health factors, and to identify risk factors for polypharmacy. METHODS: A study based on data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM), a cross-sectional, population-based survey with probability sampling in Brazilian urban areas...
December 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27798859/ageing-as-an-important-risk-factor-for-cancer
#9
REVIEW
Karel Smetana, Lukáš Lacina, Pavol Szabo, Barbora Dvořánková, Prokop Brož, Aleksi Šedo
An ageing population is a typical feature of many developed countries across the world. Analyzed from a biomedical and philosophical point of view, this phenomenon is also a potential risk factor for social sustainability of communities. The association between ageing and cancer seems to be more than apparent. Therefore, the further increase of epidemic-like incidence of malignant tumors in a population can be expected in the near future. Elderly people usually suffer from age-dependent diseases, and such polymorbidity can seriously affect the treatment of malignant tumors...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27633589/-potentially-inappropriate-medications-in-geriatrics-which-tools-to-detect-them
#10
REVIEW
Aude Desnoyer, Bertrand Guignard, Pierre-Olivier Lang, Jules Desmeules, Nicole Vogt-Ferrier, Pascal Bonnabry
BACKGROUND: Potentially inappropriate prescriptions include over-prescription, which refers to prescription of more drugs than clinically needed, mis-prescription which refers to incorrect prescription of a drug that is needed (as per drug, dose, drug interactions, duration of therapy, duplication, follow-up, etc.) and under-prescription which stands for failure to prescribe drugs that are needed. They are associated with adverse drug events, increased use of health-care services, morbimortality and health-care costs, and poorer quality of life...
November 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27488941/impact-of-preoperative-antithrombotic-therapy-on-blood-management-after-implantation-of-primary-total-knee-arthroplasty
#11
Lukas Leitner, Ewald Musser, Norbert Kastner, Jörg Friesenbichler, Daniela Hirzberger, Roman Radl, Andreas Leithner, Patrick Sadoghi
Red blood cell concentrates (RCC) substitution after total knee arthroplasty (TKA) is correlated with multifold of complications and an independent predictor for higher postoperative mortality. TKA is mainly performed in elderly patients with pre-existing polymorbidity, often requiring permanent preoperative antithrombotic therapy (PAT). The aim of this retrospective analysis was to investigate the impact of demand for PAT on inpatient blood management in patients undergoing TKA. In this study 200 patients were retrospectively evaluated after TKA for differences between PAT and non-PAT regarding demographic parameters, preoperative ASA score > 2, duration of operation, pre-, and intraoperative hemoglobin level, and postoperative parameters including amount of wound drainage, RCC requirement, and inpatient time...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27352588/-integration-of-a-palliative-care-approach-in-the-management-patients-with-polymorbidity
#12
Sophie Pautex, Catherine Weber
The number of patients with multimorbidity is steadily increasing due to medical progress and increased life expectancy. A palliative approach may be offered to some of these patients. It includes the detection and management of somatic and mental symptoms, the management of social and spiritual problems, the anticipation of care and support of the relatives. Its main goal is to improve patient's quality of life and reduce interventions that are unnecessary, or undesired by patients themselves.
May 11, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/27123730/-pain-management-in-geriatric-patients
#13
REVIEW
Jürgen Eiche, Florian Schache
Pains belong to the most frequent reasons for a doctor's visit. In elderly people, it is the result of progressive degenerative processes (e. g. , arthrosis, Osteoarthritis, degenerative spinal changes) and a higher prevalence of cancer disease to a further increase of the patients who suffer unnecessarily from pains. By the increasing polymorbidity (e.g. diabetes mellitus, vascular disease) and a declining immune competence, the prevalence of polyneuropathy and post-herpetic neuralgia rises. Insufficiently treated chronic or periodically returning pain can lead to serious interferences of the physical, cognitive and social everyday competence and therefore to a limited quality of life...
April 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27012973/often-seen-rarely-recognized-mast-cell-activation-disease-a-guide-to-diagnosis-and-therapeutic-options
#14
REVIEW
Lawrence B Afrin, Joseph H Butterfield, Martin Raithel, Gerhard J Molderings
Mast cell (MC) disease has long been thought to be just the rare disease of mastocytosis (in various forms, principally cutaneous and systemic), with aberrant MC mediator release at symptomatic levels due to neoplastic MC proliferation. Recent discoveries now show a new view is in order, with mastocytosis capping a metaphorical iceberg now called "MC activation disease" (MCAD, i.e. disease principally manifesting inappropriate MC activation), with the bulk of the iceberg being the recently recognized "MC activation syndrome" (MCAS), featuring inappropriate MC activation to symptomatic levels with little to no inappropriate MC proliferation...
2016: Annals of Medicine
https://www.readbyqxmd.com/read/26978608/-features-of-polymorbidity-in-cardiac-and-gastroenterologic-patients-from-a-therapeutic-clinic
#15
Yu A Nikolaev, E V Sevostyanova, I M Mitrofanov, V Ya Polyakov, N A Dolgova
AIM: To examine the incidence of polymorbidity (PM) and changes in its rates in 2003 to 2011 in cardiac and gastroenterologic patients living in the Novosibirsk Region and the Republic of Sakha (Yakutia) in accordance with gender, occupation, and residence. SUBJECTS AND METHODS: The dynamics of PM rates was analyzed in 13 496 patients who had been examined and treated at the Cardiology and Gastroenterology Departments, Therapeutic Clinic, Research Institute of Experimental and Clinical Medicine (Novosibirsk), 2003-2011...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26945264/hemopericardium-under-dabigatran-for-stroke-prevention-in-atrial-fibrillation
#16
Claudia Stöllberger, Maria Heger, Josef Finsterer
Spontaneous hemopericardium is a complication of anticoagulant therapy with not only vitamin-K-antagonists, but also with nonvitamin-K-antagonist oral anticoagulants. We report a polymorbid 75-year old male under a therapy with dabigatran, valsartan, amlodipine, nicorandil, furosemide, atorvastatin, bisoprolol, metformin, tizanidine, pantoprazole, and tramadol. He suffered from chest pain for 4 months. Coronary angiography showed only ectatic coronary arteries. He started taking nonsteroidal anti-inflammatory drugs...
March 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/26775802/cardiovascular-symptoms-in-patients-with-systemic-mast-cell-activation-disease
#17
REVIEW
Ulrich W Kolck, Britta Haenisch, Gerhard J Molderings
Traditionally, mast cell activation disease (MCAD) has been considered as just one rare (neoplastic) disease, mastocytosis, focused on the mast cell (MC) mediators tryptase and histamine and the suggestive, blatant symptoms of flushing and anaphylaxis. Recently another form of MCAD, the MC activation syndrome, has been recognized featuring inappropriate MC activation with little to no neoplasia and likely much more heterogeneously clonal and far more prevalent than mastocytosis. Increasing expertise and appreciation has been established for the truly very large menagerie of MC mediators and their complex patterns of release, engendering complex, nebulous presentations of chronic and acute illness best characterized as multisystem polymorbidity of generally inflammatory ± allergic theme...
August 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26390612/-effect-of-synthetic-peptides-on-aging-of-patients-with-chronic-polymorbidity-and-organic-brain-syndrome-of-the-central-nervous-system-in-remission
#18
V N Meshchaninov, E L Tkachenko, S V Zharkov, I V Gavrilov, Iu E Katyreva
We've estimated the cellular and metabolic part of geroprophylactic effects of short synthetic tripeptides vesugen and pinealon for correction of the biological age. 32 people (18 men, 12 women) aged 41-83 years with polymorbidity and the organic brain syndrome in remission participated in the study. The preparations of "Pinealon" and "Vesugen" have had the significant anabolic effect. They have improved the activity of the Central nervous system and other vital organs, which slows the rate of aging by biological age indicators...
2015: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/26314411/-treatment-concept-for-a-traumatic-lesion-of-the-prepatellar-bursa
#19
P Kaiser, G Schmidle, C Raas, M Blauth
OBJECTIVE: Rapid recovery of the skin and soft tissue of the affected knee joint with surgical debridement of the wound and gentle, as well as risk-balanced partial resection of the traumatic lacerated prepatellar bursa. Functional aftercare with directed administration of antibiotics only. INDICATIONS: Acute, traumatic laceration of the prepatellar bursa. CONTRAINDICATIONS: Heavy contamination of the wound. Large, not closable skin defect or deep abrasion...
October 2015: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/26298392/spectrum-of-digoxin-induced-ocular-toxicity-a-case-report-and-literature-review
#20
REVIEW
Delphine Renard, Eve Rubli, Nathalie Voide, François-Xavier Borruat, Laura E Rothuizen
BACKGROUND: Digoxin intoxication results in predominantly digestive, cardiac and neurological symptoms. This case is outstanding in that the intoxication occurred in a nonagenarian and induced severe, extensively documented visual symptoms as well as dysphagia and proprioceptive illusions. Moreover, it went undiagnosed for a whole month despite close medical follow-up, illustrating the difficulty in recognizing drug-induced effects in a polymorbid patient. CASE PRESENTATION: Digoxin 0...
2015: BMC Research Notes
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