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IgE Asthma

Reza Habibian, Nowruz Delirezh, Amir Abbas Farshid
Objectives: Allergic Asthma is an inflammatory disease of the lungs that is characterized by increased infiltration of leukocytes into the airways, limiting the respiratory function. Studies suggest that a defective general regulatory system against inflammation could be a significant factor in allergic asthma. It has been shown that Mesenchymal stem cells (MSCs) have a cellular immunosuppressive therapeutic potential for inflammatory disorders. We investigated whether administration of MSCs during allergen challenge would affect the underlying mechanisms in allergic airways inflammation...
May 2018: Iranian Journal of Basic Medical Sciences
L Cheng, W-C Zhou
Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. SLIT for three years is suitable for patients to acquire stable therapeutic effects, and the efficacy of single-allergen SLIT for polysensitized patients has also been confirmed...
June 16, 2018: Allergologia et Immunopathologia
Eleonora Savi, Marcello Montagni, Silvia Peveri
Molecular diagnostic is a new therapeutic approach that - allows to valuate sensitization towards a single molecule in a allergenic source and to obtain relevant information on clinical features: sensitization towards molecules as alfa amylase of wheat or lipocalins of pets, Alt a 1 of alternaria spores and Hev b 6 of latex correlates with the risk to develop asthma - has a greater sensitivity in the serum IgE identification than the whole source.
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Leena Jalota, D Richard Allison, Vinisha Prajapati, Jose J Vempilly, Vipul V Jain
OBJECTIVE: Fraction of exhaled nitric oxide (FENO ) has been proposed as a non-invasive biomarker for allergic inflammation seen in asthma. Many asthmatics in clinical practice have never had spirometry and recent data report misdiagnoses in patients with physician diagnosed (PD) asthma. The aim of this study was to assess the ability of FENO to discriminate between those with and without airflow obstruction (AO) among patients with PD-asthma. METHODS: Frequent exacerbators of PD-asthma (with 2 or more asthma exacerbations leading to emergency room visit or hospitalization within last 12 months) were enrolled...
June 18, 2018: Lung
Ioana Adriana Muntean, Ioana Corina Bocsan, Diana Deleanu
Wheat is the most commonly grown cereal. Immunological reaction to wheat may be IgE or T-cell- mediated. Asthma could be induced by inhaled flour or by exposure to allergens present in bakery products. In patients with IgE-mediated allergy to wheat proteins there is no specific therapy, except oral immunotherapy (OIT). There are few data regarding OIT with wheat protein in allergic patients. We present a case of a 32-yearold female patient, who worked for 5 years in wheat and bakery products industry, who developed an occupational asthma and chronic urticaria after flour inhalation or ingestion of foods that containit...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
Aiko Saku, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yoshihisa Kobayashi, Shin-Ichiro Kagami, Kazuhiro Kurasawa, Ryutaro Matsumura, Daiki Nakagomi, Takao Sugiyama, Takeshi Umibe, Norihiko Watanabe, Hiroshi Nakajima
OBJECTIVE: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed to reveal the risk factors for relapse in EGPA. METHODS: A total of 188 Japanese patients with EGPA diagnosed between 1996 and 2015 were identified from medical records in 10 hospitals. The diagnosis was based on the American College of Rheumatology 1990 criteria or Lanham's criteria...
June 15, 2018: Journal of Rheumatology
Wen Fu, Jing Zhao, Xinglong Liu, Yongxiang Gao, Chuan Zheng
The 'exterior-interior relationship between the lung and the large intestine' is a classical basic theory in Traditional Chinese Medicine. The present study aimed to investigate the roles of the toll like receptor/nuclear factor‑κB (TLR/NF‑κB) signaling pathway in the mutual interactions between the lung and the large intestine. A rat model of allergic asthma complicated with intestinal flora disorder was established by oral administration of Candida albicans and intraperitoneal injection with ovalbumin...
May 31, 2018: Molecular Medicine Reports
Paloma Campo, Ibon Eguiluz-Gracia, Gador Bogas, María Salas, Carmen Plaza Serón, Natalia Pérez, C Mayorga, M J Torres, Mohammed Shamji, Carmen Rondon
A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. LAR is a stable phenotype and not merely an initial state of AR...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N Lambrecht
BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM) and bronchial hyperreactivity (BHR). In clinical trials employing biologicals against interleukin (IL)-4Rα or IL-5, only a subset of moderate-to-severe asthmatics responded favorably, suggesting that distinct pathophysiological mechanisms are at play in subgroups of patients, called endotypes. However, the effect of multiple cytokine blockade using bispecific antibodies (Ab) has not been tested...
June 8, 2018: Journal of Allergy and Clinical Immunology
Eun Lee, Young-Ho Kim, Hyun-Ju Cho, Ji-Sun Yoon, Sungsu Jung, Song-I Yang, Hyung Young Kim, Ji-Won Kwon, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Soo-Jong Hong
BACKGROUND: Bronchial hyperresponsiveness (BHR), one of the key features of asthma, shows a diverse natural course in school-aged children, but, studies on BHR phenotypes are lacking. OBJECTIVE: We classified BHR phenotypes according to onset age and persistence in children and investigated the characteristics and factors associated with each phenotype in a longitudinal study. METHODS: We analyzed 1,305 elementary school children from the Children's HEalth and Environmental Research (CHEER) study, a 4-year prospective follow-up study with 2-year intervals starting at a mean age of 7 years...
June 7, 2018: Annals of Allergy, Asthma & Immunology
Jonatan Leffler, Philip A Stumbles, Deborah H Strickland
IgE sensitisation has increased significantly over the last decades and is a crucial factor in the development of allergic diseases. IgE antibodies are produced by B cells through the process of antigen presentation by dendritic cells, subsequent differentiation of CD4⁺ Th2 cells, and class switching in B cells. However, many of the factors regulating these processes remain unclear. These processes affect males and females differently, resulting in a significantly higher prevalence of IgE sensitisation in males compared to females from an early age...
May 23, 2018: International Journal of Molecular Sciences
Marsha D W Ward, Lisa B Copeland
Allergic diseases (atopy) include asthma, allergic rhinitis, conjunctivitis, and allergic sinusitis. It is estimated that up to 90% of asthmatics are atopic and have an allergy trigger for asthmatic episodes. In order to assess the risk of allergy induction associated with inhalation exposure, animal models of protein allergy have been developed. These models have been used both to identify proteins as allergens and to assess their relative potency. Often these research situations include allergens that are not well characterized or are unknown...
2018: Methods in Molecular Biology
Francisco Gómez Real, John A Burgess, Simona Villani, Julia Dratva, Joachim Heinrich, Christer Janson, Debbie Jarvis, Jennifer Koplin, Bénédicte Leynaert, Caroline Lodge, Birger N Lærum, Melanie C Matheson, Dan Norbäck, Ernst R Omenaas, Svein M Skulstad, Jordi Sunyer, Shyamali C Dharmage, Cecilie Svanes
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years...
June 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Andrea Matucci, Alessandra Vultaggio, Enrico Maggi, Ismail Kasujee
Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology. The heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergic), the histopathological background (eosinophilic vs non-eosinophilic), and the clinical manifestations, particularly in terms of severity and frequency of exacerbations. Asthma can be divided into at least two different endotypes based on the degree of Th2 inflammation (T2 'high' and T2 'low'). For patients with severe uncontrolled asthma, monoclonal antibodies (mAbs) against immunoglobulin E (IgE) or interleukin (IL)-5 are now available as add-on treatments...
June 8, 2018: Respiratory Research
Tasuku Kawano, Ryusuke Ouchi, Takahiro Ishigaki, Chiaki Masuda, Tomomitsu Miyasaka, Yuichi Ohkawara, Nobuo Ohta, Motoaki Takayanagi, Tomoko Takahashi, Isao Ohno
BACKGROUND: Bronchial asthma is characterized by type 2 T helper (Th2) cell inflammation, essentially due to a breakdown of immune tolerance to harmless environmental allergens. Etiologically, experiences of psychological stress can be associated with a heightened prevalence of asthma. However, the mechanisms underlying stress-related asthma development are unclear. In this study, we examined whether psychological stress increases susceptibility to allergic asthma by downregulating immune tolerance...
June 6, 2018: International Archives of Allergy and Immunology
Janet Rothers, Debra A Stern, I Carla Lohman, Amber Spangenberg, Anne L Wright, Avery DeVries, Donata Vercelli, Marilyn Halonen
Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a non-selected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-γ, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma...
June 4, 2018: American Journal of Respiratory Cell and Molecular Biology
Jacqueline Ho, Aneeza W Hamizan, Raquel Alvarado, Janet Rimmer, William A Sewell, Richard J Harvey
Background Eosinophilic chronic rhinosinusitis (eCRS) is linked with skewed T-helper 2 or immunoglobulin E (IgE)-mediated allergic responses, with differing diagnosis, prognosis, and management to non-eCRS. Objective The association between biomarkers and eCRS was investigated to assess the predictors of eCRS. Methods A cross-sectional study of adult patients with chronic rhinosinusitis (CRS) undergoing endoscopic sinus surgery was conducted. eCRS was defined by histopathological assessment showing >10 eosinophils/high-power field on sinus mucosal biopsy...
January 1, 2018: American Journal of Rhinology & Allergy
Ulrika Käck, Anna Asarnoj, Hans Grönlund, Magnus P Borres, Marianne van Hage, Gunnar Lilja, Jon R Konradsen
BACKGROUND: Sensitization to dog dander is an important risk factor for rhino-conjunctivitis and asthma, but not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offers new opportunities for refined characterization. OBJECTIVES: To study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children, evaluated by nasal provocation testing. METHODS: 60 children (age 10-18 years) sensitized to dog dander extract, went through nasal provocation testing with dog dander extract...
May 28, 2018: Journal of Allergy and Clinical Immunology
Vinicius F Carvalho, Emiliano O Barreto, Ana Carolina S Arantes, Magda F Serra, Tatiana Paula T Ferreira, Yago A P Jannini-Sá, Cory M Hogaboam, Marco A Martins, Patrícia M R Silva
Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on allergic airway inflammation in a model of experimental asthma in mice. Diabetes was induced by intravenous injection of alloxan into 12 h-fasted A/J mice, followed by subcutaneous sensitization with ovalbumin (OVA) and aluminum hydroxide (Al(OH)3 ), on days 5 and 19 after diabetes induction. Animals were intranasally challenged with OVA (25  μ g), from day 24 to day 26...
2018: Mediators of Inflammation
Carmen Rondón, Ibon Eguiluz-Gracia, Paloma Campo
PURPOSE OF REVIEW: To examine the recent advances on epidemiological studies, diagnostic approach and clinical management of local allergic rhinitis (LAR) in adults and children. RECENT FINDINGS: Evidence about LAR is growing especially in pediatric and Asian populations. The prevalence of LAR is lower in Asian countries compared with western countries in both children and adults. LAR is considered a chronic condition and an independent rhinitis phenotype that affects up to 26...
May 29, 2018: Current Opinion in Allergy and Clinical Immunology
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