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https://www.readbyqxmd.com/read/28342859/hydroethanolic-extract-from-echinodorus-scaber-rataj-leaves-inhibits-inflammation-in-ovalbumin-induced-allergic-asthma
#1
Suellen Iara Guirra Rosa, Fabrício Rios-Santos, Sikiru Olaitan Balogun, Danielle Ayr Tavares de Almeida, Amilcar Sabino Damazo, Thais Campos Dias da Cruz, Eduarda Pavan, Robson Dos Santos Barbosa, Tarso da Costa Alvim, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Antonio Macho, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Echinodorus scaber, Alismataceae, is popularly known in Brazil as "chapéu-de-couro". The plant leaves are used by the population as decoction, infusion, or maceration in bottled spirits, to treat inflammatory respiratory diseases. AIM OF THE STUDY: To investigate the anti-inflammatory mechanism of the hydroethanolic extract of leaves of Echinodorus scaber (HEEs) in allergic asthma. A phytochemical analysis of the extract was performed as well...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28337093/assessment-of-socioeconomic-status-and-control-of-asthma-in-adults
#2
I A Azeez, M M A Ladipo, O M Ige
BACKGROUND: Asthma is a chronic disease which places considerable economic, social and public health burdens on the society. Education, occupation and income are the most widely used indicators of socioeconomic status (SES). Studies have shown increased asthma hospital admissions for those who are materially deprived and increased asthma severity in low social class groups. The aim of this study is to determine the impact of socioeconomic status on control of asthma in adults. METHOD: The study was a cross-sectional analytical one, conducted over a year at the Medical Outpatient Clinic of the University College Hospital Ibadan...
December 2016: Annals of Ibadan Postgraduate Medicine
https://www.readbyqxmd.com/read/28325597/relationships-between-acrylamide-and-glycidamide-hemoglobin-adduct-levels-and-allergy-related-outcomes-in-general-us-population-nhanes-2005-2006
#3
Jing Guo, Dongdong Yu, Na Lv, Rongpan Bai, Chunjing Xu, Guangdi Chen, Weiming Cao
BACKGROUND: Acrylamide-induced immunotoxicity and allergic dermatitis have been reported in animal experiments and clinical reports, respectively. However, epidemiological evidence from the general population is limited. OBJECTIVES: The purpose of the present study was to estimate the associations between acrylamide exposure and allergy-related outcomes in the general US population. METHODS: A total of 6982 subjects were selected from the National Health and Nutrition Examination Survey 2005-2006 (NHANES)...
March 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28320552/association-between-severe-vitamin-d-deficiency-lung-function-and-asthma-control
#4
Seda Beyhan-Sagmen, Ozgur Baykan, Baran Balcan, Berrin Ceyhan
INTRODUCTION: To examine the relationship between severe vitamin D deficiency, asthma control, and pulmonary function in Turkish adults with asthma. METHODS: One hundred six asthmatic patients underwent pulmonary function tests skin prick test, peripheral blood eosinophil counts, IgE, body mass index and vitamin D levels were determined. Patients were divided into 2 subgroups according to vitamin D levels (vitamin D level<10ng/ml and vitamin D level≥10 ng/ml)...
March 17, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28317175/occupational-respiratory-allergy-in-peach-crop-workers
#5
Remedios Pérez-Calderón, M Ángeles Gonzalo-Garijo, Francisco José Rodríguez-Velasco, Silvia Sánchez-Vega, Borja Bartolomé-Zavala
BACKGROUND: Occupational respiratory diseases in workers of peach tree crops have been reported punctually and have been associated with sensitization to proteins present in both pollen and leaf tree. We report the study of 37 workers with respiratory symptoms related to occupational exposure to peach trees. METHODS: Prick tests and specific IgE determinations were performed with extracts from leaves and branches of peach tree. Immunodetection in leaf extract was realized by SDS-PAGE-immunoblotting with patient sera and rabbit serum anti-Pru p 3...
March 20, 2017: Allergy
https://www.readbyqxmd.com/read/28314480/airways-antiallergic-effect-and-pharmacokinetics-of-alkaloids-from-alstonia-scholaris
#6
Yun-Li Zhao, Jing Cao, Jian-Hua Shang, Ya-Ping Liu, Afsar Khan, Heng-Shan Wang, Yi Qian, Lu Liu, Min Ye, Xiao-Dong Luo
BACKGROUND: Alstonia scholaris (L.) R. Br. (Apocynaceae), an important herbal medicine, has been widely used to treat respiratory tract diseases, such as cough, asthma, phlegm, and chronic obstructive pulmonary disease. PURPOSE: To evaluate pharmacological effect of alkaloids from A. scholaris on ovalbumin induced airways allergic inflammatory model, and explore whether the dosing frequency is related to pharmacokinetics. STUDY DESIGN: After oral administration of total alkaloids, the pharmacokinetic study of it was investigated...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28306401/caregiver-s-depressive-symptoms-and-asthma-control-in-children-from-an-underserved-community
#7
Andrea Rioseco, Carolina Serrano, Juan C Celedón, Oslando Padilla, Klaus Puschel, Jose A Castro-Rodriguez
Caregiver's or maternal depression has been associated with increased asthma morbidity in children from prosperous nations, but little is known about this link in low and middle-income countries. OBJECTIVE: To examine if caregiver's depressive symptoms are associated with poor asthma control and abnormal immune responses in school-aged children. METHODS: Case-control study of 87 asthmatic children (aged 4-11 years) attending a primary care clinic in an underserved area of Santiago (Chile)...
February 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28303289/-relevance-of-nasal-provocation-testing-in-house-dust-mite-allergy
#8
B R Haxel
Patients with house dust mite allergies frequently exhibit very different symptoms to those allergic to other inhalant allergens. The frequency of comorbid allergic asthma in these patients is increased. Therefore, diagnosing patients with suspected house dust mite allergies can be difficult. It is important to distinguish between sensitization to an allergen and a clinically relevant allergy. Nasal provocation testing (NPT) is a reliable method to identify patients suitable for a causal treatment (specific immunotherapy)...
March 16, 2017: HNO
https://www.readbyqxmd.com/read/28300662/diisononyl-phthalate-induces-asthma-via-modulation-of-th1-th2-equilibrium
#9
Yun-Ho Hwang, Man-Jeong Paik, Sung-Tae Yee
Diisononyl phthalate (DINP), a member of the phthalate family, is used to plasticize polyvinyl chloride (PVC). This chemical is known to enhance airway inflammation in the OVA-induced asthma model (adjuvant effects) and aggravate allergic dermatitis. Moreover, DINP enhances the production of interleukin-4 in activated CD4(+) T cells. However, the effect of DINP itself on the differentiation of naïve CD4(+) T cells into T helper cells (Th1/Th2) in vitro and allergic asthma in vivo has not yet been studied. In this study, DINP was shown to suppress the polarization of Th1 and enhance the polarization of Th2 from naïve CD4(+) T cells in vitro...
March 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28300572/the-potential-role-of-aspiration-in-the-asthmatic-airway
#10
Eoin B Hunt, Chris Ward, Stephen Power, Ashley Sullivan, Jeffrey Pearson, Susan Lapthorne, Paul M O'Byrne, Joseph Eustace, Barry J Plant, Michael M Maher, John MacSharry, Desmond M Murphy
BACKGROUND: Many asthmatics remain sub-optimally controlled despite current treatments. Reasons include comorbidities that could aggravate asthma, including gastro-esophageal reflux (GER). We aimed to investigate whether aspiration occurs in asthmatic patients and if so does it correlate with asthma control. METHODS: Patients had ACQ-7, FeNO, and spirometry performed to characterize their level of asthma control. Barium swallow with provocation was performed to assess for predisposition to aspiration...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28297812/-the-regulative-effects-of-aspergillus-fumigatus-on-expression-of-glucocorticoid-receptor-in-asthmatic-rats
#11
X Zhou, Y J Dang, G F Wang, X Q Jin
Objective: To study the regulative effects of Aspergillus fumigatus (A.fumigatus) on expression of glucocorticoid receptor (GCR) in asthmatic rats. Methods: Wistar rats were randomly divided into 4 groups: a normal control group (UC), a normal control with A. fumigatus group (UC+ AF), an OVA group (OVA), and an OVA with A. fumigatus group (OVA+ AF). OVA and OVA+ AF groups were sensitized and challenged with OVA to establish asthmatic models. UC and UC+ AF groups were given normal saline as controls. After the last challenge, OVA+ AF and UC+ AF groups were given A...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28294591/letter-to-the-editor-can-dog-allergen-immunotherapy-reduce-concomitant-allergic-sensitization-to-other-furry-animals-a-preliminary-experience
#12
G Liccardi, L Calzetta, A Salzillo, L Billeri, G Lucà, P Rogliani
It has been shown that allergen immunotherapy (AIT) is effective in reducing symptoms of allergic asthma and rhinitis. Data on the efficacy are less convincing with regard to AIT for allergens of common pets (cats/dogs). We describe a case of dog allergy in which we explored if dog AIT (DAI) could reduce a concomitant allergic sensitization to other allergens of furry animals. Our case demonstrates the efficacy of sublingual DAI on SPTs, symptom score, and spirometric responses despite persistent exposure to dog allergens at home in a patient sensitized, but not exposed, to several other furry animals...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28294434/immunologic-regulatory-effects-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-in-a-murine-ovalbumin-asthma-model
#13
Sung-Yoon Kang, Da-Eun Park, Woo-Jung Song, Bo-Ram Bae, Ji-Won Lee, Kyoung-Hee Sohn, Hyun-Seung Lee, Hye-Ryun Kang, Heung-Woo Park, Yoon-Seok Chang, Soo-Jin Choi, Won-Il Oh, Kyung-Up Min, Sang-Heon Cho
BACKGROUND: Mesenchymal stem cells (MSCs) have multiple immunomodulatory properties and hold therapeutic potential for inflammatory diseases. However, the therapeutic and immunologic effects of human umbilical cord blood-derived MSCs (huMSCs) remain largely unexamined for asthma. OBJECTIVE: This study was to investigate the immunomodulatory properties of huMSCs in an ovalbumin (OVA)-induced murine asthma model. METHODS: Mice were injected intraperitoneally with OVA and an aluminum hydroxide adjuvant...
March 14, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#14
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28287273/novel-monoclonal-treatments-in-severe-asthma
#15
Howraman Meteran, Hanieh Meteran, Celeste Porsbjerg, Vibeke Backer
AIM: To provide a general overview of the current biological treatments and discuss their potential anti-asthmatic effects. DATA SOURCES: We reviewed articles in PubMed found using the search words "Asthma/therapy AND antibodies, monoclonal/therapeutic use AND cytokines." STUDY SELECTIONS: Only articles published in English since 2000 were considered. The search identified 29 studies; 8 additional studies were found by hand search, generating 37 studies...
March 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28284979/effect-of-polymorphisms-on-tgfb1-on-allergic-asthma-and-helminth-infection-in-an-african-admixed-population
#16
Ryan Dos Santos Costa, Camila Alexandrina Figueiredo, Maurıcio Lima Barreto, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Alvaro A Cruz, Candelaria Vergara, Nicholas Rafaels, Cassandra Foster, Joseph Potee, Monica Campbell, Rasika A Mathias, Kathleen C Barnes
BACKGROUND: Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation...
March 8, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28279683/long-term-pulmonary-complications-in-perinatally-hiv-infected-youth
#17
William T Shearer, Denise L Jacobson, Wendy Yu, George K Siberry, Murli Purswani, Suzanne Siminski, Laurie Butler, Erin Leister, Gwendolyn Scott, Russell B Van Dyke, Ram Yogev, Mary E Paul, Ana Puga, Andrew A Colin, Meyer Kattan
BACKGROUND: Increased incidence and prevalence of asthma have been documented for perinatally HIV-infected (HIV) youth 10-21 years of age (youth) compared to HIV-exposed uninfected (HEU) youth. OBJECTIVE: To perform objective pulmonary function tests (PFTs) in HIV and HEU youth with and without diagnosed asthma. METHOD: Asthma was determined in 370 participants (218 HIV, 152 HEU) by chart review and self-report at 13 sites. Interpretable PFTs (188 HIV, 132 HEU) were classified as obstructive, restrictive, or normal and reversibility was determined after bronchodilator inhalation...
March 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28277826/commonality-of-the-il-4-il-13-pathway-in-atopic-diseases
#18
Namita Gandhi, Gianluca Pirozzi, Neil Graham
Allergy results from an aberrant Type 2 inflammatory response, triggered by a wide range of environmental antigens (allergens) that lead to various immune responses, culminating in the production of immunoglobulin E (IgE). Two key cytokines, interleukin (IL)-4 and IL-13, are critical to the induction and perpetuation of the Type 2 response, and have been implicated in multiple atopic diseases. Area covered: This review summarizes recent milestone developments that have elucidated components of the pathogenesis of atopic diseases such as atopic dermatitis (AD), asthma, and chronic sinusitis with nasal polyposis (CSwNP)...
March 6, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28274526/efficacy-of-long-term-omalizumab-therapy-in-patients-with-severe-asthma
#19
Junko Saji, Takahito Yamamoto, Motonaka Arai, Masamichi Mineshita, Teruomi Miyazawa
BACKGROUND: The efficacy of omalizumab, an anti-immunoglobulin E (IgE) antibody, has been studied in patients with severe bronchial asthma. We conducted a study to evaluate, on the basis of both objective and subjective measures, the efficacy of omalizumab as a long-term therapy in patients with severe and persistent asthma. METHODS: Omalizumab was administered subcutaneously every two or four weeks. The results of pulmonary function tests, Asthma Control Test (ACT) and Asthma Health Questionnaire (AHQ)-33 scores, the dosage of methylprednisolone during the 12-month treatment period, and the number of emergency visits prior to the start of treatment with omalizumab were compared in patients pre- and post-treatment with omalizumab...
March 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28270741/sensitization-to-secretoglobin-and-lipocalins-in-a-group-of-young-children-with-risk-of-developing-respiratory-allergy
#20
Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel, Takao Fujisawa
BACKGROUND: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development. METHODS: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception...
2017: Clinical and Molecular Allergy: CMA
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