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aminolevulinic acid ganglioglioma

Pablo A Valdés, Valerie Jacobs, Brent T Harris, Brian C Wilson, Frederic Leblond, Keith D Paulsen, David W Roberts
OBJECT: Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival. Despite the benefits of complete resection and the advances in fluorescence-guided surgery, few studies have investigated the use of PpIX in low-grade gliomas (LGGs). Here, the authors describe their initial experience with 5-aminolevulinic acid (ALA)-induced PpIX fluorescence in a series of patients with LGG...
September 2015: Journal of Neurosurgery
Walter Stummer, Floriano Rodrigues, Philippe Schucht, Matthias Preuss, Dorothee Wiewrodt, Ulf Nestler, Marco Stein, José Manuel Cabezudo Artero, Nunzio Platania, Jane Skjøth-Rasmussen, Alessandro Della Puppa, John Caird, Søren Cortnum, Sam Eljamel, Christian Ewald, Laura González-García, Andrew J Martin, Ante Melada, Aurelia Peraud, Angela Brentrup, Thomas Santarius, Hans Herbert Steiner
BACKGROUND: Five-aminolevulinic acid (Gliolan, medac, Wedel, Germany, 5-ALA) is approved for fluorescence-guided resections of adult malignant gliomas. Case reports indicate that 5-ALA can be used for children, yet no prospective study has been conducted as of yet. As a basis for a study, we conducted a survey among certified European Gliolan users to collect data on their experiences with children. METHODS: Information on patient characteristics, MRI characteristics of tumors, histology, fluorescence qualities, and outcomes were requested...
December 2014: Acta Neurochirurgica
M Preuß, C Renner, W Krupp, H Christiansen, L Fischer, A Merkenschlager, W Kieß, W Müller, N Manzo, J Meixensberger, U Nestler
INTRODUCTION: Whereas in the adult population 5-Aminolevulinic acid (5-ALA) fluorescence guidance has been widely accepted for improving the extent of tumor resection, the application in children remains an off-label use. Even though most pediatric study protocols require a complete resection for improving outcome parameters, only few pediatric patients have been operated with fluorescence guidance, and it remains questionable, whether and which pediatric tumors show useful fluorescence...
August 2013: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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