Irene Giulia Rolle, Ilaria Crivellari, Andrea Zanello, Elisa Mazzega, Emiliano Dalla, Michela Bulfoni, Elisa Avolio, Alice Battistella, Marco Lazzarino, Alice Cellot, Celeste Cervellin, Sandro Sponga, Ugolino Livi, Nicoletta Finato, Gianfranco Sinagra, Aneta Aleksova, Daniela Cesselli, Antonio Paolo Beltrami
The prominent impact that coronary microcirculation disease (CMD) exerts on heart failure symptoms and prognosis, even in the presence of macrovascular atherosclerosis, has been recently acknowledged. Experimental delivery of pericytes in non-revascularized myocardial infarction improves cardiac function by stimulating angiogenesis and myocardial perfusion. Aim of this work is to verify if pericytes (Pc) residing in ischemic failing human hearts display altered mechano-transduction properties and to assess which alterations of the mechano-sensing machinery are associated with the observed impaired response to mechanical cues...
November 5, 2020: Journal of Molecular and Cellular Cardiology