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Dialysis, cancer, taiwan

Jeng-Sheng Chen, Chin-Li Lu, Li-Chung Huang, Cheng-Huang Shen, Solomon Chih-Cheng Chen
Increased urinary tract malignancy has been reported in end-stage renal disease (ESRD). However, little is known about chronic kidney disease (CKD). This study is designed to explore the association between CKD and upper tract urothelial carcinoma (UTUC).Using Taiwan's Longitudinal Health Insurance Database, we studied CKD patients between January 2000 and December 2011. The non-CKD controls were selected at a ratio of 4:1 and frequency matched by gender, age group, and index date. We used the chi-square test and t test to analyze the sociodemographic information and comorbidities...
April 2016: Medicine (Baltimore)
Shih-Feng Weng, Yu-Hsien Chiu, Ren-Long Jan, Yi-Chen Chen, Chih-Chiang Chien, Jhi-Joung Wang, Chin-Chen Chu
Patients with end-stage renal disease (ESRD) have a high mortality rate. We hypothesized that not accounting for death as a competing risk overestimates the event rate caused by ESRD. Thus, we examined the cancer risk for patients with ESRD (ESRD) after death as a competing risk event had been adjusted for. Patients with newly diagnosed ESRD (n = 64,299) between 1999 and 2007, together with age- and sex-matched controls without ESRD (ESRD) (n = 128,592) were enrolled (1:2). In a Cox proportional hazards model that included death as a competing risk, ESRD patients in Taiwan had a lower overall incidence (subdistribution hazard ratio [sdHR] = 1...
January 2016: Medicine (Baltimore)
Ming Yen Lin, Mei Chuan Kuo, Chi Chih Hung, Wen Jeng Wu, Li Tzong Chen, Ming Lung Yu, Chih-Cheng Hsu, Chien-Hung Lee, Hung-Chun Chen, Shang-Jyh Hwang
BACKGROUND: To increase the survival span after dialysis in patients with end-stage renal disease (ESRD), identifying specific cancer risks is crucial in the cancer screening of these patients. The aim of this study was to investigate the risks of various cancers in an incident dialysis group in comparison with a non-dialysis group. METHOD: We conducted a nationwide cohort study by using data from the Taiwan National Health Insurance Research Database. Patients who initially received long-term dialysis between January 1997 and December 2004, were selected and defined as the dialysis group and were matched with the non-dialysis patients (control group) according to age, sex, and index year...
2015: PloS One
Shang-Jyh Chiou, Pei-Tseng Kung, James M Naessens, Kuang-Hua Huang, Yu-Chia Chang, Yueh-Hsin Wang, Wen-Chen Tsai
AIMS: To assess whether the increased knowledge and resources available to physicians led to differences in dialysis and survival rates between physicians and non-physician patients with diabetes. METHODS: All newly diagnosed (1997-2009) type 2 diabetes patients aged ≥35 years from the National Health Insurance Program of Taiwan database were included. After propensity score matching (1:10), we estimated the relative risk of dialysis and death using Cox proportional hazards model adjusted for demographic characteristics and comorbidities...
September 2014: Diabetes Research and Clinical Practice
Yuan-Tso Cheng, Stuart M Flechner, Po-Hui Chiang
BACKGROUND: To evaluate the effect and safety of laparoscopy-assisted renal autotransplantation treatment for primary ureteral cancer (PUC). METHODS: Medical records of patients undergoing hand-assisted retroperitoneoscopic nephroureterectomy–extracorporeal total ureterectomy–renal autotransplantation–pyelocystostomy (Lap AutoTx) were analyzed. Demographic, intraoperative, and postoperative data were assessed. RESULTS: Fifteen patients diagnosed with PUC underwent this novel approach...
October 2014: Annals of Surgical Oncology
Hsin-Lin Tsai, Jei-Wen Chang, Tsai-Hun Wu, Kuang-Liang King, Ling-Yu Yang, Yu-Jiun Chan, An-Hang Yang, Fu-Pang Chang, Chin-Chen Pan, Wu-Chang Yang, Che-Chuan Loong
BACKGROUND: To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS: Three hundred seven patients who received deceased donor kidney transplants between January 2003 and December 2009 were retrospectively studied. The clinical parameters and outcomes between the domestic and tourist groups were compared...
July 15, 2014: Transplantation
Hsi-Hao Wang, Shih-Yuan Hung, Junne-Ming Sung, Kuan-Yu Hung, Jung-Der Wang
BACKGROUND: Patients undergoing maintenance dialysis are at increased risk of stroke. STUDY DESIGN: We performed a nationwide retrospective cohort study to determine the risks for ischemic stroke and hemorrhagic stroke among incident hemodialysis (HD) and peritoneal dialysis (PD) patients in comparison to a reference group in Taiwan. SETTING & PARTICIPANTS: Data for 74,192 HD patients, 5,974 PD patients, and 669,773 nondialysis individuals who were older than 18 years and had no history of stroke or cancer were retrieved from the National Health Insurance Research Database for 1998-2009...
April 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Mei-Yi Wu, Tung-Cheng Chang, Tsu-Yi Chao, Ming-Te Huang, Hui-Wen Lin
BACKGROUND: The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS: The study cohort included patients aged ≥18 years diagnosed with CKD between 2004 and 2005 (n = 15,975). The comparison cohort (n = 79,875) included five randomly selected age- and gender-matched controls for each patient in the study cohort...
November 2013: Annals of Surgical Oncology
Tze-Wah Kao, Yu-Yin Chang, Pau-Chung Chen, Chih-Cheng Hsu, Yu-Kang Chang, Yu-Hung Chang, Lukas Jyuhn-Hsiarn Lee, Kwan-Dun Wu, Tun-Jun Tsai, Jung-Der Wang
BACKGROUND: This study compared the lifetime costs for peritoneal dialysis (PD) and hemodialysis (HD) patients in Taiwan. METHODS: Using the National Health Insurance (NHI) database of all end-stage renal disease patients on maintenance dialysis registered from July 1997 to December 2005, we matched eligible PD patients with eligible HD patients on age, sex, and diabetes status. The matched patients were followed until 31 December 2006. Patients were excluded if they were less than 18 years of age, had been diagnosed with cancer before dialysis, or had been dialyzed at centers or clinics other than hospitals...
November 2013: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Shuo-Ming Ou, Yung-Tai Chen, Pei-Wen Chao, Yi-Jung Lee, Chia-Jen Liu, Chiu-Mei Yeh, Tzeng-Ji Chen, Tzen-Wen Chen, Wu-Chang Yang, Szu-Yuan Li
Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these patients. To identify any association between NSAID use and cancer risk in patients with end-stage renal disease on dialysis, we used Taiwan's National Health Insurance database to conduct a nationwide population-based, propensity score-matched cohort study...
July 2013: Kidney International
Chi-Jung Chung, Chao-Yuan Huang, Hung-Bin Tsai, Chih-Hsin Muo, Mu-Chi Chung, Chao-Hsiang Chang, Chiu-Ching Huang
Increasing evidence indicates that end-stage renal disease (ESRD) is associated with the morbidity of cancer. However, whether different dialysis modality and sex effect modify the cancer risks in ESRD patients remains unclear. A total of 3,570 newly diagnosed ESRD patients and 14,280 controls matched for age, sex, index month, and index year were recruited from the National Health Insurance Research Database in Taiwan. The ESRD status was ascertained from the registry of catastrophic illness patients. The incidence of cancer was identified through cross-referencing with the National Cancer Registry System...
2012: PloS One
Hsuen-Fu Lin, Yi-Hwei Li, Chih-Hsien Wang, Chu-Lin Chou, De-Jhen Kuo, Te-Chao Fang
BACKGROUND: An increased incidence of cancer in chronic dialysis patients has not been confirmed in the Chinese population. The aim of this population-based study was to examine the risk of various types of cancers in chronic dialysis patients in Taiwan. METHODS: Data of 92 348 chronic dialysis patients extracted from the National Health Institutes Research Database during 1997-2008 were analyzed. Patients newly diagnosed with end-stage renal disease, free of cancer and receiving dialysis for >3 months were eligible for inclusion in the study...
April 2012: Nephrology, Dialysis, Transplantation
Pei-Hsuan Weng, Kuan-Yu Hung, Hsien-Liang Huang, Jen-Hau Chen, Pei-Kun Sung, Kuo-Chin Huang
BACKGROUND AND OBJECTIVES: Chronic kidney disease (CKD) is known to be associated with increased all-cause and cardiovascular mortality, but no large studies examined the cancer-specific mortality in non-dialysis-dependent CKD patients. Such outcome data are needed for proper allocation of resources and would help to develop better preventive services. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Between 1998 and 1999, 123,717 adults were recruited from four health screening centers in Taiwan...
May 2011: Clinical Journal of the American Society of Nephrology: CJASN
Bin-Guang Su, Kai-Li Tsai, Shu-Hsing Yeh, Yi-Yi Ho, Shin-Yi Liu, Patrick A Rivers
According to the 2004 US Renal Data System's annual report, the incidence rate of chronic renal failure in Taiwan increased from 120 to 352 per million populations between 1990 and 2003. This incidence rate is the highest in the world. The prevalence rate, which ranks number two in the world (Japan ranks number one), also increased from 384 to 1630 per million populations. Based on 2005 Taiwan national statistics, there were 52,958 end-stage renal disease (ESRD) patients receiving routine dialysis treatment...
May 2010: Health Services Management Research
Chih-Hsiung Kang, Chien-Hsu Chen, Po-Hui Chiang
OBJECTIVE: In this study, we assessed the clinical and pathological characteristics of urothelial cancers of the upper urinary tract (UUT) in patient under dialysis and evaluated the efficacy and complications of surgical management of the disease. METHODS: A total of 70 dialysis patients with primary urothelial carcinoma (UC) of the UUT were identified with 5-year follow-up after surgery (61-122 months). Potential factors were analysed to determine the risk factors of subsequent tumours and unfavourable prognostic factors of overall survival...
March 2010: Japanese Journal of Clinical Oncology
Horng-Rong Chang, Hui-Pei Huang, Yu-Lin Kao, Sung-Lang Chen, Sheng-Wen Wu, Tung-Wei Hung, Jong-Da Lian, Chau-Jong Wang
Urothelial cell carcinoma is the most common type of malignancy found in long-term dialysis patients and kidney transplant recipients in Taiwan. Surgical specimens of tumorous and non-tumorous bladder tissues were collected from 12 patients with bladder cancer. Increased expressions of Ras, RhoA, Akt, PI-3K were demonstrated in the tumors as compared to adjacent control tissues. To understand the impact of Ras over-expression on bladder cancer progression, human bladder cancer TSGH 8301 cells were transfected with Ras DNA...
January 5, 2010: Chemico-biological Interactions
Li-Jen Lin, Ming-Hui Cheng, Cheng-Han Lee, Der-Chang Wung, Ching-Lan Cheng, Yea-Huei Kao Yang
OBJECTIVES: This study examined compliance with prescribing guidelines for antithrombotic therapy in patients with atrial fibrillation (AF) in Taiwan, using the 2001 joint guideline from the American College of Cardiology, American Heart Association, and European Society of Cardiology. The study also sought to identify factors associated with the appropriate prescribing of antithrombotic therapy. METHODS: Patients with AF were identified by the presence of > or =2 inpatient or outpatient claims with an International Classification of Diseases, Ninth Revision, Clinical Modification code of 427...
September 2008: Clinical Therapeutics
Chia-Yen Chen, Yung-Ming Liao, Wei-Ming Tsai, Hann-Chorng Kuo
BACKGROUND/PURPOSE: This study investigated the incidence of upper urinary tract urothelial carcinoma (UUT-UC) in eastern Taiwan and its association with chronic kidney disease (CKD). METHODS: A total of 110 patients with histologically proven UUT-UC over a recent 20-year period were retrospectively analyzed to determine the clinical profile, overall survival and correlation with CKD. RESULTS: The mean age at diagnosis was 68.7 +/- 9.8 years (range, 43-93 years), and the male to female ratio was 1 to 1...
December 2007: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Yu-Lin Kao, Yen-Chuan Ou, Chi-Rei Yang, Hao-Chung Ho, Chung-Kuang Su, Kuo-Hsiung Shu
Renal transplantation (RTx) recipients have a high incidence of cancer, including transitional cell carcinoma (TCC). Posttransplantation urologic malignancies still present a challenge for transplant surgeons. Using the Dialysis and Transplant Registry of Taichung Veterans General Hospital, a total of 55 cancers were diagnosed in 52 RTx recipients between May 1983 and September 2001. Of these, 24 RTx recipients developing TCC were identified and presented the distinctly high percentage (43.6%) of TCC that were malignancies after RTx in Taiwan...
August 2003: World Journal of Surgery
J K Lee, M J Chuang, C C Lu, L J Hao, C Y Yang, T M Han, H C Lam
There are many pathological causes and potential mechanisms for hypercalcemia. We measured intact parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) in the hypercalcemic in-patients and attempted to evaluate the roles of PTH and PTHrP in hypercalcemia due to malignancy. We performed a prospective study of 178 patients with corrected serum calcium concentrations greater than 2.74 mmol/l in a hospital over a 3-year period. We measured calcium and albumin using a Hitachi 747 autoanalyzer, and we measured PTH and PTHrP by two-site immunoradiometric assays (IRMA)...
July 1997: Journal of Endocrinological Investigation
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