keyword
MENU ▼
Read by QxMD icon Read
search

risk of psychosis

keyword
https://www.readbyqxmd.com/read/28944523/a-new-method-for-analysing-transition-to-psychosis-joint-modelling-of-time-to-event-outcome-with-time-dependent-predictors
#1
Hok Pan Yuen, Andrew Mackinnon, Barnaby Nelson
An active area in psychosis research is the identification of predictors of transition to a psychotic state among those who are assessed as being at high risk of psychosis. Many of the potential predictors are time dependent in the sense that they may change over time and are measured at a number of assessment time points. Examples are various psychopathological measures such as negative symptoms, positive symptoms, depression, and anxiety. Most research in transition to psychosis has not made use of the dynamic nature of these measures, probably because suitable statistical methods and software have not been easily available...
September 24, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28942953/metacognitive-beliefs-as-psychological-predictors-of-social-functioning-an-investigation-with-young-people-at-risk-of-psychosis
#2
Measha Bright, Sophie Parker, Paul French, David Fowler, Andrew Gumley, Anthony P Morrison, Max Birchwood, Peter B Jones, Suzanne L K Stewart, Adrian Wells
Poor social functioning has been found to be present in those at risk for psychosis. This study aimed to examine metacognitive beliefs as potential predictors of structured activity (measure of social functioning) in those with an At Risk Mental State (ARMS). Regression and correlation analyses were conducted. The sample included 109 young people. Age was found to be positively correlated to structured activity. Metacognitive beliefs concerning uncontrollability and danger of worry were found to negatively predict structured activity...
September 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28941089/improving-outcomes-of-first-episode-psychosis-an-overview
#3
Paolo Fusar-Poli, Patrick D McGorry, John M Kane
Outcomes of psychotic disorders are associated with high personal, familiar, societal and clinical burden. There is thus an urgent clinical and societal need for improving those outcomes. Recent advances in research knowledge have opened new opportunities for ameliorating outcomes of psychosis during its early clinical stages. This paper critically reviews these opportunities, summarizing the state-of-the-art knowledge and focusing on recent discoveries and future avenues for first episode research and clinical interventions...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28935170/individualized-prediction-of-psychosis-in-subjects-with-an-at-risk-mental-state
#4
Eleni Zarogianni, Amos J Storkey, Stefan Borgwardt, Renata Smieskova, Erich Studerus, Anita Riecher-Rössler, Stephen M Lawrie
Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicating our previous classification findings using an independent cohort at clinical high risk for psychosis, drawn from the prospective FePsy (Fruherkennung von Psychosen) study. The same neuroanatomical-based pattern classification pipeline, consisting of a linear Support Vector Machine (SVM) and a Recursive Feature Selection (RFE) achieved 74% accuracy in predicting later onset of psychosis...
September 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28935168/intimate-partner-violence-and-psychotic-experiences-in-four-u-s-cities
#5
Roma Shah, Tara Von Mach, Lisa Fedina, Bruce Link, Jordan DeVylder
BACKGROUND: A large body of research has established a relationship between trauma exposure, particularly during childhood, and psychotic experiences. Yet, there remains a general lack of research on adult trauma exposure, including intimate partner violence (IPV), as a risk factor for psychotic experiences. The purpose of this study is to investigate the association between IPV and psychotic experiences in U.S. cities. METHODS: Data were collected from 1615 participants in four U...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28935167/impact-of-lifetime-traumatic-experiences-on-suicidality-and-likelihood-of-conversion-in-a-cohort-of-individuals-at-clinical-high-risk-for-psychosis
#6
Margaux M Grivel, Wei Leong, Michael D Masucci, Rebecca A Altschuler, Leigh Y Arndt, Samantha L Redman, Lawrence H Yang, Gary Brucato, Ragy R Girgis
Recent research suggests that trauma history (TH) is a strong socio-environmental risk factor for the development of psychosis. While reported rates of childhood trauma are higher among individuals at clinical high-risk (CHR) for psychosis than in the general population, little research has explored the effects of trauma upon the severity of attenuated positive symptoms. We aimed to explore the specific relationships between TH and baseline symptom severity; likelihood of conversion to full-blown psychosis; suicidal ideation (SI); and suicidal behavior (SB) in a cohort of 200 help-seeking CHR individuals...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28934214/models-to-predict-relapse-in-psychosis-a-systematic-review
#7
Sarah Sullivan, Kate Northstone, Caroline Gadd, Julian Walker, Ruta Margelyte, Alison Richards, Penny Whiting
BACKGROUND: There is little evidence on the accuracy of psychosis relapse prediction models. Our objective was to undertake a systematic review of relapse prediction models in psychosis. METHOD: We conducted a literature search including studies that developed and/or validated psychosis relapse prediction models, with or without external model validation. Models had to target people with psychosis and predict relapse. The key databases searched were; Embase, Medline, Medline In-Process Citations & Daily Update, PsychINFO, BIOSIS Citation Index, CINAHL, and Science Citation Index, from inception to September 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28931135/rescuing-israeli-travellers-effects-of-substance-abuse-mental-health-geographic-region-of-rescue-gender-and-age-of-rescuees
#8
Hagit Bonny-Noach, Moran Sagiv-Alayoff
Background: Research conducted on young Israeli travellers has pointed to high substance usage rates. For some drug-using backpackers, actual extraction and rescue from their trip abroad is necessary. This study represents a first attempt to explore the influence of geographic region in which rescue occurs, cause for rescue and gender and age differences among Israeli rescuees. Methods: Sub-analysis of all logs of individual rescuees during a 5-year period from 2011 to 2016 ( N  = 86) included 66 men and 20 women, with an average age of 27...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28924227/implication-of-the-glutamate-cystine-antiporter-xct-in-schizophrenia-cases-linked-to-impaired-gsh-synthesis
#9
M Fournier, A Monin, C Ferrari, P S Baumann, P Conus, K Do
xCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress and glutamatergic neurotransmission. But data from human studies implicating xCT in the illness and clarifying the upstream mechanisms of xCT imbalance are still scarce. Low glutathione (GSH) levels and genetic risk in GCLC (Glutamate-Cysteine Ligase Catalytic subunit), the gene of limiting synthesizing enzyme for GSH, are both associated with schizophrenia...
September 18, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#10
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28918861/exercise-self-efficacy-correlates-in-people-with-psychosis
#11
Davy Vancampfort, Paul Gorczynski, Marc De Hert, Michel Probst, Annetie Naisiga, David Basangwa, James Mugisha
Despite the recognition of the importance of exercise self-efficacy in exercise adoption and maintenance, previous investigations on exercise self-efficacy in people with psychosis is scarce. The present study aimed to (1) explore if exercise self-efficacy differed between stages of behavior change in Ugandan outpatients with psychosis, and (2) assess sociodemographic, clinical and motivational correlates of exercise self-efficacy. In total, 48 patients (24 women) completed the Exercise Self-Efficacy Scale (ESES), the Patient-centered Assessment and Counseling for Exercise questionnaire, the Brief Symptoms Inventory-18 (BSI-18), and questions pertaining to intrinsic motivation in the Behavioral Regulation in Exercise Questionnaire-2...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28914382/clinical-high-risk-for-psychosis-in-children-and-adolescents-a-systematic-review
#12
REVIEW
Jordina Tor, Montserrat Dolz, Anna Sintes, Daniel Muñoz, Marta Pardo, Elena de la Serna, Olga Puig, Gisela Sugranyes, Inmaculada Baeza
The concept of being at risk for psychosis has been introduced both for adults and children and adolescents, but fewer studies have been conducted in the latter population. The aim of this study is to systematically review the articles associated with clinical description, interventions, outcome and other areas in children and adolescents at risk for psychosis. We searched in MEDLINE/PubMed and PsycINFO databases for articles published up to 30/06/16. Reviewed articles were prospective studies; written in English; original articles with Clinical High Risk (CHR) for psychosis samples; and mean age of samples younger than 18 years...
September 15, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28911915/risk-factors-of-compliance-with-self-harm-command-hallucinations-in-individuals-with-affective-and-non-affective-psychosis
#13
Jules R Dugré, Jean-Pierre Guay, Alexandre Dumais
Clinicians are often left with the difficult task of assessing and managing the risk of violent behaviors in individuals having command hallucinations, which may result in substantial rates of false positive or false negative. Moreover, findings on the association between command hallucinations and suicidal behaviors are limited. In an attempt to better understand compliance to this hallucinatory phenomenon, our objective was to identify the risk factors of compliance with self-harm command hallucinations. Secondary analyses from the MacArthur Study were performed on 82 participants with psychosis reporting such commands...
September 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28903120/opening-the-black-box-of-cognitive-behavioural-case-management-in-clients-with-ultra-high-risk-for-psychosis
#14
Jessica A Hartmann, Patrick D McGorry, Stefanie J Schmidt, G Paul Amminger, Hok Pan Yuen, Connie Markulev, Gregor E Berger, Eric Y H Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Meredith J McHugh, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Miriam R Schäfer, Monika Schlögelhofer, Stefan Smesny, Andrew Thompson, Swapna Kamal Verma, Alison R Yung, Barnaby Nelson
BACKGROUND: Cognitive-behavioural therapy (CBT) is the first-choice treatment in clients with ultra-high risk (UHR) for psychosis. However, CBT is an umbrella term for a plethora of different strategies, and little is known about the association between the intensity and content of CBT and the severity of symptomatic outcome. METHODS: A sample of 268 UHR participants received 6 months of CBT with case management (CBCM) in the context of the multi-centre NEURAPRO trial with monthly assessments of attenuated psychotic symptoms (APS)...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28901686/shifting-the-focus-toward-rare-variants-in-schizophrenia-to-close-the-gap-from-genotype-to-phenotype
#15
REVIEW
M Leonor Bustamante, Luisa Herrera, Pablo A Gaspar, Rodrigo Nieto, Alejandro Maturana, María José Villar, Valeria Salinas, Hernán Silva
Schizophrenia (SZ) is a disorder with a high heritability and a complex architecture. Several dozen genetic variants have been identified as risk factors through genome-wide association studies including large population-based samples. However, the bulk of the risk cannot be accounted for by the genes associated to date. Rare mutations have been historically seen as relevant only for some infrequent, Mendelian forms of psychosis. Recent findings, however, show that the subset of patients that present a mutation with major effect is larger than expected...
October 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28898305/-cannabis-and-its-association-with-psychosis-what-do-we-know
#16
Lucía Seré, Dolores Cardona, Marcelo Cetkovich
Psychoses are a group of diseases that cause enormous health and emotional burden for the patient and their families. In recent decades, the need for early intervention to improve their prognosis has been highlighted. It has long been postulated that cannabis use is a risk factor added to other factors such as genetics and developmental abnormalities. For this reason, and in the light of a growing movement for legalization of its use, it is vitally important to have reliable information to understand the details of the relationship between cannabis abuse and the development of psychosis...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28893493/brain-tspo-imaging-and-gray-matter-volume-in-schizophrenia-patients-and-in-people-at-ultra-high-risk-of-psychosis-an-11-c-pbr28-study
#17
Sudhakar Selvaraj, Peter S Bloomfield, Bo Cao, Mattia Veronese, Federico Turkheimer, Oliver D Howes
Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure. METHODS: Fourteen patients with schizophrenia and 14 ultra high risk for psychosis (UHR) subjects alongside two groups of age and genotype matched healthy controls received [(11)C]PBR28 PET scans to index TSPO expression, a marker of microglial activation and a 3T MRI scan...
September 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28893329/epidemiology-of-psychotic-depression-systematic-review-and-meta-analysis
#18
E Jääskeläinen, T Juola, H Korpela, H Lehtiniemi, M Nietola, J Korkeila, J Miettunen
Large amount of data have been published on non-psychotic depression (NPD), schizophrenia (SZ), and bipolar disorder, while psychotic depression (PD) as an own entity has received much smaller attention. We performed a systematic review and meta-analyses on epidemiology, especially incidence and prevalence, risk factors, and outcomes of PD. A systematic search to identify potentially relevant studies was conducted using four electronic databases and a manual search. The search identified 1764 unique potentially relevant articles, the final study included 99 articles...
September 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28892404/mechanisms-underlying-metabolic-disturbances-associated-with-psychosis-and-antipsychotic-drug-treatment
#19
Gavin P Reynolds, Olga O McGowan
The increase in cardiovascular disease and reduced life expectancy in schizophrenia likely relate to an increased prevalence of metabolic disturbances. Such metabolic risk factors in schizophrenia may result from both symptom-related effects and aetiological factors. However, a major contributory factor is that of treatment with antipsychotic drugs. These drugs differ in effects on body weight; the underlying mechanisms are not fully understood and may vary between drugs, but may include actions at receptors associated with the hypothalamic control of food intake...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28889802/prevalence-and-clinical-relevance-of-interview-assessed-psychosis-risk-symptoms-in-the-young-adult-community
#20
Frauke Schultze-Lutter, Chantal Michel, Stephan Ruhrmann, Benno G Schimmelmann
BACKGROUND: An efficient indicated prevention of psychotic disorders requires valid risk criteria that work in both clinical and community samples. Yet, ultra-high risk and basic symptom criteria were recently recommended for use in clinical samples only. Their use in the community was discouraged for lack of knowledge about their prevalence, clinical relevance and risk factors in non-clinical, community settings when validly assessed with the same instruments used in the clinic. METHODS: Using semi-structured telephone interviews with established psychosis-risk instruments, we studied the prevalence of psychosis-risk symptoms and criteria, their clinical relevance (using presence of a non-psychotic mental disorder or of functional deficits as proxy measures) and their risk factors in a random, representative young adult community sample (N=2683; age 16-40 years; response rate: 63...
September 11, 2017: Psychological Medicine
keyword
keyword
60484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"