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https://www.readbyqxmd.com/read/28654972/effect-of-electronic-reminders-financial-incentives-and-social-support-on-outcomes-after-myocardial-infarction-the-heartstrong-randomized-clinical-trial
#1
Kevin G Volpp, Andrea B Troxel, Shivan J Mehta, Laurie Norton, Jingsan Zhu, Raymond Lim, Wenli Wang, Noora Marcus, Christian Terwiesch, Kristen Caldarella, Tova Levin, Mike Relish, Nathan Negin, Aaron Smith-McLallen, Richard Snyder, Claire M Spettell, Brian Drachman, Daniel Kolansky, David A Asch
Importance: Adherence to medications prescribed after acute myocardial infarction (AMI) is low. Wireless technology and behavioral economic approaches have shown promise in improving health behaviors. Objective: To determine whether a system of medication reminders using financial incentives and social support delays subsequent vascular events in patients following AMI compared with usual care. Design, Setting, and Participants: Two-arm, randomized clinical trial with a 12-month intervention conducted from 2013 through 2016...
June 26, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28654721/comparative-evaluation-of-esthetic-changes-in-nonpitted-fluorosis-stains-when-treated-with-resin-infiltration-in-office-bleaching-and-combination-therapies
#2
Neeraj Gugnani, I K Pandit, Monika Gupta, Shalini Gugnani, Sugandhi Soni, Virender Goyal
OBJECTIVES: Dental fluorosis leads to esthetic deviation and varies from nonpitted white opacities, dark brown stains to pitting or structural breakdown of enamel surface. Treatment for fluorosis depends on the severity of condition and includes both noninvasive methods and invasive methods. Recently resin infiltration has been proposed as an alternative treatment for nonpitted fluorosis. This study was done to evaluate the esthetic changes in nonpitted fluorosis stains when treated with resin infiltration, in-office bleaching and combination therapies...
June 27, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28654682/low-intensity-cognitive-behaviour-therapy-interventions-for-obsessive-compulsive-disorder-compared-to-waiting-list-for-therapist-led-cognitive-behaviour-therapy-3-arm-randomised-controlled-trial-of-clinical-effectiveness
#3
Karina Lovell, Peter Bower, Judith Gellatly, Sarah Byford, Penny Bee, Dean McMillan, Catherine Arundel, Simon Gilbody, Lina Gega, Gillian Hardy, Shirley Reynolds, Michael Barkham, Patricia Mottram, Nicola Lidbetter, Rebecca Pedley, Jo Molle, Emily Peckham, Jasmin Knopp-Hoffer, Owen Price, Janice Connell, Margaret Heslin, Christopher Foley, Faye Plummer, Christopher Roberts
BACKGROUND: Obsessive-compulsive disorder (OCD) is prevalent and without adequate treatment usually follows a chronic course. "High-intensity" cognitive-behaviour therapy (CBT) from a specialist therapist is current "best practice." However, access is difficult because of limited numbers of therapists and because of the disabling effects of OCD symptoms. There is a potential role for "low-intensity" interventions as part of a stepped care model. Low-intensity interventions (written or web-based materials with limited therapist support) can be provided remotely, which has the potential to increase access...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28654369/gymnotus-coatesi-gymnotiformes-a-case-of-colocation-of-multiple-sites-of-18s-rdna-with-telomeric-sequences
#4
Milla de Andrade Machado, Adauto Lima Cardoso, Susana Suely Rodrigues Milhomem-Paixão, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Gymnotus coatesi is a small and rare species of banded knife fish that was originally described by LaMonte in 1935, found along the main stretch of the Amazon River. There is no described cytogenetic data on this species. We analyzed the karyotype of five specimens of G. coatesi collected from Cururutuia Stream in Bragança, Pará, Brazil. The obtained diploid number is 50 and the karyotypic formula is 24 m/sm +26 st/a. The constitutive heterochromatin is DAPI positive and distributed mainly in the centromeric and pericentromeric regions of the chromosomes...
June 27, 2017: Zebrafish
https://www.readbyqxmd.com/read/28654351/zz-z0-the-new-system-of-sex-chromosomes-in-eigenmannia-aff-trilineata-teleostei-gymnotiformes-sternopygidae-characterized-by-molecular-cytogenetics-and-dna-barcoding
#5
Cristian Araya-Jaime, Nadayca T Bonani Mateussi, Ricardo Utsunomia, Guilherme J Costa-Silva, Claudio Oliveira, Fausto Foresti
The cytogenetic characteristics of Eigenmannia aff. trilineata were analyzed by basic and molecular cytogenetics, applying fluorescent in situ hybridization, with 18S and 5S rDNA and U2 snRNA probes. The species revealed a kind of polymorphism associated to ZZ/Z0 type sex chromosomes, with 2n = 32 (8m+2sm+22a, NF = 42) in all males under analysis, whereas females evidenced 2n = 31 (8m+1sm+22a, NF = 40). C-banding showed constitutive heterochromatin restricted to the pericentromeric region of all chromosomes and single-nucleolus organized regions on pair 11...
June 27, 2017: Zebrafish
https://www.readbyqxmd.com/read/28654336/focal-therapy-for-prostate-cancer-with-in-bore-mr-guided-focused-ultrasound-two-year-follow-up-of-a-phase-i-trial-complications-and-functional-outcomes
#6
Kae Jack Tay, Christopher W S Cheng, Weber K O Lau, James Khoo, Choon Hua Thng, Jin Wei Kwek
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials and Methods Ethics approval was obtained from the centralized institutional review board for this prospective single-arm study, and patients provided informed consent. Patients with untreated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February 2013...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28654304/a-prospective-randomized-double-blind-multicenter-study-comparing-continuous-diffusion-of-oxygen-therapy-to-sham-therapy-in-the-treatment-of-diabetic-foot-ulcers
#7
Mark Q Niederauer, Joel E Michalek, David G Armstrong
BACKGROUND: Over the past generation, preclinical data have suggested that there is a potential physiologic benefit to applying oxygen topically to wounds. However, we are unaware of any studies in the literature that have robustly assessed whether this would lead to a higher proportion of healing in similarly treated people without oxygen. Therefore, the purpose of this study was to assess this in people being treated for chronic diabetic foot ulcers (DFUs). METHODS: We enrolled and randomized 100 subjects with DFUs (79% male, aged 58...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28654234/single-and-networked-zno-cnt-hybrid-tetrapods-for-selective-room-temperature-high-performance-ammonia-sensors
#8
Fabian Schütt, Vasile Postica, Rainer Adelung, Oleg Lupan
Highly porous hybrid materials with unique high-performance properties have attracted great interest from the scientific community, especially in the field of gas-sensing applications. In this work, tetrapodal-ZnO (ZnO-T) networks were functionalized with carbon nanotubes (CNTs) to form a highly efficient hybrid sensing material (ZnO-T-CNT) for ultrasensitive, selective, and rapid detection of ammonia (NH3) vapor at room temperature. By functionalizing the ZnO-T networks with 2.0 wt % of CNTs by a simple dripping procedure, an increase of 1 order of magnitude in response (from about 37 to 330) was obtained...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28654051/experimental-protocol-of-a-three-minute-all-out-arm-crank-exercise-test-in-spinal-cord-injured-and-able-bodied-individuals
#9
Joelle L Flueck
Reliable exercise protocols are required to test changes in exercise performance in elite athletes. Performance improvements in these athletes may be small; therefore, sensitive tools are fundamental to exercise physiology. There are currently many exercise tests that allow for the examination of exercise capacity in able-bodied athletes, with protocols mainly for lower-body or whole-body exercise. There is a trend to test athletes in a sport-specific setting that closely resembles the actions that the participants are used to performing...
June 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653963/does-acupressure-hit-the-mark-a-three-arm-randomized-placebo-controlled-trial-of-acupressure-for-pain-and-anxiety-relief-in-athletes-with-acute-musculoskeletal-sports-injuries
#10
Aleksandra K Mącznik, Anthony G Schneiders, Josie Athens, S John Sullivan
OBJECTIVES: Injuries are a common consequence of sports and recreational activity. The optimal management of symptoms is a crucial element of sports injury management. Acupressure has previously been shown to effectively decrease symptoms of musculoskeletal injury, thus may be considered a potentially useful intervention in the management of sport-related injuries. Therefore, this study was conducted to examine the effectiveness of acupressure in decreasing pain and anxiety in acutely injured athletes...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653801/a-putative-lysophosphatidylinositol-receptor-gpr55-modulates-hippocampal-synaptic-plasticity
#11
Katrina Hurst, Corinne Badgley, Tanner Ellsworth, Spencer Bell, Lindsey Friend, Brad Prince, Jacob Welch, Zack Cowan, Ryan Williamson, Chris Lyon, Brandon Anderson, Brian Poole, Michael Christensen, Michael McNeil, Jarrod Call, Jeffrey G Edwards
GPR55, an orphan G-protein coupled receptor, is activated by lysophosphatidylinositol (LPI) and the endocannabinoid anandamide, as well as by other compounds including THC. LPI is a potent endogenous ligand of GPR55 and neither GPR55 nor LPIs' functions in the brain are well understood. While endocannabinoids are well known to modulate brain synaptic plasticity, the potential role LPI could have on brain plasticity has never been demonstrated. Therefore, we examined not only GPR55 expression, but also the role its endogenous ligand could play in long-term potentiation, a common form of synaptic plasticity...
June 8, 2017: Hippocampus
https://www.readbyqxmd.com/read/28653615/maternal-and-neonatal-morbidity-repeat%C3%A2-cesarean-versus-a%C3%A2-trial-of-labour-after-previous%C3%A2-cesarean%C3%A2-delivery
#12
Yue-Zhou Yang, Xu-Ping Ye, Xiao-Xi Sun
PURPOSE: The purpose of this study was to perform a meta-analysis comparing the rates of uterine rupture, and other maternal and neonatal complications, between women who undergo a trial of labour (TOL) after a prior Cesarean delivery and those to undergo elective repeat Cesarean delivery (ERCD). SOURCE: Medline, Cochrane, EMBASE and Google Scholar were searched until May 6, 2015 using the keywords/phrases: trial of labour, Cesarean section, elective, repeat, pregnancy and vaginal birth...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653613/myopia-correction-in-children-a-meta-analysis
#13
Yanhui Cui, Li Li, Qian Wu, Junyang Zhao, Huihui Chu, Gang Yu, Wenbin Wei
PURPOSE: The purpose of this study was to conduct a meta-analysis comparing rigid gas permeable lenses (RGP) with soft contact lenses (SCL), spectacles and orthokeratology (OK) lenses for myopia control with respect to axial length elongation, spherical equivalent and measures of corneal curvature. METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched to September 29, 2015 using the following keywords: rigid gas permeable contact lens; refractive error; and refractive abnormalities...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653586/effect-of-high-protein-meal-replacement-on-weight-and-cardiometabolic-profile-in-overweight-obese-asian-indians-in-north-india
#14
Seema Gulati, Anoop Misra, Rajneesh Tiwari, Meenu Sharma, Ravindra M Pandey, Chander Prakash Yadav
The aim of the present study was to evaluate the impact of a high-protein meal replacement (HPMR) on weight and metabolic, lipid and inflammatory parameters in overweight/obese Asian Indians. In this 12-week open-label, parallel-arm randomised controlled trial, 122 overweight/obese men and women were administered either a HPMR or a control diet after 2 weeks of diet and exercise run-in. Body weight, waist circumference (WC), percentage body fat (%BF), fasting blood glucose, post-oral glucose tolerance test (post-OGTT) blood glucose, fasting and post-OGTT serum insulin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), kidney function and hepatic aminotransferases were assessed before and after the intervention...
June 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28653440/treatment-of-breast-cancer-related-lymphedema-with-adipose-derived-regenerative-cells-and-fat-grafts-a-feasibility-and-safety-study
#15
Navid Mohamadpour Toyserkani, Charlotte Harken Jensen, Ditte Caroline Andersen, Søren Paludan Sheikh, Jens Ahm Sørensen
Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure...
June 27, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28653400/panobinostat-plus-bortezomib-and-dexamethasone-impact-of-dose-intensity-and-administration-frequency-on-safety-in-the-panorama-1-trial
#16
Jesús F San-Miguel, Vania T M Hungria, Sung-Soo Yoon, Meral Beksac, Meletios A Dimopoulos, Ashraf Elghandour, Wieslaw W Jedrzejczak, Andreas Guenther, Thanyaphong Na Nakorn, Noppadol Siritanaratkul, Robert L Schlossman, Jian Hou, Philippe Moreau, Sagar Lonial, Jae-Hoon Lee, Hermann Einsele, Hans Salwender, Monika Sopala, Suman Redhu, Sofia Paul, Claudia Corrado, Paul G Richardson
Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panobinostat arm experienced higher rates of adverse events (AEs) and higher rates of discontinuation due to AEs. This PANORAMA 1 subanalysis examined AEs between 2 treatment phases of the study (TP1 and TP2), in which administration frequency of bortezomib and dexamethasone differed per protocol...
June 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28653345/treatment-of-sarcopenia-with-bimagrumab-results-from-a-phase-ii-randomized-controlled-proof-of-concept-study
#17
Daniel Rooks, Jens Praestgaard, Sam Hariry, Didier Laurent, Olivier Petricoul, Robert G Perry, Estelle Lach-Trifilieff, Ronenn Roubenoff
OBJECTIVES: To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility limitations. DESIGN: A 24-week, randomized, double-blind, placebo-controlled, parallel-arm, proof-of-concept study. SETTING: Five centers in the United States. PARTICIPANTS: Community-dwelling adults (N = 40) aged 65 and older with gait speed between 0.4 and 1.0 m/s over 4 m and an appendicular skeletal muscle index of 7...
June 27, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28653332/transvaginal-mesh-removal-with-native-tissue-repair-for-mesh-shrinkage-and-recurrent-uterovaginal-prolapse-following-vaginal-mesh-augmented-surgery
#18
Rodolfo Milani, Matteo Frigerio, Stefania Palmieri, Stefano Manodoro
Vaginal mesh-related complications can be difficult to treat and can often require several surgical interventions. In the case of pelvic pain or dyspareunia related to transobturator mesh tension or shrinkage, surgical treatment is indicated with the aim of mobilizing the mesh by dividing the central graft from the arms and excising all the areas of mesh contraction [1]. Removal of transobturator arms should be avoided because neovascularization can lead to bleeding that is difficult to control [2]. This article is protected by copyright...
June 27, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28653284/salvage-treatment-for-testicular-cancer-with-standard-or-high-dose-chemotherapy-a-systematic-review-of-59-studies
#19
REVIEW
Fausto Petrelli, Andrea Coinu, Giovanni Rosti, Paolo Pedrazzoli, Sandro Barni
Relapsed germ cell tumor (GCT) is a highly curable cancer with standard-dose platinum-based chemotherapy (CT); however, high-dose CT (HDCT) is seldom used as salvage therapy instead or after conventional CT. We conducted a systematic review of published trials to compare outcomes between standard-dose CT and HDCT in patients with relapsed GCT after first-line therapy for advanced disease. A literature search was carried out in multiple electronic databases (PubMed, Embase, Scopus, Web of Science, and The Cochrane Library), and studies reporting salvage treatment of relapsed GCT with standard-dose or carboplatin-etoposide-based HDCT were selected...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28653149/development-and-comparative-genomic-mapping-of-dasypyrum-villosum-6v-4s-specific-pcr-markers-using-transcriptome-data
#20
Shijin Li, Zhishan Lin, Chang Liu, Ke Wang, Lipu Du, Xingguo Ye
Twenty-five Dasypyrum villosum 6V#4S-specific PCR markers were developed using transcriptome data and further assigned to comparative genomic maps of wheat chromosome 6A, 6B, and 6D and barley chromosome 6H contrasting their homologous genes in these genomes. Two Dasypyrum villosum accessions, D.v#2 and No. 1026 from England and Russia, respectively, contain Pm21 on chromosome 6V#2S and PmV on chromosome 6V#4S. Both genes confer high resistance to powdery mildew (PM) in wheat. Even though several molecular markers have been developed to detect Pm21 and PmV, only the MBH1 marker can simultaneously detect both Pm21 and PmV...
June 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
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