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https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#1
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055158/a-phase-2a-randomized-controlled-study-to-evaluate-the-pharmacokinetic-safety-tolerability-and-clinical-effect-of-topically-applied-umeclidinium-in-subjects-with-primary-axillary-hyperhidrosis
#2
A Nasir, R Bissonnette, C Maari, J DuBois, T Pene Dumitrescu, J Haddad, Y Yamaguchi, M Dalessandro
BACKGROUND: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long acting muscarinic antagonist (LAMA) developed as a dermal formulation. OBJECTIVES: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety, and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Clinical effect was a secondary objective, measured by gravimetry and the hyperhidrosis disease severity scale (HDSS)...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055056/everolimus-in-advanced-progressive-well-differentiated-nonfunctional-neuroendocrine-tumors-radiant-4-lung-subgroup-analysis
#3
Nicola Fazio, Roberto Buzzoni, Gianfranco Delle Fave, Margot E Tesselaar, Edward Wolin, Eric Van Cutsem, Paolo Tomassetti, Jonathan Strosberg, Maurizio Voi, Lida Bubuteishvili Pacaud, Antonia Ridolfi, Fabian Herbst, Jiri Tomasek, Simron Singh, Marianne Pavel, Matthew H Kulke, Juan W Valle, James C Yao
In the phase 3, RADIANT-4 study, everolimus improved median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated (grade 1 or grade 2), nonfunctional lung or gastrointestinal neuroendocrine tumors (NETs) vs placebo (hazard ratio [HR], 0.48; 95% confidence interval [CI], 0.35-0.67; P < .00001). This exploratory analysis reports the outcomes of the subgroup of patients with lung NETs. In RADIANT-4, patients were randomized (2:1) to everolimus 10 mg/d or placebo, both with best supportive care...
October 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/29055031/impact-of-gender-neutral-or-girls-only-vaccination-against-human-papillomavirus-results-of-a-community-randomized-clinical-trial-i
#4
Matti Lehtinen, Anna Söderlund-Strand, Simopekka Vänskä, Tapio Luostarinen, Tiina Eriksson, Kari Natunen, Dan Apter, Iacopo Baussano, Katja Harjula, Mari Hokkanen, Marjo Kuortti, Johanna Palmroth, Tiina Petäjä, Eero Pukkala, Sirpa Rekonen, Mari Siitari-Mattila, Heljä-Marja Surcel, Leena Tuomivaara, Jorma Paavonen, Joakim Dillner, Gary Dubin, Geoffrey Garnett
Human papillomavirus (HPV) vaccine is efficacious but the real-life effectiveness of gender-neutral and girls-only vaccination strategies is unknown. We report a community-randomized trial on the protective effectiveness [(PE) = vaccine efficacy (VE) + herd effect (HE)] of the two strategies among females in virtually HPV vaccination naïve population. We randomized 33 Finnish communities into Arm A) gender-neutral vaccination with AS04-adjuvanted HPV16/18 vaccine (11 communities), Arm B) HPV vaccination of girls and hepatitis B-virus (HBV) vaccination of boys (11 communities) or Arm C) gender-neutral HBV vaccination (11 communities)...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29054980/one-year-language-outcomes-in-toddlers-with-language-delays-an-rct-follow-up
#5
Lauren H Hampton, Ann P Kaiser, Megan Y Roberts
OBJECTIVES: The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. METHODS: Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054956/indirect-carotid-cavernous-fistula-mimicking-ocular-myasthenia
#6
Lakshmi Leishangthem, Sudhakar Reddy Satti
71-year-old woman with progressive left-sided, monocular diplopia and ptosis. Her symptoms mimicked ocular myasthenia, but she had an indirect carotid cavernous fistula (CCF). She was diagnosed with monocular myasthenia gravis (negative acetylcholinesterase antibody) after a positive ice test and started on Mestinon and underwent a thymectomy complicated by a brachial plexus injury. Months later, she developed left-sided proptosis and ocular bruit. She was urgently referred to neuro-interventional surgery and was diagnosed with an indirect high-flow left CCF, which was treated with Onyx liquid and platinum coil embolisation...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054747/u-s-army-physical-demands-study-identification-and-validation-of-the-physically-demanding-tasks-of-combat-arms-occupations
#7
Marilyn A Sharp, Bruce S Cohen, Michael W Boye, Stephen A Foulis, Jan E Redmond, Kathleen Larcom, Jay R Hydren, Deborah L Gebhardt, Maria C Canino, Bradley J Warr, Edward J Zambraski
OBJECTIVES: In 2013, the U.S. Army began developing physical tests to predict a recruit's ability to perform the critical, physically demanding tasks (CPDTs) of combat arms jobs previously not open to women. The purpose of this paper is to describe the methodology and results of analyses of the accuracy and inclusiveness of the critical physically demanding task list. While the job analysis included seven combat arms jobs, only data from the 19D Cavalry Scout occupation are presented as the process was similar for all seven jobs...
October 5, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054653/importance-of-sediment-organic-matter-to-methane-ebullition-in-a-sub-tropical-freshwater-reservoir
#8
Alistair Grinham, Matthew Dunbabin, Simon Albert
This paper summarises the results of an extensive field campaign which demonstrates that high sediment organic matter is the primary driver of methane ebullition in a sub-tropical, freshwater reservoir. Methane emissions from freshwater reservoirs represent an important global methane source. Whilst diffusive methane fluxes are commonly used for predicting total emissions, recent studies show that the under-reported ebullitive fluxes can vary by over three orders of magnitude within an individual system and have a greater relative contribution compared to diffusion...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#9
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29054543/outcomes-of-surgically-treated-distal-radial-fractures-with-associated-triangular-fibrocartilage-complex-injury
#10
Katerina Kasapinova, Viktor Kamiloski
STUDY DESIGN: Prospective cohort. INTRODUCTION: Clinical studies that evaluate the correlation between associated lesions of the triangular fibrocartilage complex (TFCC) and outcome of distal radial fractures expressed with the patient-rated disability are missing. PURPOSE OF THE STUDY: To evaluate the outcomes of distal radius fractures associated with or without an injury of the TFCC. METHODS: Patients undergoing operative treatment for distal radial fracture were prospectively enrolled (n = 70)...
October 17, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29054505/biomonitor-2-pilot-study-early-experience-with-implantation-of-the-biotronik-biomonitor-2-implantable-cardiac-monitor
#11
Sze-Yuan Ooi, Ben Ng, Suresh Singarayar, Kevin Hellestrand, Peter Illes, Uwais Mohamed, Shakeeb Razak, Rukshen Weerasooriya
BACKGROUND: The BioMonitor 2 Pilot Study assessed the implantation procedure, the sensing amplitude and the remote monitoring transmission success rate of the second generation implantable cardiac monitor, the BioMonitor 2 (Biotronik, Berlin, Germany). METHODS: This was a prospective, multi-centre, single-arm, non-randomised study involving seven operators in five sites across Australia. Data were collected at implantation, during clinic visits at 1 week and 1 month post-implantation, and through wireless remote monitoring...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29054383/arthroscopic-surgical-treatment-of-medial-epicondylitis
#12
Alexandre Tadeu do Nascimento, Gustavo Kogake Claudio
BACKGROUND: The study purpose was to evaluate the outcomes of patients who received arthroscopic surgical treatment for medial epicondylitis refractory to conservative treatment. METHODS: This was a retrospective study of 7 patients who underwent arthroscopic surgical débridement of the common flexor tendon for treatment of medial epicondylitis refractory to conservative treatment. The patients were assessed using the Disabilities of the Arm, Shoulder and Hand score; visual analog scale for pain; and Short Form 36 Health Survey...
October 17, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29054355/the-effect-of-bisphosphonates-on-the-clinical-and-radiographic-outcomes-of-distal-radius-fractures-in-women
#13
Kristin E Shoji, Brandon E Earp, Tamara D Rozental
PURPOSE: To compare clinical and radiographic outcomes of distal radius fractures (DRF) treated with nonsurgical management in female postmenopausal patients receiving bisphosphonate (BP) therapy at the time of injury with those not receiving BP therapy. METHODS: We prospectively enrolled 33 female postmenopausal patients with 35 DRF between December 2010 and January 2014 at 2 Level I tertiary care centers. Eleven patients with 12 DRF were currently receiving BP at the time of injury (BP group) and were compared with 22 controls with 23 DRF (CONT group) who were not receiving BP at the time of injury...
October 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29053425/association-of-mannose-binding-lectin-rs1800450-and-tumor-necrotic-factor-%C3%AE-rs1800620-polymorphism-with-helicobacter-pylori-in-type-ii-diabetes-mellitus
#14
Elnaz Mortazavi, Behnaz Eslami, Parisa Aghahosseini, Fatemeh Ahron, Armagan Amininejad, Sepideh Mahmoodi, Hadis Satarpour, Nilofar Radmanesh, Hossein Rassi
Type II diabetes mellitus (T2DM) is the prevalent type of diabetes, including 90% of the cases world-wide. Helicobacter pylori plays a pathogenic role in the development of T2DM. The host genetic factors have a significant impact on the clinical outcome and anatomical distribution of H. pylori infection and polymorphisms in several genes such as tumor necrotic factor (TNF)-α and mannose-binding lectin (MBL) and are considered to increase the risk for the development of T2DM. In this study, we investigate the prevalence rate of H...
October 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29053185/expression-of-the-dna-repair-gene-mlh1-correlates-with-survival-in-patients-who-have-resected-pancreatic-cancer-and-have-received-adjuvant-chemoradiation-nrg-oncology-rtog-study-9704
#15
Yaacov R Lawrence, Jennifer Moughan, Anthony M Magliocco, Alexander C Klimowicz, William F Regine, Rex B Mowat, Thomas A DiPetrillo, William Small, Jeffry P Simko, Talia Golan, Kathryn A Winter, Chandan Guha, Christopher H Crane, Adam P Dicker
BACKGROUND: The majority of patients with pancreatic cancer who undergo curative resection experience rapid disease recurrence. In previous small studies, high expression of the mismatch-repair protein mutL protein homolog 1 (MLH1) in pancreatic cancers was associated with better outcomes. The objective of this study was to validate the association between MLH1 expression and survival in patients who underwent resection of pancreatic cancer and received adjuvant chemoradiation. METHODS: Samples were obtained from the NRG Oncology Radiation Therapy Oncology Group 9704 prospective, randomized trial (clinicaltrials...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053029/the-evidence-on-effectiveness-of-weekly-vs-triweekly-cisplatin-concurrent-with-radiotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-a-systematic-review-and-meta-analysis
#16
Jc Kennetth Jacinto, Jayson Co, Michael Benedict Mejia, Eugenio Emmanuel Regala
OBJECTIVE: This study aims to synthesize the current available evidences on the effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in the primary and adjuvant treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A systematic review and meta-analysis of literature were undertaken to assess the effectiveness of weekly vs triweekly schedule in primary and adjuvant treatment for HNSCC with adverse risk features...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29053023/n-acetylcysteine-for-nonsuicidal-self-injurious-behavior-in-adolescents-an-open-label-pilot-study
#17
Kathryn R Cullen, Bonnie Klimes-Dougan, Melinda Westlund Schreiner, Patricia Carstedt, Nicholas Marka, Katharine Nelson, Michael J Miller, Kristina Reigstad, Ana Westervelt, Meredith Gunlicks-Stoessel, Lynn E Eberly
BACKGROUND: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely available nutritional supplement that has been studied in some psychiatric disorders relevant to NSSI including mood and addictive disorders. This pilot study tested the use of NAC as a potential treatment for NSSI in youth. METHODS: Thirty-five female adolescents and young adults with NSSI aged 13-21 years were enrolled in this study that had an open-label, single-arm study design...
October 20, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29052801/coronary-flow-response-to-remote-ischemic-preconditioning-is-preserved-in-old-cardiac-patients
#18
Elpidio Santillo, Monica Migale, Fabrizio Balestrini, Demetrio Postacchini, Silvia Bustacchini, Fabrizia Lattanzio, Raffaele Antonelli-Incalzi
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on coronary flow in elderly cardiac patients has not been investigated yet. Thus, we aimed to study the change of coronary flow subsequent to RIPC in old patients with heart diseases and to identify its main correlates. METHODS: Ninety-five elderly patients (aged ≥ 65 years) accessing cardiac rehabilitation ward underwent transthoracic ultrasound evaluation of peak diastolic flow velocity of left anterior descending artery...
October 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29052676/growth-and-nanomechanical-characterization-of-nanoscale-3d-architectures-grown-via-focused-electron-beam-induced-deposition
#19
Brett B Lewis, Brittnee A Mound, Bernadeta Srijanto, Jason D Fowlkes, George M Pharr, Philip D Rack
Nanomechanical measurements of platinum-carbon 3D nanoscale architectures grown via focused electron beam induced deposition (FEBID) were performed using a nanoindentation system in a scanning electron microscope (SEM) for simultaneous in situ imaging. Compression tests were used to estimate the modulus of the platinum-carbon deposits to be in the range of 8.6-10.5 GPa. Cantilever arm bend tests resulted in a modulus estimation of 15.6 GPa. Atomic layer deposition was used to conformally coat FEBID structures with a thin film of Al2O3, which strengthened the structures and increased the measured modulus...
October 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/29052529/evaluating-a-multi-component-community-based-program-to-improve-adherence-and-retention-in-care-among-adolescents-living-with-hiv-in-zimbabwe-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Webster Mavhu, Nicola Willis, Juliet Mufuka, Collin Mangenah, Kudzanayi Mvududu, Sarah Bernays, Walter Mangezi, Tsitsi Apollo, Ricardo Araya, Helen A Weiss, Frances M Cowan
BACKGROUND: World Health Organization (WHO) adolescent HIV-testing and treatment guidelines recommend community-based interventions to support antiretroviral therapy (ART) adherence and retention in care, while acknowledging that the evidence to support this recommendation is weak. This cluster randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of a psychosocial, community-based intervention on HIV-related and psychosocial outcomes. METHODS/DESIGN: We are conducting the trial in two districts...
October 20, 2017: Trials
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