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https://www.readbyqxmd.com/read/27936442/label-free-colorimetric-detection-of-cancer-related-gene-based-on-two-step-amplification-of-molecular-machine
#1
Huo Xu, Dong Wu, Chen-Qiao Li, Zheng Lu, Xiao-Yun Liao, Jie Huang, Zai-Sheng Wu
Highly sensitive detection of K-ras gene is of great significance in biomedical research and clinical diagnosis. Here, we developed a colorimetric biosensing system for the detection of proto-oncogene K-ras based on enhanced amplification effect of DNA molecular machine, where dual isothermal circular strand-displacement amplification (D-SDA) occurs on two arms in one-to-one correspondence. Specifically, we designed a primer-locked hairpin probe (HP) and a primer-contained linear polymerization template (PPT)...
December 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27936425/did-a-lucky-shot-sink-the-submarine-h-l-hunley
#2
Rachel M Lance, Henry Warder, Cameron R Dale Bass
The H.L. Hunley was the first submarine to be successful in combat, sinking the Union vessel Housatonic outside Charleston Harbor in 1864 during the Civil War. However, despite marking a milestone in military history, little is known about this vessel or why it sank. One popular theory is the "lucky shot" theory: the hypothesis that small arms fire from the crew of the Housatonic may have sufficiently damaged the submarine to sink it. However, ballistic experiments with cast iron samples, analysis of historical experiments firing Civil War-era projectiles at cast iron samples, and calculation of the tidal currents and sinking trajectory of the submarine indicate that this theory is not likely...
December 2, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27936355/sample-size-determination-for-a-three-arm-equivalence-trial-of-poisson-and-negative-binomial-responses
#3
Yu-Wei Chang, Yi Tsong, Zhigen Zhao
Assessing equivalence or similarity has drawn much attention recently as many drug products have lost or will lose their patents in the next few years, especially certain best-selling biologics. To claim equivalence between the test treatment and the reference treatment when assay sensitivity is well-established from historical data, one has to demonstrate both superiority of the test treatment over placebo and equivalence between the test treatment and the reference treatment. Thus, there is urgency for practitioners to derive a practical way to calculate sample size for a three-arm equivalence trial...
December 9, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27936083/effectiveness-and-cost-effectiveness-of-a-cluster-randomized-prenatal-lifestyle-counseling-trial-a-seven-year-follow-up
#4
Päivi Kolu, Jani Raitanen, Jatta Puhkala, Pipsa Tuominen, Pauliina Husu, Riitta Luoto
There is a link between the pregnancy and its long-term influence on health and susceptibility to future chronic disease both in mother and offspring. The objective was to determine whether individual counseling on physical activity and diet and weight gain at five antenatal visits can prevent type 2 diabetes mellitus (T2DM) and overweight or improve glycemic parameters, among all at-risk-mothers and their children. Another objective was to evaluate whether gestational lifestyle intervention was cost-effective as measured with mother's sickness absence and quality-adjusted life years (QALY)...
2016: PloS One
https://www.readbyqxmd.com/read/27935903/prevalence-of-primary-ciliary-dyskinesia-in-consecutive-referrals-of-suspect-cases-and-the-transmission-electron-microscopy-detection-rate-a-systematic-review-and-meta-analysis
#5
Panayiotis Kouis, Panayiotis K Yiallouros, Nicos Middleton, John S Evans, Kyriacos Kyriacou, Stefania I Papatheodorou
BackgroundDiagnostic testing for Primary Ciliary Dyskinesia (PCD) usually includes Transmission Electron Microscopy (TEM), nasal Nitric Oxide, High Speed Video Microscopy and genetics. Diagnostic performance of each test should be assessed towards the development of PCD diagnostic algorithms. We systematically reviewed the literature and quantified PCD prevalence among referrals and TEM detection rate in confirmed PCD patients.MethodsMajor electronic databases were searched until December 2015 using appropriate terms...
December 9, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27935868/analysis-of-progression-free-survival-of-first-line-tyrosine-kinase-inhibitors-in-patients-with-non-small-cell-lung-cancer-harboring-leu858arg-or-exon-19-deletions
#6
Feng-Che Kuan, Shih-Hong Li, Chih-Liang Wang, Meng-Hung Lin, Ying-Huang Tsai, Cheng-Ta Yang
BACKGROUND: Gefitinib, erlotinib and afatinib provide remarkable response rates and progression-free survival compared to platinum-based chemotherapy in patients with non-small cell lung cancer harboring epidermal growth factor receptor-activating mutations, and are therefore standard first-line treatment in these patients. However, no study has compared these drugs regarding progression-free survival. MATERIALS AND METHODS: We conducted this retrospective study at a single medical center in Taiwan from February 16, 2011 to October 30, 2015...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27935564/high-prevalence-of-cranial-asymmetry-exists-in-infants-with-neonatal-brachial-plexus-palsy
#7
Megan Tang, Kimberly A Gorbutt, Ammanath Peethambaran, Lynda Yang, Virginia S Nelson, Kate Wan-Chu Chang
PURPOSE: This study aimed to: 1) evaluate the prevalence of cranial asymmetry (positional plagiocephaly) in infants with neonatal brachial plexus palsy (NBPP); 2) examine the association of patient demographics, arm function, and NBPP-related factors to positional plagiocephaly; and 3) determine percentage of spontaneous recovery from positional plagiocephaly and its association with arm function. METHODS: Infants < 1 year of age with NBPP and no previous exposure to plagiocephaly cranial remolding therapy or surgical intervention were recruited for this prospective cross-sectional study...
November 30, 2016: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/27935472/trunk-compensation-during-bimanual-reaching-at-different-heights-by-healthy-and-hemiparetic-adults
#8
Bulmaro A Valdés, Stephanie M N Glegg, H F Machiel Van der Loos
The authors explored how trunk compensation and hand symmetry in stroke survivors and healthy controls were affected by the distance and height of virtual targets during a bimanual reaching task. Participants were asked to reach to 4 different virtual targets set at: 90% of their arm length at shoulder, xiphoid process, and knee height, and 50% of their arm length at xiphoid process height. For the stroke group, for all targets, the hands' movements were more asymmetrical than those of the healthy group, with more asymmetry observed in the direction of gravity, and trunk forward displacement values were larger and more variable...
December 9, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27935464/effects-of-hypnosis-on-regression-to-primary-process-thinking
#9
Gary Grogan, Arreed Barabasz, Marianne Barabasz, Ciara Christensen
The authors tested the hypothesis that hypnotic age regression produces a shift from secondary- to primary-thought processing in hypnotizable participants. Thirty participants were tested for hypnotizability using the Elkins Scale of Hypnotizability (EHS). Participants were exposed to a tailored hypnotic arm-levitation induction and a hypnotic suggestion to age regress to 5 years of age and to have a dream. Primary-process thinking was assessed using the Primary-Process Thinking Scale. An independent t test with 2 levels of hypnotizability (middle and high) showed high hypnotizables demonstrated higher ratings of primary thought processing than those in the middle group...
January 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/27935262/elastic-tethers-between-separating-anaphase-chromosomes-in-crane-fly-spermatocytes-coordinate-chromosome-movements-to-the-two-poles
#10
Rozhan Sheykhani, Michael Berns, Arthur Forer
Separating anaphase chromosomes in crane-fly spermatocytes are connected by elastic tethers, as originally described by [LaFountain et al., 2002]: telomere-containing arm fragments severed from the arms move backwards to the partner telomeres. We have tested whether the tethers coordinate the movements of separating partner chromosomes. In other cell types anaphase chromosomes move faster, temporarily, when their kinetochore microtubules are severed. However, in crane-fly spermatocytes the chromosomes move at their usual speed when their kinetochore microtubules are severed...
December 9, 2016: Cytoskeleton
https://www.readbyqxmd.com/read/27935183/metformin-in-adults-with-type-1-diabetes-design-and-methods-of-reducing-with-metformin-vascular-adverse-lesions-removal-an-international-multicentre-trial
#11
J R Petrie, N Chaturvedi, I Ford, I Hramiak, A D Hughes, A J Jenkins, B Klein, R Klein, T C Ooi, P Rossing, N Sattar, C D A Stehouwer, H M Colhoun
INTRODUCTION: Cardiovascular (CV) disease is a major cause of reduced life expectancy in type 1 diabetes (T1D). Intensive insulin therapy prevents CV complications but is constrained by hypoglycaemia and weight gain. Adjunct metformin reduces insulin dose requirement and stabilises weight but there are no data on its cardiovascular effects. AIMS: We have initiated an international double-blind, randomized, placebo-controlled trial (REMOVAL: REducing with MetfOrmin Vascular Adverse Lesions in type 1 diabetes) to examine whether metformin reduces progression of atherosclerosis in adults with T1D...
December 9, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27934937/spatiotemporal-processing-of-somatosensory-stimuli-in-schizotypy
#12
Francesca Ferri, Ettore Ambrosini, Marcello Costantini
Unusual interaction behaviors and perceptual aberrations, like those occurring in schizotypy and schizophrenia, may in part originate from impaired remapping of environmental stimuli in the body space. Such remapping is contributed by the integration of tactile and proprioceptive information about current body posture with other exteroceptive spatial information. Surprisingly, no study has investigated whether alterations in such remapping occur in psychosis-prone individuals. Four hundred eleven students were screened with respect to schizotypal traits using the Schizotypal Personality Questionnaire...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27933679/supplementation-with-nutrients-modulating-insulin-like-growth-factor-1-negatively-correlated-with-changes-in-the-levels-of-pro-inflammatory-cytokines-in-community-dwelling-elderly-people-at-risk-of-undernutrition
#13
M Kim, M Kim, Y J Lee, H J Song, J K Shim, D H Chang, W K Yu, S-H Lee, J H Lee
BACKGROUND: Suboptimal nutrition accompanied by chronic low-grade increases in circulating cytokine levels is more common in elderly people. We explored the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in circulating cytokine levels, after providing extra protein and energy content to community-dwelling older adults at risk of undernutrition. METHODS: Sixty nondiabetic subjects, aged ≥65 years and living independently in a community for elderly people, with a serum pre-albumin level ≤30 mg dL(-1) and a body mass index <25 kg m(-2) , were recruited...
December 9, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27933574/-long-term-hrv-analysis-shows-stress-reduction-by-magnesium-intake
#14
Elmar Wienecke, Claudia Nolden
BACKGROUND: Mental pressure and stress represent an ever-increasing socio-political challenge. The heart rate variability (HRV) measurement, which has its origin in the cardiac function diagnosis, gives information on the neurovegetative activity. A low HRV shows an imbalance of the sympathetic and parasympathetic efferents and thus is an indicator of stress. METHOD: A randomized, controlled, two-armed parallel study with 100 participants and a period of 90 days was performed...
December 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27933358/embodiment-and-the-origin-of-interval-timing-kinematic-and-electromyographic-data
#15
Caspar Addyman, Sinead Rocha, Lilian Fautrelle, Robert M French, Elizabeth Thomas, Denis Mareschal
Recent evidence suggests that interval timing (the judgment of durations lasting from approximately 500 ms. to a few minutes) is closely coupled to the action control system. We used surface electromyography (EMG) and motion capture technology to explore the emergence of this coupling in 4-, 6-, and 8-month-olds. We engaged infants in an active and socially relevant arm-raising task with seven cycles and response period. In one condition, cycles were slow (every 4 s); in another, they were fast (every 2 s)...
December 9, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27933356/-injury-to-the-upper-limbs-and-prevention-in-equestrian-sports
#16
C Schröter, M Bielefeld, D Bielefeld, C Macke, C Winkelmann, P Mommsen, C Krettek, C Zeckey
The upper limb is one of the most frequently injured body regions in equestrian sports, but it is unclear which injuries are involved, and there are no data on the associated accident mechanism. The present study is aimed at evaluating the accident mechanisms, injuries of the upper limbs, and the circumstances of the accident in equestrian sports. We included 218 patients who were all treated between 2006 and 2014 at the level I trauma center at the Medical University in Hannover because of equestrian-related accidents...
December 8, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27932937/effect-of-electrolyzed-high-ph-alkaline-water-on-blood-viscosity-in-healthy-adults
#17
Joseph Weidman, Ralph E Holsworth, Bradley Brossman, Daniel J Cho, John St Cyr, Gregory Fridman
BACKGROUND: Previous research has shown fluid replacement beverages ingested after exercise can affect hydration biomarkers. No specific hydration marker is universally accepted as an ideal rehydration parameter following strenuous exercise. Currently, changes in body mass are used as a parameter during post-exercise hydration. Additional parameters are needed to fully appreciate and better understand rehydration following strenuous exercise. This randomized, double-blind, parallel-arm trial assessed the effect of high-pH water on four biomarkers after exercise-induced dehydration...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27932822/feasibility-study-assessing-the-efficacy-and-social-acceptability-of-using-dental-hygienist-therapists-as-front-line-clinicians
#18
R Macey, A M Glenny, P Brocklehurst
Background The oral health of the adult population has been improving in the United Kingdom decade upon decade. Over half of dental service activity in the National Health Service (NHS) is limited to a check-up without any further treatment. This raises a question as to whether check-ups could be provided by dental hygienist-therapists, rather than general dental practitioners. The aim of this study was to assess the feasibility of a definitive trial to evaluate the costs and effects of using dental hygienist-therapists to undertake the check-up...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932746/-distribution-of-pain-and-numbness-in-patients-with-cervical-spine-disorders
#19
Keita Kuraishi, Masaki Mizuno, Yasuyuki Umeda, Tomoki Ishigaki, Ryuta Yasuda, Takanori Sano, Masato Shiba, Fumihiro Kawakita, Yoshinari Nakatsuka, Kazuhiro Furukawa, Satoru Tanioka, Masanori Tsuji, Masayuki Kitagami, Seiji Hatazaki, Hidenori Suzuki
PURPOSE: To elucidate the distribution of improved pain and numbness after cervical decompression surgery in patients with cervical spine disorders. METHODS: This study included 4 men and 5 women aged 45 to 71 years(mean 58 years)presenting with radiculopathy and 50 men and 17 women aged 35 to 88 years(mean 66 years)presenting with myelopathy. RESULTS: All 9 patients with radiculopathy presented with neck pain, and 3 presented with cervical angina...
December 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27932695/posture-dependent-corticomotor-excitability-differs-between-the-transferred-biceps-in-individuals-with-tetraplegia-and-the-biceps-of-nonimpaired-individuals
#20
Carrie L Peterson, Lynn M Rogers, Michael S Bednar, Anne M Bryden, Michael W Keith, Eric J Perreault, Wendy M Murray
Background Following biceps transfer to enable elbow extension in individuals with tetraplegia, motor re-education may be facilitated by greater corticomotor excitability. Arm posture modulates corticomotor excitability of the nonimpaired biceps. If arm posture also modulates excitability of the transferred biceps, posture may aid in motor re-education. Objective Our objective was to determine whether multi-joint arm posture affects corticomotor excitability of the transferred biceps similar to the nonimpaired biceps...
December 8, 2016: Neurorehabilitation and Neural Repair
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