Naresh Podila, Naveen Kumar Penddinti, Mithun Rudrapal, Gourav Rakshit, Sathish Kumar Konidala, Veera Shakar Pulusu, Richie R Bhandare, Afzal B Shaik
In this study, a novel series of pyridine-based thiadiazole derivatives ( NTD1-NTD5 ) were synthesized as prospective anti-inflammatory agents by combining substituted carboxylic acid derivatives of 5-substituted-2-amino-1,3,4-thiadiazole with nicotinoyl isothiocyanate in the presence of acetone. The newly synthesized compounds were characterized by FTIR, 1 H NMR, 13 C NMR, and mass spectrometry. First, the compounds underwent rigorous in vivo testing for acute toxicity and anti-inflammatory activity and the results revealed that three compounds- NTD1 , NTD2 , and NTD3 , displayed no acute toxicity and significant anti-inflammatory activity, surpassing the efficacy of the standard drug, diclofenac...
April 30, 2024: Heliyon