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https://www.readbyqxmd.com/read/28329379/the-lysis-of-pathogenic-escherichia-coli-by-bacteriophages-releases-less-endotoxin-than-betalactams
#1
Nicolas Dufour, Raphaëlle Delattre, Jean-Damien Ricard, Laurent Debarbieux
Background: Beside numerous experimental data assessing phage therapy efficacy, questions regarding safety of this approach are not sufficiently addressed. In particular, as phages can kill bacterial cells within less than 10 minutes, the associated endotoxin release (ER) in severe infections caused by Gram-negative bacteria could be a matter of concern. Methods: Two therapeutic virulent phages and four reference antibiotics were studied in vitro for their ability to kill two pathogenic strains of Escherichia coli and generate an ER...
March 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329230/3d-echocardiographic-reference-ranges-for-normal-left-ventricular-volumes-and-strain-results-from-the-eacvi-norre-study
#2
Anne Bernard, Karima Addetia, Raluca Dulgheru, Luis Caballero, Tadafumi Sugimoto, Natela Akhaladze, George D Athanassopoulos, Daniele Barone, Monica Baroni, Nuno Cardim, Andreas Hagendorff, Krasimira Hristova, Federica Ilardi, Teresa Lopez, Gonzalo de la Morena, Bogdan A Popescu, Martin Penicka, Tolga Ozyigit, Jose David Rodrigo Carbonero, Nico van de Veire, Ralph Stephan Von Bardeleben, Dragos Vinereanu, Jose Luis Zamorano, Christophe Martinez, Julien Magne, Bernard Cosyns, Erwan Donal, Gilbert Habib, Luigi P Badano, Roberto M Lang, Patrizio Lancellotti
Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets...
December 22, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28328852/impact-of-the-quality-of-life-related-to-foot-health-in-a-sample-of-pregnant-women-a-case-control-study
#3
Daniel López-López, Inés Rodríguez-Vila, Marta Elena Losa-Iglesias, David Rodríguez-Sanz, César Calvo-Lobo, Carlos Romero-Morales, Ricardo Becerro-de-Bengoa-Vallejo
Pregnancy women coincide with numerous anatomical and physiological changes, which are believed to have a harmful effect on the quality of life related to foot health. The goal of this research was to identify and compare the impact foot health and overall health in a sample of pregnancy women and women without pregnancies with normalised reference values.A sample of 159 participants of a mean age of 30.13 ± 6.28 came to the area of midwifery center where self-reported data were registered, informants' with a 1 or various pregnancy was determined and the scores obtained were compared in the foot health status questionnaire (FHSQ)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328043/csf-tau-and-the-csf-tau-abeta-ratio-for-the-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#4
REVIEW
Craig Ritchie, Nadja Smailagic, Anna H Noel-Storr, Obioha Ukoumunne, Emma C Ladds, Steven Martin
BACKGROUND: Research suggests that measurable change in cerebrospinal fluid (CSF) biomarkers occurs years in advance of the onset of clinical symptoms (Beckett 2010). In this review, we aimed to assess the ability of CSF tau biomarkers (t-tau and p-tau) and the CSF tau (t-tau or p-tau)/ABeta ratio to enable the detection of Alzheimer's disease pathology in patients with mild cognitive impairment (MCI). These biomarkers have been proposed as important in new criteria for Alzheimer's disease dementia that incorporate biomarker abnormalities...
March 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28327474/measurement-and-properties-of-dose-area-product-ratio-in-external-small-beam-radiotherapy
#5
Jarkko Tapio Niemelä, Mari Partanen, Jarkko Ojala, Petri Sipilae, Mikko Björkqvist, Mika Kapanen, Jani Keyriläinen
In small-beam radiation therapy (RT) the measurement of beam quality parameter i.e. tissue-phantom ratio or TPR<sub>20,10</sub> with conventional point detector is a challenge. To obtain reliable results, one has to consider potential sources of error, including volume averaging and adjustment of the point detector into the narrow beam. To overcome these challenges, a different type of possible beam quality parameter in small beams was studied, namely the dose-area product ratio or DAPR<sub>20,10</sub>...
March 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28327002/use-of-imaging-to-predict-complete-response-of-colorectal-liver-metastases-after-chemotherapy-mr-imaging-versus-ct-imaging
#6
Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled...
March 22, 2017: Radiology
https://www.readbyqxmd.com/read/28326436/reference-region-selection-and-the-association-between-the-rate-of-amyloid-accumulation-over-time-and-the-baseline-amyloid-burden
#7
Janusch Blautzik, Matthias Brendel, Julia Sauerbeck, Sebastian Kotz, Franziska Scheiwein, Peter Bartenstein, John Seibyl, Axel Rominger
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients can be reported as standardized uptake value ratio (SUVR) from positron emission tomography (PET). Here, the SUVR is the ratio of the mean amyloid radioligand retention in a composite (COMP) neocortical volume of interest (VOI) to that in a reference VOI, such as the cerebellum, brainstem (BST)/pons, or white matter (WM). Some longitudinal PET investigations show that the rate of amyloid accumulation to follow-up has an inverted U relationship with baseline amyloid SUVR relative to cerebellar or brainstem/pons reference VOIs...
March 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28326349/quantitative-in-vivo-micro-computed-tomography-for-assessment-of-age-dependent-changes-in-murine-whole-body-composition
#8
Kim L Beaucage, Steven I Pollmann, Stephen M Sims, S Jeffrey Dixon, David W Holdsworth
Micro-computed tomography (micro-CT) is used routinely to quantify skeletal tissue mass in small animal models. Our goal was to evaluate repeated in vivo micro-CT imaging for monitoring whole-body composition in studies of growth and aging in mice. Male mice from 2 to 52 weeks of age were anesthetized and imaged using an eXplore Locus Ultra and/or eXplore speCZT scanner. Images were reconstructed into 3D volumes, signal-intensity thresholds were used to classify each voxel as adipose, lean or skeletal tissue, and tissue masses were calculated from known density values...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28325709/early-referral-to-coronary-artery-bypass-grafting-following-acute-coronary-syndrome-trends-and-outcomes-from-the-acute-coronary-syndrome-israeli-survey-acsis-2000-2010
#9
Robert Klempfner, Yaron D Barac, Arwa Younis, Eran Kopel, Anan Younis, Goldkorn Ronen, Elad Maor, Yaron Arbel, David Rott, Ilan Goldenberg, Dan Aravot
BACKGROUND: Limited information exists on whether changes in medical practices over the study decades have affected the outcomes of acute coronary syndrome (ACS) patients who undergo early coronary artery bypass surgery (CABG) during index hospitalisation. METHODS: Data on trends for early CABG referral and associated outcomes were obtained among 11,485 ACS patients enrolled in the biennial Acute Coronary Syndrome Israeli Surveys (ACSIS) 2000-2010. RESULTS: Among 11,485 patients, 566 (5%) were referred to early CABG...
March 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28325518/the-impact-of-age-and-gender-on-right-ventricular-diastolic-function-among-healthy-adults
#10
Antonello D'Andrea, Olga Vriz, Andreina Carbone, Francesco Ferrara, Marco Di Maio, Rosangela Cocchia, Gianluigi Tagliamonte, Edwige Acri, Caterina Driussi, Enrica Pezzullo, Rodolfo Citro, Antonio Cittadini, Raffaele Calabrò, Maria Giovanna Russo, Eduardo Bossone
BACKGROUND: Doppler echocardiography is ideally suited for assessment of diastolic function, being widely available, non-invasive, and less expensive than other techniques. However, data regarding age- and gender-matched reference values of right ventricular diastolic function are limited. This study aims to explore the physiologic variations of right ventricle (RV) diastolic function in a large cohort of healthy adults, and to investigate clinical and echocardiographic correlates. METHODS: From June 2007 to February 2014, 1168 healthy Caucasian subjects [mean age 45...
March 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28325011/research-on-eeg-features-of-attended-unattended-vigilance
#11
Chang Sun, Runge Chen, Miao Tian, Xingwei An, Hongzhi Qi, Minpeng Xu, Xuemin Wang, Dong Ming, Peng Zhou
Vigilance refers to the brain alertness to objective things, including the concentration of attention and the capability to response emergencies. It is of great importance to study vigilance monitoring to avoid accidents caused by decrease of vigilance. In this study, traditional Mackworth Clock Test (MCT) was modified to induce decline of attended and unattended vigilance. We analyzed EEG features in different levels of attended vigilance and assessed unattended vigilance by amplitude of mismatch negative (MMN) which can be evoked by audio odd ball stimulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322303/a-new-electro-optical-approach-for-conductance-measurement-an-assay-for-the-study-of-drugs-acting-on-ligand-gated-ion-channels
#12
A Menegon, S Pitassi, N Mazzocchi, L Redaelli, R Rizzetto, J F Rolland, C Poli, M Imberti, A Lanati, F Grohovaz
Ligand gated ion channels are involved in many pathophysiological processes and represent a relevant, although challenging, target for drug discovery. We propose an innovative electro-optical approach to their analysis able to derive membrane conductance values from the local membrane potential changes imposed by test current pulses and measured by fast voltage-sensitive fluorescent dyes. We exploited the potential of this proprietary method by developing a drug testing system called "ionChannel Optical High-content Microscope" (ionChannelΩ)...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28318867/efficacy-of-alendronate-for-the-prevention-of-bone-loss-in-calcar-region-following-total-hip-arthroplasty
#13
Yohei Yukizawa, Yutaka Inaba, Naomi Kobayashi, Hyonmin Choe, So Kubota, Tomoyuki Saito
BACKGROUND: Bone mineral density (BMD) loss around femoral implants, particularly in the proximal femur, is a common outcome after total hip arthroplasty. Previous studies reported the prevention of postsurgical decrease in BMD with the use of osteoporosis drug therapy. This randomized study evaluated the efficacy of alendronate and alfacalcidol for preserving BMD over a long-term follow-up. METHODS: Sixty consecutive patients with hip osteoarthritis who had undergone primary cementless total hip arthroplasty were randomly assigned to an alendronate (n = 20), alfacalcidol (n = 18), or control (n = 22) group...
February 27, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28318382/physiologic-parameters-and-their-response-to-handling-stress-in-a-neotropical-migratory-shorebird-during-the-nonbreeding-season
#14
Verónica L D'Amico, María G Palacios, Allan J Baker, Patricia M González, Enrique Madrid, Marcelo Bertellotti
Physiologic traits are promising indicators of population health in the face of rapidly changing environments. We obtained values of diverse physiologic parameters for Two-banded Plovers (Charadrius falklandicus) in coastal sites in Patagonia, Argentina, with the objectives of determining the timeline in which these parameters become affected by the stress of capture and handling and of obtaining reference values for future monitoring of these populations. We analyzed packed cell volume, white blood cell profile, heterophil /lymphocyte ratio, bacterial agglutination titer, and total protein, glucose, triglyceride, and cholesterol levels in apparently healthy birds...
March 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28317125/referenceless-magnetic-resonance-temperature-imaging-using-gaussian-process-modeling
#15
Joshua P Yung, David Fuentes, Christopher J MacLellan, Florian Maier, Yannis Liapis, John D Hazle, R Jason Stafford
PURPOSE: During magnetic resonance (MR)-guided thermal therapies, water proton resonance frequency shift (PRFS) based MR temperature imaging can quantitatively monitor tissue temperature changes. It is widely known that the PRFS technique is easily perturbed by tissue motion, tissue susceptibility changes, magnetic field drift, and modality-dependent applicator induced artifacts. Here a referenceless Gaussian process modeling (GPM) based estimation of the PRFS is investigated as a methodology to mitigate unwanted background field changes...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28316166/-analgesic-effect-and-related-mechanism-of-peripheral-acupoints-electroacupuncture-on-superficial-partial-thickness-burn-rats
#16
X Sun, Z R Wei, Z Xiao
Objective: To observe the analgesic effect and related mechanism of peripheral acupoints electroacupuncture on superficial partial-thickness burn rats. Methods: Eighty SD rats were divided into sham injury group (SI), pure burn group (PB), electroacupuncture group (E), and sham electroacupuncture group (SE) according to the random number table, with 20 rats in each group. Right posterior leg of rats in group SI were sham injured, while superficial partial-thickness scald (hereinafter referred to as burn) model was reproduced on the right posterior leg of rats in the latter three groups...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28303602/agreement-between-an-in-house-replication-competent-and-a-reference-replication-defective-recombinant-virus-assay-for-measuring-phenotypic-resistance-to-hiv-1-protease-reverse-transcriptase-and-integrase-inhibitors
#17
Francesco Saladini, Alessia Giannini, Adele Boccuto, Ilaria Vicenti, Maurizio Zazzi
BACKGROUND: Although clinical management of drug resistance is routinely based on genotypic methods, phenotypic assays remain necessary for the characterization of novel HIV-1 inhibitors, particularly against common drug-resistant variants. We describe the development and assessment of the performance of a recombinant virus assay for measuring HIV-1 susceptibility to protease (PR), reverse transcriptase (RT), and integrase (IN) inhibitors. METHODS: The system is based on the creation of replication-competent chimeric viruses through homologous recombination between patient or laboratory virus-derived PCR fragments and the corresponding NL4-3 vector where the whole Gag-PR, RT-RNaseH or IN coding regions has been deleted through inverse PCR...
March 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28301584/diagnostic-accuracy-and-added-value-of-dual-energy-subtraction-radiography-compared-to-standard-conventional-radiography-using-computed-tomography-as-standard-of-reference
#18
Katharina Martini, Marco Baessler, Stephan Baumueller, Thomas Frauenfelder
PURPOSE: To retrospectively evaluate diagnostic performance of dual-energy subtraction radiography (DESR) for interpretation of chest radiographs compared to conventional radiography (CR) using computed tomography (CT) as standard of reference. MATERIAL AND METHODS: A total of 199 patients (75 female, median age 67) were included in this institutional review board (IRB)-approved clinical trial. All patients were scanned in posteroanterior and lateral direction with dual-shot DE-technique...
2017: PloS One
https://www.readbyqxmd.com/read/28299946/single-institute-experience-with-methylphenidate-and-american-ginseng-in-cancer-related-fatigue
#19
Young D Chang, Joshua Smith, Diane Portman, Richard Kim, Ritika Oberoi-Jassal, Sahana Rajasekhara, Mellar Davis
BACKGROUND: Single therapy with methylphenidate or American ginseng contributes to the reduction in cancer-related fatigue (CRF) with different pharmacologic mechanisms and is relatively safe. However, the safety and efficacy of treating CRF with methylphenidate and AG combination therapy is unknown. AIM: The primary objective was to assess the clinical safety and the change in fatigue with numerical rating scale (NRS) on the Edmonton Symptom Assessment Scale (ESAS) after intervention with methylphenidate and AG combination therapy...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28298859/changes-in-intraocular-pressure-after-exercise-test
#20
Morteza Abdar Esfahani, Mojgan Gharipour, Hamid Fesharakinia
BACKGROUND: The decrease in intraocular pressure (IOP) within exercise has been recently suggested; however, this change remained ambiguous following exercise test. The present study aimed to assess changes in IOP induced by exercise test in patients who suspected to coronary artery disease (CAD) and indicated for exercise test evaluation. METHODS: In a cross-sectional study at the cardiovascular research center of Amin Heart Hospital in Isfahan, 101 eyes from 51 consecutive patients suspected to CAD aged 30-70 years referred for exercise testing were evaluated...
January 2017: Oman Journal of Ophthalmology
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