Fuzhou Hua, Hong Zhu, Wen Yu, Qingcui Zheng, Lieliang Zhang, Weidong Liang, Yue Lin, Fan Xiao, Pengcheng Yi, Yanhong Xiong, Yao Dong, Hua Li, Lanran Fang, Hailin Liu, Jun Ying, Xifeng Wang
Postoperative delirium (POD) is a frequent and debilitating complication, especially amongst high risk procedures, such as orthopedic surgery. This kind of neurocognitive disorder negatively affects cognitive domains, such as memory, awareness, attention, and concentration after surgery; however, its pathophysiology remains unknown. Multiple lines of evidence supporting the occurrence of inflammatory events have come forward from studies in human patients' brain and bio-fluids (CSF and serum), as well as in animal models for POD...
May 11, 2023: Journal of Neuroinflammation