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Orthopedic delirium

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https://www.readbyqxmd.com/read/27881118/electrolyte-disorders-and-aging-risk-factors-for-delirium-in-patients-undergoing-orthopedic-surgeries
#1
Li-Hong Wang, Dong-Juan Xu, Xian-Jiao Wei, Hao-Teng Chang, Guo-Hong Xu
BACKGROUND: At present, the exact mechanism of postoperative delirium has not been elucidated. The purpose of this study was to analyze the incidence of delirium in patients undergoing orthopedic surgeries and to explore possible related factors. METHODS: This is a retrospective study. We used 582 patients who had undergone orthopedic surgery between January 2011 and December 2014. The surgeries consisted of 155 cases of internal fixation for intertrochanteric fracture (IFIF), 128 cases of femoral head replacement (FHR), 169 cases of total hip arthroplasty (THA) and 130 cases of total knee arthroplasty (TKA)...
November 23, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27874185/translating-delirium-prevention-strategies-for-elderly-adults-with-hip-fracture-into-routine-clinical-care-a-pragmatic-clinical-trial
#2
Susan Freter, Katalin Koller, Michael Dunbar, Chris MacKnight, Kenneth Rockwood
OBJECTIVES: To compare the feasibility (adherence) and effectiveness (prevalence of delirium, length of stay, mortality, discharge site) of delirium-friendly preprinted postoperative orders (PPOs) for individuals with hip fracture, administered by regular orthopedic nurses, with routine postoperative orders. DESIGN: Pragmatic clinical trial to evaluate a quality improvement intervention. SETTING: Tertiary care hospital. PARTICIPANTS: Individuals aged 65 and older admitted for hip fracture repair (N = 283)...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27791037/orthopedic-surgery-modulates-neuropeptides-and-bdnf-expression-at-the-spinal-and-hippocampal-levels
#3
Ming-Dong Zhang, Swapnali Barde, Ting Yang, Beilei Lei, Lars I Eriksson, Joseph P Mathew, Thomas Andreska, Katerina Akassoglou, Tibor Harkany, Tomas G M Hökfelt, Niccolò Terrando
Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and postoperative cognitive dysfunction. Using a model of tibial fracture with intramedullary pinning in male mice, associated with cognitive deficits, we characterized the effects on the primary somatosensory system. Here we show that tibial fracture with pinning triggers cold allodynia and up-regulates nerve injury and inflammatory markers in dorsal root ganglia (DRGs) and spinal cord up to 2 wk after intervention...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27687177/safety-of-simultaneous-bilateral-total-knee-arthroplasty-using-an-extramedullary-referencing-system-results-from-2098-consecutive-patients
#4
Jai Gon Seo, Sang Min Kim, Jung Min Shin, Youngjun Kim, Byung Hoon Lee
INTRODUCTION: Simultaneous bilateral total knee arthroplasty (TKA) has been associated with a high risk of morbidity and mortality. The orthopedic surgeon must, therefore, decide whether bilateral simultaneous TKA is a safe operation to perform and endeavor to decrease the risk of serious complications or even death. METHODS: This retrospective review included 2098 consecutive patients who underwent bilateral simultaneous TKAs by the protocol used in our institution, including the use of extramedullary instruments to minimize medullary canal invasion and overlapping procedures for both knees to decrease operation time...
November 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27641367/unraveling-the-relationship-between-delirium-brain-damage-and-subsequent-cognitive-decline-in-a-cohort-of-individuals-undergoing-surgery-for-hip-fracture
#5
Sara J E Beishuizen, Rikie M Scholtens, Barbara C van Munster, Sophia E de Rooij
OBJECTIVES: To assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline. DESIGN: Substudy of a multicenter randomized controlled trial. SETTING: Surgical, orthopedic, and trauma surgery wards of two teaching hospitals. PARTICIPANTS: Individuals aged 65 and older (range 65-102) admitted for hip fracture surgery (N = 385). MEASUREMENTS: During hospitalization, presence of delirium was assessed daily...
September 19, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27577265/perioperative-cerebrospinal-fluid-and-plasma-inflammatory-markers-after-orthopedic-surgery
#6
Jan Hirsch, Susana Vacas, Niccolo Terrando, Miao Yuan, Laura P Sands, Joel Kramer, Kevin Bozic, Mervyn M Maze, Jacqueline M Leung
BACKGROUND: Postoperative delirium is prevalent in older patients and associated with worse outcomes. Recent data in animal studies demonstrate increases in inflammatory markers in plasma and cerebrospinal fluid (CSF) even after aseptic surgery, suggesting that inflammation of the central nervous system may be part of the pathogenesis of postoperative cognitive changes. We investigated the hypothesis that neuroinflammation was an important cause for postoperative delirium and cognitive dysfunction after major non-cardiac surgery...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27430902/-delirium-day-a-nationwide-point-prevalence-study-of-delirium-in-older-hospitalized-patients-using-an-easy-standardized-diagnostic-tool
#7
MULTICENTER STUDY
Giuseppe Bellelli, Alessandro Morandi, Simona G Di Santo, Andrea Mazzone, Antonio Cherubini, Enrico Mossello, Mario Bo, Angelo Bianchetti, Renzo Rozzini, Ermellina Zanetti, Massimo Musicco, Alberto Ferrari, Nicola Ferrara, Marco Trabucchi
BACKGROUND: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy...
July 18, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27321616/cognitive-reserve-and-postoperative-delirium-in-older-adults
#8
Amanda Tow, Roee Holtzer, Cuiling Wang, Alok Sharan, Sun Jin Kim, Aharon Gladstein, Yossef Blum, Joe Verghese
OBJECTIVES: To examine the role of cognitive reserve in reducing delirium incidence and severity in older adults undergoing surgery. DESIGN: Prospective cohort study. SETTING: Hospital. PARTICIPANTS: Older adults (mean age 71.2, 65% women) undergoing elective orthopedic surgery (N = 142). MEASUREMENTS: Incidence (Confusion Assessment Method) and severity (Memorial Delirium Assessment Scale) of postoperative delirium were the primary outcomes...
June 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27283273/screening-for-postoperative-delirium-in-patients-with-acute-hip-fracture-assessment-of-predictive-factors
#9
Asli Koskderelioglu, Ozlem Onder, Melike Gucuyener, Taskin Altay, Cemil Kayali, Muhtesem Gedizlioglu
AIM: The aim of the present study was to estimate the incidence and risk factors of delirium during the early postoperative period after hip fracture surgery. Furthermore, we investigated the accuracy of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for detection and assessment of delirium in orthopedic patients. METHODS: We consecutively recruited patients aged 65 years or older undergoing hip fracture surgery. The presence of delirium was determined daily by two of the authors according to the CAM-ICU criteria...
June 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27251666/blood-transfusion-strategy-and-risk-of-postoperative-delirium-in-nursing-homes-residents-with-hip-fracture-a-post-hoc-analysis-based-on-the-trife-randomized-controlled-trial
#10
Sif Blandfort, Merete Gregersen, Lars Carl Borris, Else Marie Damsgaard
OBJECTIVES: To investigate whether a liberal blood transfusion strategy [Hb levels ≥11.3 g/dL (7 mmol/L)] reduces the risk of postoperative delirium (POD) on day 10, among nursing home residents with hip fracture, compared to a restrictive transfusion strategy [Hb levels ≥9.7 g/dL (6 mmol/L)]. Furthermore, to investigate whether POD influences mortality within 90 days after hip surgery. METHODS: This is a post hoc analysis based on The TRIFE - a randomized controlled trial...
June 1, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27247600/lack-of-association-between-pre-operative-insulin-like-growth-factor-1-and-the-risk-of-post-operative-delirium-in-elderly-chinese-patients
#11
Che-Sheng Chu, Chih-Kuang Liang, Ming-Yueh Chou, Yu-Te Lin, Chien-Jen Hsu, Chin-Liang Chu, Po-Han Chou
OBJECTIVE: Postoperative delirium (POD) is a highly prevalent complex neuropsychiatric syndrome in elderly patients. However, its pathophysiology is currently unknown. Early detection and prevention of POD is important; therefore, the aim of this study was to investigate the link between preoperative insulin growth factor 1 (IGF-1) levels in the serum and POD in the Chinese elderly patients. METHODS: One hundred and three patients who were undergoing an orthopedic operation took part in the study...
May 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/26879927/validation-of-the-sour-seven-questionnaire-for-screening-delirium-in-hospitalized-seniors-by-informal-caregivers-and-untrained-nurses
#12
Richard W Shulman, Saurabh Kalra, Joanne Zhuan Jiang
BACKGROUND: Delirium is a common condition in hospitalized seniors that nonetheless often goes undetected by nurses or is delayed in being detected which negatively impacts quality of care and outcomes. We sought to develop a new screening tool for delirium, The Sour Seven Questionnaire, a 7-item questionnaire suitable to be completed from informal or untrained caregiver observation. The study aimed to develop the scoring criteria for a positive delirium screen and assess concurrent validity of the questionnaire against a geriatric psychiatrist's assessment...
2016: BMC Geriatrics
https://www.readbyqxmd.com/read/26740829/risk-of-pre-and-post-operative-delirium-and-the-delirium-elderly-at-risk-dear-tool-in-hip-fracture-patients
#13
Susan Freter, Michael Dunbar, Katalin Koller, Chris MacKnight, Kenneth Rockwood
BACKGROUND AND PURPOSE: Delirium is common after hip fracture. Previous work has shown that a simple delirium risk factor tool, the Delirium Elderly At Risk instrument (DEAR), has a high inter-rater reliability in this population. Little research has looked at the ability of risk factor screening tools to identify patients at high risk of pre-operative delirium. This study investigates the ability of the DEAR to identify patients at high risk of pre-operative delirium, as well as reporting its performance in a post-operative validation sample...
December 2015: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/26662213/the-successful-aging-after-elective-surgery-study-cohort-description-and-data-quality-procedures
#14
Eva M Schmitt, Jane S Saczynski, Cyrus M Kosar, Richard N Jones, David C Alsop, Tamara G Fong, Eran Metzger, Zara Cooper, Edward R Marcantonio, Thomas Travison, Sharon K Inouye
OBJECTIVES: To describe baseline characteristics and quality assurance procedures of the Successful Aging after Elective Surgery (SAGES) study, which was designed to examine novel risk factors and long-term outcomes associated with delirium. DESIGN: Long-term prospective cohort study. SETTING: Three academic medical centers. PARTICIPANTS: Individuals aged 70 and older (average age 77, 58% female) without recognized dementia scheduled for elective major surgery (N = 566)...
December 2015: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/26646844/development-and-initial-evaluation-of-a-point-of-care-educational-app-on-medical-topics-in-orthogeriatrics
#15
Katrin Singler, Tobias Roth, Sacha Beck, Michael Cunningham, Markus Gosch
INTRODUCTION: Research by AOTrauma's orthogeriatrics education taskforce identified ongoing educational needs for surgeons and trainees worldwide regarding the medical management of older adults with a fracture. To address practicing surgeons' preference for increased use of mobile learning, a point-of-care educational app was planned by a committee of experienced faculty. The goals were to deliver the app to surgeons, trainees, and other healthcare professionals, to measure usage, and to evaluate the impact on patient care...
January 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/26587403/influence-of-ketamine-on-early-postoperative-cognitive-function-after-orthopedic-surgery-in-elderly-patients
#16
Ki Hwa Lee, Ji Yeon Kim, Jeong Won Kim, Jang Su Park, Kyu Won Lee, Sang Yoon Jeon
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a serious and frequent complication after surgery, especially in elderly patients. Ketamine is an N-methyl D-aspartic acid receptor antagonist with demonstrated neuroprotective effects. An intravenous bolus of a sub-anesthetic dose (0.5 mg/kg) of ketamine can reduce postoperative delirium (POD) and POCD after cardiac surgery. But, the influence of ketamine on early POCD after non-cardiac surgery is unclear. OBJECTIVES: The current study aimed to evaluate the influence of ketamine on early postoperative cognitive function after orthopedic surgery in elderly patients...
October 2015: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/26547684/delirium-detection-and-improved-delirium-management-in-older-patients-hospitalized-for-hip-fracture
#17
Kristine S Todd, Jean Barry, Susan Hoppough, Eleanor McConnell
Delirium is a common and potentially devastating problem for older patients following hip fracture. Although early detection is recommended, description and evaluation of standardized approaches are scarce. The aims of this quality improvement project were to: (1) implement a clinical algorithm for improving delirium detection and management and (2) assess the impact of the clinical algorithm on length of stay, discharge disposition and patient satisfaction. The pilot study was implemented on an orthopedic unit to evaluate the effectiveness of a clinical protocol for delirium detection and management to improve outcomes...
November 2015: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/26474551/-future-of-orthogeriatrics-from-the-perspective-of-a-geriatrician
#18
A H Leischker
In the elderly, fractures and other severe injuries frequently lead to substantial restrictions in the activities of daily living (ADLs) resulting in dependency. Typical complications following a fracture include acute delirium, deep vein thrombosis, pneumonia and other infections. It has been demonstrated that early surgery (osteosynthesis) and early mobilization significantly decrease the risk of these complications. An interdisciplinary cooperation between orthopedic surgeons and geriatricians leads to a shorter length of hospitalization, better mobility and, most importantly, to an improvement in the quality of life...
January 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/26352694/effect-of-delirium-and-other-major-complications-on-outcomes-after-elective-surgery-in-older-adults
#19
MULTICENTER STUDY
Lauren J Gleason, Eva M Schmitt, Cyrus M Kosar, Patricia Tabloski, Jane S Saczynski, Thomas Robinson, Zara Cooper, Selwyn O Rogers, Richard N Jones, Edward R Marcantonio, Sharon K Inouye
IMPORTANCE: Major postoperative complications and delirium contribute independently to adverse outcomes and high resource use in patients who undergo major surgery; however, their interrelationship is not well examined. OBJECTIVE: To evaluate the association of major postoperative complications and delirium, alone and combined, with adverse outcomes after surgery. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 2 large academic medical centers of 566 patients who were 70 years or older without recognized dementia or a history of delirium and underwent elective major orthopedic, vascular, or abdominal surgical procedures with a minimum 3-day hospitalization between June 18, 2010, and August 8, 2013...
December 2015: JAMA Surgery
https://www.readbyqxmd.com/read/26246938/predictors-of-postoperative-cognitive-decline-in-very-old-patients-with-hip-fracture-a-retrospective-analysis
#20
Markus F Luger, Stephan Müller, Christian Kammerlander, Markus Gosch, Thomas J Luger
BACKGROUND: To investigate incidence and predictors of the various postoperative cognitive declines in old patients with hip fracture. METHODS: This retrospective chart study evaluated 411 patients (age ≥80 years, follow-up 5 years). After exclusion of 82 patients (preexisting dementia or delirium), 70 patients showing either diagnosed postoperative delirium (POD; group 1; N = 18, 5.5%) or an unspecified cognitive dysfunction and behavior (group 2; N = 52, 15...
December 2014: Geriatric Orthopaedic Surgery & Rehabilitation
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