keyword
MENU ▼
Read by QxMD icon Read
search

Oncovirus

keyword
https://www.readbyqxmd.com/read/27849057/cell-senescence-is-an-antiviral-defense-mechanism
#1
Maite Baz-Martínez, Sabela Da Silva-Álvarez, Estefanía Rodríguez, Jorge Guerra, Ahmed El Motiam, Anxo Vidal, Tomás García-Caballero, Miguel González-Barcia, Laura Sánchez, César Muñoz-Fontela, Manuel Collado, Carmen Rivas
Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27830995/oncogenic-role-of-tumor-viruses-in-humans
#2
Nimrah Akram, Muhammad Imran, Mamoona Noreen, Fayyaz Ahmed, Muhammad Atif, Zareen Fatima, Ahmed Bilal Waqar
Viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. Viral replications can affect cellular genes of the host in multiple cancerous ways. Approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. Viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. Oncogenesis is a multistep phenomenon in which normal host cells are transformed into cancerous cells on the basis of host genetic variability...
November 10, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27531881/the-other-side-of-the-coin-leveraging-epstein-barr-virus-in-research-and-therapy
#3
REVIEW
Fenggang Yu, Wei Jian Tan, Yanan Lu, Paul A MacAry, Kwok Seng Loh
Epstein-Barr virus is (EBV) a ubiquitous virus prevalent in 90% of the human population. Transmitted through infected saliva, EBV is the causative agent of infectious mononucleosis (IM) and is further implicated in malignancies of lymphoid and epithelial origins. In the past few decades, research efforts primarily focused on dissecting the mechanism of EBV-induced oncogenesis. Here, we present an alternate facet of the oncovirus EBV, on its applications in research and therapy. Finally, discussions on the prospective utilization of EBV in nasopharyngeal carcinoma (NPC) diagnosis and therapy will also be presented...
September 2016: Oral Oncology
https://www.readbyqxmd.com/read/27447661/kshv-mediated-angiogenesis-in-tumor-progression
#4
REVIEW
Pravinkumar Purushothaman, Timsy Uppal, Roni Sarkar, Subhash C Verma
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 is closely linked to the pathogenesis of Kaposi's sarcoma (KS) and two other B-cell lymphoproliferative diseases: primary effusion lymphoma (PEL) and a plasmablastic variant of multicentric Castleman's disease (MCD). KS is an invasive tumor of endothelial cells most commonly found in untreated HIV-AIDS or immuno-compromised individuals. KS tumors are highly vascularized and have abnormal, excessive neo-angiogenesis, inflammation, and proliferation of infected endothelial cells...
2016: Viruses
https://www.readbyqxmd.com/read/27415011/molecular-evidence-of-viral-dna-in-non-small-cell-lung-cancer-and-non-neoplastic-lung
#5
Lary A Robinson, Crystal J Jaing, Christine Pierce Campbell, Anthony Magliocco, Yin Xiong, Genevra Magliocco, James B Thissen, Scott Antonia
BACKGROUND: Although ∼20% of human cancers are caused by microorganisms, only suspicion exists for a microbial cause of lung cancer. Potential infectious agents were investigated in non-small cell lung cancer (NSCLC) and non-neoplastic lung. METHODS: Seventy NSCLC tumours (33 squamous cell carcinomas, 17 adenocarcinomas, 10 adenocarcinomas with lepidic spread, and 10 oligometastases) and 10 non-neoplastic lung specimens were evaluated for molecular evidence of microorganisms...
August 9, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27410918/association-of-epstein-barr-virus-ebv-but-not-human-papillomavirus-hpv-with-gingivitis-and-or-periodontitis-in-transplanted-individuals
#6
Camila Freze Baez, Flavia Savassi-Ribas, Wilker Menezes da Rocha, Stéphanie G S Almeida, Marianna T V Gonçalves, Maria Angelica A M Guimarães, Silvia Maria B Cavalcanti, Rafael B Varella
The aim of this study was to investigate the association of EBV and HPV with gingivitis and/or periodontitis according to the immunologic status. To this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by PCR for both viruses. According to the results, EBV was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not HPV (p = 0.766). EBV-HPV co-detections did not enhance the presence of tissue injury as well...
July 11, 2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27376743/viral-noncoding-rnas-in-cancer-biology
#7
Zhi Li, Shujun Fu, Lun-Quan Sun
Over 12 % of all human cancers are caused by oncoviruses, primarily including Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), and Kaposi's sarcoma herpesvirus (KSHV). In addition to viral oncoproteins, a variety of noncoding RNAs (ncRNAs) produced by oncoviruses have been recognized as important cofactors that contribute to the oncogenic events. In this chapter, we will focus on the recent understanding of the long and short noncoding RNAs, as well as microRNAs of the viruses, and discuss their roles in the biology of multistep oncogenesis mediated by established human oncoviruses...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27338099/targeting-epstein-barr-virus-transformed-b-lymphoblastoid-cells-using-antibodies-with-t-cell-receptor-like-specificities
#8
Junyun Lai, Wei Jian Tan, Chien Tei Too, Joanna Ai Ling Choo, Lan Hiong Wong, Fatimah Bte Mustafa, Nalini Srinivasan, Angeline Pei Chiew Lim, Youjia Zhong, Nicholas R J Gascoigne, Brendon J Hanson, Soh Ha Chan, Jianzhu Chen, Paul A MacAry
Epstein-Barr virus (EBV) is an oncovirus associated with several human malignancies including posttransplant lymphoproliferative disease in immunosuppressed patients. We show here that anti-EBV T-cell receptor-like monoclonal antibodies (TCR-like mAbs) E1, L1, and L2 bound to their respective HLA-A*0201-restricted EBV peptides EBNA1562-570, LMP1125-133, and LMP2A426-434 with high affinities and specificities. These mAbs recognized endogenously presented targets on EBV B lymphoblastoid cell lines (BLCLs), but not peripheral blood mononuclear cells, from which they were derived...
September 8, 2016: Blood
https://www.readbyqxmd.com/read/27325641/oncomir-or-tumor-suppressor-the-duplicity-of-micrornas-in-cancer
#9
REVIEW
Alexander A Svoronos, Donald M Engelman, Frank J Slack
MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation and reducing mRNA stability. To this end, there is a great deal of interest in modifying miRNA expression levels for the treatment of cancer. However, the literature is fraught with inconsistent accounts as to whether various miRNAs are oncogenic or tumor suppressive. In this review, we directly examine these inconsistencies and propose several mechanisms to explain them...
July 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27279361/the-epithelial-mesenchymal-transition-emt-is-regulated-by-oncoviruses-in-cancer
#10
REVIEW
Xue Chen, Ann M Bode, Zigang Dong, Ya Cao
The epithelial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchymal cells, is critical for embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. Recently, the role of EMT in carcinogenesis has attracted much attention. Oncoviruses, including human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and hepatitis B and C viruses (HBVs, HCVs), are known to be involved in the etiology of cancer and have been found to play important roles in cancer metastasis, especially in the EMT process...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27153384/pa-seq-for-global-identification-of-rna-polyadenylation-sites-of-kaposi-s-sarcoma-associated-herpesvirus-transcripts
#11
Ting Ni, Vladimir Majerciak, Zhi-Ming Zheng, Jun Zhu
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human oncovirus linked to the development of several malignancies in immunocompromised patients. Like other herpesviruses, KSHV has a large DNA genome encoding more than 100 distinct gene products. Despite being transcribed and processed by cellular machinery, the structure and organization of KSHV genes in the virus genome differ from what is observed in cellular genes from the human genome. A typical feature of KSHV expression is the production of polycistronic transcripts initiated from different promoters but sharing the same polyadenylation site (pA site)...
2016: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/27109286/viral-infections-associated-with-oral-cancers-and-diseases-in-the-context-of-hiv-a-workshop-report
#12
D J Speicher, V Ramirez-Amador, D P Dittmer, J Webster-Cyriaque, M T Goodman, A-B Moscicki
Human herpesviruses (HHVs) and human papillomavirus (HPV) are common in the general population and, in immunocompetent people, are mostly carried asymptomatically. However, once an individual becomes immunocompromised by age, illness or HIV infection these dormant viruses can manifest and produce disease. In HIV-positive patients, there is an increased risk of disease caused by HHVs and HPV infections and cancers caused by the oncoviruses Epstein-Barr Virus, HHV-8 and HPV. This workshop examined four questions regarding the viruses associated with oral cancers and disease in the HIV-positive and -negative populations, the immune response, and biomarkers useful for accurate diagnostics of these infections and their sequalae...
April 2016: Oral Diseases
https://www.readbyqxmd.com/read/27066794/review-the-contribution-of-both-nature-and-nurture-to-carcinogenesis-and-progression-in-solid-tumours
#13
REVIEW
Iain Joseph Hyndman
Cancer is a leading cause of mortality worldwide. Cancer arises due to a series of somatic mutations that accumulate within the nucleus of a cell which enable the cell to proliferate in an unregulated manner. These mutations arise as a result of both endogenous and exogenous factors. Genes that are commonly mutated in cancer cells are involved in cell cycle regulation, growth and proliferation. It is known that both nature and nurture play important roles in cancer development through complex gene-environment interactions; however, the exact mechanism of these interactions in carcinogenesis is presently unclear...
April 2016: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/26690493/non-human-cancers-in-aids-patients
#14
Vicente Soriano, Pablo Barreiro
Neoplasms are more frequent in HIV-positive persons than in non-infected individuals. The incidence of malignancies associated to oncoviruses increases with low CD4 counts in HIV carriers. This is the case for Kaposi sarcoma, Castleman disease or effusive cavity lymphomas due to HHV-8, anorectal or cervical cancer due to human papillomavirus, and Burkitt lymphoma or large B-cell lymphoma due to Epstein-Barr virus.
October 2015: AIDS Reviews
https://www.readbyqxmd.com/read/26569308/meta-analysis-of-dna-tumor-viral-integration-site-selection-indicates-a-role-for-repeats-gene-expression-and-epigenetics
#15
Janet M Doolittle-Hall, Danielle L Cunningham Glasspoole, William T Seaman, Jennifer Webster-Cyriaque
Oncoviruses cause tremendous global cancer burden. For several DNA tumor viruses, human genome integration is consistently associated with cancer development. However, genomic features associated with tumor viral integration are poorly understood. We sought to define genomic determinants for 1897 loci prone to hosting human papillomavirus (HPV), hepatitis B virus (HBV) or Merkel cell polyomavirus (MCPyV). These were compared to HIV, whose enzyme-mediated integration is well understood. A comprehensive catalog of integration sites was constructed from the literature and experimentally-determined HPV integration sites...
November 10, 2015: Cancers
https://www.readbyqxmd.com/read/26353884/hpv-infection-of-the-head-and-neck-region-and-its-stem-cells
#16
REVIEW
A N Pullos, R M Castilho, C H Squarize
The human papillomavirus (HPV) is an etiologic agent associated with the development of head and neck squamous carcinoma (HNSCC)-in particular, oropharyngeal squamous cell carcinoma. The HPV-positive HNSCC is characterized by genetic alterations, clinical progression, and therapeutic response, which are distinct from HPV-negative head and neck cancers, suggesting that virus-associated tumors constitute a unique entity among head and neck cancers. Malignant stem cells, or cancer stem cells, are a subpopulation of tumor cells that self-renew, initiate new tumors upon transplantation, and are resistant to therapy, and their discovery has revealed novel effects of oncovirus infection in cancer...
November 2015: Journal of Dental Research
https://www.readbyqxmd.com/read/26307954/anti-tnf%C3%AE-therapy-for-inflammatory-bowel-diseases-is-associated-with-epstein-barr-virus-lytic-activation
#17
Sameer Lapsia, Siva Koganti, Salvatore Spadaro, Ramona Rajapakse, Anupama Chawla, Sumita Bhaduri-McIntosh
Anti-TNFα therapy, known to suppress T-cell immunity, is increasingly gaining popularity for treatment of autoimmune diseases including inflammatory bowel diseases (IBD). T-cell suppression increases the risk of B-cell EBV-lymphoproliferative diseases and lymphomas. Since EBV-lytic activation is essential for development of EBV-lymphomas and there have been reports of EBV-lymphomas in patients treated with anti-TNFα therapy, we investigated if patients treated with anti-TNFα antibodies demonstrate greater EBV-lytic activity in blood...
February 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/25842165/dna-damage-checkpoint-recovery-and-cancer-development
#18
REVIEW
Haiyong Wang, Xiaoshan Zhang, Lisong Teng, Randy J Legerski
Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle machinery in response to different genotoxic stresses, and later found to play an important role in the process of tumorigenesis by acting as a guard against DNA over-replication. As a counterpart of checkpoint activation, the checkpoint recovery machinery is working in opposition, aiming to reverse the checkpoint activation and resume the normal cell cycle. The DNA damage response (DDR) and oncogene induced senescence (OIS) are frequently found in precancerous lesions, and believed to constitute a barrier to tumorigenesis, however, the DDR and OIS have been observed to be diminished in advanced cancers of most tissue origins...
June 10, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/25839773/bk-virus-as-a-potential-oncovirus-for-bladder-cancer-in-a-renal-transplant-patient
#19
Wen-Yao Yin, Ming-Che Lee, Ning-Sheng Lai, Ming-Chi Lu
Renal transplant patients have high risk for bladder cancer. The reactivation of BK virus is common in renal transplant patients especially in the urinary tract. There was some evidence suggesting that the reactivation of BK virus (BKV) in renal transplant patients may associate with the development of bladder cancer. Here we demonstrated that a patient that had persistent elevated BKV viruria (urine BKV DNA concentration more than 10(11) copies/ml) after renal transplantation. Then, bladder cancer was found in 13 months after kidney transplantation...
April 2015: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/25681443/oncovirus-kaposi-sarcoma-herpesvirus-kshv-represses-tumor-suppressor-pdlim2-to-persistently-activate-nuclear-factor-%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-and-stat3-transcription-factors-for-tumorigenesis-and-tumor-maintenance
#20
Fan Sun, Yadong Xiao, Zhaoxia Qu
Kaposi sarcoma herpesvirus (KSHV) is the most common cause of malignancies among AIDS patients. However, how KSHV induces tumorigenesis remains largely unknown. Here, we demonstrate that one important mechanism underlying the tumorigenesis of KSHV is through transcriptional repression of the tumor suppressor gene PDZ-LIM domain-containing protein 2 (PDLIM2). PDLIM2 expression is repressed in KSHV-transformed human umbilical vascular endothelial cells as well as in KSHV-associated cancer cell lines and primary tumors...
March 20, 2015: Journal of Biological Chemistry
keyword
keyword
60463
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"