keyword
MENU ▼
Read by QxMD icon Read
search

Pseudomonas aeruginosa

keyword
https://www.readbyqxmd.com/read/28742861/targeting-the-permeability-barrier-and-peptidoglycan-recycling-pathways-to-disarm-pseudomonas-aeruginosa-against-the-innate-immune-system
#1
Gabriel Torrens, Marcelo Pérez-Gallego, Bartolomé Moya, Marta Munar-Bestard, Laura Zamorano, Gabriel Cabot, Jesús Blázquez, Juan A Ayala, Antonio Oliver, Carlos Juan
Antimicrobial resistance is a continuously increasing threat that severely compromises our antibiotic arsenal and causes thousands of deaths due to hospital-acquired infections by pathogens such as Pseudomonas aeruginosa, situation further aggravated by the limited development of new antibiotics. Thus, alternative strategies such as those targeting bacterial resistance mechanisms, virulence or potentiating the activity of our immune system resources are urgently needed. We have recently shown that mutations simultaneously causing the peptidoglycan recycling blockage and the β-lactamase AmpC overexpression impair the virulence of P...
2017: PloS One
https://www.readbyqxmd.com/read/28741939/the-influence-of-electric-fields-on-biofouling-of-carbonaceous-electrodes
#2
Soumya Pandit, Sneha Shanbhag, Meagan S Mauter, Yoram Oren, Moshe Herzberg
Biofouling commonly occurs on carbonaceous capacitive deionization electrodes in the process of treating natural waters. Although previous work reported the effect of electric fields on bacterial mortality for variety of medical and engineered applications, the effect of electrode surface properties and the magnitude and polarity of applied electric fields on biofilm development has not been comprehensively investigated. This paper studies the formation of Pseudomonas aeruginosa biofilm on Papyex graphite (PA) and carbon aerogel (CA) in presence and absence of an electric field...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28739780/multicenter-evaluation-of-ceftazidime-avibactam-and-ceftolozane-tazobactam-inhibitory-activity-against-meropenem-non-susceptible-p-aeruginosa-from-blood-respiratory-tract-and-wounds
#3
Mordechai Grupper, Christina Sutherland, David P Nicolau
The recent escalation of carbapenem-resistant Pseudomonas aeruginosa has been recognized globally and threatens to erode the widespread clinical utility of this class of compounds for this prevalent healthcare associate pathogen. Herein, we compared the in-vitro inhibitory activity of ceftazidime-avibactam and ceftolozane-tazobactam against 290 meropenem non-susceptible Pseudomonas aeruginosa non-duplicate clinical isolates from 34 US hospitals using reference broth microdilution methods. Ceftazidime-avibactam and ceftolozane-tazobactam were active, with ceftolozane-tazobactam having significantly higher inhibitory activity than ceftazidime-avibactam...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738848/influence-of-borderline-cefepime-mic-on-the-outcome-of-cefepime-susceptible-pseudomonas-aeruginosa-bacteremia-treated-with-a-maximal-cefepime-dose-a-hospital-based-retrospective-study
#4
Ting-Yi Su, Jung-Jr Ye, Chien-Chang Yang, Ching-Tai Huang, Ju-Hsin Chia, Ming-Hsun Lee
BACKGROUND: We assessed the influence of current cefepime minimal inhibitory concentration (MIC) breakpoints and the maximal cefepime dose on treatment outcomes in patients with bacteremia caused by cefepime-susceptible Pseudomonas aeruginosa. METHODS: Adult patients hospitalized between July 2010 and June 2014 with a positive blood culture for cefepime-susceptible P. aeruginosa and receipt of cefepime as the primary therapy throughout the course were reviewed. Cefepime Etest(®) MICs and clinical outcomes for P...
July 24, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28738715/antimicrobial-modulatory-and-chemical-analysis-of-the-oil-of-croton-limae
#5
Tiago Rodrigues Leite, Maria Arlene Pessoa da Silva, Antônio Carlito Bezerra Dos Santos, Henrique Douglas Melo Coutinho, Antonia Eliene Duarte, José Galberto Martins da Costa
CONTEXT: Croton sp. are plants with a well-reported antimicrobial activity. Croton limae A.P. Gomes, M.F. Sales P.E. Berry (Euphorbiaceae), known as 'marmeleiro-prateado', is commonly used to manage abdominal pain in Brazil. OBJECTIVE: This work evaluates the phytochemical composition, antimicrobial and modulatory activities of the essential oil of C. limae leaves (EOCL). MATERIALS AND METHODS: The minimum inhibitory concentration (MIC) and the modulation of the antibiotic activity were determined using a microdilution method...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28738346/synergistic-activity-of-berberine-with-azithromycin-against-pseudomonas-aeruginosa-isolated-from-patients-with-cystic-fibrosis-of-lung-in-vitro-and-in-vivo
#6
YongTao Li, JianRong Huang, LanJuan Li, LinSheng Liu
BACKGROUND/AIMS: Pseudomonas aeruginosa (PA) is one of the major opportunistic pathogens which can cause chronic lung infection of cystic fibrosis (CF). The formation of PA biofilm promotes CF development and restricts the antimicrobial efficacies of current antibiotics. METHODS: The antimicrobial effects of azithromycin (AZM) and berberine (BER) alone and in combination were evaluated using microdilution method, checkerboard assay, time-kill test, qRT-PCR analysis and absorption method...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738321/serum-phospholipid-fatty-acid-composition-in-cystic-fibrosis-patients-with-and-without-liver-cirrhosis
#7
Sławomira Drzymała-Czyż, Mariusz Szczepanik, Patrycja Krzyżanowska, Monika Duś-Żuchowska, Andrzej Pogorzelski, Ewa Sapiejka, Paweł Juszczak, Aleksandra Lisowska, Berthold Koletzko, Jarosław Walkowiak
BACKGROUND/AIMS: Cystic fibrosis (CF) liver disease is the third most frequent cause of death in CF patients. Although it alters fatty acid (FA) metabolism, data concerning the profile of FA in CF patients with liver cirrhosis is lacking. This study aimed to assess the FA composition of serum phospholipids in CF patients with and without liver cirrhosis. METHODS: The study comprised 25 CF patients with liver cirrhosis and 25 without it. We assessed Z-scores for body height and weight, lung function, exocrine pancreatic sufficiency and colonization with Pseudomonas aeruginosa...
July 22, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28737283/prevalence-of-hearing-and-vestibular-loss-in-cystic-fibrosis-patients-exposed-to-aminoglycosides
#8
Jaynee A Handelsman, Samya Z Nasr, Crystal Pitts, William M King
AIM: Cystic Fibrosis (CF) patients frequently use aminoglycosides (AGS) to treat CF exacerbation due to colonization with Pseudomonas aeruginosa. Although AGS can cause vestibular and auditory sensory losses that can negatively impact quality of life, little is known about the prevalence of vestibular loss in this population. The aim of this study was to determine the prevalence of hearing loss and/or vestibular dysfunction in CF patients treated with AGS. METHODS: The relationship between hearing status and vestibular status was also investigated...
July 24, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28737038/evolution-of-aggregate-structure-in-solutions-of-anionic-monorhamnolipids-experimental-and-computational-results
#9
Ryan J Eismin, Elango Munusamy, Laurel L Kegel, David E Hogan, Raina M Maier, Steven D Schwartz, Jeanne E Pemberton
The evolution of solution aggregates of the anionic form of the native monorhamnolipid (mRL) mixture produced by Pseudomonas aeruginosa ATCC 9027 is explored at pH 8.0 using both experimental and computational approaches. Experiments utilizing surface tension measurements, dynamic light scattering, and both steady-state and time-resolved fluorescence spectroscopy reveal solution aggregation properties. All-atom molecular dynamics simulations on self-assemblies of the most abundant monorhamnolipid molecule, l-rhamnosyl-β-hydroxydecanoyl-β-hydroxydecanoate (Rha-C10-C10), in its anionic state explore the formation of aggregates and the role of hydrogen bonding, substantiating the experimental results...
July 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28736974/topical-sevoflurane-for-chronic-venous-ulcers-infected-by-multi-drug-resistant-organisms
#10
Adrián Imbernón-Moya, Francisco Javier Ortiz-de Frutos, Mónica Sanjuan-Alvarez, Isabel Portero-Sanchez, Raúl Merinero-Palomares, Victoria Alcazar
Several anaesthetic drugs have demonstrated antibacterial properties in vitro. Anaesthetics can primarily affect the cell wall of both susceptible and multi-resistant bacteria. They may also have a synergistic effect with conventional antibiotics through an unknown mechanism. We present three cases of a chronic venous ulcer infected by multi-resistant bacteria refractory to conventional systemic antibiotics, including Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA). Treatment with topical sevoflurane was performed for 1 month without systemic antibiotics...
July 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28736716/mucositis-and-oral-infections-secondary-to-gram-negative-rods-in-patients-with-prolonged-neutropenia
#11
Mindy M Sampson, Sowmya Nanjappa, John N Greene
Patients with prolonged neutropenia are at risk for a variety of complications and infections including the development of mucositis and oral ulcers. The changes in oral flora during chemotherapy and its effects on the development of infections of the oral cavity have been studied with inconsistent results. However, there is evidence that supports the colonization of gram negative rods in patients undergoing chemotherapy. In this report, we present two leukemic patients who developed oral ulcers secondary to multi-drug resistant Pseudomonas aeruginosa...
2017: IDCases
https://www.readbyqxmd.com/read/28735882/antibiotic-resistance-and-population-structure-of-cystic-fibrosis-pseudomonas-aeruginosa-isolates-from-a-spanish-multi-centre-study
#12
Carla López-Causapé, Juan de Dios-Caballero, Marta Cobo, Amparo Escribano, Óscar Asensio, Antonio Oliver, Rosa Del Campo, Rafael Cantón
The first Spanish multi-centre study on the microbiology of cystic fibrosis (CF) was conducted from 2013 to 2014. The study involved 24 CF units from 17 hospitals, and recruited 341 patients. The aim of this study was to characterise Pseudomonas aeruginosa isolates, 79 of which were recovered from 75 (22%) patients. The study determined the population structure, antibiotic susceptibility profile and genetic background of the strains. Fifty-five percent of the isolates were multi-drug-resistant, and 16% were extensively-drug-resistant...
July 20, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28735760/first-characterization-of-immunogenic-conjugates-of-vi-negative-salmonella-typhi-o-specific-polysaccharides-with-repa-protein-for-vaccine-development
#13
M Salman, F St Michael, A Ali, A Jabbar, C Cairns, A C Hayes, M Rahman, M Iqbal, A Haque, A D Cox
Efficacious typhoid vaccines for young children will significantly reduce the disease burden in developing world. The Vi polysaccharide based conjugate vaccines (Vi-rEPA) against Salmonella Typhi Vi positive strains has shown high efficacy but may be ineffective against Vi negative S. Typhi. In this study, for the first time, we report the synthesis and evaluation of polysaccharide-protein conjugates of Vi negative S. Typhi as potential vaccine candidates. Four different conjugates were synthesized using recombinant exoprotein A of Pseudomonas aeruginosa (rEPA) and human serum albumin (HSA) as the carrier proteins, using either direct reductive amination or an intermediate linker molecule, adipic acid dihydrazide (ADH)...
July 20, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28735046/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-healthcare-associated-infections-in-australia-and-new-zealand-report-from-an-antimicrobial-surveillance-program-2013-2015
#14
M A Pfaller, D Shortridge, H S Sader, R K Flamm, M Castaneheira
OBJECTIVES: To evaluate the in vitro activity of ceftolozane-tazobactam and comparator agents tested against isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients in Australia and New Zealand with healthcare-associated infection. METHODS: A total of 1,459 gram-negative organisms (440P. aeruginosa and 1,019 Enterobacteriaceae) were consecutively collected from 11 medical centers located in Australia and New Zealand. The organisms were tested for susceptibility by broth microdilution methods as described by the CLSI M07-A10 document and the results interpreted according to EUCAST and CLSI breakpoint criteria...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28733908/assessment-of-cultivable-oral-bacterial-flora-from-important-venomous-snakes-of-india-and-their-antibiotic-susceptibilities
#15
Innus K Shaikh, Prashant P Dixit, Balasaheb S Pawade, Mugdha Potnis-Lele, Babasaheb P Kurhe
Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities...
July 21, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28733718/antimicrobial-resistance-in-the-next-30%C3%A2-years-humankind-bugs-and-drugs-a-visionary-approach
#16
REVIEW
Matteo Bassetti, Garyphallia Poulakou, Etienne Ruppe, Emilio Bouza, Sebastian J Van Hal, Adrian Brink
PURPOSE: To describe the current standards of care and major recent advances with regard to antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in this field. METHODS: Review of medical literature and expert opinion were used in the development of this review. RESULTS: There is undoubtedly a large clinical and public health burden associated with AMR in ICU, but it is challenging to quantify the associated excess morbidity and mortality...
July 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28733150/seven-new-lignan-glycosides-from-the-branches-of-alangium-kurzii-craib-var-laxifolium
#17
Jie Ren, Yang-Guo Xie, Ying-Ying Huang, Sheng-Lan Zhu, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang
Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis CI1304, Aeromonas hydrophila CI1008, Escherichia coli CI151012, Vibrio parahaemolyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302...
July 19, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28732782/antimicrobial-activity-of-disinfectants-commonly-used-in-the-food-industry-in-mexico
#18
Maricarmen Iñiguez-Moreno, María Guadalupe Avila-Novoa, Elizabeth Iñiguez-Moreno, Pedro Javier Guerrero-Medina, Melesio Gutiérrez-Lomelí
OBJECTIVES: Disinfectants are widely used in food processing environments for microorganism control; their activity can vary according the microorganism and their used in the appropriated concentrations is vital. Hence, the aim of this study was determined the effectiveness and minimum inhibitory concentration (MIC) of 15 disinfectants commonly used in the food industry in Mexico. METHODS: The antimicrobial activity and the MIC were determined according to AOAC and CLSI, respectively, with approved strains...
July 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28732733/antibacterial-activities-and-preservative-effect-of-chitosan-oligosaccharide-maillard-reaction-products-on-penaeus-vannamei
#19
Tao Sun, Yingying Qin, Honglei Xu, Jing Xie, Dongmei Hu, Bin Xue, Xinyi Hua
The purpose of this study was to understand the influence of Maillard reaction (MR) on bioactivity of chitosan oligosaccharide (COS). The antibacterial activity against Pseudomonas aeruginosa and Vibrio parahaemolyticus and preservative effect of two kinds of COS MR products (MRPs) on Penaeus vannamei were evaluated. The structures of CG (MRPs of COS and glucose) and CM (MRPs of COS and maltose) were characterized by FT-IR and their molecular weights were measured by gel permeation chromatography (GPC). The results showed that CG has enhanced antibacterial activity and preservative effect compared to COS by evaluating total volatile base-nitrogen (TVB-N), trimethylamine (TMA), pH, total bacterial count (TBC) and sensory evaluation...
July 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28732084/increased-parb-level-affects-expression-of-stress-response-adaptation-and-virulence-operons-and-potentiates-repression-of-promoters-adjacent-to-the-high-affinity-binding-sites-pars3-and-pars4-in-pseudomonas-aeruginosa
#20
Adam Kawalek, Krzysztof Glabski, Aneta Agnieszka Bartosik, Anna Fogtman, Grazyna Jagura-Burdzy
Similarly to its homologs in other bacteria, Pseudomonas aeruginosa partitioning protein ParB facilitates segregation of newly replicated chromosomes. Lack of ParB is not lethal but results in increased frequency of anucleate cells production, longer division time, cell elongation, altered colony morphology and defective swarming and swimming motility. Unlike in other bacteria, inactivation of parB leads to major changes of the transcriptome, suggesting that, directly or indirectly, ParB plays a role in regulation of gene expression in this organism...
2017: PloS One
keyword
keyword
6046
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"