Zheng Li, Yi Xia, Li-Na Feng, Jie-Rong Chen, Hong-Min Li, Jing Cui, Qing-Qing Cai, Kar Seng Sim, Maarja-Liisa Nairismägi, Yurike Laurensia, Wee Yang Meah, Wen-Sheng Liu, Yun-Miao Guo, Li-Zhen Chen, Qi-Sheng Feng, Chi Pui Pang, Li Jia Chen, Soo Hong Chew, Richard P Ebstein, Jia Nee Foo, Jianjun Liu, Jeslin Ha, Lay Poh Khoo, Suk Teng Chin, Yi-Xin Zeng, Tin Aung, Balram Chowbay, Colin Phipps Diong, Fen Zhang, Yan-Hui Liu, Tiffany Tang, Miriam Tao, Richard Quek, Farid Mohamad, Soo Yong Tan, Bin Tean Teh, Siok Bian Ng, Wee Joo Chng, Choon Kiat Ong, Yukinori Okada, Soumya Raychaudhuri, Soon Thye Lim, Wen Tan, Rou-Jun Peng, Chiea Chuen Khor, Jin-Xin Bei
BACKGROUND: Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare and aggressive malignancy that occurs predominantly in Asian and Latin American populations. Although Epstein-Barr virus infection is a known risk factor, other risk factors and the pathogenesis of NKTCL are not well understood. We aimed to identify common genetic variants affecting individual risk of NKTCL. METHODS: We did a genome-wide association study of 189 patients with extranodal NKTCL, nasal type (WHO classification criteria; cases) and 957 controls from Guangdong province, southern China...
September 2016: Lancet Oncology