keyword
https://read.qxmd.com/read/38423954/survival-following-lung-volume-reduction-procedures-results-from-the-uk-lung-volume-reduction-uklvr-registry
#1
MULTICENTER STUDY
S C Buttery, A Lewis, A Alzetani, C E Bolton, K J Curtis, J W Dodd, A M Habib, A Hussain, T Havelock, S Jordan, C Kallis, S V Kemp, A Kirk, R A Lawson, R Mahadeva, M Munavvar, B Naidu, S Rathinam, M Shackcloth, P L Shah, S Tenconi, N S Hopkinson
INTRODUCTION: Lung volume reduction surgery (LVRS) and endobronchial valve (EBV) placement can produce substantial benefits in appropriately selected people with emphysema. The UK Lung Volume Reduction (UKLVR) registry is a national multicentre observational study set up to support quality standards and assess outcomes from LVR procedures at specialist centres across the UK. METHODS: Data were analysed for all patients undergoing an LVR procedure (LVRS/EBV) who were recruited into the study at participating centres between January 2017 and June 2022, including; disease severity and risk assessment, compliance with guidelines for selection, procedural complications and survival to February 2023...
February 29, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38417085/a-focused-review-of-epstein-barr-virus-infections-and-ptld-in-pediatric-transplant-recipients-guidance-from-the-ipta-and-ecil-guidelines
#2
REVIEW
Masaki Yamada, Arnaud G L'Huillier, Michael Green
Epstein-Barr Virus (EBV) diseases, including EBV-associated post-transplant lymphoproliferative disorder (PTLD) remain important causes of morbidity and mortality in children undergoing solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT). Despite progress in the prevention of EBV disease including PTLD (EBV/PTLD) in HCT, key questions in the prevention, and management of these infectious complications remain unanswered. The goal of this manuscript is to highlight key points and recommendations derived from the consensus guidelines published by the International Pediatric Transplant Association and the European Conference on Infections in Leukemia for children undergoing SOT and HCT, respectively...
February 28, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38371438/an-evaluation-of-treatment-outcomes-and-associated-factors-in-nasopharyngeal-cancer-patients-at-a-tertiary-cancer-center-in-the-united-arab-emirates
#3
JOURNAL ARTICLE
Abdulrahman Bin Sumaida, Nandan M Shanbhag, Hussain A Aby Ali, Noor Jaafar, Khalifa AlKaabi, Khalid Balaraj
Background and objective Nasopharyngeal carcinoma (NPC) presents a complex epidemiological pattern influenced by demographic characteristics, risk factors such as Epstein-Barr virus (EBV) infection, and smoking. Understanding the clinical profile and optimizing treatment strategies for NPC requires comprehensive analyses of these factors. In light of this, this study aimed to analyze the epidemiological patterns, histological characteristics, and treatment outcomes of NPC patients diagnosed and treated at a single center from 2016 to 2023...
February 2024: Curēus
https://read.qxmd.com/read/38333536/how-does-post-covid-differ-from-other-post-viral-conditions-in-childhood-and-adolescence-0-20-years-old-a-systematic-review
#4
JOURNAL ARTICLE
Chiara Minotti, Carla McKenzie, Isabelle Dewandel, Carien Bekker, Giulia Sturniolo, Denis Doni, Carlo Giaquinto, Marieke M Van Der Zalm, Daniele Donà
BACKGROUND: Post Coronavirus disease (COVID) and other post-viral infection syndromes present an overlap of pathogenesis, onset, progression, and symptom profile. We aimed to systematically describe studies on post-viral conditions and determine the entity of post COVID compared to other post-viral conditions in children. METHODS: We conducted a systematic search of the Embase, MEDLINE, Cochrane Library, and GoogleScholar databases (January 1946-3 November 2023), according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38254872/embracing-personalized-strategies-in-radiotherapy-for-nasopharyngeal-carcinoma-beyond-the-conventional-bounds-of-fields-and-borders
#5
REVIEW
Pui Lam Yip, Rui You, Ming-Yuan Chen, Melvin L K Chua
Radiotherapy is the primary treatment modality for non-metastatic nasopharyngeal carcinoma (NPC) across all TN-stages. Locoregional control rates have been impressive even from the 2D radiotherapy (RT) era, except when the ability to deliver optimal dose coverage to the tumor is compromised. However, short- and long-term complications following head and neck RT are potentially debilitating, and thus, there has been much research investigating technological advances in RT delivery over the past decades, with the primary goal of limiting normal tissue damage...
January 16, 2024: Cancers
https://read.qxmd.com/read/38239511/a-comparative-study-of-seroprevalence-of-17-common-pathogens-among-airline-pilots-and-office-workers
#6
JOURNAL ARTICLE
Andrés Santiago Sáez, Ángel García Martín, Manuel Gómez Serrano, Miryam Liaño Riera, Piercarlo Minoretti
Background The variation in infection risk among individuals is thought to be partially influenced by occupational factors. This study aims to investigate the seropositivity rates of 17 common infectious agents in male airline pilots (APs), a professional group known to experience a high prevalence of cardiovascular and gastrointestinal diseases. Methodology In our study, we employed a case-control design with 100 male APs as cases, matched by age, sex, and tenure (i.e., at least five years of service) to 100 male office workers (OWs) who served as controls...
December 2023: Curēus
https://read.qxmd.com/read/38238987/are-analytical-performance-specifications-derived-from-reference-intervals-of-any-use-in-the-veterinary-clinical-laboratory-a-preliminary-study-on-the-empirical-biological-variation-model
#7
JOURNAL ARTICLE
Simone Manzocchi, Liesl J van Rooyen
BACKGROUND: Analytical performance specifications (APS) are vital for method evaluation and quality control validation. However, the limited availability of biological variation (BV) data, regulatory guidelines, and expert opinion (EO) may present challenges in veterinary medicine. The empirical biological variation (EBV) approach, based on population reference intervals (pRI), has emerged as an alternative method to derive APS in human medicine. OBJECTIVES: This study aimed to assess the practicality and usefulness of the EBV approach in deriving performance limits for various measurands in dogs and cats...
January 18, 2024: Veterinary Clinical Pathology
https://read.qxmd.com/read/38224334/global-burden-risk-factors-clinicopathological-characteristics-molecular-biomarkers-and-outcomes-of-microsatellite-instability-high-gastric-cancer
#8
JOURNAL ARTICLE
Zhishan Zhang, Jinyuan Huang, Yingying Li, Huimeng Yan, Junxing Xie, Jing Wang, Bin Zhao
Microsatellite instability-high (MSI-H) has gained considerable interests since it was approved as a tumor-agnostic biomarker in immunotherapy. However, the reported characteristics of MSI-H gastric cancer (GC) are inconsistent due to the biological complexity. Here, we aim to clarify the prevalence, risk factors, clinicopathological/molecular features and outcomes of MSI-H GC though a comprehensive review on 43246 patients from 134 cohorts. Overall, the proportion of MSI-H GC was 14.5% (95% CI, 13.3%-15.8%)...
January 12, 2024: Aging
https://read.qxmd.com/read/38184072/quantification-of-low-level-cytomegalovirus-and-epstein-barr-virus-dnaemia-by-digital-pcr
#9
JOURNAL ARTICLE
DeVon N Hunter-Schlichting, Rachel I Vogel, Melissa A Geller, Heather H Nelson
BACKGROUND: Digital PCR (dPCR) can quantify cell-free viral DNA (DNAemia), a biomarker of active viral infection. To accelerate epidemiologic investigation into low-level viral reactivation in chronic disease, we have evaluated the performance of dPCR to detect cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNAemia across platforms and blood matrices. METHODS: The droplet-based (BioRad) dPCR platform performance was compared to chip-based (BioMark), and assay validation followed dMIQE guidelines...
January 4, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38101290/aflatoxin-b1-and-viruses-combined-pathogenesis-a-mini-systematics-review-of-invitro-and-invivo-studies
#10
REVIEW
Mehdi Ahmadi, Ramin Shahbahrami, Fatemeh Khajeh, Sepideh Khodaeivandi, Ehsan Kakavandi, Reza Hazrati Raziabad, Kiandokht Ghanati
INTRODUCTION: The combined pathogenesis of Aflatoxin B1 (AFB1) and several viruses such as HBV, EBV and influenza virus have been investigated yet the molecular mechanism of their interaction and possible synergistic effects is not fully understood. OBJECTIVES: The aim of the current systematic review was to review in-vitro and in-vivo studies investigating the combined pathogenesis of aflatoxins and viruses. METHODS: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
December 14, 2023: Acta Histochemica
https://read.qxmd.com/read/38007049/demystifying-the-global-outbreak-of-severe-acute-hepatitis-of-unknown-aetiology-in-children-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Julie Phan, Guy D Eslick, Elizabeth J Elliott
BACKGROUND: The sudden outbreak of severe acute hepatitis of unknown aetiology (SAHUA) in the first half of 2022 affected more than 1010 children in 35 countries worldwide. Dire clinical outcomes, such as acute liver failure necessitating transplantation, neurological symptoms, long-term sequelae, and death, highlight the need to determine the pathogenesis of this condition. Hypotheses on the aetiology include adenovirus and SARS-CoV-2 infections and an aberrant immune response to multiple pathogen exposure following lifting of lockdown measures but further investigation is required to reach an informed consensus...
January 2024: Journal of Infection
https://read.qxmd.com/read/38003218/pre-emptive-use-of-rituximab-in-epstein-barr-virus-reactivation-incidence-predictive-factors-monitoring-and-outcomes
#12
JOURNAL ARTICLE
Apostolia Papalexandri, Eleni Gavriilaki, Anna Vardi, Nikolaos Kotsiou, Christos Demosthenous, Natassa Constantinou, Tasoula Touloumenidou, Panagiota Zerva, Fotini Kika, Michalis Iskas, Ioannis Batsis, Despina Mallouri, Evangelia Yannaki, Achilles Anagnostopoulos, Ioanna Sakellari
Post-transplant lymphoproliferative disease (PTLD) is a fatal complication of hematopoietic cell transplantation (HCT) associated with the Epstein-Barr virus (EBV). Multiple factors such as transplant type, graft-versus-host disease (GVHD), human leukocyte antigens (HLA) mismatch, patient age, and T-lymphocyte-depleting treatments increase the risk of PTLD. EBV reactivation in hematopoietic cell transplant recipients is monitored through periodic quantitative polymerase chain reaction (Q-PCR) tests. However, substantial uncertainty persists regarding the clinically significant EBV levels for these patients...
November 7, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37936498/pulmonary-squamous-cell-carcinoma-and-lymphoepithelial-carcinoma%C3%A2-%C3%A2-morphology-molecular-characteristics-and-differential-diagnosis
#13
REVIEW
Sabina Berezowska, Marie Maillard, Mark Keyter, Bettina Bisig
Squamous cell carcinoma (SCC) comprises one of the major groups of non-small-cell carcinoma of the lung, and is subtyped into keratinising, non-keratinising and basaloid SCC. SCC can readily be diagnosed using histomorphology alone in keratinising SCC. Confirmatory immunohistochemical analyses should always be applied in non-keratinising and basaloid tumours to exclude differential diagnoses, most prominently adenocarcinoma and high-grade neuroendocrine carcinoma, which may have important therapeutic consequences...
November 7, 2023: Histopathology
https://read.qxmd.com/read/37902971/factors-associated-with-symptom-persistence-in-pans-part-ii-presenting-features-medical-comorbidities-and-ivig-treatment-history
#14
JOURNAL ARTICLE
Denise Calaprice-Whitty, Angela Tang, Janice Tona
Objective: Individuals with Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) experience neuropsychiatric symptoms following an infection or other trigger. Although PANS is typically described as relapsing-remitting, a large community-based 2017 study revealed a range of courses. The present study examined clinical predictors of symptom persistence, measured as % days symptom-free , in this same sample. Methods: A 146-question online survey gathered histories (infections and other triggers, medical and developmental comorbidities), symptomatology, interventions, and outcomes (including school functioning) of PANS patients...
October 30, 2023: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/37781359/case-report-non-negligible-epstein-barr-virus-associated-posttransplant-lymphoproliferative-disorders-in-a-lung-transplant-recipient
#15
Juan Hu, Yong-Wei Yu, Dong-Sheng Han, Xue-Jie Li, Yi-Qi Zhang, Hong-Liu Cai, Yong-Hong Xiao, Xia Zheng
BACKGROUND: Posttransplant lymphoproliferative disorders (PTLDs) are uncommon but serious complications in patients following solid organ transplantation. Primary Epstein-Barr virus (EBV) infection is a risk factor for the development of PTLD, especially early-onset PTLD, in EBV-negative recipients. To date, however, there are no specific guidelines on the threshold of EBV-DNA load for therapeutic intervention, the source for measurement (e.g., blood, bronchoalveolar fluid), or the use of antiviral agents as prophylaxis for early PTLD prevention in EBV-mismatched patients...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753076/pd-1-blockade-and-radiotherapy-combination-for-advanced-epstein-barr-virus-associated-intrahepatic-cholangiocarcinoma-a-case-report-and-literature-review
#16
REVIEW
Chun-Xu Liao, Chang-Song Deng, Xia Liang, Jian-Chuan Yang, Zhi-Zhong Chen, Xiao-Ying Lin, Cai-Feng Lin, Shen Chen, Song-Song Wu
Advanced intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of biliary epithelial cells, known for its extremely unfavorable prognosis. In the absence of intervention, patients typically survive for less than 5 months. Current guidelines from the Chinese Society of Clinical Oncology (CSCO), National Comprehensive Cancer Network (NCCN), and European Society for Medical Oncology (ESMO) recommend chemotherapy-based systemic therapy as the standard treatment for advanced ICC. However, the first-line regimen, consisting of gemcitabine in combination with cisplatin, generally results in a median survival of approximately one year, which is considered suboptimal...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37729847/enteroviral-central-nervous-system-infections-in-patients-with-lyme-neuroborreliosis
#17
JOURNAL ARTICLE
Karol Perlejewski, Marek Radkowski, Agnieszka Pawełczyk, Małgorzata Rydzanicz, Tomasz Dzieciątkowski, Michał Makowiecki, Marcin Paciorek, Renata Welc-Falęciak, Andrzej Horban, Tomasz Laskus
Patients with Lyme neuroborreliosis (LNB) are rarely tested for the presence of neurovirulent viruses other than tick-borne encephalitis virus (TBEV); however, such coinfections could be of clinical importance. The aim of the study was to search for the presence of neurotropic viruses in a LNB patients. Fourteen patients admitted with signs and symptoms of neuroinfection who were eventually diagnosed to have LNB (according to the guidelines of the European Federation of Neurological Societies) were subjects of the study...
September 18, 2023: Ticks and Tick-borne Diseases
https://read.qxmd.com/read/37728704/updated-guidelines-for-chronic-active-epstein-barr-virus-disease
#18
REVIEW
Jun-Ichi Kawada, Yoshinori Ito, Koichi Ohshima, Masaki Yamada, Shinsuke Kataoka, Hideki Muramatsu, Akihisa Sawada, Taizo Wada, Ken-Ichi Imadome, Ayako Arai, Keiji Iwatsuki, Shouichi Ohga, Hiroshi Kimura
Chronic active Epstein-Barr virus disease (CAEBV), formerly named chronic active Epstein-Barr virus infection, is characterized by systemic inflammation and clonal proliferation of Epstein-Barr virus (EBV)-infected T or NK cells. As CAEBV is a potentially life-threatening illness, appropriate diagnosis and therapeutic interventions are necessary for favorable clinical outcomes. Substantial evidence regarding the pathogenesis and treatment of CAEBV has been accumulated since previous guidelines for the diagnosis of CAEBV were proposed...
November 2023: International Journal of Hematology
https://read.qxmd.com/read/37637768/epstein-barr-viral-infection-and-the-risk-for-breast-cancer-a-systematic-review
#19
REVIEW
Arjola Agolli, Angela Ishak, Mahima Viswanathan, Edzel Lorraine Co, Jeevan Shivakumar, Olsi Agolli
Background : The prevalence of breast cancer has increased and has currently become one of the most common cancers. Although the majority of the world's population is infected with Epstein Barr Virus (EBV) during their lives, the severity of symptoms varies and not everyone infected with EBV is diagnosed with cancer. EBV might increase the risk for breast cancer either by activating the HER2/HER3 signaling cascades or by creating a state of prolonged immune stimulation. Materials and Methods : A systematic search of several electronic databases including PubMed, ScienceDirect, Cochrane, EBSCOhost, JSTOR, and Scopus, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted...
April 1, 2023: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/37621598/acute-hepatitis-of-unknown-etiology-in-an-adult-female-a-case-report
#20
Lucinda Dass, Alexandra Marie Malabanan Pacia, Mahgol Hamidi
BACKGROUND: Acute liver injury (ALI) refers to inflammation of the hepatic parenchyma without hepatic encephalopathy that lasts less than 6 mo. When the etiology is unknown, Acute Hepatitis of Unknown Origin (AHUO) can present as a diagnostic and treatment challenge. AHUO in the adult population is unusual and poorly documented. It has an incidence between 11% and 75%. Currently, no treatment guidelines exist. With no identified cause, treatment is often blind, and the wrong treatment plan may have unintended consequences...
August 6, 2023: World Journal of Clinical Cases
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