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Acute pancreatitis, pancreatic cancer

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https://www.readbyqxmd.com/read/29138810/angiotensin-converting-enzyme-2-angiotensin-1-7-mas-axis-prevents-pancreatic-acinar-cell-inflammatory-response-via-inhibition-of-the-p38-mitogen-activated-protein-kinase-nuclear-factor-%C3%AE%C2%BAb-pathway
#1
Xiaozheng Yu, Lijian Cui, Fei Hou, Xiaoya Liu, Yan Wang, Yan Wen, Cheng Chi, Chunyun Li, Ruixia Liu, Chenghong Yin
The aim of the present study was to investigate the role of the angiotensin-converting enzyme (ACE)2-angiotensin‑(Ang)-(1-7)-Mas axis in the pathogenesis of pancreatitis and the association between this axis and the p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor (NF-κB) signaling pathway in pancreatic acinar cells. Mouse pancreatic acinar cancer (MPC-83) cells were stimulated with 10 nM caerulein (CAE) to create an in vitro model of acute pancreatitis, and collected for analysis at 2, 6, 12, 24 and 48 h post stimulation...
November 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29132523/pancreatitis-and-pancreatic-cancer
#2
REVIEW
Anne Walling, Robert Freelove
Most cases of acute pancreatitis are related to gallstones. More than 80% resolve within a few days. The diagnosis is based on upper abdominal pain, elevated lipase and/or amylase, and transabdominal ultrasound findings. Management requires early aggressive hydration, pain control, nutritional support, and monitoring for progression. Patients who develop hypovolemia, systemic inflammatory response, pancreatic necrosis, and organ failure have high mortality, risk of recurrence, and progression to chronic pancreatitis (CP)...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29115416/annexin-a2-and-cancer-a-systematic-review
#3
Maria V Christensen, Claus K Høgdall, Kirsten M Jochumsen, Estrid V S Høgdall
Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma, prostate cancer and urothelial carcinoma were evaluated...
November 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29104587/notch-and-its-oncogenic-activity-in-human-malignancies
#4
REVIEW
Marlena Brzozowa-Zasada, Adam Piecuch, Marek Michalski, Oliwia Segiet, Józef Kurek, Marzena Harabin-Słowińska, Romuald Wojnicz
Background: Increasing evidence has demonstrated that Notch signaling is deregulated in human hematological malignancies and solid tumors. This signaling has a protumorigenic effect but may also act as a tumor suppressor. How induction of a single pathway gives rise to the opposite effects in different cell types is still unknown. Methods: This review article includes available data from peer-reviewed publications associated with the role of Notch signaling during cancer pathogenesis...
2017: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29094173/imaging-of-post-operative-pancreas-and-complications-after-pancreatic-adenocarcinoma-resection
#5
Nima Hafezi-Nejad, Elliot K Fishman, Atif Zaheer
Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related deaths. With surgical resection being the only definitive treatment, improvements in technique has led to an increase in number of candidates undergoing resection by inclusion of borderline resectable disease patients to the clearly resectable group. Post-operative complications associated with pancreaticoduodenectomy and distal pancreatectomy include delayed gastric emptying, anastomotic failures, fistula formation, strictures, abscess, infarction, etc...
November 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29079901/diabetes-and-the-pancreatobiliary-diseases
#6
REVIEW
Muhammad Shafqet, Kaveh Sharzehi
PURPOSE OF REVIEW: The emphasis of this review article is to bring to the forefront the spectrum of pancreatobiliary disorders and their association with diabetes. We hope to systematically discuss the link between diabetes and disorders of the pancreas including acute and chronic pancreatitis, as well as pancreatic cancer. We also hope to review and highlight the literature with respect to other cancers of the biliary tree including gallbladder and cholangiocarcinoma. Lastly, we discuss diabetes and biliary dyskinesia...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29061632/neoadjuvant-s-1-with-concurrent-radiotherapy-followed-by-surgery-for-borderline-resectable-pancreatic-cancer-study-protocol-for-an-open-label-multicentre-prospective-phase-ii-trial-jaspac05
#7
Shinichiro Takahashi, Izumi Ohno, Masafumi Ikeda, Tatsushi Kobayashi, Tetsuo Akimoto, Motohiro Kojima, Masaru Konishi, Katsuhiko Uesaka
INTRODUCTION: Borderline resectable pancreatic cancer (BRPC) can involve the portal vein, superior mesenteric vein, superior mesenteric artery, coeliac axis or hepatic artery, and has a high probability of positive surgical margins and poor prognosis after resection. Neoadjuvant chemoradiation is expected to provide substantial local control and prolong survival in patients with BRPC. METHODS AND ANALYSIS: This open-label, multicentre, prospective phase II trial will assess S-1 with concurrent radiotherapy as preoperative treatment for BRPC...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29028284/tissue-factor-bearing-microparticles-and-inflammation-a-potential-mechanism-for-the-development-of-venous-thromboembolism-in-cancer
#8
REVIEW
K Date, C Ettelaie, A Maraveyas
Cancer is associated with an increased risk of venous thromboembolism (VTE); the exact mechanisms for the induction of VTE remain to be fully elucidated, yet it is widely acknowledged that tissue factor-positive microparticles (TF-MPs) may play a significant role. However, TF-MPs have yet to be accepted as a bona fide biomarker for cancer-associated VTE, as the presence of elevated TF-MPs levels is not always accompanied by thrombosis; interestingly in certain cases, particularly in pancreatic cancer, VTE seems to be more likely in the context of acute inflammation...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29025374/the-prognostic-significance-of-cancer-associated-fibroblasts-in-pancreatic-ductal-adenocarcinoma
#9
Hyunjin Park, Yangkyu Lee, Hyejung Lee, Jin-Won Kim, Jin-Hyeok Hwang, Jaihwan Kim, Yoo-Seok Yoon, Ho-Seong Han, Haeryoung Kim
Cancer-associated fibroblasts are abundant in the desmoplastic stroma of pancreatic ductal adenocarcinomas and are considered to play important roles in tumor progression. In this study, we investigated the expression status of secreted protein acidic and rich in cysteine, periostin, fibroblast-activated protein, and the newly developed proCOL11A1 antibody in the stroma of surgically resected pancreatic ductal adenocarcinomas and their prognostic implications. Tissue microarrays were constructed from 155 surgically resected pancreatic ductal adenocarcinomas and paired non-neoplastic pancreata and from another independent set of 48 normal/benign pancreata, and immunohistochemical stains were performed for proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#10
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28989651/fluorometric-probing-of-the-lipase-level-as-acute-pancreatitis-biomarkers-based-on-interfacially-controlled-aggregation-induced-emission-aie
#11
Jie Shi, Qianchun Deng, Chuyun Wan, Mingming Zheng, Fenghong Huang, Bo Tang
As a sudden inflammation of the pancreas, acute pancreatitis presents severe complications and a high mortality rate, despite treatment. Lipase in serum serves as an essential biomarker of acute pancreatitis and even pancreatic cancer. Therefore, developing robust, convenient and sensitive probing of lipase levels is greatly needed. In this work, we present glutamate functionalized tetraphenylethylene (TPE) as a "turn-on" fluorescent probe (S1) based on the aggregation-induced emission (AIE) mechanism for lipase levels with new recognition units...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28969260/tamoxifen-induced-pancreatitis-an-unusual-complication-of-commonly-used-drug
#12
Pritam Suresh Chandra Kataria, Pradip Piraji Kendre, Apurva Ashok Patel, Murtaza Zoher Bohra, Nahush Tahiliani
Tamoxifen is a selective oestrogen receptor modulator used for the treatment of oestrogen/progesterone receptor positive breast cancer. It possess antagonistic or agonistic activity depending on the tissue location i.e., antagonistic action on breast but agonist action on endometrium and bones. The side effects of tamoxifen include hot flushes, gynaecologic symptoms (vaginal dryness, vaginal discharge), depression, forgetfulness, sleep alterations, weight gain, alteration of lipoprotein metabolism, thromboembolic disorder...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965123/identification-of-mirna-mrna-network-associated-with-acute-myeloid-leukemia-survival
#13
Chunmei Zhang, Guanchen Bai, Weijie Zhu, Dongfang Bai, Gaofeng Bi
BACKGROUND Acute myeloid leukemia (AML) is a common hematologic malignancy of adults. The pathophysiological mechanism of AML is not well understood. The purpose of this study was to examine the crucial miRNAs and mRNAs associated with AML survival. MATERIAL AND METHODS The full clinical dataset of miRNA and mRNA expression profiling of AML patients was downloaded from The Cancer Genome Atlas database. Univariate Cox regression analysis was performed to obtain those miRNAs and mRNAs associated with AML survival...
October 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28945721/asparaginase-toxicities-identification-and-management-in-patients-with-acute-lymphoblastic-leukemia%C3%A2
#14
Van Thu Huynh, Sharon Bergeron
BACKGROUND: Acute lymphoblastic leukemia (ALL) is a common cancer in children, and outcomes have greatly improved because of the refinement of multiagent chemotherapy regimens that include intensified asparaginase therapy. Asparaginase, a cornerstone of modern pediatric chemotherapy regimens for ALL and asparaginase-containing protocols, is increasingly used in adolescent and adult patients historically treated with asparaginase-free regimens. 
. OBJECTIVES: This article is an overview of commonly encountered asparaginase-
associated toxicities and offers recommendations for treatment management...
October 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28935288/the-potential-role-of-gut-microbiota-in-pancreatic-disease-a-systematic-review
#15
REVIEW
Robert Memba, Sinead N Duggan, Hazel M Ni Chonchubhair, Oonagh M Griffin, Yasir Bashir, Donal B O'Connor, Anne Murphy, Jean McMahon, Yuri Volcov, Barbara M Ryan, Kevin C Conlon
BACKGROUND: Several studies have suggested a link between microbiota imbalance and some gastrointestinal, inflammatory and neoplastic diseases. However, the role in pancreatic diseases remain unclear. To evaluate the available evidence for pancreatic diseases, we undertook a systematic review. METHODS: OVID Medline (1946-2017), EMBASE (1980-2017) and the Cochrane Central Register of Controlled Trials (CENTRAL Issue 3, 2017) were searched for studies on microbiota in pancreatic disease...
September 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28925877/4-aryl-heteroaryl-4h-fused-pyrans-as-anti-proliferative-agents-design-synthesis-and-biological-evaluation
#16
Dinesh Kumar, Gurpreet Singh, Pooja Sharma, Arem Qayum, Girish Mahajan, M J Mintoo, Shashank Kumar Singh, Dilip Manikrao Mondhe, Pms Bedi, Subheet K Jain, Girish Kumar Gupta
The current study is focused on the design and synthesis of 4-aryl/heteroaryl-4H-fused pyrans as anti-proliferative agents. All the synthesized molecules were screened against a panel of human carcinoma cell lines. Significant inhibition was exhibited by the compounds against HCT-116 (Colon) and PC-3 (Prostate) cell lines while A-549 (Lung) cell lines, MiaPaCa-2 (Pancreatic) cell lines and HL-60 (Leukemia Cancer) cell lines were almost resistant to the exposure of the test compounds. Compound FP-(v)n displayed noteworthy cytotoxicity towards HCT-116 malignant cells with IC50 value of 0...
September 18, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28921009/radiation-overexposure-from-repeated-ct-scans-in-young-adults-with-acute-abdominal-pain
#17
Massimo Tonolini, Elena Valconi, Angelo Vanzulli, Roberto Bianco
PURPOSE: The purpose of this study is to assess the dose of ionizing radiation caused by repeated CT scans performed to investigate non-traumatic acute abdominal conditions in young adults. METHODS: Over 26 months, we collected a cohort of patients aged 18 to 45 years who were subject to at least one urgent contrast-enhanced abdomen/pelvis CT. Patients affected with urolithiasis, HIV infection, tumors, and vascular and chronic inflammatory bowel diseases were excluded...
September 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28910237/effects-of-once-weekly-exenatide-on-cardiovascular-outcomes-in-type-2-diabetes
#18
RANDOMIZED CONTROLLED TRIAL
Rury R Holman, M Angelyn Bethel, Robert J Mentz, Vivian P Thompson, Yuliya Lokhnygina, John B Buse, Juliana C Chan, Jasmine Choi, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Steven P Marso, Peter Öhman, Neha J Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez
BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke...
September 28, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28890817/proton-beam-reirradiation-for-locally-recurrent-pancreatic-adenocarcinoma
#19
Pamela J Boimel, Abigail T Berman, Jonathan Li, Smith Apisarnthanarax, Stefan Both, Kristi Lelionis, Gary L Larson, Ursina Teitelbaum, John N Lukens, Edgar Ben-Josef, James M Metz, John P Plastaras
BACKGROUND: Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity and mortality. Retreatment options for these patients are limited. Proton beam reirradiation (PRT) may limit dose and toxicity to previously irradiated normal tissues in patients without evidence of metastatic disease. METHODS: Between 8/2010-2/2015, 15 patients with isolated, locally-recurrent pancreatic cancer were treated with PRT...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28858943/increased-risk-of-mortality-associated-with-pancreatic-exocrine-insufficiency-in-patients-with-chronic-pancreatitis
#20
Daniel de la Iglesia-Garcia, Nicolau Vallejo-Senra, Julio Iglesias-Garcia, Andrea López-López, Laura Nieto, J Enrique Domínguez-Muñoz
BACKGROUND: Pancreatic exocrine insufficiency (PEI) is a common serious complication in chronic pancreatitis (CP); however, little is known about its effect on mortality in these patients. In this study, we assessed the mortality risk of PEI in patients with CP. STUDY: A prospective, longitudinal cohort study conducted in patients with CP under long-term follow-up. CP and PEI were diagnosed using pancreatic imaging and the C-labeled mixed triglyceride breath test, respectively...
August 30, 2017: Journal of Clinical Gastroenterology
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