keyword
MENU ▼
Read by QxMD icon Read
search

Diindolylmethane

keyword
https://www.readbyqxmd.com/read/28267258/normal-human-immune-cells-are-sensitive-to-telomerase-inhibition-by-brassica-derived-3-3-diindolylmethane-partly-mediated-via-er%C3%AE-%C3%AE-ap1-signalling
#1
Corinna Herz, Hoai Thi Thu Tran, Steffen Landerer, Johanna Gaus, Nina Schlotz, Lia Lehr, Wolfgang R Schäfer, Oliver Treeck, Grace Akinyi Odongo, Ivan Skatchov, Evelyn Lamy
SCOPE: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from Brassica plants are regarded as promising anticancer phytochemicals. The enzyme telomerase is a very attractive target for cancer therapeutics; in normal cells such as lymphocytes, it plays a decisive role for cell maintenance. The effect of I3C and DIM on telomerase in normal human immune cells (PBMC) was studied compared to leukaemia cells (HL-60). Signalling of telomerase regulation via estrogen receptor (ER) was addressed...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28250973/mpp-induces-necrostatin-1-and-ferrostatin-1-sensitive-necrotic-death-of-neuronal-sh-sy5y-cells
#2
Keisuke Ito, Yutaka Eguchi, Yusuke Imagawa, Shuji Akai, Hideki Mochizuki, Yoshihide Tsujimoto
Regulation of cell death is potentially a powerful treatment modality for intractable diseases such as neurodegenerative diseases. Although there have been many reports about the possible involvement of various types of cell death in neurodegenerative diseases, it is still unclear exactly how neurons die in patients with these diseases, thus treatment strategies based on cell death regulation have not been established yet. To obtain some insight into the mechanisms of cell death involved in neurodegenerative diseases, we studied the effect of 1-methyl-4-phenylpyridinium (MPP+) on the human neuroblastoma cell line SH-SY5Y (a widely used model of Parkinson's disease)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28117016/food-as-pharma-the-case-of-glucosinolates
#3
Edoardo Capuano, Matthijs Dekker, Ruud Verkerk, Teresa Oliviero
BACKGROUND: Glucosinolates (GLSs) are dietary plant secondary metabolites occurring in the order Brassicales with potential health effects, in particular as anti-carcinogenic compounds. GLSs are converted into a variety of breakdown products (BPs) upon plant tissue damage and by the gut microbiota. GLS biological activity is related to BPs rather than to GLSs themselves. METHODS: we have reviewed the most recent scientific literature on the metabolic fate and the biological effect of GLSs with particular emphasis on the epidemiological evidence for health effect and evidence from clinical trials...
January 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28109136/therapeutic-potential-of-targeting-wnt-%C3%AE-catenin-pathway-in-treatment-of-colorectal-cancer-rational-and-progress
#4
Afsane Bahrami, Forouzan Amerizadeh, Soodabeh ShahidSales, Majid Khazaei, Majid Ghayour-Mobarhan, Hamid Reza Sadeghnia, Mina Maftouh, Seyed Mahdi Hassanian, Amir Avan
Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3-diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI-724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab...
January 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28063342/linking-genomic-responses-of-gonads-with-reproductive-impairment-in-marine-medaka-oryzias-melastigma-exposed-chronically-to-the-chemopreventive-and-antifouling-agent-3-3-diindolylmethane-dim
#5
Lianguo Chen, Doris W T Au, Chenyan Hu, Weipeng Zhang, Bingsheng Zhou, Lin Cai, John P Giesy, Pei-Yuan Qian
3,3'-Diindolylmethane (DIM) has been promoted as an effective chemopreventive and antifouling additive. However, the concurrent risks or side effects of DIM are not fully understood, especially on tissues responsive to estrogen. Therefore, this study employed marine medaka (Oryzias melastigma) as a test model to evaluate relative safety and explore mechanisms of toxic action of DIM on development and function of gonad after chronic (28days) aqueous exposure to relatively low doses (0μg/L or 8.5μg/L). Integration of comprehensive toxicogenomic analysis at the transcriptome and proteome levels with apical endpoints, such as production of eggs and swimming performance of larvae, elucidated the molecular linkage in gonad from bottom up along the reproductive adverse outcome pathway...
February 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/27700072/effect-of-oral-administration-of-3-3-diindolylmethane-on-dextran-sodium-sulfate-induced-acute-colitis-in-mice
#6
Eun-Joo Jeon, Munkhtugs Davaatseren, Jin-Taek Hwang, Jae Ho Park, Haeng Jeon Hur, Ae Sin Lee, Mi Jeong Sung
In patients with inflammatory bowel disease (IBD), inflammation is induced and maintained by lymphangiogenesis and angiogenesis. 3,3'-Diindolylmethane (DIM) is a natural product formed in acidic conditions from indole-3-carbinol in cruciferous vegetables, and it is known for its chemotherapeutic activity. This study evaluated DIM's effects on angiogenesis, lymphangiogenesis, and inflammation in a mouse colitis model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
October 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27682980/regulation-of-pcgem1-by-p54-nrb-in-prostate-cancer
#7
Tsui-Ting Ho, Jianguo Huang, Nanjiang Zhou, Ziqiang Zhang, Pratirodh Koirala, Xinchun Zhou, Fangting Wu, Xianfeng Ding, Yin-Yuan Mo
PCGEM1 is a long non-coding RNA (lncRNA) that is often upregulated in prostate cancer. However, little is known how PCGEM1 is regulated. In the present study, we show transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. While ectopic expression of p54/nrb increases, suppression of p54/nrb by RNAi or knockout (KO) reduces PCGEM1. Moreover, rescue experiments indicate that re-expression of p54/nrb in KO cells restores the ability to induce PCGEM1, leading to upregulation of the androgen receptor splice variant AR3 which has been shown to play a role in castration resistance...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27677308/ahr-cyp1a1-interplay-triggers-lymphatic-barrier-breaching-in-breast-cancer-spheroids-by-inducing-12-s-hete-synthesis
#8
Chi Huu Nguyen, Stefan Brenner, Nicole Huttary, Atanas Georgiev Atanasov, Verena Maria Dirsch, Waranya Chatuphonprasert, Sivio Holzner, Serena Stadler, Juliane Riha, Sigurd Krieger, Rainer de Martin, Zsuzsanna Bago-Horvath, Georg Krupitza, Walter Jäger
A causal link between overexpression of aryl hydrocarbon receptor (AHR) and its target cytochrome P450 1A1 (CYP1A1) and metastatic outgrowth of various cancer entities has been established. Nevertheless, the mechanism how AHR/CYP1A1 support metastasis formation is still little understood. In vitro we discovered a potential mechanism facilitating tumour dissemination based on the production of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE). Utilising a three-dimensional lymph endothelial cell (LEC) monolayer & MDA-MB231 breast cancer cell spheroid co-culture model in combination with knock-down approach allowed elucidation of the molecular/biochemical basis of AHR/CYP1A1-induced tumour breaching through the LEC barrier...
September 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27671815/indole-3-carbinol-and-its-role-in-chronic-diseases
#9
Barbara Licznerska, Wanda Baer-Dubowska
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27609226/3-3-diindolylmethane-mitigates-total-body-irradiation-induced-hematopoietic-injury-in-mice
#10
Lu Lu, Jiali Dong, Deguan Li, Junling Zhang, Saijun Fan
We have reported that hematopoietic system injury induced by total body irradiation (TBI) leads to generation of intracellular reactive oxygen species (ROS) and DNA damage, which are ameliorated by antioxidant agents. In the present study, we reported that administration of DIM, a potent antioxidant agent, not only protected mice against TBI-induced lethality, also ameliorated TBI-induced hematopoietic injury. The latter effect was probably attributable to DIM's inhibition of TBI-induced increases in ROS production in hematopoietic stem cells (HSCs) and the phosphorylation of histone H2AX (γ-H2AX)...
September 5, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27586082/novel-diindolylmethane-derivatives-based-nlc-formulations-to-improve-the-oral-bioavailability-and-anticancer-effects-in-triple-negative-breast-cancer
#11
Chandraiah Godugu, Ravi Doddapaneni, Stephen H Safe, Mandip Singh
The present study demonstrates the promising anticancer effects of novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 in aggressive TNBC models. In vitro studies demonstrated that these compounds possess strong anticancer effects. Caco-2 permeability studies resulted in poor permeability and poor oral bioavailability was demonstrated by pharmacokinetic studies. Nano structured lipid carrier (NLC) formulations were prepared to increase the clinical acceptance of these compounds. Significant increase in oral bioavailability was observed with NLC formulations...
November 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27538743/harnessing-the-power-of-cruciferous-vegetables-developing-a-biomarker-for-brassica-vegetable-consumption-using-urinary-3-3-diindolylmethane
#12
Naomi Fujioka, Benjamin W Ransom, Steven G Carmella, Pramod Upadhyaya, Bruce R Lindgren, Astia Roper-Batker, Dorothy K Hatsukami, Vincent A Fritz, Charles Rohwer, Stephen S Hecht
Glucobrassicin in Brassica vegetables gives rise to indole-3-carbinol (I3C), a compound with potent anticancer effects in preclinical models. We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from Brassica vegetables is reflected in urinary DIM and that this effect plateaus...
October 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27447608/cellular-and-molecular-mechanisms-of-3-3-diindolylmethane-in-gastrointestinal-cancer
#13
REVIEW
Soo Mi Kim
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. This review presents the latest findings on the use, targets, and modes of action of DIM for the treatment of human gastrointestinal cancers. DIM acts upon several cellular and molecular processes in gastrointestinal cancer cells, including apoptosis, autophagy, invasion, cell cycle regulation, metastasis, angiogenesis, and endoplasmic reticulum (ER) stress...
July 19, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27431593/design-and-synthesis-of-2-2-diindolylmethanes-to-selectively-target-certain-g-quadruplex-dna-structures
#14
Madeleine Livendahl, Jan Jamroskovic, Svetlana Ivanova, Peter Demirel, Nasim Sabouri, Erik Chorell
G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2'-diindolylmethanes have been designed and synthesized in this work based on the condensation of 3,6- or 3,7-disubstituted indoles with aldehydes. The developed class of compounds efficiently stabilizes G4 structures without inducing conformational changes in such structures. Furthermore, the 2,2'-diindolylmethanes target certain G4 structures more efficiently than others and this G4 selectivity can be altered by chemical modifications of the compounds...
September 5, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27430727/the-autism-related-gene-snrpn-regulates-cortical-and-spine-development-via-controlling-nuclear-receptor-nr4a1
#15
Huiping Li, Pingping Zhao, Qiong Xu, Shifang Shan, Chunchun Hu, Zilong Qiu, Xiu Xu
The small nuclear ribonucleoprotein polypeptide N (SNRPN) gene, encoding the RNA-associated SmN protein, duplications or deletions of which are strongly associated with neurodevelopmental disabilities. SNRPN-coding protein is highly expressed in the brain. However, the role of SNRPN protein in neural development remains largely unknown. Here we showed that the expression of SNRPN increased markedly during postnatal brain development. Overexpression or knockdown of SNRPN in cortical neurons impaired neurite outgrowth, neuron migration, and the distribution of dendritic spines...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27405772/lipid-based-oral-delivery-systems-for-skin-deposition-of-a-potential-chemopreventive-dim-derivative-characterization-and-evaluation
#16
Cedar H A Boakye, Ketan Patel, Apurva R Patel, Henrique A M Faria, Valtencir Zucolotto, Stephen Safe, Mandip Singh
The objective of this study was to explore the oral route as a viable potential for the skin deposition of a novel diindolylmethane derivative (DIM-D) for chemoprevention activity. Various lipid-based oral delivery systems were optimized and compared for enhancing DIM-D's oral bioavailability and skin deposition. Preformulation studies were performed to evaluate the log P and solubility of DIM-D. Microsomal metabolism, P-glycoprotein efflux, and caco-2 monolayer permeability of DIM-D were determined. Comparative evaluation of the oral absorption and skin deposition of DIM-D-loaded various lipid-based formulations was performed in rats...
October 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27372603/3-3-diindolylmethane-induces-anti-human-gastric-cancer-cells-by-the-mir-30e-atg5-modulating-autophagy
#17
Yang Ye, Yanfei Fang, Wenxia Xu, Qiang Wang, Jianwei Zhou, Rongzhu Lu
3,3'-Diindolylmethane (DIM), a class of relatively non-toxic indole derivatives from cruciferous vegetables, has been reported as a promising anticancer phytochemical, but the underlying molecular mechanism is not completely elucidated. In the present study we report a novel regulation of autophagy by DIM in human gastric cancer cells. We found that DIM dose-dependently inhibited the growth of gastric cancer cells in vitro and in vivo. Moreover, ATG5 and LC3 were activated by DIM in gastric cancer cells. Furthermore, miR-30e was down-regulated by DIM and miR-30e targeted the 3'-UTR of ATG5 to inhibit its translation...
September 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27307186/development-of-novel-application-of-3-3-diindolylmethane-sensitizing-multidrug-resistance-human-breast-cancer-cells-to-%C3%AE-irradiation
#18
Wenjing Wang, Maomin Lv, Yanlin Wang, Jingang Zhang
CONTEXT: Multidrug resistance (MDR) is known as a major obstacle to effective cancer therapy. The effects of irradiation on MDR in cancer cells had rarely been reported. OBJECTIVE: The effect of 3,3'-diindolylmethane (DIM) sensitizing MDR human breast carcinoma to γ-irradiation was investigated. MATERIALS AND METHODS: MCF-7/ADR cells were exposed to different concentrations of DIM (0-30 μM) for 48 or 2 h before IR (γ-Co(60), 10 Gy, room temperature) then cultured for 48 h...
December 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27301886/retraction-down-regulation-of-upa-and-upar-by-3-3-diindolylmethane-contributes-to-the-inhibition-of-cell-growth-and-migration-of-breast-cancer-cells-by-ahmad-et-al
#19
(no author information available yet)
The above article, published online on August 19, 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the third author and the corresponding author that found Figure 5C to be inappropriately re-used and re-labeled. REFERENCE Ahmad A, Kong D, Wang Z, Sarkar SH, Banerjee S, Sarkar FH. 2009. Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells...
2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27261275/chemopreventive-properties-of-3-3-diindolylmethane-in-breast-cancer-evidence-from-experimental-and-human-studies
#20
Cynthia A Thomson, Emily Ho, Meghan B Strom
Diet is a modifiable factor associated with the risk of several cancers, with convincing evidence showing a link between diet and breast cancer. The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer chemoprevention. This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. Research of the cancer-preventive activity of DIM has yielded basic mechanistic, animal, and human trial data. Further, this body of evidence is largely supported by observational studies...
July 2016: Nutrition Reviews
keyword
keyword
60445
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"