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Placenta fetal programming

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https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#1
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/29034064/personalized-therapy-against-preeclampsia-by-replenishing-placental-protein-13-pp13-targeted-to-patients-with-impaired-pp13-molecule-or-function
#2
REVIEW
Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
Hypertensive disorders affect about one third of all people aged 20 and above, and are treated with anti-hypertensive drugs. Preeclampsia (PE) is one form of such disorders that only develops during pregnancy. It affects ten million pregnant women globally and additionally causes fetal loss and major newborn disabilities. The syndrome's origin is multifactorial, and anti-hypertensive drugs are ineffective in treating it. Biomarkers are helpful for predict its development. Generic drugs, such as low dose aspirin, were proven effective in preventing preterm PE...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28979893/prenatal-maternal-stress-and-the-risk-of-asthma-in-children
#3
REVIEW
Konstantinos Douros, Maria Moustaki, Sophia Tsabouri, Anna Papadopoulou, Marios Papadopoulos, Kostas N Priftis
Emerging evidence indicate that maternal prenatal stress (MPS) can result in a range of long-term adverse effects in the offspring. The underlying mechanism of MPS is not fully understood. However, its complexity is emphasized by the number of purportedly involved pathways namely, placental deregulated metabolism of maternal steroids, impaired maturation of fetal HPA axis, imbalanced efflux of commensal bacteria across the placenta, and skewed immune development toward Th2. Fetal programming probably exerts a pivotal role in the end result of the above pathways through the modulation of gene expression...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28962690/early-and-late-onset-preeclampsia-and-the-tissue-specific-epigenome-of-the-placenta-and-newborn
#4
Emilie M Herzog, Alex J Eggink, Sten P Willemsen, Roderick C Slieker, Kim P J Wijnands, Janine F Felix, Jun Chen, Andrew Stubbs, Peter J van der Spek, Joyce B van Meurs, Régine P M Steegers-Theunissen
INTRODUCTION: Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing maternal cardiovascular- and metabolic risk factors. We hypothesize that PE is associated with altered epigenetic programming of placental and fetal tissues and that these epigenetic changes might elucidate the increased cardiovascular- and metabolic disease susceptibility in PE offspring...
October 2017: Placenta
https://www.readbyqxmd.com/read/28926727/early-pregnancy-intrauterine-fetal-exposure-to-maternal-smoking-and-impact-on-fetal-telomere-length
#5
Hooman Mirzakhani, Immaculata De Vivo, J Steven Leeder, Roger Gaedigk, Carrie A Vyhlidal, Scott T Weiss, Kelan Tantisira
BACKGROUND: Reduced telomere length, or its accelerated attrition, has been implicated in aging, mortality, and several human diseases, including respiratory diseases. Age dependent manifestation of telomere-mediated disease during life span indicates the role of developmental stage in these diseases and highlights the importance of fetal developmental process in utero and at earlier life stages. Environmental determinants during developmental and later stages of life could affect telomere length...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28895534/molecular-conservation-of-marsupial-and-eutherian-placentation-and-lactation
#6
Michael W Guernsey, Edward B Chuong, Guillaume Cornelis, Marilyn B Renfree, Julie C Baker
Eutherians are often mistakenly termed 'placental mammals', but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate that the anatomically simple tammar placenta expresses a dynamic molecular program that is reminiscent of eutherian placentation, including both fetal and maternal signals...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28888333/maternal-long-chain-polyunsaturated-fatty-acid-status-and-pregnancy-complications
#7
REVIEW
Nisha Wadhwani, Vidya Patil, Sadhana Joshi
Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders...
August 15, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28871576/first-trimester-combined-screening-for-preeclampsia-and-small-for-gestational-age-a-single-centre-experience-and-validation-of-the-fmf-screening-algorithm
#8
Beatrice Mosimann, Chantal Pfiffner, Sofia Amylidi-Mohr, Lorenz Risch, Daniel Surbek, Luigi Raio
AIM OF THE STUDY: Preeclampsia (PE) is associated with severe maternal and fetal morbidity in the acute presentation and there is increasing evidence that it is also an important risk factor for cardiovascular disease later in life. Therefore, preventive strategies are of utmost importance. The Fetal Medicine Foundation (FMF) London recently developed a first trimester screening algorithm for placenta-related pregnancy complications, in particular early onset preeclampsia (eoPE) requiring delivery before 34 weeks, and preterm small for gestational age (pSGA), with a birth weight <5th percentile and delivery before 37 weeks of gestation, based on maternal history and characteristics, and biochemical and biophysical parameters...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28794104/prenatal-hypoxia-and-placental-oxidative-stress-linkages-to-developmental-origins-of-cardiovascular-disease
#9
REVIEW
Mais M Aljunaidy, Jude S Morton, Christy-Lynn M Cooke, Sandra T Davidge
Intrauterine growth restriction (IUGR, a pregnancy complication where the fetus does not reach its genetic growth potential) is a leading cause of fetal morbidity and mortality with a significant impact on population health. IUGR is associated with gestational hypoxia; which can lead to placental oxidative stress and fetal programming of cardiovascular disease. Mitochondria are a major source of placental oxidative stress and may provide a therapeutic target to mitigate the detrimental effects of placental oxidative stress on pregnancy outcomes...
October 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28755466/hypospadias-intrauterine-growth-restriction-and-abnormalities-of-the-placenta
#10
M Hassan Toufaily, Drucilla J Roberts, Marie-Noel Westgate, Anne-Therese Hunt, Lewis B Holmes
BACKGROUND: Hypospadias is more common among male infants with growth restriction, defined as a birth weight less than the 10(th) centile, than in infants with a normal birth weight. Intrauterine growth retardation (IUGR) has been associated, also, with abnormalities of the placenta, such as maternal vascular malperfusion. In a consecutive sample of newborn infants, the association between hypospadias, IUGR and abnormalities of the placenta could be analyzed. METHODS: Affected infants were identified among 289,365 liveborn and stillborn infants in the Active Malformations Surveillance Program between 1972 and 2012...
July 29, 2017: Birth defects research
https://www.readbyqxmd.com/read/28751217/human-placenta-expresses-both-peripheral-and-neuronal-isoform-of-tryptophan-hydroxylase
#11
Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancourt
The role of placental serotonin has been an active topic of research notably because of its crucial role in brain development. However, which cell types synthesize serotonin in human placenta remains unknown. Moreover, it is not known if the two tryptophan hydroxylase isoforms (TPH1 and TPH2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. Human placentas were obtained in first trimester or at term, and trophoblast cells were isolated and purified using a magnetic cell sorter and placed in primary culture...
September 2017: Biochimie
https://www.readbyqxmd.com/read/28744866/effect-of-moderate-30-percent-global-maternal-nutrient-reduction-on-fetal-and-postnatal-baboon-phenotype
#12
Cun Li, Susan Jenkins, Vicki Mattern, Anthony G Comuzzie, Laura A Cox, Hillary F Huber, Peter W Nathanielsz
BACKGROUND: Most developmental programming studies on maternal nutrient reduction (MNR) are in altricial rodents whose maternal nutritional burden and offspring developmental trajectory differ from precocial non-human primates and humans. METHODS: Control (CTR) baboon mothers ate ad libitum; MNR mothers ate 70% global control diet in pregnancy and lactation. RESULTS: We present offspring morphometry, blood cortisol, and adrenocorticotropin (ACTH) during second half of gestation (G) and first three postnatal years...
July 26, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28730238/altered-expression-of-mtor-and-autophagy-in-term-normal-human-placentas
#13
Qiu Xia Zhang, Quan Na, Weiwei Song
Mammalian target of rapamycin (mTOR) and autophagy have been implied in trophoblast cells proliferation and invasion. This study investigated whether mTOR and autophagy were involved in placental development and fetal programming. A total of 90 term normal placentas (37-42 gestational weeks) were collected from women who underwent elective cesarean section, with large for gestational age (LGA), fetal growth restriction (FGR), and appropriate for gestational age (AGA) infants (n=30, respectively). Capillary volume density within peripheral villi significantly decreased in the FGR placentas compared with the AGA group (p<0...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#14
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28707738/prenatal-exposure-to-dexamethasone-in-the-mouse-induces-sex-specific-differences-in-placental-gene-expression
#15
Ji-Yeon Lee, Hyo Jung Yun, Clara Yuri Kim, Yong Woo Cho, Yongmin Lee, Myoung Hee Kim
Prenatal stress during pregnancy leads to sex-specific effects on fetal development and disease susceptibility over the life span; however, the origin of sex differences has not been identified. The placenta not only plays a key role in fetal growth and development throughout pregnancy, but also affects the fetal programming underlying subsequent adult health and accounts. Therefore, sex-specific adaptation of the placenta may be central to the sex differences in fetal growth and survival. Here, we analyzed the effects of prenatal dexamethasone (Dex) on sex-specific changes in placental gene expression using RNA-Seq...
July 14, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28693373/prenatal-growth-patterns-and-birthweight-are-associated-with-differential-dna-methylation-and-gene-expression-of-cardiometabolic-risk-genes-in-human-placentas-a-discovery-based-approach
#16
Pao-Yang Chen, Alison Chu, Wen-Wei Liao, Liudmilla Rubbi, Carla Janzen, Fei-Man Hsu, Shanthie Thamotharan, Amit Ganguly, Larry Lam, Dennis Montoya, Matteo Pellegrini, Sherin U Devaskar
Inherent genetic programming and environmental factors affect fetal growth in utero. Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or large for gestational age (LGA), demonstrate that these newborns are at increased risk of cardiometabolic disease in adulthood. There is growing evidence that the in utero environment leads to epigenetic modification, contributing to eventual risk of developing heart disease or diabetes. In this study, we used reduced representation bisulfite sequencing to examine genome-wide DNA methylation variation in placental samples from offspring born IUGR, LGA, and appropriate for gestational age (AGA) and to identify differential methylation of genes important for conferring risk of cardiometabolic disease...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28623979/placental-glucose-transporter-glut-1-is-down-regulated-in-preeclampsia
#17
Benjamin P Lüscher, Camilla Marini, Marianne S Joerger-Messerli, Xiao Huang, Matthias A Hediger, Christiane Albrecht, Marc U Baumann, Daniel V Surbek
INTRODUCTION: Transplacental fetal glucose supply is predominantly regulated by glucose transporter-1 (GLUT1). Altered expression and/or function of GLUT1 may affect the intrauterine environment, which could compromise fetal development and may contribute to fetal programming. To date it is unknown whether placental GLUT1 is affected by preeclampsia, which is often associated with intrauterine growth restriction (IUGR). We addressed the hypothesis that preeclampsia leads to decreased expression and function of placental GLUT1...
July 2017: Placenta
https://www.readbyqxmd.com/read/28613964/early-and-late-onset-preeclampsia-and-the-dna-methylation-of-circadian-clock-and-clock-controlled-genes-in-placental-and-newborn-tissues
#18
C B van den Berg, I Chaves, E M Herzog, S P Willemsen, G T J van der Horst, R P M Steegers-Theunissen
The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of preeclampsia (PE). Fetal and placental developments are influenced by epigenetic programming. There is some evidence that PE is controlled to an altered circadian homeostasis. In a nested case-control study embedded in the Rotterdam Periconceptional Cohort, we obtained placental tissue, umbilical cord leukocytes (UCL), and human umbilical venous endothelial cells of 13 early-onset PE, 16 late-onset PE and 83 controls comprising 36 uncomplicated and 47 complicated pregnancies, i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28604825/burden-and-impact-of-plasmodium-vivax-in-pregnancy-a-multi-centre-prospective-observational-study
#19
MULTICENTER STUDY
Azucena Bardají, Flor Ernestina Martínez-Espinosa, Myriam Arévalo-Herrera, Norma Padilla, Swati Kochar, Maria Ome-Kaius, Camila Bôtto-Menezes, María Eugenia Castellanos, Dhanpat Kumar Kochar, Sanjay Kumar Kochar, Inoni Betuela, Ivo Mueller, Stephen Rogerson, Chetan Chitnis, Dhiraj Hans, Michela Menegon, Carlo Severini, Hernando Del Portillo, Carlota Dobaño, Alfredo Mayor, Jaume Ordi, Mireia Piqueras, Sergi Sanz, Mats Wahlgren, Laurence Slutsker, Meghna Desai, Clara Menéndez
BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28502862/11-beta-hydroxysteroid-dehydrogenase-2-promoter-methylation-is-associated-with-placental-protein-expression-in-small-for-gestational-age-newborns
#20
Maria-Luisa Lazo-de-la-Vega-Monroy, Martha-Olivia Solís-Martínez, Gustavo Romero-Gutiérrez, Victor E Aguirre-Arzola, Katarzyna Wrobel, Kazimierz Wrobel, Silvio Zaina, Gloria Barbosa-Sabanero
Small for gestational age infants have greater risk of developing metabolic diseases in adult life. It has been suggested that low birth weight may result from glucocorticoid excess in utero, a key mechanism in fetal programming. The placental enzyme 11-beta hydroxysteroid dehydrogenase type 2 (11β-HSD2, HSD11B2 gene) acts as a barrier protecting the fetus from maternal corticosteroid deleterious effects. Low placental 11β-HSD2 transcription and activity have been associated with low birth weight, yet the mechanism regulating its protein expression is not fully understood...
May 11, 2017: Steroids
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