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Placenta fetal programming

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https://www.readbyqxmd.com/read/28794104/prenatal-hypoxia-and-placental-oxidative-stress-linkages-to-developmental-origins-of-cardiovascular-disease
#1
Mais M Aljunaidy, Jude S Morton, Christy-Lynn Cooke, Sandra T Davidge
Intrauterine growth restriction (IUGR, a pregnancy complication where the fetus does not reach its genetic growth potential) is a leading cause of fetal morbidity and mortality with a significant impact on population health. IUGR is associated with gestational hypoxia; which can lead to placental oxidative stress and fetal programming of cardiovascular disease. Mitochondria are a major source of placental oxidative stress and may provide a therapeutic target to mitigate the detrimental effects of placental oxidative stress on pregnancy outcomes...
August 9, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28755466/hypospadias-intrauterine-growth-restriction-and-abnormalities-of-the-placenta
#2
M Hassan Toufaily, Drucilla J Roberts, Marie-Noel Westgate, Anne-Therese Hunt, Lewis B Holmes
BACKGROUND: Hypospadias is more common among male infants with growth restriction, defined as a birth weight less than the 10(th) centile, than in infants with a normal birth weight. Intrauterine growth retardation (IUGR) has been associated, also, with abnormalities of the placenta, such as maternal vascular malperfusion. In a consecutive sample of newborn infants, the association between hypospadias, IUGR and abnormalities of the placenta could be analyzed. METHODS: Affected infants were identified among 289,365 liveborn and stillborn infants in the Active Malformations Surveillance Program between 1972 and 2012...
July 29, 2017: Birth defects research
https://www.readbyqxmd.com/read/28751217/human-placenta-expresses-both-peripheral-and-neuronal-isoform-of-tryptophan-hydroxylase
#3
Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancourt
The role of placental serotonin has been an active topic of research notably because of its crucial role in brain development. However, which cell types synthesize serotonin in human placenta remains unknown. Moreover, it is not known if the two tryptophan hydroxylase isoforms (TPH1 and TPH2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. Human placentas were obtained in first trimester or at term, and trophoblast cells were isolated and purified using a magnetic cell sorter and placed in primary culture...
September 2017: Biochimie
https://www.readbyqxmd.com/read/28744866/effect-of-moderate-30-percent-global-maternal-nutrient-reduction-on-fetal-and-postnatal-baboon-phenotype
#4
Cun Li, Susan Jenkins, Vicki Mattern, Anthony G Comuzzie, Laura A Cox, Hillary F Huber, Peter W Nathanielsz
BACKGROUND: Most developmental programming studies on maternal nutrient reduction (MNR) are in altricial rodents whose maternal nutritional burden and offspring developmental trajectory differ from precocial non-human primates and humans. METHODS: Control (CTR) baboon mothers ate ad libitum; MNR mothers ate 70% global control diet in pregnancy and lactation. RESULTS: We present offspring morphometry, blood cortisol, and adrenocorticotropin (ACTH) during second half of gestation (G) and first three postnatal years...
July 26, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28730238/altered-expression-of-mtor-and-autophagy-in-term-normal-human-placentas
#5
Qiu Xia Zhang, Quan Na, Weiwei Song
Mammalian target of rapamycin (mTOR) and autophagy have been implied in trophoblast cells proliferation and invasion. This study investigated whether mTOR and autophagy were involved in placental development and fetal programming. A total of 90 term normal placentas (37-42 gestational weeks) were collected from women who underwent elective cesarean section, with large for gestational age (LGA), fetal growth restriction (FGR), and appropriate for gestational age (AGA) infants (n=30, respectively). Capillary volume density within peripheral villi significantly decreased in the FGR placentas compared with the AGA group (p<0...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#6
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28707738/prenatal-exposure-to-dexamethasone-in-the-mouse-induces-sex-specific-differences-in-placental-gene-expression
#7
Ji-Yeon Lee, Hyo Jung Yun, Clara Yuri Kim, Yong Woo Cho, Yongmin Lee, Myoung Hee Kim
Prenatal stress during pregnancy leads to sex-specific effects on fetal development and disease susceptibility over the life span; however, the origin of sex differences has not been identified. The placenta not only plays a key role in fetal growth and development throughout pregnancy, but also affects the fetal programming underlying subsequent adult health and accounts. Therefore, sex-specific adaptation of the placenta may be central to the sex differences in fetal growth and survival. Here, we analyzed the effects of prenatal dexamethasone (Dex) on sex-specific changes in placental gene expression using RNA-Seq...
July 14, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28693373/prenatal-growth-patterns-and-birthweight-are-associated-with-differential-dna-methylation-and-gene-expression-of-cardiometabolic-risk-genes-in-human-placentas-a-discovery-based-approach
#8
Pao-Yang Chen, Alison Chu, Wen-Wei Liao, Liudmilla Rubbi, Carla Janzen, Fei-Man Hsu, Shanthie Thamotharan, Amit Ganguly, Larry Lam, Dennis Montoya, Matteo Pellegrini, Sherin U Devaskar
Inherent genetic programming and environmental factors affect fetal growth in utero. Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or large for gestational age (LGA), demonstrate that these newborns are at increased risk of cardiometabolic disease in adulthood. There is growing evidence that the in utero environment leads to epigenetic modification, contributing to eventual risk of developing heart disease or diabetes. In this study, we used reduced representation bisulfite sequencing to examine genome-wide DNA methylation variation in placental samples from offspring born IUGR, LGA, and appropriate for gestational age (AGA) and to identify differential methylation of genes important for conferring risk of cardiometabolic disease...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28623979/placental-glucose-transporter-glut-1-is-down-regulated-in-preeclampsia
#9
Benjamin P Lüscher, Camilla Marini, Marianne S Joerger-Messerli, Xiao Huang, Matthias A Hediger, Christiane Albrecht, Marc U Baumann, Daniel V Surbek
INTRODUCTION: Transplacental fetal glucose supply is predominantly regulated by glucose transporter-1 (GLUT1). Altered expression and/or function of GLUT1 may affect the intrauterine environment, which could compromise fetal development and may contribute to fetal programming. To date it is unknown whether placental GLUT1 is affected by preeclampsia, which is often associated with intrauterine growth restriction (IUGR). We addressed the hypothesis that preeclampsia leads to decreased expression and function of placental GLUT1...
July 2017: Placenta
https://www.readbyqxmd.com/read/28613964/early-and-late-onset-preeclampsia-and-the-dna-methylation-of-circadian-clock-and-clock-controlled-genes-in-placental-and-newborn-tissues
#10
C B van den Berg, I Chaves, E M Herzog, S P Willemsen, G T J van der Horst, R P M Steegers-Theunissen
The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of preeclampsia (PE). Fetal and placental developments are influenced by epigenetic programming. There is some evidence that PE is controlled to an altered circadian homeostasis. In a nested case-control study embedded in the Rotterdam Periconceptional Cohort, we obtained placental tissue, umbilical cord leukocytes (UCL), and human umbilical venous endothelial cells of 13 early-onset PE, 16 late-onset PE and 83 controls comprising 36 uncomplicated and 47 complicated pregnancies, i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28604825/burden-and-impact-of-plasmodium-vivax-in-pregnancy-a-multi-centre-prospective-observational-study
#11
MULTICENTER STUDY
Azucena Bardají, Flor Ernestina Martínez-Espinosa, Myriam Arévalo-Herrera, Norma Padilla, Swati Kochar, Maria Ome-Kaius, Camila Bôtto-Menezes, María Eugenia Castellanos, Dhanpat Kumar Kochar, Sanjay Kumar Kochar, Inoni Betuela, Ivo Mueller, Stephen Rogerson, Chetan Chitnis, Dhiraj Hans, Michela Menegon, Carlo Severini, Hernando Del Portillo, Carlota Dobaño, Alfredo Mayor, Jaume Ordi, Mireia Piqueras, Sergi Sanz, Mats Wahlgren, Laurence Slutsker, Meghna Desai, Clara Menéndez
BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28502862/11-beta-hydroxysteroid-dehydrogenase-2-promoter-methylation-is-associated-with-placental-protein-expression-in-small-for-gestational-age-newborns
#12
Maria-Luisa Lazo-de-la-Vega-Monroy, Martha-Olivia Solís-Martínez, Gustavo Romero-Gutiérrez, Victor E Aguirre-Arzola, Katarzyna Wrobel, Kazimierz Wrobel, Silvio Zaina, Gloria Barbosa-Sabanero
Small for gestational age infants have greater risk of developing metabolic diseases in adult life. It has been suggested that low birth weight may result from glucocorticoid excess in utero, a key mechanism in fetal programming. The placental enzyme 11-beta hydroxysteroid dehydrogenase type 2 (11β-HSD2, HSD11B2 gene) acts as a barrier protecting the fetus from maternal corticosteroid deleterious effects. Low placental 11β-HSD2 transcription and activity have been associated with low birth weight, yet the mechanism regulating its protein expression is not fully understood...
May 11, 2017: Steroids
https://www.readbyqxmd.com/read/28490442/dexamethasone-and-sex-regulate-placental-glucocorticoid-receptor-isoforms-in-mice
#13
James Sm Cuffe, Zarqa Saif, Anthony V Perkins, Karen M Moritz, Vicki L Clifton
Maternal dexamethasone exposure in the mouse impairs placental development and programs adult disease in a sexually dimorphic manner. Glucocorticoids bind to different glucocorticoid receptor (GR) isoforms to regulate gene transcription and cellular signaling. We hypothesized that sexually dimorphic placental responses to glucocorticoids are due to differences in GR isoforms present in the placenta. Pregnant C57Bl6 mice were exposed to saline or dexamethasone from E12.5 until E14.5 (1µg/kg/h) before the collection of placentae...
May 10, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28486003/placental-lipoprotein-lipase-dna-methylation-alterations-are-associated-with-gestational-diabetes-and-body-composition-at-5%C3%A2-years-of-age
#14
Valérie Gagné-Ouellet, Andrée-Anne Houde, Simon-Pierre Guay, Patrice Perron, Daniel Gaudet, Renée Guérin, Baillargeon Jean-Patrice, Hivert Marie-France, Diane Brisson, Luigi Bouchard
Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming. The aims of this study were to assess whether placental DNA methylation (DNAm) marks were associated with maternal GDM status and to offspring body composition at 5 years old in a prospective birth cohort. DNAm levels were measured in the fetal side of the placenta in 66 samples (24 from GDM mothers) using bisDNA-pyrosequencing...
May 9, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28451583/pregnancy-an-underutilized-window-of-opportunity-to-improve-long-term-maternal-and-infant-health-an-appeal-for-continuous-family-care-and-interdisciplinary-communication
#15
REVIEW
Birgit Arabin, Ahmet A Baschat
Physiologic adaptations during pregnancy unmask a woman's predisposition to diseases. Complications are increasingly predicted by first-trimester algorithms, amplify a pre-existing maternal phenotype and accelerate risks for chronic diseases in the offspring up to adulthood (Barker hypothesis). Recent evidence suggests that vice versa, pregnancy diseases also indicate maternal and even grandparent's risks for chronic diseases (reverse Barker hypothesis). Pub-Med and Embase were reviewed for Mesh terms "fetal programming" and "pregnancy complications combined with maternal disease" until January 2017...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28422862/prevalence-of-abnormally-invasive-placenta-among-deliveries-in-mainland-china-a-prisma-compliant-systematic-review-and-meta-analysis
#16
REVIEW
Dazhi Fan, Song Li, Shuzhen Wu, Wen Wang, Shaoxin Ye, Qing Xia, Li Liu, Jinping Feng, Song Wu, Xiaoling Guo, Zhengping Liu
BACKGROUND: Abnormally invasive placenta (AIP) or placenta accreta (PA) is considered numerous adverse maternal and fetal-neonatal complications. There has been no detailed study to characterize the prevalence of AIP among deliveries in mainland China. OBJECTIVES: We aimed to fill this gap and obtained overall and regional estimates of AIP prevalence via a systematic review and meta-analysis. METHODS: This systematic review and meta-analysis was totally performed following the Meta-analysis of Observational Studies in Epidemiology guidelines for systematic reviews of observational studies, and the Preferred Reporting Items for Systematic reviews and Meta-Analysis statement for reporting systematic reviews and meta-analysis...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28394461/successful-treatment-of-infertility-in-a-female-sumatran-orangutan-pongo-abelii
#17
Neil Maclachlan, Gordon Hunt, Sarah Fowkes, Melissa Frost, John Miller, Gari Purcell-Jones, Peter Sullivan, Alberto Barbon, Andrew Routh, Francisco J López, Eluned C Price
In 2011, a female Sumatran orangutan housed at Durrell Wildlife Conservation Trust became infertile following a massive antepartum hemorrhage in labor and the delivery of a stillborn infant. The placenta was infected with Pantoea sp. Hysterosalpingography (HSG) revealed blocked fallopian tubes, and pressurized fallopian tube perfusion was used to reverse the tubal occlusion. She subsequently conceived and following an intensive training program, we were able to measure umbilical artery waveform analysis for fetal well-being and placental localization to exclude placenta previa, which could complicate pregnancy and lead to catastrophic hemorrhage...
March 2017: Zoo Biology
https://www.readbyqxmd.com/read/28382413/neurodevelopmental-consequences-in-offspring-of-mothers-with-preeclampsia-during-pregnancy-underlying-biological-mechanism-via-imprinting-genes
#18
REVIEW
Yoko Nomura, Rosalind M John, Anna Bugge Janssen, Charles Davey, Jackie Finik, Jessica Buthmann, Vivette Glover, Luca Lambertini
PURPOSE: Preeclampsia is known to be a leading cause of mortality and morbidity among mothers and their infants. Approximately 3-8% of all pregnancies in the US are complicated by preeclampsia and another 5-7% by hypertensive symptoms. However, less is known about its long-term influence on infant neurobehavioral development. The current review attempts to demonstrate new evidence for imprinting gene dysregulation caused by hypertension, which may explain the link between maternal preeclampsia and neurocognitive dysregulation in offspring...
June 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28380326/sex-specific-differences-and-developmental-programming-for-diseases-in-later-life
#19
Deepali P Sundrani, Suchitra S Roy, Anjali T Jadhav, Sadhana R Joshi
Epidemiological data indicate that developmental programming of various non-communicable diseases (NCDs) occurs as a consequence of altered maternal metabolic and physiological status due to a number of environmental insults during pregnancy. Sex-specific differences have also been reported in most NCDs. Evidence suggests that beginning from conception, the maternal and neonatal metabolic environment, including hormones, contributes to sex-specific placental development. The placenta then regulates the sex-specific differences in NCDs via the epigenetic mechanisms that are further affected by hormones...
April 6, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28379294/colony-stimulating-factor-2-acts-from-days-5-to-7-of-development-to-modify-programming-of-the-bovine-conceptus-at-day-86-of-gestation%C3%A2
#20
Luiz G Siqueira, Paula Tribulo, Zhiyuan Chen, Anna C Denicol, M Sofia Ortega, Veronica M Negrón-Pérez, Jasmine Kannampuzha-Francis, Ky G Pohler, Rocio M Rivera, Peter J Hansen
Colony-stimulating factor 2 (CSF2) is an embryokine that improves competence of the embryo to establish pregnancy and which may participate in developmental programming. We tested whether culture of bovine embryos with CSF2 alters fetal development and alleviates abnormalities associated with in vitro production (IVP) of embryos. Pregnancies were established by artificial insemination (AI), transfer of an IVP embryo (IVP), or transfer of an IVP embryo treated with 10 ng/ml CSF2 from day 5 to 7 of development (CSF2)...
April 1, 2017: Biology of Reproduction
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