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premature ovarian failure

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https://www.readbyqxmd.com/read/27912078/mouse-double-minute-2-homolog-actively-suppresses-p53-activity-in-oocytes-during-mouse-folliculogenesis
#1
Chen-Xi Zhang, Qin Zhang, Yin-Yin Xie, Xue-Yan He, Cong Xiang, Xiao-Shuang Hou, Ying Zhou, Lai Chen, Guo-Xin Zhang, Geng Liu
The p53 signaling network is indispensible in cellular stress responses and tumor suppression. Negative regulations of p53 by mouse double minute 2 and 4 homologs (MDM2) and (MDM4) are an integrated component of the network and have been implicated in regulating the stress responses and the maintenance of normal development and homeostasis of multiple somatic cell lineages. However, the regulatory role of MDM2 on p53 and stress responses in female germ cells remains undetermined. Here, we used the Cre-loxP system to delete Mdm2 in oocytes at different stages of folliculogenesis in mice...
November 29, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#2
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27876427/fmr1-premutation-not-only-important-in-premature-ovarian-failure-but-also-in-diminished-ovarian-reserve
#3
Ali Eslami, Kamelia Farahmand, Mehdi Totonchi, Tahereh Madani, Ummulbanin Asadpour, Shabnam Zari Moradi, Hamid Gourabi, Anahita Mohseni-Meybodi
It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but their role in diminished ovarian reserve (DOR) is not clearly established. Moreover, the impact of smaller repeats at the boundary of premutation and normal is less clear. Therefore, we have compared the frequency of these intermediate (45-54 repeats) and premutation (>55) sized FMR1 CGG repeats among a patients group including 188 DOR and 173 POF women and 200 controls. FSH and LH concentrations were also compared between intermediate and premutation ranges in patients...
November 23, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27830391/robotically-assisted-laparoscopic-ovarian-transposition-in-women-with-lower-gastrointestinal-cancer-undergoing-pelvic-radiotherapy
#4
Vasileios D Sioulas, Soledad Jorge, Jing-Yi Chern, Maria B Schiavone, Martin R Weiser, Joanne F Kelvin, Ginger J Gardner, Yukio Sonoda, Nadeem R Abu-Rustum, Karyn A Goodman, Mario M Leitao
BACKGROUND: Pelvic radiotherapy (RT) is a standard component of the management for patients with locally advanced rectal cancer or squamous cell carcinoma of the anus. Pelvic RT leads to permanent and irreversible ovarian failure in young women. This study aimed to determine the effectiveness of robotically assisted laparoscopic ovarian transposition (OT) before RT in women with rectal or anal cancer who wanted to preserve normal ovarian function. METHODS: The study reviewed the medical records of all patients treated at our institution from August 2009 to October 2014 who received robotically assisted laparoscopic OT for rectal or anal cancer before RT...
November 9, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27802832/reproductive-issues-in-patients-undergoing-hematopoietic-stem-cell-transplantation-an-update
#5
REVIEW
Maurizio Guida, Maria Antonietta Castaldi, Rosa Rosamilio, Valentina Giudice, Francesco Orio, Carmine Selleri
In 1963 George Mathé announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. Since than much progress has been made and nowadays Hematopoietic Stem Cell Transplantation (HSCT) is considered the most effective treatment of numerous severe haematological diseases. Gynaecological complications in HSCT women represent a serious concern for these patients, but often underestimated by clinicians in the view of Overall Survival. The main gynaecological complications of HSCT are represented by: premature ovarian failure (POF), thrombocytopenia-associated menorrhagia, genital symptoms or sexual problems in course of chronic GVHD (cGVHD), osteoporosis, secondary solid tumours due to immunosuppressive drugs to treat cGVHD and severity of cGVHD, and fertility and pregnancy issues...
November 1, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27787477/assessment-of-ovarian-reserve-and-fertility-preservation-strategies-in-children-treated-for-cancer
#6
Laura Guzy, Isabelle Demeestere
INTRODUCTION: The survival rate of chemotherapy treatments of malignant cancer or non- malignant conditions are continuously improving. As a result, there is an increased number of patients who received a gonadotoxic treatment during childhood and who later face fertility issues. Depending on the extent of the damage to the ovaries, acute or late complications may occur. Acute ovarian failure is defined by permanent amenorrhea after a high-risk treatment. When the drugs used are less gonadotoxic, ovarian insufficiency might appear later...
October 27, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27775808/letter-to-the-editor-dtc-chemotherapy-regimen-is-associated-with-higher-incidence-of-premature-ovarian-failure-in-women-of-reproductive-age-with-breast-cancer
#7
L Del Pup, G Codacci Pisanelli, S Schettini, M Guido, F A Peccatori
No abstract text is available yet for this article.
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27769945/akt-activation-by-evodiae-fructus-extract-protects-ovary-against-4-vinylcyclohexene-diepoxide-induced-ovotoxicity
#8
Eun-Young Nam, Sun Ah Kim, Heejung Kim, Su-Hyun Kim, Jae-Hyun Han, Ju-Hee Lee, Dong-Il Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Evodiae Fructus (EF) is the dried, unripe fruit of Evodia rutaecarpa Benth., and one of the main components of traditional herbal prescriptions issued for the treatment of sterility caused by irregular menstruation in Korea. However, scientific evidence regarding the efficacy and action mechanism of EF is lacking. AIM OF THE STUDY: In this study, the authors established an in vitro screening tool to identify promising new drug candidates in herbal medicines for the prevention and treatment of premature ovarian failure...
October 18, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27759460/occult-form-of-premature-ovarian-insufficiency
#9
I G Shestakova, V E Radzinsky, M B Khamoshina
Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Despite the description of different genetic, immune and iatrogenic factors of POI, the etiology of most cases of this disease are unexplained, and optimal management strategies are still unclear. Recent data showed that POI may have a long period of oligomenorrhea before the fully developed form (complete ovarian failure stage), with the occurrence of amenorrhea and climacteric symptoms...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27753132/premature-ovarian-insufficiency-is-a-lifelong-condition
#10
Jane Stewart
No abstract text is available yet for this article.
October 18, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27729272/cyclophosphamide-promotes-the-proliferation-inhibition-of-mouse-ovarian-granulosa-cells-and-premature-ovarian-failure-by-activating-the-lncrna-meg3-p53-p66shc-pathway
#11
Ying Xiong, Te Liu, Suwei Wang, Huiying Chi, Chuan Chen, Jin Zheng
The dysfunction of ovarian granulosa cells (OGCs) directly affects the premature ovarian failure (POF). In vivo experiments showed that cyclophosphamide significantly induced mouse ovarian atrophy and proliferation inhibition of OGCs. The expressions of p53, p66Shc and p16 were significantly higher in OGCs of the cyclophosphamide treatment group. MTT assay showed that cyclophosphamide effectively inhibited the proliferation of OGCs in vitro. SA-β-Gal staining showed that the OGCs in the cyclophosphamide treatment group had many senescent cells...
October 8, 2016: Gene
https://www.readbyqxmd.com/read/27716277/array-cgh-diagnosis-in-ovarian-failure-identification-of-new-molecular-actors-for-ovarian-physiology
#12
Sylvie Jaillard, Linda Akloul, Marion Beaumont, Houda Hamdi-Roze, Christele Dubourg, Sylvie Odent, Solène Duros, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Célia Ravel
BACKGROUND: Ovarian failure (OF) is considered premature if it occurs before the age of 40. This study investigates the genetic aetiology underlying OF in women under the age of 40 years. METHODS: We conducted an experimental prospective study performing all genome microarrays in 60 patients younger than 40 years presenting an OF revealed by a decrease of circulating Anti-Müllerian Hormone (AMH) and leading to an oocyte donation program. RESULTS: We identified nine significant copy number variations (CNVs) including candidate genes potentially implicated in reproductive function...
October 3, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27698028/a-grafted-ovarian-fragment-rescues-host-fertility-after-chemotherapy
#13
Iordan Stefanov Batchvarov, Rachel Williamson Taylor, Ximena Bustamante-Marín, Michael Czerwinski, Erika Segear Johnson, Sally Kornbluth, Blanche Capel
STUDY QUESTION: Can host fertility be rescued by grafting of a fragment of a healthy ovary soon after chemotherapy? SUMMARY ANSWER: We found that grafting a green fluorescent protein (GFP)-positive fragment from a healthy isogenic ovary to the left ovary of a chemo-treated host rescued function and fertility of the grafted host ovary, and resulted in the production of host-derived offspring as late as the sixth litter after chemotherapy (CTx) treatment, whereas none of the ungrafted controls produced a second litter...
October 3, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27689876/lh-prevents-cisplatin-induced-apoptosis-in-oocytes-and-preserves-female-fertility-in-mouse
#14
Valerio Rossi, Monica Lispi, Salvatore Longobardi, Maurizio Mattei, Francesca Di Rella, Antonietta Salustri, Massimo De Felici, Francesca G Klinger
Premature ovarian failure and female infertility are frequent side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes to the damaging effects of irradiation and chemotherapy on DNA. We report here a robust protective effect of luteinizing hormone (LH) on the primordial follicle pool of prepubertal ovaries against the cisplatin (Cs)-induced apoptosis. In vitro LH treatment of prepubertal ovarian fragments generated anti-apoptotic signals by a subset of ovarian somatic cells expressing LH receptor (LHR) through cAMP/PKA and Akt pathways...
September 30, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27687697/widespread-dna-hypomethylation-and-differential-gene-expression-in-turner-syndrome
#15
Christian Trolle, Morten Muhlig Nielsen, Anne Skakkebæk, Philippe Lamy, Søren Vang, Jakob Hedegaard, Iver Nordentoft, Torben Falck Ørntoft, Jakob Skou Pedersen, Claus Højbjerg Gravholt
Adults with 45,X monosomy (Turner syndrome) reflect a surviving minority since more than 99% of fetuses with 45,X monosomy die in utero. In adulthood 45,X monosomy is associated with increased morbidity and mortality, although strikingly heterogeneous with some individuals left untouched while others suffer from cardiovascular disease, autoimmune disease and infertility. The present study investigates the leukocyte DNAmethylation profile by using the 450K-Illumina Infinium assay and the leukocyte RNA-expression profile in 45,X monosomy compared with karyotypically normal female and male controls...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27651498/ovarioleukodystrophy-due-to-eif2b5-mutations
#16
R T Ibitoye, S A Renowden, H J Faulkner, N J Scolding, C M Rice
Ovarioleukodystrophy-the co-occurrence of leukodystrophy and premature ovarian failure-is a rare presentation now recognised to be part of the clinical spectrum of vanishing white matter disease. We describe a woman with epilepsy and neuroimaging changes consistent with leukoencephalopathy who presented with non-convulsive status epilepticus after starting hormone replacement therapy in the context of premature ovarian failure. Genetic testing confirmed her to be a compound heterozygote for EIF2B5 mutations; the gene encodes a subunit of eukaryotic translation initiation factor 2B...
September 20, 2016: Practical Neurology
https://www.readbyqxmd.com/read/27647193/hydrogen-rich-water-exerting-a-protective-effect-on-ovarian-reserve-function-in-a-mouse-model-of-immune-premature-ovarian-failure-induced-by-zona-pellucida-3
#17
Xin He, Shu-Yu Wang, Cheng-Hong Yin, Tong Wang, Chan-Wei Jia, Yan-Min Ma
BACKGROUND: Premature ovarian failure (POF) is a disease that affects female fertility but has few effective treatments. Ovarian reserve function plays an important role in female fertility. Recent studies have reported that hydrogen can protect male fertility. Therefore, we explored the potential protective effect of hydrogen-rich water on ovarian reserve function through a mouse immune POF model. METHODS: To set up immune POF model, fifty female BALB/c mice were randomly divided into four groups: Control (mice consumed normal water, n = 10), hydrogen (mice consumed hydrogen-rich water, n = 10), model (mice were immunized with zona pellucida glycoprotein 3 [ZP3] and consumed normal water, n = 15), and model-hydrogen (mice were immunized with ZP3 and consumed hydrogen-rich water, n = 15) groups...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27644002/controversies-over-the-use-of-gnrh-agonists-for-reduction-of-chemotherapy-induced-gonadotoxicity
#18
M F Garrido-Oyarzún, C Castelo-Branco
The increase in cancer incidence in younger people and the significant improvement in long and permanent remission have brought concern about their reproductive future and quality of life. Up to two-thirds of adult female patients undergoing chemotherapy for malignancies eventually develop premature ovarian failure. This condition is related to many complaints including vasomotor symptoms, osteoporosis, increased risk of cardiovascular diseases, sexual dysfunction, and infertility. Therefore, protection against iatrogenic infertility and loss of endocrine ovarian function caused by chemotherapy is currently of high priority...
September 17, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27612992/the-comparison-of-animal-models-for-premature-ovarian-failure-established-by-several-different-source-of-inducers
#19
Ting Zhang, Dawei Yan, Yang Yang, Aicui Ma, Lei Li, Zhonghui Wang, Qi Pan, Zuyue Sun
The objective of this study was to compare premature ovarian failure animal models established by several different source of inducers. Female ICR mice, KM mice, and SD rats were treated by cyclophosphamide at 120 mg/kg, busulfan at 12 mg/kg, cisplatin at 3 or 4 mg/kg, 4-vinylcyclohexene diepoxide at 160 mg/kg, 35% galactose food pellet, and tripterygium glycosides at 50 mg/kg, respectively. Parameters were analyzed by body weight, serum concentration level of related hormones, ovarian and uterine pathological examination...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27581083/dysregulation-of-follicle-development-in-a-mouse-model-of-premature-ovarian-insufficiency
#20
P Grasa, S Sheikh, N Krzys, K Millar, S Janjua, P Nawaggi, S A Williams
Premature ovarian insufficiency (POI) occurs in 1% of reproductive-age women. The ovarian manifestation ranges from the presence of a variable population of follicles (follicular) to the absence of follicles (afollicular), and in the majority of cases the cause is unknown. A transgenic mouse model of follicular POI, the Double Mutant (DM), arises from oocyte-specific deletion of Mgat1 and C1galt1 required for the generation of O- and N-glycans. DM females are subfertile at 6 weeks, infertile by 9 weeks and exhibit POI by 12 weeks of age...
November 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
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