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premature ovarian failure

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https://www.readbyqxmd.com/read/28499912/cyclophosphamide-and-acrolein-induced-oxidative-stress-leading-to-deterioration-of-metaphase-ii-mouse-oocyte-quality
#1
Roohi Jeelani, Sana N Khan, Faten Shaeib, Hamid-Reza Kohan-Ghadr, Sarah R Aldhaheri, Tohid Najafi, Mili Thakur, Robert Morris, Husam M Abu-Soud
Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and or its main metabolite, acrolein, affect female fertility remains unclear, but it is thought to be caused by an overproduction of reactive oxygen species (ROS). Here, we investigated the effect of CTX on metaphase II mouse oocytes obtained from treated animal (120mg/kg, 24 h of single treatment), and oocytes directly exposed to increasing concentrations of CTX and acrolein (n=480; 0, 5, 10, 25, 50, and 100μM) with and without cumulus cells (CCs) for 45min which correlates to the time of maximum peak plasma concentrations after administration...
May 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28485514/incidence-puberty-and-fertility-in-45-x-47-xxx-mosaicism-report-of-a-patient-and-a-literature-review
#2
Han Hyuk Lim, Hong Ryang Kil, Sun Hoe Koo
Turner syndrome (TS), characterized by short stature and premature ovarian failure, is caused by chromosomal aberrations with total or partial loss of one of the two X chromosomes. Spontaneous puberty, menarche, and pregnancy occur in some patients depending on the abnormality of the X. Moreover, spontaneous pregnancy is uncommon (<0.5%) for TS with 45,X monosomy. Among TS patients, 45,X/47,XXX karyotype is extremely rare. Previous reports have demonstrated that TS with 45,X/47,XXX is less severe than common TS due to higher occurrence of puberty (83%), menarche (57-67%), and fertility (14%) and lower occurrence of congenital anomalies (<5%)...
May 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28483347/the-potentiality-of-two-dimensional-preantral-follicle-culture-as-an-in-vitro-model-in-predicting-premature-ovarian-failure
#3
Ting Zhang, Ying Chen, Yang Yang, Zhonghui Wang, Qi Pan, Sichong Xu, Zuyue Sun
The purpose of this study is to identify the potential of a two-dimensional preantral follicle culture as an in vitro model of predicting premature ovarian failure. The two-dimensional preantral follicles culture method was established by cultivating preantral follicles collected from ICR F1 hybrids (aged 12-14days) for 12days. The preantral follicles were incubated with 0.54mg/ml cyclophosphamide, 0.5mg/ml busulfan, 0.12mg/ml cisplatin, 3.12mg/ml 4-vinylcyclohexene diepoxide, 5mg/ml D (+) galactose, and 0...
May 5, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28479757/premature-ovarian-failure-an-unusual-manifestation-of-systemic-sclerosis
#4
Aruna Nigam, Anupam Prakash, Shikha Sharma, Narendra Kumar
A 31-year-old woman presented with secondary amenorrhoea and inability to conceive, which was of 3 years duration. She had Raynaud's phenomenon for 16 years, primary hypothyroidism for 5 years, digital ulcers for 4 years and skin tightening for 2 years. She had an expressionless face, with loss of wrinkles and restriction of the mouth opening along with flexion contractures of the hands and the terminal digit resorptions. Investigations showed Antinuclear antibodies (ANA) and anti-Scl 70 positivity confirming the presence of systemic sclerosis (SSc)...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28454580/association-of-skewed-x-chromosome-inactivation-with-fmr1-cgg-repeat-length-and-anti-mullerian-hormone-levels-a-cohort-study
#5
David H Barad, Sarah Darmon, Andrea Weghofer, Gary J Latham, Filipovic-Sadic, Qi Wang, Vitaly A Kushnir, David F Albertini, Norbert Gleicher
BACKGROUND: Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, if so, is also associated with age adjusted antimüllerian hormone (AMH) levels as an indicator of functional ovarian reserve (FOR). METHODS: DNA samples of 58 women were analyzed for methylation status and confirmation of CGGn repeat length...
April 28, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28453508/viable-options-for-fertility-preservation-in-breast-cancer-patients-a-focus-on-latin-america
#6
Matteo Lambertini, Oranite Goldrat, Regina Barragan-Carrillo, Giulia Viglietti, Isabelle Demeestere, Cynthia Villarreal-Garza
Thanks to the improved survival outcomes observed in recent years, a growing attention has been given to the quality of life issues faced by young women with breast cancer such as fertility preservation and concerns related to future pregnancies. However, several challenges remain for young women with breast cancer considering undergoing fertility preservation strategies. Further specific issues on this regard should be taken into account in Latin America, where patients and physicians face particular barriers that hinder the routine adoption of this practice...
March 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28452156/understanding-follicle-growth-in-vitro-are-we-getting-closer-to-obtaining-mature-oocytes-from-in-vitro-grown-human-follicles-of-humans
#7
REVIEW
Yilmaz Guzel, Ozgur Oktem
Obtaining and fertilizing mature oocytes from immature follicles that were grown outside the body has conceptually attracted scientists for centuries, with initial attempts first documented in the 19(th) century. Significant progress has been made since then, due in part to a better understanding of folliculogenesis and improved techniques of in vitro follicle growth. Indeed, in vitro growth is now considered a reasonable approach to preserve or restore fertility when immature follicles and their oocytes need to be grown and matured outside the body...
April 27, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28439292/effects-of-bushen-tianjing-recipe-in-a-rat-model-of-tripterygium-glycoside-induced-premature-ovarian-failure
#8
Xiaofeng Xu, Yong Tan, Guorong Jiang, Xuanyi Chen, Rensheng Lai, Lurong Zhang, Guoqiang Liang
BACKGROUND: Bushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying molecular mechanism. In the present study, we investigated the effects of BTR in a tripterygium glycoside (TG)-induced-POF rat model. METHODS: Three doses of BTR were administered via intragastric gavage to adult female Sprague-Dawley (SD) rats with TG-induced POF...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28408160/physical-training-promotes-similar-effects-to-the-blockade-of-angiotensin-converting-enzyme-on-the-cardiac-morphology-and-function-in-old-female-rats-subjected-to-premature-ovarian-failure
#9
Ana Carolina S Felix, Sabrina G V Dutra, Ada C Gastaldi, Pâmela C Bonfim, Suenimeire Vieira, Hugo Celso Dutra de Souza
We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left ventricular contractibility (Langendorff Technique). Female Wistar ovariectomized (OVX) rats (n=42) were assigned to one of four groups: OVX, vehicle treated only; OVX-EM, Enalapril Maleate only (EM, 10mg·kg(-1)·d(-1)); OVX-T, aerobic trained only; and OVX-EMT, treated with Enalapril Maleate and aerobic trained...
April 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28398024/gonadotropin-releasing-hormone-analogues-for-the-prevention-of-chemotherapy-induced-premature-ovarian-failure-in-breast-cancer-patients
#10
Benedetta Conte, Lucia Del Mastro
Since the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual disfunction, and infertility1-5. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women6,7...
April 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28397217/-study-of-two-chinese-families-affected-with-resistant-ovarian-syndrome-resulted-from-novel-mutations-of-fshr-gene
#11
Wen Li, Wenbin He, Lihua Zhou, Xiao Hu, Shuangfei Li, Fei Gong, Yueqiu Tan
OBJECTIVE: To explore the genetic etiology for two Chinese families affected with hypergonadotropic amenorrhea and normal number of antral follicles. METHODS: Peripheral venous blood samples were collected from the families for the extraction of genomic DNA. Mutations of FSHR and LHCGR genes were screened using PCR and Sanger sequencing. Suspected pathogenic mutations were verified in other members of the families. Bioinformatics software and NCBI were used to analyze the pathogenicity of the mutations...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28395560/fertility-preservation-in-women-with-cns-tumors
#12
Alicia Tosoni, Damiano Balestrini, Alba A Brandes
Fertility impairment due to treatments is a major concern for adolescents and young adult patients who survived cancer. Areas covered: Chemotherapy may determine a detrimental effect on ovary function, leading to infertility, and premature ovarian failure. Embryo and oocyte cryopreservation is a standard strategy for fertility preservation; other strategies, such as gonadal tissue cryopreservation and the use of gonadotropin - releasing hormone agonist, are still considered experimental. There are few data available regarding the effect of pregnancy on glioma, which indicates tumor progression during pregnancy in 33-45% of patients...
May 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28389753/the-role-of-hsp70-in-the-regulation-of-autophagy-in-gametogenesis-pregnancy-and-parturition
#13
Steven S Witkin, Tomi T Kanninen, Giovanni Sisti
Induction of the 70 kDa heat shock protein (hsp70) and autophagy are two major mechanisms that promote cell homeostasis during the rapid cell growth and differentiation characteristic of reproduction. Hsp70 insures proper assembly, conformation, and intracellular transport of nascent proteins. Autophagy removes from the cytoplasm proteins, other macromolecules, and organelles that are no longer functional or needed and recycles their components for synthesis of new products under nutritionally limiting conditions...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28389520/oocyte-stem-cells-fact-or-fantasy
#14
Corrina J Horan, Suzannah Alice Williams
For many decades, the dogma prevailed that female mammals had a finite pool of oocytes at birth and this was gradually exhausted during a lifetime of reproductive function. However, in 2004, a new era began in the field of female oogenesis. A study was published that appeared to detect oocyte-stem cells capable of generating new eggs within mouse ovaries. This study was highly controversial and the years since this initial finding have produced extensive research and even more extensive debate into their possibility...
April 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28378324/review-of-clinical-indicators-including-serum-anti-m%C3%A3-llerian-hormone-levels-for-identification-of-women-who-should-consider-egg-freezing
#15
Fiona Martyn, Yvonne O'Brien, Mary Wingfield
OBJECTIVE: To identify women, on the basis of clinical history and serum anti-Müllerian hormone (AMH) levels, who are at risk of premature ovarian insufficiency and thereby guide appropriate early referral for egg freezing. METHODS: In a retrospective study, data were reviewed from women attending two fertility clinics in Dublin, Ireland, between August 2011 and December 2012. Case histories of women aged 35 years or younger were assessed to identify risk factors for reduced ovarian reserve, including endometriosis, ovarian surgery, and family history of premature ovarian failure (POF)...
April 4, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28377898/bmp15-and-gdf9-gene-mutations-in-premature-ovarian-failure
#16
Ravindra Kumar, Madhuri Alwani, Susmit Kosta, Ravjyot Kaur, Sarita Agarwal
BACKGROUND: Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. Mutations in bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been shown to be associated with POF. METHODS: Genomic DNA was isolated from 52 idiopathic premature ovarian failure patients and 100 normal control individuals. Exons of BMP15 and GDF9 gene were amplified using PCR method and subjected to directed sequencing...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28342855/regulation-of-reproduction-via-tight-control-of-gonadotropin-hormone-levels
#17
Djurdjica Coss
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH levels exhibit rhythmic changes throughout the menstrual or estrous cycle that are correlated with pulse frequency of GnRH. Lack of gonadotropins leads to infertility or amenorrhea. Dysfunctions in the tightly controlled ratio due to levels slightly outside the normal range occur in a larger number of women and are correlated with polycystic ovaries and premature ovarian failure...
March 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28333228/efficacy-of-ovarian-tissue-cryopreservation-for-fertility-preservation-lessons-learned-from-545-cases
#18
P Jadoul, A Guilmain, J Squifflet, M Luyckx, R Votino, C Wyns, M M Dolmans
STUDY QUESTION: How effective is ovarian tissue cryopreservation (OTC)? SUMMARY ANSWER: In our cohort of patients who underwent OTC, premature ovarian failure (POF) rates, return rates and pregnancy rates after autotransplantation were 31.5, 4.4 and 33%, respectively. WHAT IS KNOWN ALREADY: OTC for fertility purposes has been performed for >20 years now. With over 86 live births reported worldwide and success rates of ~30% after autotransplantation of frozen-thawed ovarian cortex, the procedure should no longer be considered experimental...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28323927/exome-sequencing-reveals-mutations-in-aire-as-a-cause-of-isolated-hypoparathyroidism
#19
Dong Li, Elizabeth A Streeten, Alice Chan, Wint Lwin, Lifeng Tian, Renata Pellegrino da Silva, Cecilia E Kim, Mark S Anderson, Hakon Hakonarson, Michael A Levine
Context: Most cases of autosomal recessive hypoparathyroidism (HYPO) are caused by loss-of-function mutations in GCM2 or PTH. Objective: The objective of this study was to identify the underlying genetic basis for isolated HYPO in a kindred in which 3 of 10 siblings were affected. Subjects: We studied the parents and the three adult affected subjects, each of whom was diagnosed with HYPO in the first decade of life. Methods: We collected clinical and biochemical data and performed whole exome sequencing analysis on DNA from the three affected subjects after negative genetic testing for known causes of HYPO...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28284481/premature-ovarian-failure-in-french-canadian-leigh-syndrome
#20
Chiraz Ghaddhab, Charles Morin, Catherine Brunel-Guitton, Grant A Mitchell, Guy Van Vliet, Céline Huot
In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases.
May 2017: Journal of Pediatrics
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