keyword
MENU ▼
Read by QxMD icon Read
search

premature ovarian failure

keyword
https://www.readbyqxmd.com/read/29781764/charged-iron-particles-found-in-galactic-cosmic-rays-are-potent-inducers-of-epithelial-ovarian-tumors
#1
Birendra Mishra, Gregory W Lawson, Ryan Ripperdan, Laura Ortiz, Ulrike Luderer
Astronauts traveling in deep space are exposed to high-charge and energy (HZE) particles from galactic cosmic rays. We have previously determined that irradiation of adult female mice with iron HZE particles induces DNA double-strand breaks, oxidative damage and apoptosis in ovarian follicles, causing premature ovarian failure. These effects occur at lower doses than with conventional photon irradiation. Ovarian failure with resultant loss of negative feedback and elevated levels of gonadotropin hormones is thought to play a role in the pathophysiology of ovarian cancer...
May 21, 2018: Radiation Research
https://www.readbyqxmd.com/read/29780295/successful-in-vitro-fertilization-and-embryo-transfer-after-transplantation-of-cryopreserved-ovarian-tissue-report-of-the-first-korean-case
#2
Jung Ryeol Lee, Dayong Lee, Soohyeon Park, Eun Chan Paik, Seul Ki Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
For patients at risk of premature ovarian failure with cancer treatment, it is an important option to re-implant the ovarian tissue (OT) after cryopreservation to preserve endocrine function and fertility. With this technique, about 30% of pregnancy success rate and about 90 live births have been reported to date. However, there has been no case report of successful in vitro fertilization (IVF) and embryo transfer (ET) with oocytes collected from transplanted cryopreserved OT in Korea. We report a 30-year old woman with rectal cancer who underwent IVF and ET after cryopreserved OT thawing and re-implantation...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29778464/peroxiredoxin-2-deficiency-accelerates-age-related-ovarian-failure-through-the-reactive-oxygen-species-mediated-jnk-pathway-in-mice
#3
Sun-Ji Park, Jung-Hak Kim, Dong Gil Lee, Jin-Man Kim, Dong-Seok Lee
Reactive oxygen species (ROS) produced in biological reactions have been shown to contribute to ovarian aging. Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that protects cells by scavenging ROS; however, its effect on age-related, oxidative stress-associated ovarian failure has not been reported. Here, we investigated its role in age-related ovarian dysfunction and 4-vinylcyclohexene diepoxide (VCD)-induced premature ovarian failure using Prx2-deficient mice. Compared to those in wildtype (WT) mice, serum levels of anti-Müllerian hormone, 17β-estradiol, and progesterone and numbers of follicles and corpora lutea were significantly lower in 18-month-old Prx2-/- mice...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29770151/research-on-establishment-of-abnormal-phlegmatic-syndrome-with-premature-ovarian-failure-rat-model-and-effects-of-balgham-munziq-treatment
#4
Muladili Yuemaier, Mayire Tuerhong, Abulizi Keremu, Nafeisha Kadeer, Ayiguzhali Aimaiti, Xilinguli Wushouer, Adilijiang Yiming, Xiamixinuer Yilike
This study aimed to establish and explore the biological basis of abnormal phlegmatic syndrome with premature ovarian failure (POF) model in rats based on the Uighur medicine (UM) in the first place and investigate the effects of unique herbal medicine, Balgham Munziq (BMq). Mature female Wistar rats were fed with spinach and coriander in cold and humid condition for approximately 20 weeks until abnormal phlegmatic syndrome (APS) model was established. When APS model was confirmed by Uighur medical experts, APS with POF disease rats were subdivided into APS with POF disease model group and APS with POF disease treated with BMq group; the rest of them were subdivided into APS model group and APS treated with BMq group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29755593/effect-of-stem-cell-transplantation-of-premature-ovarian-failure-in-animal-models-and-patients-a-meta-analysis-and-case-report
#5
Lei Chen, Shilei Guo, Cui Wei, Honglan Li, Haiya Wang, Yan Xu
Stem cell transplantation has been considered a promising therapeutic approach for premature ovarian failure (POF). However, to date, no quantitative data analysis of stem cell therapy for POF has been performed. Therefore, the present study performed a meta-analysis to assess the efficacy of stem cell transplantation in improving ovarian function in animal models of POF. In addition, a case report of a patient with POF subjected to stem cell treatment was included to demonstrate that stem cell therapy also contributes to the recovery of ovarian function in patients...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29752839/the-role-of-mtor-in-ovarian-cancer-polycystic-ovary-syndrome-and-ovarian-aging
#6
REVIEW
Jin Liu, Dai-Chao Wu, Li-Hua Qu, Hong-Qing Liao, Mei-Xiang Li
The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions...
May 12, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29749518/effects-of-chronic-unpredictable-mild-stress-on-ovarian-reserve-in-female-rats-feasibility-analysis-of-a-rat-model-of-premature-ovarian-failure
#7
Xiao-Yan Fu, Hao-Hao Chen, Ning Zhang, Ming-Xing Ding, Ying-Er Qiu, Xiao-Ming Pan, Yuan-Shu Fang, Yi-Ping Lin, Qun Zheng, Wen-Qian Wang
Premature ovarian failure (POF) results from a number of disorders. The POF model is primarily based on chemotherapeutic injury, and hence is not suitable for assessing the effects of chronic stress on ovarian function. Therefore, improved animal models are required to analyze the effects of chronic stress on ovarian reserve. The feasibility of the chronic unpredictable mild stress (CUMS) method for establishing a model of POF was examined. The depressive behavior exhibited by rats was evaluated with the open field and sucrose preference tests...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29731629/nanosized-titanium-dioxide-induced-premature-ovarian-failure-is-associated-with-abnormalities-in-serum-parameters-in-female-mice
#8
Fashui Hong, Ling Wang
Background: Exposure to titanium dioxide nanoparticles (TiO2 NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO2 NPs application on premature ovarian failure (POF) have rarely been evaluated to date. Methods: In this study, female mice were continuously exposed to TiO2 NPs at doses of 2.5, 5 or 10 mg/kg via gavage instillation for 30 days, and investigated the serum hormones and autoimmunity markers associated with POF...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29725001/ablation-of-beta-subunit-of-protein-kinase-ck2-in-mouse-oocytes-causes-follicle-atresia-and-premature-ovarian-failure
#9
Qiu-Xia Liang, Zhen-Bo Wang, Fei Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Qian Zhou, Heide Schatten, Filhol-Cochet Odile, Boldyreff Brigitte, Qing-Yuan Sun, Wei-Ping Qian
Premature ovarian failure (POF), a major cause of female infertility, is a complex disorder, but the molecular mechanisms underlying the disorder are only poorly understood. Here we report that protein kinase CK2 contributes to maintaining follicular survival through PI3K/AKT pathway and DNA damage response pathway. Targeted deletion of CK2β in mouse oocytes from the primordial follicle stage resulted in female infertility, which was attributed to POF incurring by massive follicle atresia. Downregulated PI3K/AKT signaling was found after CK2β deletion, indicated by reduced level of phosphorylated AKT (S473, T308, and S129) and altered AKT targets related to cell survival...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29721306/case-report-cerebral-leukodystrophy-and-the-gonadal-endocrinopathy-a-rare-but-real-association
#10
Mohammad Humayun, Abidullah Khan
A 30 year old married Pakistani woman presented in January 2018 with an eight month history of progressive left sided weakness, ataxia, spasticity, underdeveloped secondary sexual characteristics and primary infertility. She was the elder sister of a 19 year old bed bound woman who was diagnosed with vanishing white matter (VWM) disease 12 months previously. The MRI scan of the brain  demonstrated diffuse leukodystrophy and her hormonal assays were significant for premature ovarian failure. Results from her genetic tests demonstrated a point mutation in eukaryotic initiation factor 2B (EIF2B)...
2018: F1000Research
https://www.readbyqxmd.com/read/29703097/the-sex-life-of-women-surviving-breast-cancer
#11
Anna Ghizzani, Simone Bruni, Stefano Luisi
The diagnosis of breast cancer elicits diverse emotional responses in patients and partners. Surviving cancer has raised new needs and caretakers must understand the medical and psychological latent effects of oncology therapy. Improving patients' well-being is crucial as 19 million survivors are expected in the next decade in the United States alone. In general, sexuality contributes to one's well-being but when it is disrupted by the occurrence of cancer, women withdraw emotionally, no longer feel desirable due to esthetic damage, and become overwhelmed by the thought of sex...
April 27, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29699594/beneficial-effects-of-curcumin-and-capsaicin-on-cyclophosphamide-induced-premature-ovarian-failure-in-a-rat-model
#12
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29683020/premature-ovarian-failure-short-stature-and-hashimoto-s-disease-in-an-18-year-old-adolescent-girl-with-46-x-i-x-q10
#13
Xiang Hu, Qiao Zhang, Feng Gao, Lu-Lu Chen
Premature ovarian failure (POF) is a heterogeneous condition affecting girls and women. We detected a previously healthy 18-year-old adolescent girl, presented with amenorrhea over six months, as well as circulating levels of estradiol lower decreased and follicle-stimulating hormone (FSH) increased. She was 138 cm tall. Results of laboratory tests and/or ultrasound investigations showed 46, X, i(X)(q10) karyotype and Hashimoto's disease. This case suggests that pubertal onset and progression, as well as karyotype analysis, should be evaluated in girls with Hashimoto's disease and short stature...
April 22, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29620680/triptorelin-for-fertility-preservation-in-adolescents-treated-with-chemotherapy-for-cancer
#14
Mariaclaudia Meli, Manuela Caruso-Nicoletti, Milena La Spina, Luca Lo Nigro, Piera Samperi, Salvatore D'Amico, Francesco Bellia, Vito Miraglia, Maria Licciardello, Emanuela Cannata, Silvia Marino, Carla Cimino, Federica Puglisi, Laura Lo Valvo, Agnese Pezzulla, Giovanna Russo, Andrea Di Cataldo
BACKGROUND: Triptorelin, a gonadotropin releasing hormone analogue, can be administered to postpubertal female individuals with cancer who receive chemotherapy to obtain menstrual suppression and decrease the risk of hemorrhage caused by thrombocytopenia. Our goal was to assess whether triptorelin also has a protective role against the gonadotoxicity of chemotherapy. PATIENTS AND METHODS: This retrospective observational study includes all postmenarchal female patients who presented to our Unit from 2000 to 2015 and received chemotherapy for cancer...
April 3, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29619566/utility-of-pediatric-female-fertility-preservation-discussions-following-pelvic-radiation
#15
Rebecca M Rentea, Ashwini S Poola, Joy M Fulbright, Shawn D St Peter, Sohail R Shah
INTRODUCTION: While many childhood cancers are curable with therapy, adverse consequences in fertility exist. We sought to assess the number of female patients with pelvic tumors receiving radiation therapy, and the proportion that undergo measures for fertility preservation (FP). METHODS: A total of 53 female patients treated with pelvic tumors from 2000 to 2016 were retrospectively identified. RESULTS: 19 (34%) of these patients underwent pelvic radiation therapy (pXRT)...
April 4, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29615109/human-chorionic-plate-derived-mesenchymal-stem-cells-transplantation-restores-ovarian-function-in-a-chemotherapy-induced-mouse-model-of-premature-ovarian-failure
#16
Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu
BACKGROUND: Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of MSCs derived from the chorionic plate (CP-MSCs) for premature ovarian failure (POF). METHODS: We investigated the restorative effects of CP-MSCs on cyclophosphamide (CTX)-induced POF. The POF mouse models were established via intraperitoneal injection of 50 mg/kg CTX into female mice for 15 consecutive days...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29607913/eldecalcitol-increases-bone-mass-in-patients-with-turner-syndrome-who-have-insufficient-bone-mass-acquisition-after-estrogen-replacement-therapy
#17
Taku Tsuburai, Tomomi Nakamura, Hiromi Yoshikata, Etsuko Miyagi, Hideya Sakakibara
Most patients with Turner syndrome (TS) exhibit amenorrhea due to premature ovarian failure. Therefore, estrogen replacement therapy (ERT) is required; however, even after undergoing ERT, it is not rare for bone mass acquisition to be insufficient. This study was conducted in two stages, involving a cross-sectional and a prospective interventional study. We recruited 52 TS patients undergoing ERT due to amenorrhea (categorized into low (LB group; n = 23), and normal (NB group; n = 29) bone mass groups) and 7 TS patients who maintained ovarian function (spontaneous menstrual cycle group (MC group)) as controls...
March 31, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29592908/dilated-cardiomyopathy-and-premature-ovarian-failure-unveiling-propionic-aciduria
#18
Sarah Grotto, Bénédicte Sudrié-Arnaud, Valérie Drouin-Garraud, Catherine Nafeh-Bizet, Bernadette Chadefaux-Vekemans, Stéphanie Gobin, Soumeya Bekri, Abdellah Tebani
No abstract text is available yet for this article.
April 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29567538/current-approaches-for-the-treatment-of-premature-ovarian-failure-with-stem-cell-therapy
#19
REVIEW
Golshan Sheikhansari, Leili Aghebati-Maleki, Mohammad Nouri, Farhad Jadidi-Niaragh, Mehdi Yousefi
One of the common disorders found in women is premature ovarian failure (POF). Recently some studies have explained premature ovarian insufficiency (POI). The causes of it are unknown although various types of study have been done. The most common causes such as genetic and autoimmune conditions can have a role in POF and can lead to infertility. Some characterization of POF are hypo-oestrogenism (estrogen deficiency), increased gonadotropin level and most importantly amenorrhea. The main purpose of this review is to describe the cause and treatment of POF, especially stem cell therapy proposed in previous studies...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29556332/biological-function-of-ribosomal-protein-l10-on-cell-behavior-in-human-epithelial-ovarian-cancer
#20
Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu
Ribosomal protein L10 (RPL10) is one of large ribosomal proteins and plays a role in Wilms' tumor and premature ovarian failure. However, the function of RPL10 in human epithelial ovarian cancer (EOC) remains unknown. The purpose of this study was to examine the expression level and function of RPL10 in EOC. RPL10 protein expression was detected by immunohistochemistry and Western blot. The association RPL10 expression with clinical features was analyzed. Loss-of-function and gain-of-function approaches were applied in cellular assays, including cell viability, migration, invasion, and apoptosis...
2018: Journal of Cancer
keyword
keyword
60443
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"