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https://www.readbyqxmd.com/read/29220742/meta-analyses-of-newer-antiepileptic-drugs-as-adjunct-for-treatment-of-focal-epilepsy-in-children
#1
Nurul-Ain Mohd-Tahir, Shu-Chuen Li
AIM: This study conducted a systematic review evaluating the effectiveness of newer antiepileptic drugs (AEDs) (namely, lamotrigine, levetiracetam, topiramate, vigabatrin, zonisamide, oxcarbazepine, perampanel, gabapentin, and stiripentol) as add-on for treatment of focal epilepsy in children. METHODS: Articles were retrieved from EMBASE, Medline and Cochrane Library from inception to January 2016. Treatment outcomes were analysed based on responder, seizure-free, withdrawal and adverse event rates...
November 22, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29220705/therapeutic-landscapes-and-longevity-wellness-tourism-in-bama
#2
Liyuan Huang, Honggang Xu
Due to the rising demand for healthcare products and concern over environmental pollution, wellness tourism has been booming in China in recent years. The therapeutic landscape theory provides a multi-scale interpretation of wellness tourism to explore how wellness tourists achieve health in healing places. By presenting the results of 83 interviews conducted in Bama, China, this study reveals that the "longevity village" Bama, endorsed by centenarians, provides a retreat that combines natural beauty and a harmonious neighbourhood for wellness tourists...
November 28, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29220520/gaps-in-workplace-education-for-prevention-of-occupational-skin-disease
#3
Tanya Gupta, Victoria H Arrandale, Irena Kudla, D Linn Holness
Background: Occupational contact dermatitis (OCD) is a common occupational disease. Evidence suggests that education and training are effective prevention strategies. In spite of these known prevention strategies, workers continue to develop OCD. Little is reported regarding the actual training experience of workers. Objective: To examine the training experience of workers with contact dermatitis to identify areas for improvement. Methods: Participants were workers being assessed for contact dermatitis in an occupational health clinic...
December 5, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29220491/cnvcaller-highly-efficient-and-widely-applicable-software-for-detecting-copy-number-variations-in-large-populations
#4
Xihong Wang, Zhuqing Zheng, Yudong Cai, Ting Chen, Chao Li, Weiwei Fu, Yu Jiang
Background: The increasing amount of sequencing data available for a wide variety of species can be theoretically used for detecting copy number variations (CNVs) at the population level. However, the growing sample sizes and the divergent complexity of non-human genomes challenge the efficiency and robustness of current human-oriented CNV detection methods. Results: Here, we present CNVcaller, a read-depth method for discovering CNVs in population sequencing data...
December 4, 2017: GigaScience
https://www.readbyqxmd.com/read/29220415/effect-of-3d-microstructure-of-dermal-papillae-on-sed-concentration-at-a-mechanoreceptor-location
#5
Trung Quang Pham, Takayuki Hoshi, Yoshihiro Tanaka, Akihito Sano
The feeling of touch is an essential human sensation. Four types of mechanoreceptors (i.e., FA-I, SA-I, FA-II, and SA-II) in human skin signalize physical properties, such as shape, size, and texture, of an object that is touched and transmit the signal to the brain. Previous studies attempted to investigate the mechanical properties of skin microstructure and their effect on mechanoreceptors by using finite element modeling. However, very few studies have focused on the three-dimensional microstructure of dermal papillae, and this is related to that of FA-I receptors...
2017: PloS One
https://www.readbyqxmd.com/read/29220373/can-nerve-regeneration-on-an-artificial-nerve-conduit-be-enhanced-by-ethanol-induced-cervical-sympathetic-ganglion-block
#6
Yoshiki Shionoya, Katsuhisa Sunada, Keiji Shigeno, Akira Nakada, Michitaka Honda, Tatsuo Nakamura
This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments-in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN) repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99...
2017: PloS One
https://www.readbyqxmd.com/read/29220365/a-novel-methodology-for-strengthening-human-rights-based-monitoring-in-public-health-family-planning-indicators-as-an-illustrative-example
#7
Sofia Gruskin, Laura Ferguson, Shubha Kumar, Alexandra Nicholson, Moazzam Ali, Rajat Khosla
OBJECTIVE: The last few years have seen a rise in the number of global and national initiatives that seek to incorporate human rights into public health practice. Nonetheless, a lack of clarity persists regarding the most appropriate indicators to monitor rights concerns in these efforts. The objective of this work was to develop a systematic methodology for use in determining the extent to which indicators commonly used in public health capture human rights concerns, using contraceptive services and programmes as a case study...
2017: PloS One
https://www.readbyqxmd.com/read/29218682/the-rimes-statement-a-checklist-to-assess-the-quality-of-studies-evaluating-risk-minimization-programs-for-medicinal-products
#8
Meredith Y Smith, Andrea Russell, Priya Bahri, Peter G M Mol, Sarah Frise, Emily Freeman, Elaine H Morrato
INTRODUCTION: Pharmaceutical risk minimization programs involve interventions designed to support safe and appropriate use of medicines. Currently, information regarding the evaluation of these programs is not publicly reported in a standardized and transparent manner. To address this gap, we developed and piloted a quality reporting checklist entitled the Reporting recommendations Intended for pharmaceutical risk Minimization Evaluation Studies (RIMES). METHODS: Checklist development was guided by three sources: (1) a theoretical framework derived from program theory and process evaluation; (2) public health intervention design and evaluation principles; and (3) a review of existing quality reporting checklists...
December 7, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29218661/the-sages-fundamental-use-of-surgical-energy-program-fuse-history-development-and-purpose
#9
P Fuchshuber, S Schwaitzberg, D Jones, S B Jones, L Feldman, M Munro, T Robinson, G Purcell-Jackson, D Mikami, A Madani, M Brunt, B Dunkin, C Gugliemi, L Groah, R Lim, J Mischna, C R Voyles
BACKGROUND: Adverse events due to energy device use in surgical operating rooms are a daily occurrence. These occur at a rate of approximately 1-2 per 1000 operations. Hundreds of operating room fires occur each year in the United States, some causing severe injury and even mortality. The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) therefore created the first comprehensive educational curriculum on the safe use of surgical energy devices, called Fundamental Use of Surgical Energy (FUSE)...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218595/quantitative-testing-of-prescriber-knowledge-regarding-the-risks-and-safe-use-of-albiglutide
#10
Carol Koro, Janet Pientka, Veronica Bainbridge, Natalie O'Donnell, Monika Stender, Annette Stemhagen
BACKGROUND: The risk of pancreatitis and potential risk of medullary thyroid carcinoma associated with glucagon-like peptide-1 receptor agonists prompted the US Food and Drug Administration to require a Risk Evaluation and Mitigation Strategy for albiglutide, including education for prescribers and subsequent assessment of their knowledge of the risks and safe use of albiglutide via a quantitative survey. OBJECTIVE: The objective of this study was to assess prescribers' knowledge of the risks related to medullary thyroid carcinoma, pancreatitis, and the appropriate patient population for albiglutide...
December 7, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29218549/accuracy-and-reliability-of-a-subcutaneous-continuous-glucose-monitoring-device-in-critically-ill-patients
#11
S Rijkenberg, S C van Steen, J H DeVries, P H J van der Voort
Subcutaneous continuous glucose monitoring (CGM) may have benefits in achieving glycemic control in critically ill patients. The aim of this study was to assess the accuracy and reliability of the FreeStyle Navigator I in critically ill patients and to assess patient related factors influencing the accuracy and reliability. This study is a retrospective analysis of data from a randomized controlled trial conducted in a 20-bed mixed intensive care unit. Analytical accuracy, clinical accuracy and reliability were assessed against arterial blood glucose samples as reference...
December 7, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29218437/d-lactic-acidosis-in-humans-systematic-literature-review
#12
Davide G A M Bianchetti, Giacomo S Amelio, Sebastiano A G Lava, Mario G Bianchetti, Giacomo D Simonetti, Carlo Agostoni, Emilio F Fossali, Gregorio P Milani
BACKGROUND: D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome. It has been documented exclusively in case reports and small case series. METHODS: We performed a review of the literature in the National Library of Medicine and Excerpta Medica databases. RESULTS: We identified 84 original reports published between 1977 and 2017. D-lactic acidosis was observed in 98 individuals ranging in age from 7 months to 86 years with short bowel syndrome...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29218400/-emotional-robots-in-a-nursing-context-empirical-analysis-of-the-present-use-and-the-effects-of-paro-and-pleo
#13
REVIEW
Stefanie Baisch, Thorsten Kolling, Saskia Rühl, Barbara Klein, Johannes Pantel, Frank Oswald, Monika Knopf
BACKGROUND: It has been questioned by researchers in robotics as well in the general public to what extent companion-type robots can support the elderly with the fulfillment of their psychological and social needs. Although these robots have already been used in care settings in Germany, research has referred little to this practical experience in order to analyze their impact and benefit. To start to close this gap, the current article reports on the current use of companion-type robots in care settings, on the effects reported by professional caregivers as well as on the role of psychosocial needs in the acceptance and use of companion-type robots by the elderly...
December 7, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29218053/marker-development-for-phylogenomics-the-case-of-orobanchaceae-a-plant-family-with-contrasting-nutritional-modes
#14
Xi Li, Baohai Hao, Da Pan, Gerald M Schneeweiss
Phylogenomic approaches, employing next-generation sequencing (NGS) techniques, have revolutionized systematic and evolutionary biology. Target enrichment is an efficient and cost-effective method in phylogenomics and is becoming increasingly popular. Depending on availability and quality of reference data as well as on biological features of the study system, (semi-)automated identification of suitable markers will require specific bioinformatic pipelines. Here, we established a highly flexible bioinformatic pipeline, BaitsFinder, to identify putative orthologous single copy genes (SCGs) and to construct bait sequences in a single workflow...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29217949/the-effect-of-psychosocial-factors-and-patients-perception-of-tuberculosis-treatment-non-adherence-in-addis-ababa-ethiopia
#15
Habteyes Hailu Tola, Gholamreza Garmaroudi, Davoud Shojaeizadeh, Azar Tol, Mir Saeed Yekaninejad, Luche Tadesse Ejeta, Abebaw Kebede, Desta Kassa
Background: Although there are several studies reported on factors affecting tuberculosis (TB) treatment non-adherence, there is information gap on psychosocial and patients' perceptions aspects. Therefore, this study was aimed to investigate the effect of psychosocial factors and patients' perceptions on TB treatment non-adherence in Ethiopia. Methods: A cross sectional study was conducted in Addis Ababa from May to December, 2014. Thirty one health facilities were randomly selected and 698 TB patients, who had been on treatment, were enrolled consecutively using patient registration number...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217836/drug-development-for-neurodevelopmental-disorders-lessons-learned-from-fragile-x-syndrome
#16
REVIEW
Elizabeth M Berry-Kravis, Lothar Lindemann, Aia E Jønch, George Apostol, Mark F Bear, Randall L Carpenter, Jacqueline N Crawley, Aurore Curie, Vincent Des Portes, Farah Hossain, Fabrizio Gasparini, Baltazar Gomez-Mancilla, David Hessl, Eva Loth, Sebastian H Scharf, Paul P Wang, Florian Von Raison, Randi Hagerman, Will Spooren, Sébastien Jacquemont
Neurodevelopmental disorders such as fragile X syndrome (FXS) result in lifelong cognitive and behavioural deficits and represent a major public health burden. FXS is the most frequent monogenic form of intellectual disability and autism, and the underlying pathophysiology linked to its causal gene, FMR1, has been the focus of intense research. Key alterations in synaptic function thought to underlie this neurodevelopmental disorder have been characterized and rescued in animal models of FXS using genetic and pharmacological approaches...
December 8, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29217685/scale-free-amplitude-modulation-of-neuronal-oscillations-tracks-comprehension-of-accelerated-speech
#17
Ana Filipa Teixeira Borges, Anne-Lise Giraud, Huibert D Mansvelder, Klaus Linkenkaer-Hansen
Speech comprehension is preserved up to a three-fold acceleration but rapidly deteriorates at higher speeds. Current models posit that perceptual resilience to accelerated speech is limited by the brain's ability to parse speech into syllabic units using delta/theta oscillations. Here, we ask whether the involvement of neuronal oscillations in processing accelerated speech also relates to their scale-free amplitude modulation as indexed by the strength of long-range temporal correlations (LRTC). We recorded magnetoencephalography (MEG) while 24 human subjects (12 females) listened to radio news uttered at different comprehensible rates, at a mostly unintelligible rate, and at this same speed interleaved with silence gaps...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217522/drosophila-syd-1-has-rhogap-activity-that-is-required-for-presynaptic-clustering-of-bruchpilot-elks-but-not-neurexin-1
#18
Michael A Spinner, David A Walla, Tory G Herman
Syd-1 proteins are required for presynaptic development in worm, fly, and mouse. Syd-1s in all three species contain a Rho GTPase activating protein (GAP)-like domain of unclear significance. Invertebrate Syd-1s are thought to lack GAP activity, and mouse mSYD1A has GAP activity that is thought to be dispensible for its function. Here we show that Drosophila melanogaster Syd-1 can interact with all six fly Rhos and has GAP activity toward Rac1 and Cdc42. During development, fly Syd-1 clusters multiple presynaptic proteins at the neuromuscular junction (NMJ), including the cell adhesion molecule Neurexin (Nrx-1) and the active zone (AZ) component Bruchpilot (Brp), both of which Syd-1 binds directly...
December 7, 2017: Genetics
https://www.readbyqxmd.com/read/29217464/the-relationship-between-trait-psychopathy-and-emotional-intelligence-a-meta-analytic-review
#19
REVIEW
A Megías, R Gómez-Leal, M J Gutiérrez-Cobo, R Cabello, P Fernández-Berrocal
Psychopathy is a personality construct that has been related to important emotional deficits. These findings have led to a growing interest in exploring if psychopathic traits are associated with emotional intelligence (EI). However, the literature exploring this association has revealed conflicting results. The aim of the present study was to provide a reliable estimate of the relationship between psychopathy traits and EI (measured as performance-based ability) through meta-analysis. A quantitative and systematic review of the literature using Scopus, Medline, Pubmed, and PsicINFO showed a total of 13 studies meeting inclusion criteria with a combined sample of 2401 participants...
December 4, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29217285/outcomes-and-palliative-care-utilization-in-patients-with-dementia-and-acute-abdominal-emergency-opportunities-for-surgical-quality-improvement
#20
Ana Berlin, Franchesca Hwang, Ranbir Singh, Sri Ram Pentakota, Roshansa Singh, Brad Chernock, Anne C Mosenthal
BACKGROUND: When patients with dementia develop acute surgical abdomen, patients, surrogates, and surgeons need accurate prognostic information to facilitate goal-concordant decision making. Palliative care can assist with communication, symptom management, and family and caregiver support in this population. We aimed to characterize outcomes and patterns of palliative care utilization among patients with dementia, presenting with abdominal surgical emergency. METHOD: We retrospectively queried the National Inpatient Sample for patients aged >50 years with dementia and acute abdominal emergency who were admitted nonelectively 2009-2013, utilizing ICD-9-CM codes for dementia and surgical indication...
December 4, 2017: Surgery
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