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https://www.readbyqxmd.com/read/29045933/chemical-transformation-of-silver-nanoparticles-in-aquatic-environments-mechanism-morphology-and-toxicity
#1
REVIEW
Weicheng Zhang, Bangding Xiao, Tao Fang
Silver nanoparticles (Ag NPs) have been inevitably introduced into ecological environment during their extensive applications in daily human life. Thermodynamically, Ag NPs are unstable and transform into other species under various aqueous conditions. Ag NPs and their transformation products pose potential threats to environment and humans. However, the complex environmental conditions and transformations of Ag NPs complicate their human health and environmental risk assessment. To bridge the knowledge gap, four essential environmental transformations, oxidative dissolution, sulfidation, chlorination and photoreduction, of Ag NPs are reviewed herein...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/29045889/the-pathway-to-a-universal-influenza-vaccine
#2
Catharine I Paules, Hilary D Marston, Robert W Eisinger, David Baltimore, Anthony S Fauci
Development of a universal influenza vaccine is a research priority for the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health. To facilitate this goal, we convened a workshop in Rockville, Maryland to identify knowledge gaps in influenza research and develop strategies to fill them.
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045877/self-organization-of-ftsz-polymers-in-solution-reveals-spacer-role-of-the-disordered-c-terminal-tail
#3
Sonia Huecas, Erney Ramírez-Aportela, Albert Vergoñós, Rafael Núñez-Ramírez, Oscar Llorca, J Fernando Díaz, David Juan-Rodríguez, María A Oliva, Patricia Castellen, José M Andreu
FtsZ is a self-assembling GTPase that forms, below the inner membrane, the mid-cell Z-ring guiding bacterial division. FtsZ monomers polymerize head to tail forming tubulin-like dynamic protofilaments, whose organization in the Z-ring is an unresolved problem. Rather than forming a well-defined structure, FtsZ protofilaments laterally associate in vitro into polymorphic condensates typically imaged on surfaces. We describe here nanoscale self-organizing properties of FtsZ assemblies in solution that underlie Z-ring assembly, employing time-resolved x-ray scattering and cryo-electron microscopy...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045869/metastability-gap-in-the-phase-diagram-of-monoclonal-igg-antibody
#4
Jacob B Rowe, Rachel A Cancel, Tyler D Evangelous, Rhiannon P Flynn, Sergei Pechenov, J Anand Subramony, Jifeng Zhang, Ying Wang
Crystallization of IgG antibodies has important applications in the fields of structural biology, biotechnology, and biopharmaceutics. However, a rational approach to crystallize antibodies is still lacking. In this work, we report a method to estimate the solubility of antibodies at various temperatures. We experimentally determined the full phase diagram of an IgG antibody. Using the full diagram, we examined the metastability gaps, i.e., the distance between the crystal solubility line and the liquid-liquid coexistence curve, of IgG antibodies...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045805/triclocarban-enhances-short-chain-fatty-acids-production-from-anaerobic-fermentation-of-waste-activated-sludge
#5
Yali Wang, Dongbo Wang, Yiwen Liu, Qilin Wang, Fei Chen, Qi Yang, Xiaoming Li, Guangming Zeng, Hailong Li
Triclocarban (TCC), one typical antibacterial agent being widely used in various applications, was found to be present in waste activated sludge at significant levels. To date, however, its effect on anaerobic fermentation of sludge has not been investigated. This work therefore aims to fill this knowledge gap. Experimental results showed that when TCC content in sludge increased from 26.7 ± 5.3 to 520.5 ± 12.6 mg per kilogram total suspended solids, the maximum concentration of short-chain fatty acids (SCFA) increased from 32...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29045729/knockout-mice-for-dyslexia-susceptibility-gene-homologs-kiaa0319-and-kiaa0319l-have-unaffected-neuronal-migration-but-display-abnormal-auditory-processing
#6
Luiz G Guidi, Jane Mattley, Isabel Martinez-Garay, Anthony P Monaco, Jennifer F Linden, Antonio Velayos-Baeza, Zoltán Molnár
Developmental dyslexia is a neurodevelopmental disorder that affects reading ability caused by genetic and non-genetic factors. Amongst the susceptibility genes identified to date, KIAA0319 is a prime candidate. RNA-interference experiments in rats suggested its involvement in cortical migration but we could not confirm these findings in Kiaa0319-mutant mice. Given its homologous gene Kiaa0319L (AU040320) has also been proposed to play a role in neuronal migration, we interrogated whether absence of AU040320 alone or together with KIAA0319 affects migration in the developing brain...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045626/primary-and-heterotrophic-productivity-relate-to-multi-kingdom-diversity-in-a-hypersaline-mat
#7
Hans C Bernstein, Colin J Brislawn, Karl Dana, Tobias Flores-Wentz, Alexandra B Cory, Sarah J Fansler, James K Fredrickson, James J Moran
Benthic microbial ecosystems are widespread yet knowledge gaps still remain on the relationships between the diversity of species across kingdoms and productivity. Here, we ask two fundamental questions: 1) How does species diversity relate to the rates of primary and heterotrophic productivity? 2) How do diel variations in light-energy inputs influence productivity and microbiome diversity? To answer these questions, microbial mats from a magnesium sulfate hypersaline Lake were used to establish microcosms...
October 17, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#8
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045411/mating-induced-sexual-inhibition-in-the-jumping-spider-servaea-incana-araneae-salticidae-a-fast-acting-and-long-lasting-effect
#9
Vivian Mendez, Rowan H McGinley, Phillip W Taylor
Mating-induced sexual inhibition has been studied extensively as an important facet of many insect mating systems but remains little understood in spiders. Once mated, females of many spider species become unreceptive and aggressive toward males, but the speed of onset and persistence of this effect are not known. Addressing this gap, the present study considers (1) mating tendency of virgins, latency to remating, and lifetime mating frequency and (2) how quickly sexual inhibition is expressed after the first mating in female Servaea incana jumping spiders...
2017: PloS One
https://www.readbyqxmd.com/read/29045391/network-control-principles-predict-neuron-function-in-the-caenorhabditis-elegans-connectome
#10
Gang Yan, Petra E Vértes, Emma K Towlson, Yee Lian Chew, Denise S Walker, William R Schafer, Albert-László Barabási
Recent studies on the controllability of complex systems offer a powerful mathematical framework to systematically explore the structure-function relationship in biological, social, and technological networks. Despite theoretical advances, we lack direct experimental proof of the validity of these widely used control principles. Here we fill this gap by applying a control framework to the connectome of the nematode Caenorhabditis elegans, allowing us to predict the involvement of each C. elegans neuron in locomotor behaviours...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29045350/donor-human-milk-and-fortifier-use-in-united-states-level-2-3-and-4-neonatal-care-hospitals
#11
Maryanne Tigchelaar Perrin
OBJECTIVE: In 2011 the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of this study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facilities in 2015 and to identify factors associated with non-use. METHODS: Data from the 2015 Maternity Practices in Infant Nutrition and Care survey, conducted by the Center for Disease Control and Prevention, was analyzed for questions about feeding practices within neonatal hospitals...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045206/a-devastating-delay-zika-and-the-implementation-gap
#12
Stephanie R Morain, Susan H Wootton, Catherine Eppes
The epidemic of Zika in the Americas and the virus’s effects on fetal development have jolted the U.S. medical community and the broader public. Zika’s relatively recent emergence has necessitated rapid research on its virology and pathogenesis, transmission, clinical manifestations, and diagnosis...
October 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29045164/ehealth-literacy-research-quo-vadis
#13
Lena Griebel, Heidi Enwald, Heidi Gilstad, Anna-Lena Pohl, Julia Moreland, Martin Sedlmayr
The concept of electronic health (eHealth) literacy evolved from the social and information sciences and describes competencies necessary to use electronic health services. As it is a rather new topic, and as there is no current overview of the state of the art in research, it is not possible to identify research gaps. Therefore, the objective of this viewpoint article is to increase knowledge on the current state of the art of research in eHealth literacy and to identify gaps in scientific research which should be focused on by the research community in the future...
October 18, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/29044939/synthesis-and-characterization-of-high-quantum-yield-and-oscillator-strength-6-chloro-2-4-cynophenyl-4-phenyl-quinoline-cl-cn-dpq-organic-phosphor-for-solid-state-lighting
#14
Minakshi Ghate, H K Dahule, N Thejo Kalyani, S J Dhoble
A novel blue luminescent 6-chloro-2-(4-cynophenyl) substituted diphenyl quinoline (Cl-CN DPQ) organic phosphor has been synthesized by the acid-catalyzed Friedlander reaction and then characterized to confirm structural, optical and thermal properties. Structural properties of Cl-CN-DPQ were analyzed by Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) spectroscopy, X-ray diffraction technique (XRD) and scanning electron microscopy (SEM) and energy dispersive analysis of X-ray (EDAX) spectroscopy...
October 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29044932/right-heart-dysfunction-and-failure-in-heart-failure-with-preserved-ejection-fraction-mechanisms-and-management-position-statement-on-behalf-of-the-heart-failure-association-of-the-european-society-of-cardiology
#15
REVIEW
Thomas M Gorter, Dirk J van Veldhuisen, Johann Bauersachs, Barry A Borlaug, Jelena Celutkiene, Andrew J S Coats, Marisa G Crespo-Leiro, Marco Guazzi, Veli-Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S P Lam, Lars H Lund, Alexander R Lyon, Alexandre Mebazaa, Christian Mueller, Walter J Paulus, Burkert Pieske, Massimo F Piepoli, Frank Ruschitzka, Frans H Rutten, Petar M Seferovic, Scott D Solomon, Sanjiv J Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschöpe, Rudolf A de Boer
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients...
October 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29044904/diabetes-mellitus-and-als-time-to-bridge-the-gap-between-the-bench-and-the-bed-side
#16
Ali Jawaid, Anooshay Abid, Paul E Schulz
The article of D'Ovidio et al.(1) in the current issue of European Journal of Neurology is an important addition to the growing body of evidence supporting a disease-modifying effect of metabolic disorders in neurodegenerative diseases (NDDs). Eight years ago, we first showed a protective effect of type 2 diabetes mellitus (T2DM) in ALS. Using a very large clinical cohort (n=2,371), we found that pre-morbid T2DM was associated with a reduced risk for ALS and a 4 year delay in onset.(2) Since then, a number of studies have independently confirmed a protective effect of T2DM in ALS...
October 17, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29044826/implementation-and-evaluation-of-the-victorian-suicide-register
#17
Georgina Sutherland, Allison Milner, Jeremy Dwyer, Lyndal Bugeja, Alan Woodward, Jo Robinson, Jane Pirkis
OBJECTIVE: The Victorian Suicide Register (VSR) is a state-based suicide surveillance system that contains detailed information on people who die by suicide and the circumstances surrounding their death. In this paper, we provide an overview of the VSR and then describe the evaluation, which used the Centres for Disease Control and Prevention guidelines for surveillance system evaluation as a framework. METHODS: The evaluation drew on three data sources to assess whether the VSR: i) embodies the attributes of a good public health surveillance system; and ii) can be used to inform community-based suicide prevention efforts...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29044726/a-new-design-strategy-for-efficient-thermally-activated-delayed-fluorescence-organic-emitters-from-twisted-to-planar-structures
#18
Xian-Kai Chen, Youichi Tsuchiya, Yuma Ishikawa, Cheng Zhong, Chihaya Adachi, Jean-Luc Brédas
In the traditional molecular design of thermally activated delayed fluorescence (TADF) emitters composed of electron-donor and electron-acceptor moieties, achieving a small singlet-triplet energy gap (ΔEST ) in strongly twisted structures usually translates into a small fluorescence oscillator strength, which can significantly decrease the emission quantum yield and limit efficiency in organic light-emitting diode devices. Here, based on the results of quantum-chemical calculations on TADF emitters composed of carbazole donor and 2,4,6-triphenyl-1,3,5-triazine acceptor moieties, a new strategy is proposed for the molecular design of efficient TADF emitters that combine a small ΔEST with a large fluorescence oscillator strength...
October 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29044647/epilepsy-and-astrocyte-energy-metabolism
#19
Detlev Boison, Christian Steinhäuser
Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability and sudden, synchronized electrical discharges that can manifest as seizures. It is now increasingly recognized that impaired astrocyte function and energy homeostasis play key roles in the pathogenesis of epilepsy. Excessive neuronal discharges can only happen, if adequate energy sources are made available to neurons. Conversely, energy depletion during seizures is an endogenous mechanism of seizure termination. Astrocytes control neuronal energy homeostasis through neurometabolic coupling...
October 17, 2017: Glia
https://www.readbyqxmd.com/read/29044437/a-novel-dihydrocoumarin-under-experimental-and-theoretical-characterization
#20
W F Vaz, J M F Custodio, N M N Rodrigues, L G Santin, S S Oliveira, R Gargano, F A P Osório, G L B Aquino, A J Camargo, M S Oliveira, H B Napolitano
Coumarins are natural and synthetic active ingredients widely applied in diverse types of medicinal treatments, such as cancer, inflammation, infection, and enzyme inhibition (monoamine oxidase B). Dihydrocoumarin compounds are of great interest in organic chemistry due to their structural versatilities and, as part of our investigations concerning the structural characterization of small molecules, this work focuses on crystal structure and spectroscopic characterization of the synthesized and crystallized compound 4-(4-methoxyphenyl)-3,4-dihydro-chromen-2-one (C16H14O3)...
October 18, 2017: Journal of Molecular Modeling
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