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https://www.readbyqxmd.com/read/28231640/mind-the-gap-mechanisms-regulating-the-endothelial-barrier
#1
REVIEW
Mariya Y Radeva, Jens Waschke
The endothelial barrier consists of intercellular contacts localized in the cleft between endothelial cells, which is covered by the glycocalyx in a sieve-like manner. Both types of barrier-forming junctions, i.e. the adherens junction (AJ) serving mechanical anchorage and mechanotransduction and the tight junction (TJ) sealing the intercellular space to limit paracelullar permeability, are tethered to the actin cytoskeleton. Under resting conditions, the endothelium thereby builds a selective layer controlling the exchange of fluid and solutes with the surrounding tissue...
February 23, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28231557/comparison-of-body-s-center-of-mass-motion-relative-to-center-of-pressure-between-treadmill-and-over-ground-walking
#2
Hsuan-Lun Lu, Tung-Wu Lu, Hsiu-Chen Lin, Wing P Chan
Treadmills have been used in rehabilitation settings to provide convenient protocols and continuous monitoring of movement over multiple cycles at well-controlled speeds for gait and balance training. However, the potential differences in the movement control may affect the translation of the training outcomes to real life over-ground walking (OW). The similarities and differences in the balance control between treadmill walking (TW) and OW have largely been unexplored. The current study bridged the gap by comparing the motions of the body's center of mass (COM) relative to the center of pressure (COP) between TW and OW, in terms of the COM-COP inclination angle (IA) and its rate of change (RCIA)...
February 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28231512/the-impact-of-third-generation-genomic-technologies-on-plant-genome-assembly
#3
REVIEW
Wen-Biao Jiao, Korbinian Schneeberger
Since the introduction of next generation sequencing, plant genome assembly projects do not need to rely on dedicated research facilities or community-wide consortia anymore, even individual research groups can sequence and assemble the genomes they are interested in. However, such assemblies are typically not based on the entire breadth of genomic technologies including genetic and physical maps and their contiguities tend to be low compared to the full-length gold standard reference sequences. Recently emerging third generation genomic technologies like long-read sequencing or optical mapping promise to bridge this quality gap and enable simple and cost-effective solutions for chromosomal-level assemblies...
February 20, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28231503/ecotoxicity-assessment-of-ionic-as-iii-as-v-in-iii-and-ga-iii-species-potentially-released-from-novel-iii-v-semiconductor-materials
#4
Chao Zeng, Adrian Gonzalez-Alvarez, Emily Orenstein, Jim A Field, Farhang Shadman, Reyes Sierra-Alvarez
III-V materials such as indium arsenide (InAs) and gallium arsenide (GaAs) are increasingly used in electronic and photovoltaic devices. The extensive application of these materials may lead to release of III-V ionic species during semiconductor manufacturing or disposal of decommissioned devices into the environment. Although arsenic is recognized as an important contaminant due to its high toxicity, there is a lack of information about the toxic effects of indium and gallium ions. In this study, acute toxicity of As(III), As(V), In(III) and Ga(III) species was evaluated using two microbial assays testing for methanogenic activity and O2 uptake, as well as two bioassays targeting aquatic organisms, including the marine bacterium Aliivibrio fischeri (bioluminescence inhibition) and the crustacean Daphnia magna (mortality)...
February 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28231429/two-dimensional-excitonic-photoluminescence-in-graphene-on-a-cu-surface
#5
Youngsin Park, Yooseok Kim, Chang Woo Myung, Robert Anthony Taylor, Christopher C S Chan, Benjamin P L Reid, Tim J Puchtler, Robin J Nicholas, Laishram Tomba Singh, Geunsik Lee, Chan-Cuk Hwang, Chong-Yun Park, Kwang S Kim
Despite having outstanding electrical properties, graphene is unsuitable for optical devices because of its zero band gap. Here, we report two-dimensional excitonic photoluminescence (PL) from graphene grown on a Cu(111) surface, which shows an unexpected and remarkably sharp strong emission near 3.16 eV (full-width at half-maximum ≤ 3meV) and multiple emissions around 3.18 eV. As temperature increases, these emissions blue-shift, displaying the characteristic negative thermal coefficient of graphene. The observed PL originates from the significantly suppressed dispersion of excited electrons in graphene caused by hybridization of graphene π and Cu d orbitals of the 1st and 2nd Cu layers at a shifted saddle point 0...
February 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28231239/surveillance-for-health-care-access-and-health-services-use-adults-aged-18-64-years-behavioral-risk-factor-surveillance-system-united-states-2014
#6
Catherine A Okoro, Guixiang Zhao, Jared B Fox, Paul I Eke, Kurt J Greenlund, Machell Town
PROBLEM/CONDITION: As a result of the 2010 Patient Protection and Affordable Care Act, millions of U.S. adults attained health insurance coverage. However, millions of adults remain uninsured or underinsured. Compared with adults without barriers to health care, adults who lack health insurance coverage, have coverage gaps, or skip or delay care because of limited personal finances might face increased risk for poor physical and mental health and premature mortality. PERIOD COVERED: 2014...
February 24, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28230999/design-of-contact-electrodes-for-semiconductor-nanowire-solar-energy-harvesting-devices
#7
Tzu-Ging Lin, Sarath Ramadurgam, Chen Yang
Transparent, low resistive contacts are critical for efficient solar energy harvesting devices. It is important to reconsider the material choices and electrode design as devices move from 2D films to 1D nanostructures. In this paper, we study the effectiveness of indium tin oxide (ITO) and metals, such as Ag and Cu, as contacts in 2D and 1D systems. Although ITO has been studied extensively and developed into an effective transparent contact for 2D devices, our results show that effectiveness does not translate to 1D systems...
February 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28230973/unique-opto-electronic-structure-and-photo-reduction-properties-of-sulfur-doped-lead-chromates-explaining-their-instability-in-paintings
#8
Vanousheh Rahemi, Nasrin Sarmadian, Willemien Anaf, Koen Janssens, Dirk Lamoen, Bart Partoens, Karolien De Wael
Chrome yellow refers to a group of synthetic inorganic pigments that became popular as an artist's material from the second quarter of the 19th century. The color of the pigment, in which the chromate ion acts as a chromophore, is related to its chemical composition (PbCr1-xSxO4, with 0≤x≤0.8) and crystalline structure (monoclinic/orthorhombic). Their shades range from the yellow-orange to the paler yellow tones with increasing sulfate amount. These pigments show remarkable signs of degradation after limited time periods...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230911/interventions-to-reduce-the-stigma-of-eating-disorders-a-systematic-review-and-meta-analysis
#9
REVIEW
Joanna R Doley, Laura M Hart, Arthur A Stukas, Katja Petrovic, Ayoub Bouguettaya, Susan J Paxton
Stigma is a problem for individuals with eating disorders (EDs), forming a barrier to disclosure and help-seeking. Interventions to reduce ED stigma may help remove these barriers; however, it is not known which strategies (e.g., explaining etiology to reduce blame, contact with a person with an ED, or educating about ED) are effective in reducing stigma and related outcomes. This review described effectiveness of intervention strategies, and identified gaps in the literature. A search of four databases was performed using the terms (eating disorder* OR bulimi* OR anorexi* OR binge-eating disorder) AND (stigma* OR stereotyp* OR beliefs OR negative attitudes) AND (program OR experiment OR intervention OR education), with additional texts sought through LISTSERVs...
February 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28230596/the-efficacy-of-immediate-implant-placement-in-extraction-sockets-for-alveolar-bone-preservation-a-clinical-evaluation-using-three-dimensional-cone-beam-computerized-tomography-and-resonance-frequency-analysis-value
#10
Ali Al Qabbani, Noor Hayati A Razak, Sausan Al Kawas, Suzina Sheikh Abdul Hamid, Saad Wahbi, A R Samsudin
The aim of this study was to determine the efficacy of immediate implant placement with alveolar bone augmentation on socket preservation following atraumatic tooth extraction and comparing it with a tooth alveolar socket that was allowed to heal in a conventional way.Twenty medically fit patients (8 males and 12 females aged between 18 and 40 years) who needed noncomplicated tooth extraction of mandibular premolar teeth were divided randomly and equally into 2 groups. In Group I, the empty extraction socket was left untreated and allowed to heal in a conventional way...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230594/alveolar-molding-effect-in-infants-with-unilateral-cleft-lip-and-palate-comparison-of-two-and-three-dimensional-measurements
#11
Won Hee Lim, Eun Woo Park, Hwa Sung Chae, Soon Man Kwon, Hoi-In Jung, Seung-Hak Baek
The purpose of this study was to compare the results of two- (2D) and three-dimensional (3D) measurements for the alveolar molding effect in patients with unilateral cleft lip and palate. The sample consisted of 23 unilateral cleft lip and palate infants treated with nasoalveolar molding (NAM) appliance. Dental models were fabricated at initial visit (T0; mean age, 23.5 days after birth) and after alveolar molding therapy (T1; mean duration, 83 days). For 3D measurement, virtual models were constructed using a laser scanner and 3D software...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230454/adherence-persistence-and-health-care-costs-for-patients-receiving-dipeptidyl-peptidase-4-inhibitors
#12
Karen L Rascati, Karen Worley, Yunus Meah, Damian Everhart
BACKGROUND: The dipeptidyl peptidase-4 (DPP-4) inhibitors are among the newer, yet more established, classes of diabetes medications. OBJECTIVE: To compare adherence, persistence, and health care costs among patients taking DPP-4 inhibitors. METHODS: Claims were extracted from Humana Medicare Advantage Prescription Drug (MAPD) or commercial plans for patients aged > 18 years with ≥ 1 prescription filled for a DPP-4 inhibitor between July 1, 2011, and March 31, 2013...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230450/characteristics-and-medication-use-of-psoriasis-patients-who-may-or-may-not-qualify-for-randomized-controlled-trials
#13
William Malatestinic, Beth Nordstrom, Jashin J Wu, Orin Goldblum, Kathleen Solotkin, Chen-Yen Lin, Kristin Kistler, Kathy Fraeman, Joseph Johnston, Lcdr Lesley Hawley, Nicholas Sicignano, Andre Araujo
BACKGROUND: Clinical trials impose exclusion criteria that may limit the generalizability of results. OBJECTIVES: To (a) determine the percentage of real-world patients who would qualify for psoriasis randomized controlled trials; (b) ascertain differences between moderate-to-severe psoriasis patients who would be eligible, ineligible, or potentially eligible for clinical trials; and (c) compare their biologic treatment patterns. METHODS: Moderate-to-severe psoriasis patients were identified from the U...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230368/structural-electronic-and-optical-properties-of-k2sn3o7-with-an-offset-hollandite-structure
#14
Rebecca D McAuliffe, Christopher A Miller, Xiao Zhang, Benjamin S Hulbert, Ashfia Huq, Clarina Dela Cruz, André Schleife, Daniel P Shoemaker
We present the compound K2Sn3O7, a Sn(4+)-containing oxide with a unique structure type among oxides. The compound is orthorhombic and reminiscent of an offset hollandite, where open channels hold a row of four K(+) per channel per cell. UV-visible spectroscopy indicates a wide band gap semiconductor, which is confirmed by first-principles electronic-structure calculations of band structures, densities of states, and optical properties. The continued discovery of new structure types in ternary tin oxides should remain a priority for the identification of prospective ion conductors and transparent conducting compounds...
February 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28230351/fabrication-and-demonstration-of-mercury-disc-well-probes-for-stripping-based-cyclic-voltammetry-scanning-electrochemical-microscopy
#15
Zachary J Barton, Joaquín Rodríguez-López
Scanning electrochemical microscopy (SECM) is a rising technique for the study of energy storage materials. Hg-based probes allow the extension of SECM investigations to ionic processes, but the risk of irreversible Hg amalgam saturation limits their operation to rapid timescales and dilute analyte solutions. Here, we report a novel fabrication protocol for Hg disc-well ultramicroelectrodes (UMEs), which retain access to stripping information but are less susceptible to amalgam saturation than traditional Hg sphere-caps or thin-films...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230350/cyclic-voltammetry-probe-approach-curves-with-alkali-amalgams-at-mercury-sphere-cap-scanning-electrochemical-microscopy-probes
#16
Zachary J Barton, Joaquín Rodríguez-López
We report a method of precisely positioning a Hg-based ultramicroelectrode (UME) for scanning electrochemical microscopy (SECM) investigations of any substrate. Hg-based probes are capable of performing amalgamation reactions with metal cations, which avoid unwanted side reactions and positive feedback mechanisms that can prove problematic for traditional probe positioning methods. However, prolonged collection of ions eventually leads to saturation of the amalgam accompanied by irreversible loss of Hg. In order to obtain negative feedback positioning control without risking damage to the SECM probe, we implement cyclic voltammetry probe approach surfaces (CV-PASs), consisting of CVs performed between incremental motor movements...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230283/low-band-gap-bistetracene-based-organic-semiconductors-exhibiting-air-stability-high-aromaticity-and-mobility
#17
Kamal Sbargoud, Masashi Mamada, Tanguy Jousselin-Oba, Yasunori Takeda, Shizuo Tokito, Abderrahim Yassar, Jérôme Marrot, Michel Frigoli
The benchmark of soluble organic semiconductors based on acenes is the 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN). However TIPS-PEN still suffers from photoinduced oxidation due to its low aromaticity. Increasing the aromaticity while keeping similar optical and electrochemical properties and shape suitable for good transport can be achieved with two-dimensional polycyclic aromatic hydrocarbons (2D-PAHs). Herein, we present an efficient synthesis and characterization of bistetracene derivatives that exhibit a band gap up to 1...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28230223/observation-of-charge-transfer-cascades-in-%C3%AE-fe2o3-irox-photoanodes-by-operando-x-ray-absorption-spectroscopy
#18
Alessandro Minguzzi, Alberto Naldoni, Ottavio Lugaresi, Elisabetta Achilli, Francesco D'Acapito, Francesco Malara, Cristina Locatelli, Alberto Vertova, Sandra Rondinini, Paolo Ghigna
Electrochemical devices for energy conversion and storage are central for a sustainable economy. The performance of electrodes is driven by charge transfer across different layer materials and an understanding of the mechanistics is pivotal to gain improved efficiency. Here, we directly observe the transfer of photogenerated charge carriers in a photoanode made of hematite (α-Fe2O3) and a hydrous iridium oxide (IrOx) overlayer, which plays a key role in photoelectrochemical water oxidation. Through the use of operando X-ray absorption spectroscopy (XAS), we probe the change in occupancy of the Ir 5d levels during optical band gap excitation of α-Fe2O3...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28230219/piezochromism-and-structural-and-electronic-properties-of-benz-a-anthracene-under-pressure
#19
Weizhao Cai, Rong Zhang, Yansun Yao, Shanti Deemyad
We report a combined experimental and theoretical study of the high pressure behavior of a herringbone-type hydrocarbon benz[a]anthracene (BaA) using fluorescence spectroscopy, X-ray diffraction, optical absorption, photoconductivity measurements, and first-principles density functional theory (DFT) calculations. The ambient-pressure molecular solid phase of BaA was found to be stable up to ∼15.0 GPa. Increasing the external pressure within this region would induce a reversible piezochromic colour change in the sample, from yellow-green to light brown...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28230215/graphene-modulated-photo-absorption-in-adsorbed-azobenzene-monolayers
#20
Qiang Fu, Caterina Cocchi, Dmitrii Nabok, Andris Gulans, Claudia Draxl
The impact of graphene on the photo-absorption properties of trans- and cis-azobenzene monolayers is studied in the framework of density-functional theory and many-body perturbation theory. We find that, despite the weak hybridization between the electronic bands of graphene and those of the azobenzene monolayers, graphene remarkably modulates the absorption spectra of the adsorbates. The excitation energies are affected via two counteracting mechanisms: substrate polarization reduces the band-gap of azobenzene, and enhanced dielectric screening weakens the attractive interaction between electrons and holes...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
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