keyword
https://read.qxmd.com/read/38527548/efficient-remediation-of-di-2-ethylhexyl-phthalate-and-plant-growth-promotion-with-the-application-of-a-phosphate-solubilizing-compound-microbial-agent
#21
JOURNAL ARTICLE
Xiaowen Sun, Xue Zhang, Zhi Li, Tan Wang, Jie Zeng, Yangquan Liu, Zhe Li, Lin Li
The ecotoxic endocrine-disrupting chemical di-(2-ethylhexyl) phthalate (DEHP) is ubiquitous in agricultural soil, posing a serious threat to human health. Here, we report efficient soil-borne DEHP degradation and plant growth promotion by a microbial organic fertilizer GK-PPB prepared by combining a recycled garden waste-kitchen waste compost product with ternary compound microbial agent PPB-MA, composed of Penicillium oxalic MB08F, Pseudomonas simiae MB751, and Bacillus temulences MB05B. The combination of MB08F and MB751 provided synergistic phosphorus solubilization, and MB05B enhanced the DEHP degradation capacity of MB08F via bioemulsification...
March 23, 2024: Science of the Total Environment
https://read.qxmd.com/read/38526283/activation-of-autophagy-by-citri-reticulatae-semen-extract-ameliorates-amyloid-beta-induced-cell-death-and-cognition-deficits-in-alzheimer-s-disease
#22
JOURNAL ARTICLE
Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law
JOURNAL/nrgr/04.03/01300535-202419110-00027/figure1/v/2024-03-08T184507Z/r/image-tiff Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer's disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson's and Huntington's diseases, however, the effect of Citri Reticulatae Semen on Alzheimer's disease remains unelucidated. In the current study, the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38525032/germline-proliferation-trades-off-with-lipid-metabolism-in-drosophila
#23
JOURNAL ARTICLE
Marisa A Rodrigues, Chantal Dauphin-Villemant, Margot Paris, Martin Kapun, Esra Durmaz Mitchell, Envel Kerdaffrec, Thomas Flatt
Little is known about the metabolic basis of life-history trade-offs but lipid stores seem to play a pivotal role. During reproduction, an energetically highly costly process, animals mobilize fat reserves. Conversely, reduced or curtailed reproduction promotes lipid storage in many animals. Systemic signals from the gonad seem to be involved: Caenorhabditis elegans lacking germline stem cells display endocrine changes, have increased fat stores and are long-lived. Similarly, germline-ablated Drosophila melanogaster exhibit major somatic physiological changes, but whether and how germline loss affects lipid metabolism remains largely unclear...
April 2024: Evolution Letters
https://read.qxmd.com/read/38520870/unveil-the-mechanism-for-ehmt-a-novel-triterpenoid-inhibits-proliferation-and-induces-apoptosis-in-colon-cancer-through-ros-mediated-jnk-signaling-pathway
#24
JOURNAL ARTICLE
Qiushuang Wu, Min Song, Siyuan Luo, Libin Guo, Qingwen Zhang, Hang Fai Kwok
Colon cancer ranks among the most prevalent malignancies worldwide, trailing only lung and breast cancer in incidence. Despite the availability of numerous therapeutic strategies, the burden of new cases and fatalities remains high in countries undergoing socioeconomic transitions. Natural products offer promising avenues for developing more effective and less toxic anticancer agents, expanding the clinical arsenal. In this investigation, we isolated a triterpenoid, (21 S,23 R,24 R)-21,23-epoxy-24-hydroxy-21-methoxytirucalla-7,25-dien-3-one (EHMT), from the fruits of Melia azedarach L...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38519128/role-of-glr-1-in-age-dependent-short-term-memory-decline
#25
JOURNAL ARTICLE
Vaibhav Gharat, Fabian Peter, Dominique J-F de Quervain, Andreas Papassotiropoulos, Attila Stetak
As the global elderly population grows, age-related cognitive decline is becoming an increasingly significant healthcare issue, often leading to various neuropsychiatric disorders. Among the many molecular players involved in memory, AMPA-type glutamate receptors are known to regulate learning and memory, but how their dynamics change with age and affect memory decline is not well understood. Here, we examined the in vivo properties of the AMPA type glutamate receptor GLR-1 in the AVA interneuron of the C. elegans nervous system during physiological aging...
March 22, 2024: ENeuro
https://read.qxmd.com/read/38517971/chemosensory-detection-of-polyamine-metabolites-guides-c-elegans-to-nutritive-microbes
#26
JOURNAL ARTICLE
Benjamin Brissette, Lia Ficaro, Chenguang Li, Drew R Jones, Sharad Ramanathan, Niels Ringstad
Much is known about molecular mechanisms by which animals detect pathogenic microbes, but how animals sense beneficial microbes remains poorly understood. The roundworm Caenorhabditis elegans is a microbivore that must distinguish nutritive microbes from pathogens. We characterized a neural circuit used by C. elegans to rapidly discriminate between nutritive bacteria and pathogens. Distinct sensory neuron populations responded to chemical cues from nutritive Escherichia coli and pathogenic Enterococcus faecalis , and these neural signals are decoded by downstream AIB interneurons...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38517909/transcriptome-analyses-describe-the-consequences-of-persistent-hif-1-over-activation-in-caenorhabditis-elegans
#27
JOURNAL ARTICLE
Dingxia Feng, Long Qu, Jo Anne Powell-Coffman
Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organism C. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly, C. elegans mutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation...
2024: PloS One
https://read.qxmd.com/read/38517838/see-elegans-simple-to-use-accurate-and-automatic-3d-detection-of-neural-activity-from-densely-packed-neurons
#28
JOURNAL ARTICLE
Enrico Lanza, Valeria Lucente, Martina Nicoletti, Silvia Schwartz, Ilaria F Cavallo, Davide Caprini, Christopher W Connor, Mashel Fatema A Saifuddin, Julia M Miller, Noelle D L'Etoile, Viola Folli
In the emerging field of whole-brain imaging at single-cell resolution, which represents one of the new frontiers to investigate the link between brain activity and behavior, the nematode Caenorhabditis elegans offers one of the most characterized models for systems neuroscience. Whole-brain recordings consist of 3D time series of volumes that need to be processed to obtain neuronal traces. Current solutions for this task are either computationally demanding or limited to specific acquisition setups. Here, we propose See Elegans, a direct programming algorithm that combines different techniques for automatic neuron segmentation and tracking without the need for the RFP channel, and we compare it with other available algorithms...
2024: PloS One
https://read.qxmd.com/read/38517352/natural-flavonoid-hesperetin-blocks-amyloid-%C3%AE-protein-fibrillogenesis-depolymerizes-preformed-fibrils-and-alleviates-cytotoxicity-caused-by-amyloids
#29
JOURNAL ARTICLE
Qinchen Dong, Zhan Cui, Xinming Wu, Li Li, Fuping Lu, Fufeng Liu
The aggregation of β-amyloid (Aβ) peptides to form amyloid plaques is one of the primary hallmarks for Alzheimer's disease (AD). Dietary flavonoid supplements containing hesperetin have an ability to decline the risk of developing AD, but the molecular mechanism is still unclear. In this work, hesperetin, a flavanone abundant in citrus fruits, has been proven to prevent the formation of Aβ aggregates and depolymerized preformed fibrils in a concentration-dependent fashion. Hesperetin inhibited the conformational conversion from the natural structure to a β-sheet-rich conformation...
March 22, 2024: Food & Function
https://read.qxmd.com/read/38516572/outcrossing-in-caenorhabditis-elegans-increases-in-response-to-food-limitation
#30
JOURNAL ARTICLE
Samuel P Slowinski, Jennifer D Gresham, Eric R Cui, Katharine Haspel, Curtis M Lively, Levi T Morran
Theory predicts that organisms should diversify their offspring when faced with a stressful environment. This prediction has received empirical support across diverse groups of organisms and stressors. For example, when encountered by Caenorhabditis elegans during early development, food limitation (a common environmental stressor) induces the nematodes to arrest in a developmental stage called dauer and to increase their propensity to outcross when they are subsequently provided with food and enabled to develop to maturity...
March 2024: Ecology and Evolution
https://read.qxmd.com/read/38515852/leaf-extract-of-garcinia-atroviridis-promotes-anti-heat-stress-and-antioxidant-effects-in-caenorhabditis-elegans
#31
JOURNAL ARTICLE
Sirithip Chuaijit, Chuchard Punsawad, Veronica Winoto, Waluga Plaingam, Itti Kongkaew, Atidtaya Phetcharat, Takafumi Ichikawa, Makoto Kubo, Fumitaka Kawakami, Aman Tedasen, Moragot Chatatikun
Introduction: Garcinia atroviridis has been used for traditional medicines, healthy foods and tea. The chemical compositions and biological activities of fruit, stem bark and root have been widely studied. However, the phytochemical components and the biological activities in Garcinia atroviridis leaves (GAL) are limited. This research aims to study the phytochemical components and the stress resistance effects of GAL in Caenorhabditis elegans ( C. elegans ). Methods: To investigate the chemical components and antioxidant activities of GAL extract, the ethanol extract was characterized by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF MS) analysis and C...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38514005/food-preference-based-screening-method-for-identification-of-effectors-of-substance-use-disorders-using-caenorhabditis-elegans
#32
JOURNAL ARTICLE
Aaron Taehwan Kim, Sida Li, Yoo Kim, Young-Jai You, Yeonhwa Park
Substance use disorder (SUD) affects over 61 million Americans aged 12 and over. Thus, identifying novel chemicals contributing to SUD will be critical for developing efficient prevention and mitigation strategies. Considering the complexity of the actions and effects of these substances on human behavior, a high-throughput platform using a living organism is ideal. We developed a quick and easy screening assay using Caenorhabditis elegans. C. elegans prefers high-quality food (Escherichia coli HB101) over low-quality food (Bacillus megaterium), with a food preference index of approximately 0...
March 19, 2024: Life Sciences
https://read.qxmd.com/read/38513719/characterization-of-the-pristionchus-pacificus-epigenetic-toolkit-reveals-the-evolutionary-loss-of-the-histone-methyltransferase-complex-prc2
#33
JOURNAL ARTICLE
Audrey Brown, Adriaan B Meiborg, Mirita Franz-Wachtel, Boris Macek, Spencer Gordon, Ofer Rog, Cameron J Weadick, Michael S Werner
Comparative approaches have revealed both divergent and convergent paths to achieving shared developmental outcomes. Thus, only through assembling multiple case studies can we understand biological principles. Yet, despite appreciating the conservation - or lack thereof - of developmental networks, the conservation of epigenetic mechanisms regulating these networks is poorly understood. The nematode Pristionchus pacificus has emerged as a model system of plasticity and epigenetic regulation as it exhibits a bacterivorous or omnivorous morph depending on its environment...
March 21, 2024: Genetics
https://read.qxmd.com/read/38508494/meta-analysis-of-the-transcriptome-identifies-aberrant-rna-processing-as-common-feature-of-aging-in-multiple-species
#34
JOURNAL ARTICLE
Gee-Yoon Lee, Seokjin Ham, Jooyeon Sohn, Hyunwoo C Kwon, Seung-Jae V Lee
Aging is accompanied by the gradual deregulation of the transcriptome. However, whether age-dependent changes in the transcriptome are evolutionarily conserved or diverged remains largely unexplored. Here, we performed a meta-analysis examining the age-dependent changes in the transcriptome using publicly available datasets of eleven representative metazoans, ranging from Caenorhabditis elegans to human. To identify the transcriptomic changes associated with aging, we analyzed various aspects of the transcriptome, including genome composition, RNA processing, and functional consequences...
March 18, 2024: Molecules and Cells
https://read.qxmd.com/read/38508369/photoaged-polystyrene-nanoplastics-exposure-results-in-reproductive-toxicity-due-to-oxidative-damage-in-caenorhabditis-elegans
#35
JOURNAL ARTICLE
Rocío Errázuriz León, Vicente André Araya Salcedo, Francisco Javier Novoa San Miguel, Cynthia Rosa Andrea Llanquinao Tardio, Adolfo Andrés Tobar Briceño, Stefano Francesco Cherubini Fouilloux, Marcela Barbosa de Matos, Cesar Saldías, Walter Ruggeri Waldman, Christian Espinosa-Bustos, Maria Fernanda Hornos Carneiro
The increase of plastic production together with the incipient reuse/recycling system has resulted in massive discards into the environment. This has facilitated the formation of micro- and nanoplastics (MNPs) which poses major risk for environmental health. Although some studies have investigated the effects of pristine MNPs on reproductive health, the effects of weathered MNPs have been poorly investigated. Here we show in Caenorhabditis elegans that exposure to photoaged polystyrene nanoplastics (PSNP-UV) results in worse reproductive performance than pristine PSNP (i...
March 18, 2024: Environmental Pollution
https://read.qxmd.com/read/38507953/smc-5-6-complex-subunit-nse-1-plays-a-crucial-role-in-meiosis-and-dna-repair-in-caenorhabditis-elegans
#36
JOURNAL ARTICLE
Arome Solomon Odiba, Chiemekam Samuel Ezechukwu, Guiyan Liao, Ye Hong, Wenxia Fang, Cheng Jin, Anton Gartner, Bin Wang
The SMC5/6 complex is evolutionarily conserved across all eukaryotes and plays a pivotal role in preserving genomic stability. Mutations in genes encoding SMC5/6 complex subunits have been associated with human lung disease, immunodeficiency, and chromosome breakage syndrome. Despite its critical importance, much about the SMC5/6 complex remains to be elucidated. Various evidences have suggested possible role of a subunit of the SMC5/6 complex, NSE1, in chromosome segregation and DNA repair. Current knowledge regarding the role of NSE1 is primarily derived from single-cell-based analyses in yeasts, Arabidopsis thaliana, and human cell lines...
March 12, 2024: DNA Repair
https://read.qxmd.com/read/38507729/omnipolyphilins-a-and-b-chlorinated-cyclotetrapeptides-and-naphtho-%C3%AE-pyranones-from-the-plant-nematode-derived-fungus-polyphilus-sieberi
#37
JOURNAL ARTICLE
Jan-Peer Wennrich, Sherif S Ebada, Ellen Sepanian, Caren Holzenkamp, Syeda J Khalid, Hedda Schrey, Wolfgang Maier, Attila Mándi, Tibor Kurtán, Samad Ashrafi, Marc Stadler
Chemical exploration for two isolates of the recently described ascomycete species Polyphilus sieberi , derived from the eggs of the plant parasitic nematode Heterodera filipjevi , afforded the identification of many compounds that belong to various metabolite families: two previously undescribed chlorinated cyclotetrapeptides, omnipolyphilins A ( 1 ) and B ( 2 ), one new pyranonaphthoquinone, ventiloquinone P ( 3 ), a 6,6'-binaphto-α-pyranone dimer, talaroderxine D ( 4 ) in addition to nine known metabolites ( 5 - 13 ) were isolated from this biocontrol candidate...
March 20, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38507211/simplified-quantification-of-progenitor-zone-size-an-indicator-of-germ-stem-cell-niche-activity-in-the-nematode-caenorhabditis-elegans
#38
JOURNAL ARTICLE
Sarah R Fausett, Caroline A Laury, Rachel E Magallon, Christian Braendle
Germ stem cell (GSC) niches are fundamental for the maintenance of the immortal germ cell lineage across generations. In the nematode Caenorhabditis elegans, the simple GSC system has served as an important model for understanding stem cell biology and underlying genetic architecture. GSC niche activity in C. elegans is highly sensitive to subtle environmental and genetic variation. Quantifying variation in the C. elegans GSC niche is therefore essential; however, most methods to do so remain labor-intensive and time-consuming when screening large numbers of individuals...
March 21, 2024: Methods in Molecular Biology
https://read.qxmd.com/read/38506902/inhibition-of-cers1-in-skeletal-muscle-exacerbates-age-related-muscle-dysfunction
#39
JOURNAL ARTICLE
Martin Wohlwend, Pirkka-Pekka Laurila, Ludger J E Goeminne, Tanes Lima, Ioanna Daskalaki, Xiaoxu Li, Giacomo von Alvensleben, Barbara Crisol, Renata Mangione, Hector Gallart-Ayala, Olivier Burri, Stephen Butler, Jonathan Morris, Nigel Turner, Julijana Ivanisevic, Johan Auwerx
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis of age-related skeletal muscle impairment. In humans, CERS1 abundance declines with aging in skeletal muscle cells and, correlates with biological pathways involved in muscle function and myogenesis. Furthermore, CERS1 is upregulated during myogenic differentiation...
March 20, 2024: ELife
https://read.qxmd.com/read/38505394/modulating-cell-proliferation-by-asymmetric-division-a-conserved-pattern-in-the-early-embryogenesis-of-nematode-species
#40
JOURNAL ARTICLE
Guoye Guan, Ce Luo, Lei-Han Tang, Chao Tang
In the early stage of the nematode Caenorhabditis elegans embryogenesis, the zygote divides asymmetrically into a symmetric fast lineage and an asymmetric slow lineage, producing 16 and 8 cells respectively almost at the same time, followed by the onset of gastrulation. It was recently reported that this cell division pattern is optimal for rapid cell proliferation. In this work, we compare the cell lineages of 9 nematode species, revealing that this pattern is conserved for >60 million years. It further suggests that such lineage design has an important functional role and it might speed up embryonic development in the nematode kingdom, not limited to C...
2024: microPublication. Biology
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