keyword
https://read.qxmd.com/read/38335449/synthesis-quality-control-and-bench-to-bed-translation-of-a-new-68-ga-ga-labeled-nota-conjugated-bisphosphonate-for-imaging-skeletal-metastases-by-positron-emission-tomography
#21
JOURNAL ARTICLE
Sudipta Chakraborty, Sucheta Chatterjee, Rubel Chakravarty, Haldhar D Sarma, Raviteja Nanabala, Dibakar Goswami, Ajith Joy, Maroor Raghavan Ambikalamajan Pillai
Background : Early detection of skeletal metastasis is of great interest to determine the prognosis of cancer. Positron emission tomography-computed tomography (PET-CT) imaging provides a better temporal and spectral resolution than single photon emission computed tomography-computed tomography (SPECT-CT) imaging, and hence is more suitable to detect small metastatic lesions. Although [18 F]NaF has been approved by U.S. FDA for a similar purpose, requirement of a medical cyclotron for its regular formulation restricts its extensive utilization...
February 9, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38331870/bispecific-antibodies-and-car-t-cells-dueling-immunotherapies-for-large-b-cell-lymphomas
#22
REVIEW
Asaad Trabolsi, Artavazd Arumov, Jonathan H Schatz
Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory (rel/ref) disease. A small minority of these can be cured with standard chemoimmunotherapy/stem-cell transplant salvage approaches. CD19-directed chimeric antigen receptor T-cell (CAR-19) therapies are increasingly altering the prognostic landscape for rel/ref patients with DLBCL and related aggressive B-cell non-Hodgkin lymphomas...
February 8, 2024: Blood Cancer Journal
https://read.qxmd.com/read/38330545/the-universal-effects-of-low-dose-interleukin-2-across-13-autoimmune-diseases-in-a-basket-clinical-trial
#23
JOURNAL ARTICLE
Roberta Lorenzon, Claire Ribet, Fabien Pitoiset, Selim Aractingi, Beatrice Banneville, Laurent Beaugerie, Francis Berenbaum, Patrice Cacoub, Julien Champey, Olivier Chazouilleres, Christophe Corpechot, Bruno Fautrel, Arsène Mekinian, Elodie Regnier, David Saadoun, Joe-Elie Salem, Jérémie Sellam, Philippe Seksik, Eric Vicaut, Michelle Rosenzwajg, David Klatzmann
BACKGROUND: A Tregs insufficiency is central to autoimmune and inflammatory diseases pathophysiology and low dose interleukin-2 (IL-2LD ) can specifically activate Tregs. OBJECTIVE: To assess IL-2LD therapeutic potential and select diseases for further clinical development, we performed an open-label, phase 2a, disease-finding, "basket trial" involving patients with one of 13 different autoimmune diseases. METHODS: 81 patients treated with IL-2LD (1 million IU/day) for 5 days, followed by fortnightly injections...
February 7, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38330412/-call-for-special-issue-papers-advances-in-molecular-medicine
#24
JOURNAL ARTICLE
Maulin P Shah
No abstract text is available yet for this article.
February 8, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38329243/-medication-management-of-copd
#25
JOURNAL ARTICLE
Marina Gueçamburu, Maeva Zysman
MEDICATION MANAGEMENT OF COPD. The management of chronic obstructive pulmonary disease (COPD) is based on drug and non-drug measures. Inhaled therapies are the major issues including the use of short-acting bronchodilators for respiratory symptoms. If symptoms are daily, such as disabling dyspnea or frequent exacerbations, daily treatment with a long-acting bronchodilator is proposed: anti-muscarinic (LAMA) or β2-agonist (LABA). If there is no improvement, escalation to dual and then triple therapy is proposed...
January 2024: La Revue du Praticien
https://read.qxmd.com/read/38324047/theranostic-innovation-by-humane-n-of-one-cancer-care-in-real-world-patients
#26
JOURNAL ARTICLE
J Harvey Turner
Patients with relapsed or refractory metastatic cancer unresponsive to standard therapies have motivated nuclear physicians to develop innovative radioligands, precisely targeted to tumor molecular receptors, for effective treatment of specific advanced malignancies. Individual practitioners in departments of nuclear medicine across the world have performed first-in-human studies on compassionate patient usage N-of-One protocols. These physician-sponsored studies then evolved into early-phase clinical trials and obtained real-world data to demonstrate real-world evidence of effectiveness in prolonging survival and enhancing quality of life of many so-called "End-Stage" cancer patients...
February 7, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38324046/radiotherapy-and-anrotinib-in-malignant-glomus-tumor-of-the-bladder-a-case-report-and-literature-review
#27
JOURNAL ARTICLE
Jing Ai, Shuang Zhang, Yimeng Qian, Lin Kang, Litao Zhang, Jing Zhao
Background: Malignant glomus tumors (MGTs) are rare malignancies, which grow rapidly and are aggressive. Surgical resection has been regarded as the standard management, but treatment options for those unresectable tumors are limited, resulting in a high recurrence rate and poor prognosis. Case Description: An 85-year-old man presented with gross hematuria and was diagnosed with MGTs of bladder. The patient achieved long-term local control after multimodal therapy comprising radiotherapy, iodine-125 seeds brachytherapy, transcatheter arterial chemoembolization, and antiangiogenic targeted therapy...
February 7, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38324045/evaluating-the-diagnostic-efficacy-of-99m-tc-methionine-single-photon-emission-computed-tomography-computed-tomography-a-head-to-head-comparison-with-11-c-methionine-positron-emission-tomography-magnetic-resonance-imaging-in-glioma-patients
#28
JOURNAL ARTICLE
Pardeep Kumar, Aishwarya Kumar, Chandana Nagaraj, Nishanth Sadashiva, Jitender Saini, Sandhya Mangalore, Archith Rajan, Keerti Sitani, Manish Beniwal, Vani Santosh, Harish Basavaraja, Puja Panwar Hazari, Anil Kumar Mishra
Background: Amino acid positron emission tomography (PET) imaging plays a significant role in the diagnosis of gliomas and in differentiating tumor recurrence from necrosis. In this study, the authors have evaluated the diagnostic efficacy of [99m Tc]Tc-methionine single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with [11 C]methionine PET-magnetic resonance imaging (MRI) in delineating tumors. Methods: Thirty-one (primary: 16 and postoperative: 15) patients of confirmed (either MRI or histopathological proven) glioma underwent both [99m Tc]Tc-methionine SPECT-CT and [11 C]methionine PET-MRI...
February 7, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38314598/no-correlation-between-anti-drug-antibodies-and-therapeutic-response-in-tunisian-patients-with-chronic-inflammatory-diseases-treated-by-tnf-blockers
#29
JOURNAL ARTICLE
Selma Bouden, Lilia Laadhar, Jihene Soua, Meriam Ben Messaoud, Leila Rouached, Imene Ayadi, Olfa Saidane, Aicha Ben Tekaya, Ines Mahmoud, Sonia Rekik, Héla Sahli Srairi, Rawdha Tekaya, Syrine Bellakhal, Monia Fekih, Leila Abdelmoula, Maryem Kallel
INTRODUCTION: Tumor necrosis factor alpha (TNF alpha) blockers such as infliximab (IFX) and adalimumab (ADA) had significantly changed the course of inflammatory diseases such as rheumatoid arthritis (RA), spondyloarthritis (SpA) and Crohn's disease (CD). However, about 30% of patients do not respond to these treatments. This lack of response may be due to the formation of antibodies against these drugs (anti-drug antibodies: ADAbs). The aim of this study was to determine the prevalence of ADAbs against IFX and ADA, and the trough serum concentration of IFX and ADA in RA, SpA or CD patients and to assess their impact on the therapeutic response...
January 2, 2024: Current Rheumatology Reviews
https://read.qxmd.com/read/38306618/injectable-and-thermo-sensitive-hydrogel-with-platelet-rich-plasma-for-enhanced-biotherapy-of-skin-wound-healing
#30
JOURNAL ARTICLE
Gengjun Liu, Yuanming Yang, Yan Liu, Ying Li, Mingyuan Jiang, Yaxin Li, Zifan Meng, Zhen Zhao, Zheng Liu, Jiao Liu, Dongmei Ge, Haiyan Wang
The rapid and effective healing of skin wounds resulted from severe injuries and full-layer skin defects remains a pressing clinical challenge in contemporary medical practice. The reduction of wound infection and rapid healing is helpful to rebuild and repair skin tissue. Here, a thermo-sensitive chitosan (CS)-based wound dressing hydrogel incorporating β-glycerophosphate (GP), hydroxy propyl cellulose (HPC), graphene oxide (GO), and platelet-rich plasma (PRP) is developed, which exhibits the dual functions of antibacterial properties and repair promotion...
February 2, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38297876/-effects-of-different-surgical-methods-on-the-application-of-topical-hormones-in-the-sinus-after-operation
#31
JOURNAL ARTICLE
Meimei Zhao, Jinrui Ma, Shuangyuan Yang, Hui Liu, Zhou Wang, Yuxiang Zhao
<b/>Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease in otorhinolaryngology, in which eosinophilic chronic rhinosinusitis with nasal polyps represents the difficult-to-treat chronic rhinosinusitis (DTCRS) with poor prognosis. DTCRS has a poor prognosis, which seriously affects people's physical and mental health, and is treated with various means, including medication, biotherapy and surgery. In recent years, endoscopic sinus surgery and postoperative local administration of nasal hormones as one of its treatment methods have achieved good results...
February 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://read.qxmd.com/read/38294484/-adult-iga-vasculitis
#32
JOURNAL ARTICLE
Antoine Hankard, Alexandra Audemard-Verger
ADULT IGA VASCULITIS. IgA vasculitis previously named rheumatoid purpura is a rare systemic vasculitis in adults involving small vessels and associated with the presence of immunoglobulin A deposits. IgA vasculitis is often triggerd by infections, taking medication and vaccination. It is characterised by the presence of vascular purpura associated with joint (arthralgia), gastrointestinal (abdominal pain) and sometimes renal involvement (glomerulonephritis). Gastrointestinal involvement can be lifethreatening (bowel perforation), while the longterm prognosis is shaped by the renal involvement (renal failure)...
December 2023: La Revue du Praticien
https://read.qxmd.com/read/38284228/from-biomaterials-to-biotherapy-cuttlefish-ink-with-protoporphyrin-ix-nanoconjugates-for-synergistic-sonodynamic-photothermal-therapy
#33
JOURNAL ARTICLE
Yan Li, Liu Huang, Xun Li, Peng Geng, Juanjuan Xiang, Wei Wang, Bin Yang, Yong Zheng, Haichuang Lan, Shuzhang Xiao
Biologically produced nanomaterials capable of therapeutic purposes have received increasing interest in tumor therapy because of their intrinsic biocompatibility. In this study, we made cuttlefish ink (extracted from cuttlefish) and protoporphyrin IX (PpIX) nanoconjugates (CIPs) where PpIX was an endogenous organic compound. In the case of CIPs, PpIX could be triggered by ultrasound (US) for sonodynamic therapy (SDT), and the cuttlefish ink could be excited by a near-infrared laser for photothermal therapy (PTT)...
January 29, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38275616/translational-relevance-of-advanced-age-and-atherosclerosis-in-preclinical-trials-of-biotherapies-for-peripheral-artery-disease
#34
REVIEW
Keith A Webster
Approximately 6% of adults worldwide suffer from peripheral artery disease (PAD), primarily caused by atherosclerosis of lower limb arteries. Despite optimal medical care and revascularization, many PAD patients remain symptomatic and progress to critical limb ischemia (CLI) and risk major amputation. Delivery of pro-angiogenic factors as proteins or DNA, stem, or progenitor cells confers vascular regeneration and functional recovery in animal models of CLI, but the effects are not well replicated in patients and no pro-angiogenic biopharmacological procedures are approved in the US, EU, or China...
January 22, 2024: Genes
https://read.qxmd.com/read/38269553/-elderly-onset-crohn-s-disease-clinical-and-therapeutic-features
#35
JOURNAL ARTICLE
Hanen Elloumi, Habiba Dabbebi
Crohn's disease (CD) is a pathology that typically affects young people. With the aging of the population, there is an increase of its incidence in the elderly. Several studies have compared the clinical and therapeutic features of the CD in the elderly and young patients with discordant results. The objective of this work was to identify the clinical and therapeutic characteristics of elderly onset CD. The clinical presentation of CD in the elderly has some peculiarities. It seems that the disease has a less severe profile...
December 1, 2023: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://read.qxmd.com/read/38266774/-risk-factors-for-high-grade-squamous-intraepithelial-lesions-or-cervical-cancer-in-chronic-inflammatory-bowel-disease
#36
JOURNAL ARTICLE
Clémence Dujardin, Thibault Balcaen, Antoine Vanoost, Denis Chatelain, Jean Gondry, Mathurin Fumery, Arthur Foulon
INTRODUCTION: Chronic inflammatory bowel disease (IBD) is thought to increase the risk of high-grade histological intraepithelial lesions (HGIL) and cervical cancer. The risk factors for developing these lesions are poorly understood. MATERIALS AND METHODS: This is a single-center retrospective case-control study including IBD patients followed at our University Hospital Center from 2011 to 2021 who presented with HGIL or cervical cancer. Four controls were case-matched according to IBD type, age, active smoking and multiparity...
January 22, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38265813/influence-of-early-versus-delayed-hepatic-artery-perfusion-scan-on-90-y-selective-internal-radiation-therapy-planning
#37
JOURNAL ARTICLE
Bilal Kovan, Dilara Denizmen, Caner Civan, Serkan Kuyumcu, Emine Goknur Isik, Duygu Has Simsek, Zeynep Gozde Ozkan, Arzu Poyanli, Bayram Demir, Yasemin Sanli
Purpose: The aim of this study was to evaluate the effect of an increase in the time interval between hepatic intra-arterial injection of 99mTc-macroaggregated albumin (MAA) and hepatic artery perfusion scintigraphy (HAPS) on the lung shunt fraction (LSF) and perfused volume (PV) calculations in the treatment planning of selective internal radiation therapy (SIRT). Methods: The authors enrolled 51 HAPS sessions from 40 patients diagnosed with primary or metastatic liver malignancy. All patients underwent scan at the first and fourth hour after hepatic arterial injection of 99mTc-MAA...
January 24, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38265676/a-novel-method-for-real-time-quantification-of-radioligand-binding-to-living-tumor-cells-in-vitro
#38
JOURNAL ARTICLE
Tom Bäck, Per Albertsson, Emma Aneheim, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Stig Palm
Background: Real-time quantification of radioligand binding to cells under in vivo -like conditions improves evaluation of clinical potential. Materials and Methods: SKOV-3 tumor cells were grown in a monolayer on a thin glass plate placed in a sealable shallow chamber with a continuous flow of 125 I-trastuzumab solution. The time-dependent cell binding was measured using a NaI detector, and the binding parameters were derived by computational analysis. Results: The detection efficiency of 125 I was 65 cps/kBq for radioligand bound to the cells...
January 23, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38265675/-90-y-yttria-alumino-silicate-glass-microspheres-a-biosimilar-formulation-to-therasphere-for-cost-effective-treatment-of-liver-cancer
#39
JOURNAL ARTICLE
K V Vimalnath, Ardhi Rajeswari, Anupam Dixit, Rubel Chakravarty, Haldhar D Sarma, Suyash Kulkarni, Ashish Jha, Ameya Puranik, Venkatesh Rangarajan, Madhumita Goswami, Sudipta Chakraborty
Background: Selective internal radiation therapy (SIRT) using a suitable β-emitting radionuclide is a promising treatment modality for unresectable liver carcinoma. Yttrium-90 [ T 1/2  = 64.2 h, E β (max) = 2.28 MeV, no detectable γ-photon] is the most preferred radioisotope for SIRT owing to its favorable decay characteristics. Objective: The present study describes indigenous development and evaluation of intrinsically radiolabeled [90 Y]yttria alumino silicate ([90 Y]YAS) glass microsphere, a formulation biosimilar to "TheraSphere" (commercially available, U...
January 23, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38252866/standardization-of-the-verification-nurse-role-in-the-delivery-of-chemotherapy-and-biotherapy
#40
JOURNAL ARTICLE
Lisa Caltieri, Mary Schumann, Katie Hambright, Julie Smith, Asya Borthwick, Linda Temperino
After a chemotherapy overdose in 1994 resulted in the death of one patient and the permanent injury of another, the role of the verification nurse was created at a National Cancer Institute-designated comprehensive cancer c.
January 18, 2024: Clinical Journal of Oncology Nursing
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