keyword
MENU ▼
Read by QxMD icon Read
search

Biotherapy

keyword
https://www.readbyqxmd.com/read/28325220/action-of-antibiotic-oxacillin-on-in%C3%A2-vitro-growth-of-methicillin-resistant-staphylococcus-aureus-mrsa-previously-treated-with-homeopathic-medicines
#1
Tânia Aguiar Passeti, Leandro Ribeiro Bissoli, Ana Paula Macedo, Registila Beltrame Libame, Susana Diniz, Silvia Waisse
BACKGROUND: Resistance to antibiotics is a major public health concern worldwide. New treatment options are needed and homeopathy is one such option. We sought to assess the effect of the homeopathic medicine Belladonna (Bell) and a nosode (biotherapy) prepared from a multi-drug resistant bacterial species, methicillin-resistant Staphylococcus aureus (MRSA), on the same bacterium. METHODS: Bell and MRSA nosode were prepared in 6cH and 30cH potencies in 30% alcohol and sterile water, according to the Brazilian Homeopathic Pharmacopeia and tested on MRSA National Collection of Type Cultures (NCTC) 10442...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28321034/galectin-9-as-a-predictive-marker-for-the-onset-of-immune-related-adverse-effects-associated-with-anti-ccr4-moab-therapy-in-patients-with-adult-t-cell-leukemia
#2
Tareg Omer Mohammed, Haorile Chagan-Yasutan, Yugo Ashino, Wakana Nakayama, Yayoi Takahashi, Taizo Shimomura, Tetsuhiro Fujimoto, Yuko Watanabe, Toshiro Niki, Hitoshi Suzushima, Toshio Hattori
Adult T-cell leukemia/lymphoma (ATL/ATLL) is one of the most malignant lymphomas with poor prognosis. ATL/ATLL cells express CC chemokine receptor 4, and mogamulizumab (anti-CCR4 monoclonal antibody) exhibits strong cytotoxicity for ATL/ATLL cells. We analyzed plasma samples of 6 patients with ATL/ATLL treated with chemotherapy followed by mogamulizumab therapy (mogatherapy) for changes in the levels of biomarkers in relation to immune-related adverse effects. As treatment is often associated with skin eruptions, we investigated the profiles of inflammatory cytokines, including galectin-9 (Gal-9), which becomes increased in various infectious diseases and allergic patients...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28315535/high-dose-interleukin-2-evaluation-of-a-standardized-order-set-for-biotherapy-in-an-intensive-care-unit%C3%A2
#3
Rusticio Portillas, Barbara Turner, Audrey Jeffers, Lee-Lynn Chen, Mary Champagne
BACKGROUND: Life-threatening toxicity may result from administration of high-dose (HD) interleukin-2 (IL-2). Patients receiving HD IL-2 treatment often experience severe adverse side effects, which result in the interruption of treatment. 
. OBJECTIVES: A standardized order set (SOS) was developed for patients with melanoma or renal cell carcinoma receiving HD IL-2. The aims of the study were to determine compliance of clinicians to the SOS, report the completed doses and major side effects of HD IL-2, and document the satisfaction level of clinicians...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28315319/interferon-alpha2a-and-systemic-corticosteroid-in-monotherapy-in-chronic-uveitis-results-of-the-randomised-controlled-birdferon-study
#4
Christine Fardeau, Anne Simon, Benoît Rodde, Fabiana Viscogliosi, Pierre Labalette, Vincent Looten, Sophie Tézenas du Montcel, Phuc LeHoang
PURPOSE: Macular edema is the leading cause of vision loss in bilateral chronic non-infectious posterior uveitis, and is used to being treated using corticosteroids, immunosuppressive agents and biotherapies. The aim of this trial was to assess and compare the efficacy and safety of corticosteroids and IFN-α in adults with such conditions. STUDY DESIGN: Randomized controlled trial SUBJECTS: Adult patients with bilateral posterior autoimmune non-infectious and non-tumoral uveitis complicated by macular edema in at least one eye, were recruited...
March 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314176/metronomic-and-metronomic-like-therapies-in-neuroendocrine-tumors-rationale-and-clinical-perspectives
#5
REVIEW
Ioana Lambrescu, Simona Fica, Diana Martins, Francesca Spada, Chiara Cella, Emilio Bertani, Manila Rubino, Bianca Gibelli, Chiara Grana, Guido Bonomo, Luigi Funicelli, Davide Ravizza, Eleonora Pisa, Dario Zerini, Antonio Ungaro, Nicola Fazio
Metronomic therapy is characterized by the administration of regular low doses of certain drugs with very low toxicity. There have been numerous debates over the empirical approach of this regimen, but fewest side effects are always something to consider in order to improve patients' quality of life. Neuroendocrine tumors (NETs) are rare malignancies relatively slow-growing; therefore their treatment is often chronic, involving several different therapies for tumor growth control. Knowing that these tumors are highly vascularized, the anti-angiogenic aspect is highly regarded as something to be targeted in all patients harboring NETs...
February 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28254560/homeopathic-medicines-cause-th1-predominance-and-induce-spleen-and-megakaryocytes-changes-in-balb-c-mice-infected-with-leishmania-infantum
#6
Ana Paula Bacellar Cajueiro, Ester Puna Goma, Hilton Antônio Mata Dos Santos, Igor Almeida Rodrigues, Helena Keiko Toma, Silvana Marques Araújo, Leoni Villano Bonamin, Nelson Brêtas de Noronha Gomes, Morgana Teixeira Lima Castelo-Branco, Edilma Paraguai de Souza Dias, Alexandre Dos Santos Pyrrho, Carla Holandino
The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10(-30)) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×10(7)L. infantum promastigotes, divided into eight groups: G1 (healthy), G2 (infected with L. infantum), G3 (BioLi30× pre-treated), G4 (BioLi30× pre/post-treated), G5 (BioLi30× post-treated), G6 (Water 30× post-treated), G7 (Antimonium crudum 30× post-treated) and G8 (Glucantime® post-treated)...
February 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28191780/cancer-stem-cells-therapeutic-target-database-the-first-comprehensive-database-for-therapeutic-targets-of-cancer-stem-cells
#7
Xiaoqing Hu, Ye Cong, Huizhe Howard Luo, Sijin Wu, Liyuan Eric Zhao, Quentin Liu, Yongliang Yang
Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong self-renewal capabilities and may contribute to the failure of conventional cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and promising approach that may eradicate malignant tumors. However, the lack of information on validated targets of CSCs has greatly hindered the development of CSC-directed therapeutics. Herein, we describe the Cancer Stem Cells Therapeutic Target Database (CSCTT), the first online database to provide a rich bioinformatics resource for the display, search, and analysis of structure, function, and related annotation for therapeutic targets of cancer stem cells...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28176648/oncolytic-viruses-the-best-is-yet-to-come
#8
Chantal G Lemay, Brian A Keller, Robert E Edge, Masato Abei, John C Bell
Oncolytic viruses are a promising anti-cancer platform, achieving significant pre-clinical and clinical milestones in recent years. A full arsenal of selective, safe, and effective viruses has been developed with some emerging pre-clinical research focusing on optimizing these therapies in the face of remaining challenges, both in the bloodstream and in the tumour microenvironment. Herein we discuss the recent progress in pre-clinical virotherapy research to address these challenges, with special focus on innovative strategies that seek to complement the current strengths of virotherapy, ensuring an optimal multi-faceted attack on cancer...
February 6, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28152887/utilizing-a-case-management-system-to-reduce-the-response-time-for-symptom-management-calls-in-a-high-volume-practice
#9
Larry Edward Bilbrey
170 Background: A five physician, three nurse practitioner,community oncology clinic experiences high call volumes (average 352 daily), many of which are related to side-effects of chemo/biotherapy and health related issues. A study was completed to decrease the time for a patient symptom management call to be addressed and concluded. METHODS: Initial primary data were collected over a four month period (April-August 2015) using the phone system and the Electronic Health Record (EHR) reporting capabilities, by cross-referencing the caller-ID data with the EHR patient demographics data; only documented symptom management calls within the EHR were included...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28058537/in-vivo-efficacy-of-a-biotherapic-and-eugenol-formulation-against-rhipicephalus-microplus
#10
Paula Pimentel Valente, Gustavo Henrique Ferreira Abreu Moreira, Matheus Ferreira Serafini, Elias Jorge Facury-Filho, Antônio Último Carvalho, André Augusto Gomes Faraco, Rachel Oliveira Castilho, Múcio Flávio Barbosa Ribeiro
The control of Rhipicephalus microplus is essential to prevent cattle discomfort and economic losses. However, increased resistance and acaricides inefficiency lead producers to adopt strategies that could result in the accumulation of chemical residues in meat and milk with possibilities of poisoning in animals and people. This scenario demonstrates the necessity of research into the identification of novel, effective and environmentally safe therapeutic options for cattle tick control. The objectives of this study were to develop and assess the efficacy of R...
January 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28025189/cardiopoietic-cell-therapy-for-advanced-ischemic-heart-failure-results-at-39-weeks-of-the-prospective-randomized-double-blind-sham-controlled-chart-1-clinical-trial
#11
Jozef Bartunek, Andre Terzic, Beth A Davison, Gerasimos S Filippatos, Slavica Radovanovic, Branko Beleslin, Bela Merkely, Piotr Musialek, Wojciech Wojakowski, Peter Andreka, Ivan G Horvath, Amos Katz, Dariouch Dolatabadi, Badih El Nakadi, Aleksandra Arandjelovic, Istvan Edes, Petar M Seferovic, Slobodan Obradovic, Marc Vanderheyden, Nikola Jagic, Ivo Petrov, Shaul Atar, Majdi Halabi, Valeri L Gelev, Michael K Shochat, Jaroslaw D Kasprzak, Ricardo Sanz-Ruiz, Guy R Heyndrickx, Noémi Nyolczas, Victor Legrand, Antoine Guédès, Alex Heyse, Tiziano Moccetti, Francisco Fernandez-Aviles, Pilar Jimenez-Quevedo, Antoni Bayes-Genis, Jose Maria Hernandez-Garcia, Flavio Ribichini, Marcin Gruchala, Scott A Waldman, John R Teerlink, Bernard J Gersh, Thomas J Povsic, Timothy D Henry, Marco Metra, Roger J Hajjar, Michal Tendera, Atta Behfar, Bertrand Alexandre, Aymeric Seron, Wendy Gattis Stough, Warren Sherman, Gad Cotter, William Wijns
AIMS: Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. METHODS AND RESULTS: This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion...
December 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28024866/saccharomyces-boulardii-probiotic-associated-fungemia-questioning-the-safety-of-this-preventive-probiotic-s-use
#12
Isabella W Martin, Rita Tonner, Julie Trivedi, Heather Miller, Richard Lee, Xinglun Liang, Leo Rotello, Elena Isenbergh, Jennifer Anderson, Trish Perl, Sean X Zhang
We report a case of fungemia in an immunocompetent patient after administration of probiotic containing Saccharomyces boulardii. We demonstrated the strain relatedness of the yeast from the probiotic capsule and the yeast causing fungal infection using genomic and proteomic typing methods. Our study questions the safety of this preventative biotherapy.
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27943621/the-protective-effect-of-human-platelet-lysate-in-models-of-neurodegenerative-disease-involvement-of-the-akt-and-mek-pathways
#13
Flore Gouel, Bruce Do Van, Ming-Li Chou, Aurélie Jonneaux, Caroline Moreau, Régis Bordet, Thierry Burnouf, Jean-Christophe Devedjian, David Devos
Neurodegenerative diseases have huge economic and societal impacts, and place an immense emotional burden on patients and caregivers. Given that platelets have an essential physiological role in wound healing and tissue repair, human platelet lysates (HPLs) are being developed as a novel, effective biotherapy for neurodegenerative diseases. HPLs constitute abundant, readily accessible sources of physiological mixtures of many growth factors (GFs), with demonstrable effects on neuron survival and thus the development, maintenance, function and plasticity of the vertebrate nervous system...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27928789/-surgical-management-of-locally-advanced-digestive-tract-neuroendocrine-neoplasm-with-or-without-liver-metastasis
#14
Xiaosong Wang, Jiangfeng Qiu, Zhiyong Wu
Neuroendocrine tumors in the digestive tract are rare, however their incidences increased obviously for the past few years. The purpose of this paper is to elucidate the surgical management of locally advanced digestive tract neuroendocrine neoplasms(NENs) with or without liver metastasis and to discuss the present classification of gastrointestinal NENs in order to provide reference for clinicians. WHO re-classified the gastroenteropancreatic NENs in 2010, but this classification remains many questions and needs further clinical trials to answer...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27914572/different-treatment-schemes-and-dynamizations-of-trypanosoma-cruzi-biotherapies-what-information-do-they-transfer-to-the-organism-in-infected-mice
#15
Fabiana Nabarro Ferraz, Franciele Karina da Veiga, Denise Lessa Aleixo, Miguel Spack Júnior, Silvana Marques de Araújo
BACKGROUND: The use of biotherapies in Trypanosoma cruzi infection can provide an understanding about effects of these highly diluted medications. OBJECTIVES: To evaluate different treatment schemes and dynamizations of biotherapies prepared from blood trypomastigotes (buffy coat) in mice infected with T. cruzi. METHODS: Swiss mice infected with Y strain of T. cruzi were divided into two experiments. Experiment 1, all treated groups received biotherapy 7dH (10 μL/mL ad libitum) in different treatment schemes: TB7dH - treated 3 days before infection; TBA7dH - treated 3 days before and after infection; TBAe...
November 2016: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/27909436/evaluation-of-anti-inflammatory-effects-of-steroids-and-arthritis-related-biotherapies-in-an-in-vitro-coculture-model-with-immune-cells-and-synoviocytes
#16
Mélissa Noack, Ndiémé Ndongo-Thiam, Pierre Miossec
BACKGROUND: During rheumatoid arthritis (RA), steroids and biotherapies are used alone and combined. Efficacy has been established in clinical trials but their differential effects at the cellular level are less documented. The aim was to study these cellular effects using an in vitro model with synoviocytes interacting with peripheral blood mononuclear cells (PBMC) to reproduce the interactions in the RA synovium. METHODS: Activated-PBMC were cocultured with RA synoviocytes during 48 h...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27869551/critical-limb-ischaemia-and-the-response-to-bone-marrow-derived-cell-therapy-according-to-tcpo2-measurement
#17
Mario Maufus, Marie Antoinette Sevestre-Pietri, Carmine Sessa, Bernard Pignon, Harald Egelhofer, Stephane Dupas, Philippe Nguyen, Celine Genty, Gilles Pernod
BACKGROUND: Cell therapy is an emerging potential biotherapy for critical limb ischaemia (CLI) patients who are not eligible for revascularization. However, the findings on this technique's efficacy are inconsistent. Trials investigating this topic focused on the more severe CLI patients who were often beyond any therapy. Therefore, identifying those who may truly benefit from cell transplantation is now warranted. To this end, we studied the prognostic value of tcPO2 for major amputation after 1 year in patients treated with bone marrow-derived cells...
November 21, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27834948/the-antitumor-efficacy-of-anti-p21ras-scfv-mediated-by-the-dual-promoter-regulated-recombinant-adenovirus-kghv300
#18
X Y Pan, X J Liu, J Li, S J Zhen, D X Liu, Q Feng, W X Zhao, Y Luo, Y L Zhang, H W Li, J L Yang
Ras mutations and overexpression of the Ras protein, p21Ras, are main causes of cancer development and progression, which has made the Ras gene and p21Ras important targets for therapy of Ras-driven cancers. We previously prepared recombinant adenovirus KGHV100 based on replication-defective adenovirus type 5, which could intracellularly express anti-p21Ras single chain fragment viable antibodies (scFv) and repress tumor growth in vitro and in vivo. However, the anti-tumor effects of this anti-p21Ras scFv were limited by short-term scFv expression due to a replication defect of KGHV100...
December 22, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27825567/prevalence-of-rheumatoid-arthritis-in-the-french-west-indies-results-of-the-epppra-study-in-martinique
#19
Lauren Brunier, Marie Bleterry, Sylvie Merle, Christian Derancourt, Katlyn Polomat, Véronique Dehlinger, Christophe Deligny, Georges Jean-Baptiste, Serge Arfi, Rishika Banydeen, Michel De Bandt
OBJECTIVES: Studies suggest that rheumatoid arthritis (RA) is less frequent in African populations. However, no recent precise data exists for Afro-Caribbeans. The EPPPRA project is a prospective epidemiological survey to describe prevalence and clinical aspects of RA in the French West Indies (Martinique, Guadeloupe, French Guiana). METHODS: EPPPRA involved all rheumatologists from the French West Indies who included all patients with a known clinical diagnosis of RA, during a one-year period...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27813277/comparison-between-weekly-cisplatin-enhanced-radiotherapy-and-cetuximab-enhanced-radiotherapy-in-locally-advanced-head-and-neck-cancer-first-retrospective-study-in-asian-population
#20
Sheh Rawat, Parveen Ahlawat, Anjali Kakria, Gaurav Kumar, Ranga Rao Rangaraju, Abhishek Puri, Manoj Pal, Deepika Chauhan, Bharti Devnani, Pranav Chadha
AIM: To present a direct comparison between chemotherapy-enhanced radiotherapy (CERT) and biotherapy-enhanced radiotherapy (BERT) in locally advanced head and neck cancer. METHODS: It is a retrospective analysis of 53 patients with locally advanced head and neck cancer treated from August 2006 to December 2008. For CERT, patients received weekly cisplatin (40 mg/m(2) ) and for BERT, a loading dose of 400 mg/m(2) of cetuximab given one week prior to radiotherapy followed by 250 mg/m(2) given weekly along with radiotherapy...
November 3, 2016: Asia-Pacific Journal of Clinical Oncology
keyword
keyword
60436
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"