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https://www.readbyqxmd.com/read/28816745/restoration-of-normal-sympathetic-neural-function-in-heart-failure-following-baroreflex-activation-therapy-final-43-month-study-report
#1
Raffaella Dell'Oro, Edoardo Gronda, Gino Seravalle, Giuseppe Costantino, Luca Alberti, Barbara Baronio, Tiziana Staine, Emilio Vanoli, Giuseppe Mancia, Guido Grassi
BACKGROUND: Baroreflex activation therapy (BAT) exerts in severe heart failure sympathoinhibitory effects, improving clinical variables and reducing hospitalization rate. The current follow-up study was aimed at determining the long-term effects of BAT, assessing whether BAT in heart failure allows to restore physiological levels of sympathetic function. METHODS: Seven patients out of the 11 heart failure patients aged 66.5 ± 3 years (mean ± SEM) in New York Heart Association Class III with left ventricular ejection fraction 40% or less and impaired functional capacity recruited in the study survived at the final follow-up (43...
August 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28811213/hemodynamic-characteristics-of-suspected-stroke-in-the-emergency-department
#2
Joseph B Miller, Richard M Nowak, Brian P Reed, Salvatore DiSomma, Prabath Nanayakkara, Michele Moyer, Scott Millis, Harish Kinni, Phillip Levy
BACKGROUND: Systemic hemodynamic characteristics of patients with suspected acute ischemic stroke are poorly described. The objective of this study was to identify baseline hemodynamic characteristics of emergency department (ED) patients with suspected acute stroke. METHODS: This was a planned analysis of the stroke cohort from a multicenter registry of hemodynamic profiling of ED patients. The registry prospectively collected non-invasive hemodynamic measurements of patients with suspicion for acute stroke within 12h of symptom onset...
August 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28802510/aortic-dilatation-associated-with-bicuspid-aortic-valve-relation-to-sex-hemodynamics-and-valve-morphology-the-national-heart-lung-and-blood-institute-sponsored-national-registry-of-genetically-triggered-thoracic-aortic-aneurysms-and-cardiovascular-conditions
#3
Mary J Roman, Norma L Pugh, Richard B Devereux, Kim A Eagle, Kathryn Holmes, Scott A LeMaire, Rita K Milewski, Shaine A Morris, Siddharth K Prakash, Reed E Pyeritz, William J Ravekes, Ralph V Shohet, Howard K Song, Federico M Asch
This study analyzed the impact of sex, hemodynamic profile, and valve fusion pattern on aortopathy associated with bicuspid aortic valve (BAV). The National Heart Lung and Blood Institute-sponsored National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) provided comprehensive information on a large population of well-characterized patients with BAV. Of 969 enrolled patients with BAV, 551 (57%, 77% male) had already undergone valvular and/or aortic surgery...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28795259/comparison-of-outcomes-using-balloon-expandable-versus-self-expanding-transcatheter-prostheses-according-to-the-extent-of-aortic-valve-calcification
#4
Won-Keun Kim, Johannes Blumenstein, Christoph Liebetrau, Andreas Rolf, Luise Gaede, Arnaud Van Linden, Mani Arsalan, Mirko Doss, Jan G P Tijssen, Christian W Hamm, Thomas Walther, Helge Möllmann
BACKGROUND: Device landing zone (DLZ) calcification is an important determinant of procedural success in transcatheter aortic valve implantation (TAVI). OBJECTIVE: To evaluate the impact of DLZ calcification on procedural outcome with different types of transcatheter heart valves (THVs). METHODS: Aortic valve calcium density (AVCdens) was determined by non-contrast-enhanced computed tomography in 1232 patients undergoing transfemoral TAVI...
August 9, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28780036/transcatheter-tricuspid-valve-repair-with%C3%A2-a-new-transcatheter-coaptation-system-for-the-treatment-of-severe-tricuspid-regurgitation-1-year-clinical-and-echocardiographic-results
#5
Gidon Perlman, Fabien Praz, Rishi Puri, Hadass Ofek, Jian Ye, Francois Philippon, Thierry Carrel, Philippe Pibarot, Adrian Attinger, Nay Min Htun, Danny Dvir, Robert Moss, Francisco Campelo-Parada, Elisabeth Bédard, David Reineke, Aris Moschovitis, Sandra Lauck, Philipp Blanke, Jonathon Leipsic, Stephan Windecker, Josep Rodés-Cabau, John Webb
OBJECTIVES: This study sought to describe the 1-year experience with the transcatheter FORMA system for severe tricuspid regurgitation (TR). BACKGROUND: Severe TR is associated with significant morbidity and mortality. Novel transcatheter therapies have been recently developed. METHODS: Eighteen patients underwent device implantation at 3 centers in Canada and Switzerland. Baseline characteristics, procedural, 30-day, and 1-year outcomes were prospectively evaluated using multimodality imaging and hemodynamic and clinical assessments...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28770948/curative-treatment-of-hypertension-by-physical-exercise
#6
M Lou, X-F Zong, L-L Wang
Hypertension, one of the most common chronic and sporadic conditions, figures among the important worldwide public-health challenges, and it is a major risk for heart disease, stroke, kidney disease and other complications, including dementia. Hypertension is neglected by individuals, and the prevalence of this condition continues to rise across the world. A great number of patients receiving medical intervention is not successfully treated, while adequate curative health services are dependent on the exact update data of the countrywide prevalence of known and undetected cases...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28760462/histone-modification-is-correlated-with-reverse-lv-remodeling-in-nonischemic-dilated-cardiomyopathy
#7
Emiko Ito, Shigeru Miyagawa, Satsuki Fukushima, Yasushi Yoshikawa, Shunsuke Saito, Tetsuya Saito, Akima Harada, Maki Takeda, Noriyuki Kashiyama, Yuki Nakamura, Motoko Shiozaki, Koichi Toda, Yoshiki Sawa
BACKGROUND: Although implantation of a left ventricular assist device (LVAD) induces reverse remodeling of the left ventricle in end-stage nonischemic dilated cardiomyopathy (DCM), the underlying mechanism is not fully understood. It has been shown that epigenetic modification, such as methylation or acetylation of the histone, is one of the most important upstream signals in cardiac failure. This study hypothesized that histone profiles may be modified by LVAD implantation for end-stage nonischemic DCM, in association with reverse left ventricular remodeling...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28755660/computational-and-experimental-assessment-of-influences-of-hemodynamic-shear-stress-on-carotid-plaque
#8
Hui Zhou, Long Meng, Wei Zhou, Lin Xin, Xiangxiang Xia, Shuai Li, Hairong Zheng, Lili Niu
BACKGROUND: Studies have identified hemodynamic shear stress as an important determinant of endothelial function and atherosclerosis. In this study, we assess the influences of hemodynamic shear stress on carotid plaques. METHODS: Carotid stenosis phantoms with three severity (30, 50, 70%) were made from 10% polyvinyl alcohol (PVA) cryogel. The phantoms were placed in a pulsatile flow loop with the same systolic/diastolic phase (35/65) and inlet flow rate (16 L/h)...
July 29, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28754993/neurometabolic-and-electrophysiological-changes-during-cortical-spreading-depolarization-multimodal-approach-based-on-a-lactate-glucose-dual-microbiosensor-arrays
#9
Cátia F Lourenço, Ana Ledo, Greg A Gerhardt, João Laranjinha, Rui M Barbosa
Spreading depolarization (SD) is a slow propagating wave of strong depolarization of neural cells, implicated in several neuropathological conditions. The breakdown of brain homeostasis promotes significant hemodynamic and metabolic alterations, which impacts on neuronal function. In this work we aimed to develop an innovative multimodal approach, encompassing metabolic, electric and hemodynamic measurements, tailored but not limited to study SD. This was based on a novel dual-biosensor based on microelectrode arrays designed to simultaneously monitor lactate and glucose fluctuations and ongoing neuronal activity with high spatial and temporal resolution...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28754719/visualisation-of-three-pathways-for-macromolecule-transport-across-cultured-endothelium-and-their-modification-by-flow
#10
Mean Ghim, Paola Alpresa, Sung Yang, Sietse T Braakman, Stephen G Gray, Spencer J Sherwin, Maarten van Reeuwijk, Peter D Weinberg
Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger arterial disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. Here we visualised pathways for macromolecule transport and determined the effect on these pathways of different types of flow...
July 28, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28754423/gender-differences-and-outcomes-in-left-ventricular-assist-device-support-the-european-registry-for-patients-with-mechanical-circulatory-support
#11
Christina Magnussen, Alexander M Bernhardt, Francisco M Ojeda, Florian M Wagner, Jan Gummert, Theo M M H de By, Thomas Krabatsch, Paul Mohacsi, Meike Rybczynski, Dorit Knappe, Bjoern Sill, Tobias Deuse, Stefan Blankenberg, Renate B Schnabel, Hermann Reichenspurner
BACKGROUND: Despite the increasing use of ventricular assist devices (VADs), gender differences in indications, hemodynamics, and outcome are not well understood. We examined gender differences and gender-specific predictors for perioperative outcome in patients on ventricular support. METHODS: Multicenter data of 966 patients (median age 55 years, 151 women) from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) were analyzed. Median follow-up was 1...
July 4, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28744783/towards-the-identification-of-hemodynamic-parameters-involved-in-arteriovenous-fistula-maturation-and-failure-a-review
#12
Marco Franzoni, Michael T Walsh
Native arteriovenous fistulas have a high failure rate mainly due to the lack of maturation and uncontrolled neo-intimal hyperplasia development. Newly established hemodynamics is thought to be central in driving the fistula fate, after surgical creation. To investigate the effects of realistic wall shear stress stimuli on endothelial cells, an in vitro approach is necessary in order to reduce the complexity of the in vivo environment. After a systematic review, realistic WSS waveforms were selected and analysed in terms of magnitude, temporal gradient, presence of reversing phases (oscillatory shear index, OSI) and frequency content (hemodynamics index, HI)...
July 25, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28738745/is-ultrasound-guided-suction-curettage-a-reliable-option-for-treatment-of-cesarean-scar-pregnancy-a-cross-sectional-retrospective-study
#13
Hüseyin Çağlayan Özcan, Mete Gurol Uğur, Özcan Balat, Seyhun Sucu, Aynur Mustafa, Neslihan Bayramoğlu Tepe, Berna Kaya Uğur
PURPOSE: The purpose of our study is to present clinical courses and outcomes of 50 first-trimester cesarean scar pregnancy (CSP) cases, which are managed either with transabdominal ultrasound (TAUS)-guided suction curettage alone or abdominal hysterotomy. METHODS: We retrospectively analyzed our records from 2011 to 2016 at a single-center. TAUS-guided suction curettage alone was preferred in hemodynamically stable patients when the myometrial thickness was ≥ 3 mm and there was no vascular invasion...
July 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28736085/low-cardiac-output-syndrome-in-the-postoperative-period-of-cardiac-surgery-profile-differences-in-clinical-course-and-prognosis-the-esbaga-study
#14
J L Pérez Vela, J J Jiménez Rivera, M Á Alcalá Llorente, B González de Marcos, H Torrado, C García Laborda, M D Fernández Zamora, F J González Fernández, J C Martín Benítez
OBJECTIVES: An analysis is made of the clinical profile, evolution and differences in morbidity and mortality of low cardiac output syndrome (LCOS) in the postoperative period of cardiac surgery, according to the 3 diagnostic subgroups defined by the SEMICYUC Consensus 2012. DESIGN: A multicenter, prospective cohort study was carried out. SETTING: ICUs of Spanish hospitals with cardiac surgery. PATIENTS: A consecutive sample of 2,070 cardiac surgery patients was included, with the analysis of 137 patients with LCOS...
July 20, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28720191/sustained-accelerated-idioventricular-rhythm-in-a-centrifuge-simulated-suborbital-spaceflight
#15
Rahul Suresh, Rebecca S Blue, Charles Mathers, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: Hypergravitational exposures during human centrifugation are known to provoke dysrhythmias, including sinus dysrhythmias/tachycardias, premature atrial/ventricular contractions, and even atrial fibrillations or flutter patterns. However, events are generally short-lived and resolve rapidly after cessation of acceleration. This case report describes a prolonged ectopic ventricular rhythm in response to high G exposure. CASE REPORT: A previously healthy 30-yr-old man voluntarily participated in centrifuge trials as a part of a larger study, experiencing a total of 7 centrifuge runs over 48 h...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28709412/study-protocol-safety-and-efficacy-of-propranolol-0-2-eye-drops-in-newborns-with-a-precocious-stage-of-retinopathy-of-prematurity-drop-rop-0-2-a-multicenter-open-label-single-arm-phase-ii-trial
#16
Luca Filippi, Giacomo Cavallaro, Elettra Berti, Letizia Padrini, Gabriella Araimo, Giulia Regiroli, Valentina Bozzetti, Chiara De Angelis, Paolo Tagliabue, Barbara Tomasini, Giuseppe Buonocore, Massimo Agosti, Angela Bossi, Gaetano Chirico, Salvatore Aversa, Roberta Pasqualetti, Pina Fortunato, Silvia Osnaghi, Barbara Cavallotti, Maurizio Vanni, Giulia Borsari, Simone Donati, Giuseppe Nascimbeni, Giancarlo la Marca, Giulia Forni, Silvano Milani, Ivan Cortinovis, Paola Bagnoli, Massimo Dal Monte, Anna Maria Calvani, Alessandra Pugi, Eduardo Villamor, Gianpaolo Donzelli, Fabio Mosca
BACKGROUND: Retinopathy of prematurity (ROP) still represents one of the leading causes of visual impairment in childhood. Systemic propranolol has proven to be effective in reducing ROP progression in preterm newborns, although safety was not sufficiently guaranteed. On the contrary, topical treatment with propranolol eye micro-drops at a concentration of 0.1% had an optimal safety profile in preterm newborns with ROP, but was not sufficiently effective in reducing the disease progression if administered at an advanced stage (during stage 2)...
July 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28707302/dialysate-sodium-and-intradialytic-hypotension
#17
Wael F Hussein, Brigitte Schiller
Intradialytic hypotension (IDH) is a common complication in hemodialysis, particularly with the time and frequency constraints of standard session delivery in contemporary practice. High intradialytic weight gain (IDWG), high ultrafiltration rates (UFR), and frequent IDH are highly interlinked, and separately or together contribute to the high cardiovascular morbidity and mortality observed in the hemodialysis population. Using a lower concentration of sodium in the dialysate (D-Na) reduces sodium delivery to the patient during dialysis, and several studies reported the beneficial effect in controlling IDWG, UFR, and hypertension...
July 13, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28694489/high-frequency-components-of-hemodynamic-shear-stress-profiles-are-a-major-determinant-of-shear-mediated-platelet-activation-in-therapeutic-blood-recirculating-devices
#18
Filippo Consolo, Jawaad Sheriff, Silvia Gorla, Nicolò Magri, Danny Bluestein, Federico Pappalardo, Marvin J Slepian, Gianfranco B Fiore, Alberto Redaelli
We systematically analyzed the relative contributions of frequency component elements of hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating devices as to overall platelet activation over time. We demonstrated that high frequency oscillations are the major determinants for priming, triggering and yielding activated "prothrombotic behavior" for stimulated platelets, even if the imparted shear stress has low magnitude and brief exposure time. Conversely, the low frequency components of the stress signal, with limited oscillations over time, did not induce significant activation, despite being of high magnitude and/or exposure time...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692817/complications-of-hematopoietic-stem-transplantation-bacterial-infections
#19
REVIEW
Ali S Omrani, Reem S Almaghrabi
Bacterial infections remain a common complication of hematopoietic stem cell transplantation (HSCT), especially in the pre-engraftment phase. The risk of bacterial infections is mainly related to neutropenia, mucositis, and the presence of vascular lines. Most parts of the world have witnessed a shift in epidemiology toward Gram-negative bacteria; a large proportion of which are resistant to fluoroquinolones, extended-spectrum beta-lactams, carbapenems, and in some units even colistin. Meticulous infection control practices are essential for prevention of bacterial infections in HSCT...
July 3, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28687937/short-term-effects-of-a-combined-nutraceutical-on-lipid-level-fatty-liver-biomarkers-hemodynamic-parameters-and-estimated-cardiovascular-disease-risk-a-double-blind-placebo-controlled-randomized-clinical-trial
#20
Arrigo F G Cicero, Federica Fogacci, Marilisa Bove, Maddalena Veronesi, Manfredi Rizzo, Marina Giovannini, Claudio Borghi
INTRODUCTION: There is a growing interest in nutraceuticals improving cardiovascular risk factor levels and related organ damage. METHODS: This double-blind, placebo-controlled randomized clinical trial aims to compare the effect of a combined nutraceutical containing red yeast rice (10 mg), phytosterols (800 mg), and L-tyrosol (5 mg) on lipid profile, blood pressure, endothelial function, and arterial stiffness in a group of 60 patients with polygenic hypercholesterolemia resistant to Mediterranean diet...
July 7, 2017: Advances in Therapy
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