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Katalin Csordás, Olivér Eipel, Márta Hegyi, Monika Csóka, Eva Pap, Gábor Kovács
UNLABELLED: Monitoring the pharmacokinetic parameters of different anticancer drugs is necessary because they might have several side effects. AIM: Pharmacokinetic and toxicity evaluation of high-dose methotrexate treatments in children with acute lymphoblastic leukemia. PATIENTS AND METHODS: 43 children (28 boys, 15 girls, mean age: 7.03 years) in 147 cases were treated with 5 g/m2/24h MTX according to ALL-BFM 1995 and 2002 protocols. Methotrexate and 7-hydroxi-methotrexate levels were measured with high pressure liquid chromatography at 24, 36, 48 hours...
October 2, 2011: Orvosi Hetilap
M Kazandi, V Turan
OBJECTIVE: The assessment of ectopic pregnancy, its risk factors and comparison of the treatment modalities. MATERIAL AND DESIGN: Between January 2002 and July 2009, 254 ectopic pregnancies were reviewed retrospectively at the Department of Obstetrics and Gynecology, Ege University. Complaints of patients, localizations of ectopic pregnancy and comparison of patients, whether they had medical therapy or surgery, were evaluated. Metotrexate (50 mg/m2 IM) was used in hemodinamically stable patients (hCG concentrations of patients varied between 450 IU/1 and 3660 IU/1)...
2011: Clinical and Experimental Obstetrics & Gynecology
James A Russell, Qiuli Duan, M Ahsan Chaudhry, Mary Lynn Savoie, Alexander Balogh, A Robert Turner, Loree Larratt, Jan Storek, Nizar J Bahlis, Christopher B Brown, Diana Quinlan, Michelle Geddes, Nancy Zacarias, Andrew Daly, Peter Duggan, Douglas A Stewart
Two hundred patients received hematopoietic stem cell transplantation (HSCT) from matched sibling donors (MSD) after myeloablative conditioning including fludarabine (Flu) and once-daily intravenous busulfan (Bu). Thymoglobulin (TG) was added to methotexate (MTX) and cyclosporine (CsA) as graft-versus-host disease (GVHD) prophylaxis. For low-risk (acute leukemia CR1/CR2, CML CP1) patients projected 5-year nonrelapse mortality (NRM) and overall survival (OS) were 4% and 76% for those <or=45 years old (n = 54) and 6% and 83% for those >45 (n = 31)...
August 2008: Biology of Blood and Marrow Transplantation
A Peretz
Low back pain is a frequent symptom to consult the general practioner or the osteo-articular specialist. It is important to identify patients with inflammatory back pain (5 to 10 %) because the management and the treatment are different. Spondylarthropathies, especially ankylosing spondylitis (AS) are the most frequently encountered. The inflammatory characteristics of pain give clues for the diagnosis and allow to make appropriate management. Biological tests and imaging from X rays to MRI are used. As therapy is primarily based on NSAID use, in case of unsatifactory response in peripheral arthritis, disease modyfing drugs such as salazopyrine and methotexate (MTX) are used...
September 2007: Revue Médicale de Bruxelles
No abstract text is available yet for this article.
October 1961: Cancer Chemotherapy Reports. Part 1
Z Pietrzak
In prospective study from 1988 to 1992 I analysed possibility of early non-invasive detection and treatment of ectopic pregnancy. In this purpose I used a gynecological examination, estimation of concentration of beta-hCG and progesterone in serum, transvaginal ultrasound and in certain patients, curettage. The fusion of all these methods permits to gain right diagnosis of ectopic pregnancy. In this work I described diagnostic and therapeutic algorithm of ectopic pregnancy allows in using conservative treatment in this pathology...
January 2001: Ginekologia Polska
R Ferone, S Roland
The molecular weight of dihydrofolate reductase (5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC from protozoa has been reported to be 5- to 10-fold larger than the isofunctional enzyme of most other organisms studied, based on gel filtration. This enzyme from the protozoal flagellate Crithidia fasciculata has been purified to homogeneity and found to be a bifunctional protein with thymidylate synthase (5,10-methylene tetrahydrofolate:dUMP C-methyltransferase, EC activity. The purified protein, eluted from methotrexate-Sepharose columns by dihydrofolate, migrated as a single band on both nondenaturing and denaturing polyacrylamide gel electrophoresis...
October 1980: Proceedings of the National Academy of Sciences of the United States of America
E A Neuwelt, E P Frenkel, S Rapoport, P Barnett
Infusion of 25% mannitol into the internal carotid artery of the dog results in a reversible disruption of the blood-brain barrier (BBB). This osmotic BBB disruption enhances the penetratin of systemically administered methotrexate (MTX) into the ipsilateral cerebral hemisphere. Brain methotexate levels were maximized by giving this chemotherapeutic drug by the intracarotid rather than the intravenous route after osmotic BBB disruption. Assays of MTX levels in cerebrospinal fluid were found to be a very unreliable and inconsistent monitor of brain MTX levels after osmotic BBB disruption...
July 1980: Neurosurgery
A Nyfors, H Poulsen
Eightyeight patients with severe, recalcitrant psoriasis had liver biopsies performed before and after Methotrexate (MTX) therapy. MTX was given for an average of 26 months as a single, weekly, oral dose of 25 mg maximum. The mean cumulative dose was 1733 mg (range 175-4590 mg). A statistically significant increase in the number of pathological post-MTX liver biopsies was found (p less than 0.0001). Of the 88 patients 6 developed cirrhosis and another 5 developed fibrosis, in all 12.5 per cent, during MTX therapy (95 per cent confidence limits for cirrhosis: 3-14 per cent)...
May 1976: Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology
M R Gasco
Charge-transfer complexes of hematoporphyrin with pteridine derivatives (folic acid, folinic acid, methotrexate) were studied in solutions buffered at pH 7.5 - 9 -10. The association constants for folic acid are pH dependent; at pH 7.5 the constant is 1240 wheras at pH 10 it is only 65. The association constant for folinic acid was determined only at pH 7.5 and was found to be 55. The association constants of methotexate are approximately the same at different pH's.
April 1976: Il Farmaco; Edizione Scientifica
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