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Immunosenescence

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https://www.readbyqxmd.com/read/28095513/changes-in-circulating-b-cell-subsets-associated-with-aging-and-acute-siv-infection-in-rhesus-macaques
#1
W L William Chang, Denise F Gonzalez, Hung T Kieu, Luis D Castillo, Ilhem Messaoudi, Xiaoying Shen, Georgia D Tomaras, Barbara L Shacklett, Peter A Barry, Ellen E Sparger
Aging and certain viral infections can negatively impact humoral responses in humans. To further develop the nonhuman primate (NHP) model for investigating B cell dynamics in human aging and infectious disease, a flow cytometric panel was developed to characterize circulating rhesus B cell subsets. Significant differences between human and macaque B cells included the proportions of cells within IgD+ and switched memory populations and a prominent CD21-CD27+ unswitched memory population detected only in macaques...
2017: PloS One
https://www.readbyqxmd.com/read/28054583/common-variable-immunodeficiency-patients-with-a-phenotypic-profile-of-immunosenescence-present-with-thrombocytopenia
#2
Jan Stuchlý, Veronika Kanderová, Marcela Vlková, Ivana Heřmanová, Lucie Slámová, Ondřej Pelák, Eli Taraldsrud, Dalibor Jílek, Pavlína Králíc Ková, Børre Fevang, Marie Trková, Ondřej Hrušák, Eva Froňková, Anna Šedivá, Jiří Litzman, Tomáš Kalina
Common variable immunodeficiency (CVID) is a heterogeneous group of diseases. Our aim was to define sub-groups of CVID patients with similar phenotypes and clinical characteristics. Using eight-color flow cytometry, we analyzed both B- and T-cell phenotypes in a cohort of 88 CVID patients and 48 healthy donors. A hierarchical clustering of probability binning "bins" yielded a separate cluster of 22 CVID patients with an abnormal phenotype. We showed coordinated proportional changes in naïve CD4+ T-cells (decreased), intermediate CD27- CD28+ CD4+ T-cells (increased) and CD21low B-cells (increased) that were stable for over three years...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28042001/relationship-between-ccr5-wt-%C3%AE-32-heterozygosity-and-hiv-1-reservoir-size-in-adolescents-and-young-adults-with-perinatally-acquired-hiv-1-infection
#3
Marta Martínez-Bonet, A González-Serna, Maria Isabel Clemente, Sara Morón-López, Laura Díaz, Marisa Navarro, Maria C Puertas, Manuel Leal, Ezequiel Ruiz-Mateos, Javier Martinez-Picado, Maria Angeles Muñoz Fernández
BACKGROUND: Several host factors contribute to HIV disease progression in the absence of combination antiretroviral therapy (cART). Among them, the CC-chemokine receptor 5 (CCR5) is known to be the main coreceptor used by HIV-1 to enter target cells during the early stages of an HIV-1 infection. OBJECTIVE: We evaluated the association of CCR5((WT/Δ32)) heterozygosity with HIV-1 reservoir size, lymphocyte differentiation, activation and immunosenescence in adolescents and young adults with perinatally acquired HIV-infection receiving cART...
December 29, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28038993/inflammaging-and-omics-in-human-longevity
#4
REVIEW
Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi
Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omic data - particularly on glycomics - collected on centenarians, supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli conceptualized as "molecular garbage"; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a "local fire" which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly informative set/combination of omic markers able to better grasp the complex molecular core of inflammaging in elderly and centenarians...
December 27, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28024956/effectiveness-of-mf59-adjuvanted-seasonal-influenza-vaccine-in-the-elderly-a-systematic-review-and-meta-analysis
#5
REVIEW
Alexander Domnich, Lucia Arata, Daniela Amicizia, Joan Puig-Barberà, Roberto Gasparini, Donatella Panatto
BACKGROUND: In the elderly, traditional influenza inactivated vaccines are often only modestly immunogenic, owing to immunosenescence. Given that adjuvantation is a means of enhancing the immune response, the trivalent inactivated vaccine adjuvanted with MF59 (MF59-TIV) was specifically designed to overcome this problem. Considering that, for ethical reasons, the absolute effectiveness of an influenza vaccine in the elderly cannot be demonstrated in placebo-controlled studies, the present study aimed to assess the effectiveness of MF59-TIV in preventing influenza-related outcomes in the elderly...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/28005421/is-chronic-obstructive-pulmonary-disease-an-accelerated-aging-disease
#6
William MacNee
Aging is one of the most important risk factors for most chronic diseases. The worldwide increase in life expectancy has been accompanied by an increase in the prevalence of age-related diseases that result in significant morbidity and mortality and place an enormous burden on healthcare and resources. Aging is a progressive degeneration of the tissues that has a negative impact on the structure and function of vital organs. The lung ages, resulting in decreased function and reduced capacity to respond to environmental stresses and injury...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28005419/aging-of-the-immune-system-mechanisms-and-therapeutic-targets
#7
Cornelia M Weyand, Jörg J Goronzy
Beginning with the sixth decade of life, the human immune system undergoes dramatic aging-related changes, which continuously progress to a state of immunosenescence. The aging immune system loses the ability to protect against infections and cancer and fails to support appropriate wound healing. Vaccine responses are typically impaired in older individuals. Conversely, inflammatory responses mediated by the innate immune system gain in intensity and duration, rendering older individuals susceptible to tissue-damaging immunity and inflammatory disease...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27995612/-inflamm-aging-influences-immune-cell-survival-factors-in-human-bone-marrow
#8
Luca Pangrazzi, Andreas Meryk, Erin Naismith, Rafal Koziel, Julian Lair, Martin Krismer, Klemens Trieb, Beatrix Grubeck-Loebenstein
The bone marrow (BM) plays a key role in the long-term maintenance of immunological memory. However, the impact of aging on the production of survival factors for effector/memory T cells and plasma cells in the human BM has not been studied. We now show that the expression of molecules involved in the maintenance of immunological memory in the human BM changes with age. While IL-15, which protects potentially harmful CD8(+) CD28(-) senescent T cells, increases, IL-7 decreases. IL-6, which may synergize with IL-15, is also overexpressed...
December 19, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27988944/immunosenescence-the-importance-of-considering-age-in-health-and-disease
#9
EDITORIAL
B Weinberger
No abstract text is available yet for this article.
January 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27976725/modulation-of-gut-microbiota-and-delayed-immunosenescence-as-a-result-of-syringaresinol-consumption-in-middle-aged-mice
#10
Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Lm, Hang-Rae Kim
Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3(+) T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3(+) regulatory T cells (Tregs)...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27960211/the-modern-diagnostic-approach-to-community-acquired-pneumonia-in-adults
#11
James D Chalmers
Respiratory tract infections, the majority of which are community acquired, are among the leading causes of death worldwide and a leading indication for hospital admission. The burden of disease demonstrates a "U"-shaped distribution, primarily affecting young children as the immune system matures, and older adults as the process of immunosenescence and accumulation of comorbidities leads to increased susceptibility to infection. Diagnosis of community-acquired pneumonia (CAP) is traditionally based on demonstration of a new infiltrate on a chest radiograph in a patient presenting with an acute respiratory illness or sepsis...
December 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27959617/senescence-in-copd-and-its-comorbidities
#12
Peter J Barnes
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening, cellular senescence, activation of PI3 kinase-mTOR signaling, impaired autophagy, mitochondrial dysfunction, stem cell exhaustion, epigenetic changes, abnormal microRNA profiles, immunosenescence, and a low-grade chronic inflammation (inflammaging). Many of these pathways are driven by chronic exogenous and endogenous oxidative stress...
December 9, 2016: Annual Review of Physiology
https://www.readbyqxmd.com/read/27938930/clinical-characteristics-and-outcomes-in-a-population-with-disseminated-herpes-zoster-a-retrospective-cohort-study
#13
M L Bollea-Garlatti, L A Bollea-Garlatti, A S Vacas, A C Torre, A M Kowalczuk, R L Galimberti, B L Ferreyro
INTRODUCTION: Shingles is the cutaneous expression of the reactivation of latent varicella zoster virus infection in sensory ganglia. It presents as vesicles in the corresponding dermatome. The condition is called disseminated herpes zoster (DHZ) when more than 2 contiguous dermatomes are affected, more than 20 vesicles are observed outside the initial dermatome, or involvement is systemic. DHZ is rare and most frequently occurs in immunocompromised patients. OBJECTIVES: To describe the epidemiology, predisposing factors, clinical presentation, laboratory findings, and clinical course of patients with DHZ, and to compare the findings in immunocompromised and immunocompetent patients...
December 6, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27932110/effect-of-cytomegalovirus-infection-on-survival-of-older-kidney-transplant-patients-d-r-impact-of-valganciclovir-prophylaxis-versus-preemptive-therapy
#14
E Luna, F Caravaca, F Ferreira, N Fernandez, P Martín, M L Vargas, J Saenz de Santamaría, G Garcia Pino, L Azevedo, A Muñoz Sanz
BACKGROUND: Kidney transplant patients with D+/R+ serology can be treated with either prophylaxis or preemptive valganciclovir. The older transplant population suffers severe immunosenescence, especially patients with latent cytomegalovirus (CMV) infection (R+). They are more likely to develop indirect CMV effects. Likewise, many patients have significant cardiovascular comorbidity, which makes them more sensitive to these indirect effects. The aim of this study was to evaluate the incidence of CMV viremia and indirect effects on survival, comparing prophylaxis (V) against preemptive (P) valganciclovir in an older kidney transplant population...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27919492/corrigendum-to-immunologic-mechanisms-of-fingolimod-and-the-role-of-immunosenescence-in-the-risk-of-cryptococcal-infection-a-case-report-and-review-of-literature-mult-scler-relat-disord-9-2016-158-162
#15
Elena Grebenciucova, Anthony T Reder, Jacqueline T Bernard
No abstract text is available yet for this article.
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27907136/immune-activation-and-bacterial-translocation-a-link-between-impaired-immune-recovery-and-frequent-visceral-leishmaniasis-relapses-in-hiv-infected-patients
#16
Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M Da-Cruz, Joanna R Santos-Oliveira
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience frequent relapses. VL/HIV patients were allocated to non-relapsing (NR, n = 6) and relapsing (R, n = 11) groups and were followed from the active phase of VL up to 12 months post-treatment (mpt)...
2016: PloS One
https://www.readbyqxmd.com/read/27903254/mir-96-mir-145-and-mir-9-expression-increases-and-igf-1r-and-foxo1-expression-decreases-in-peripheral-blood-mononuclear-cells-of-aging-humans
#17
Monika Budzinska, Magdalena Owczarz, Eliza Pawlik-Pachucka, Malgorzata Roszkowska-Gancarz, Przemyslaw Slusarczyk, Monika Puzianowska-Kuznicka
BACKGROUND: In mammals, the IGF-1 pathway affects the phenotype of aging. Since the function of the immune system is modulated by IGF-1, it is plausible that immunosenescence might in part result from altered control by this pathway. We therefore examined whether the expression of IGF-1R, FOXO1, and FOXO3a in peripheral blood mononuclear cells (PBMC) changes with age and if this might be due to changes in the expression of select miRNAs. METHODS: The expression of IGF-1R, FOXO1, FOXO3a, as well as of miR-9, miR-96, miR-99a, miR-132, miR-145, and miR-182 was examined in PBMC of young (27...
November 30, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27885527/insights-into-mortality-patterns-and-causes-of-death-through-a-process-point-of-view-model
#18
James J Anderson, Ting Li, David J Sharrow
Process point of view (POV) models of mortality, such as the Strehler-Mildvan and stochastic vitality models, represent death in terms of the loss of survival capacity through challenges and dissipation. Drawing on hallmarks of aging, we link these concepts to candidate biological mechanisms through a framework that defines death as challenges to vitality where distal factors defined the age-evolution of vitality and proximal factors define the probability distribution of challenges. To illustrate the process POV, we hypothesize that the immune system is a mortality nexus, characterized by two vitality streams: increasing vitality representing immune system development and immunosenescence representing vitality dissipation...
November 24, 2016: Biogerontology
https://www.readbyqxmd.com/read/27879545/epstein-barr-virus-associated-mucocutaneous-ulcer-in-a-patient-with-t-cell-acute-lymphoblastic-leukemia-importance-of-accurate-diagnosis-and-conservative-management
#19
Anant Vatsayan, Ashish Gupta, Sanjay Ahuja, Rachel Egler, Rose C Beck, Yousif Matloub
Epstein-Barr virus-associated mucocutaneous ulcer (EBV-MCU) is a recently characterized entity that falls under the spectrum of EBV-lymphoproliferative disorders. First described in 2010 by Dojcinov et al, it is an EBV-driven localized proliferation of B cells, occurring in mucocutaneous tissues including the skin, the oropharynx, and the gastrointestinal tract of immunosuppressed patients in the absence of an intact T-cell repertoire. Typically, it has been described in elderly patients with age-related immunosenescence and patients who are on immunosuppressive therapy...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27876574/the-emerging-role-of-ecm-crosslinking-in-t-cell-mobility-as-a-hallmark-of-immunosenescence-in-humans
#20
REVIEW
Jean-Francois Moreau, Thomas Pradeu, Andrea Grignolio, Christine Nardini, Filippo Castiglione, Paolo Tieri, Miriam Capri, Stefano Salvioli, Jean-Luc Taupin, Paolo Garagnani, Claudio Franceschi
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of "inflammaging". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM)...
November 19, 2016: Ageing Research Reviews
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