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https://www.readbyqxmd.com/read/29141388/-effects-of-smp-30-overexpression-on-apoptosis-of-human-lens-epithelial-cells-induced-by-ultraviolet-b-irradiation
#1
H Teng, L Y Huang, F Tian, L J Dong, H Zhang
Objective: This study was to observe the effect of SMP-30 on ultraviolet B (UVB)-induced apoptosis of human lens epithelial cells(HLE-B3) in vitro. Methods: Experimental study. The SMP-30 cDNA was amplified by PCR and inserted into the pRFP-N1 expressing vector which had been double digested by XhoI/HindIII. HLE-B3 cells were cultured and divided into three groups: normal group, pRFP-N1 vector plasmid group and pRFP-N1-SMP-30 plasmid group (SMP-30). Then cells were exposed to UVB and the survival rate of cells was detected by MTT assay...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29141385/-clinical-observation-of-visual-quality-after-the-individual-implantation-of-intraocular-lens-guided-by-corneal-q-value
#2
F F Cai, G Y Zheng, H J Wang, L Li, Y Liu
Objective: To describe the feasibility of individual IOL implantation guided by corneal Q value and observe patients postoperative visual quality under different residual spherical aberration. Methods: Prospective study. One hundred and twenty cases (171 eyes)cataract patients in our hospital were selected for the individual implantation of intraocular lens guided by corneal Q value which obtained by Oberscan before operation. Based on spherical aberration calculated by corneal Q value, choose appropriate IOL personalitily to make postoperative whole eye surface aberration +0...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29141287/-observation-of-systemic-adverse-reactions-by-specific-immunotherapy-and-analysis-of-risk-factors-in-allergic-rhinitis
#3
Y Shen, S L Hong, M Zhang, X Ke
Objective: To investigate the systemic adverse effects of specific subcutaneous immunotherapy (SCIT) in patients with allergic rhinitis (AR) and explore the possible risk factors. Methods: A retrospective study was conducted on AR patients who underwent SCIT from January 2014 to January 2017 in Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University. For patients with adverse reactions, the detailed medical history during treatment was reviewed. Results: A total of 1608 injections were performed on 102 patients, there were 12 cases / 21 times systemic adverse events, including systemic urticaria, angioedema and Grade Ⅰ systemic adverse reactions...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29141153/using-observational-data-to-calibrate-simulation-models
#4
Eleanor J Murray, James M Robins, George R Seage, Sara Lodi, Emily P Hyle, Krishna P Reddy, Kenneth A Freedberg, Miguel A Hernán
BACKGROUND: Individual-level simulation models are valuable tools for comparing the impact of clinical or public health interventions on population health and cost outcomes over time. However, a key challenge is ensuring that outcome estimates correctly reflect real-world impacts. Calibration to targets obtained from randomized trials may be insufficient if trials do not exist for populations, time periods, or interventions of interest. Observational data can provide a wider range of calibration targets but requires methods to adjust for treatment-confounder feedback...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29141152/tm-values-and-unfolded-fraction-can-predict-aggregation-rates-for-gcsf-variant-formulations-but-not-under-predominantly-native-conditions
#5
Mathew J Robinson, Paul Matejtschuk, Adrian F Bristow, Paul A Dalby
Protein engineering and formulation optimisation strategies can be taken to minimise protein aggregation in the biopharmaceutical industry. Short-term stability measures such as the mid-point transition temperature (Tm) for global unfolding provide convenient surrogates for longer-term (eg 2-year) degradation kinetics, with which to optimise formulations on practical time-scales. While successful in some cases, their limitations have not been fully evaluated or understood. Tm values are known to correlate with chemical degradation kinetics for wild-type granulocyte colony stimulating factor (GCSF) at pH 4-5...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29141085/the-contribution-of-foveal-and-peripheral-visual-information-to-ensemble-representation-of-face-race
#6
Wonmo Jung, Isabelle Bülthoff, Regine G M Armann
The brain can only attend to a fraction of all the information that is entering the visual system at any given moment. One way of overcoming the so-called bottleneck of selective attention (e.g., J. M. Wolfe, Võ, Evans, & Greene, 2011) is to make use of redundant visual information and extract summarized statistical information of the whole visual scene. Such ensemble representation occurs for low-level features of textures or simple objects, but it has also been reported for complex high-level properties...
November 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29141051/molecular-and-epidemiological-characterization-of-carbapenemase-producing-enterobacteriaceae-in-norway-2007-to-2014
#7
Ørjan Samuelsen, Søren Overballe-Petersen, Jørgen Vildershøj Bjørnholt, Sylvain Brisse, Michel Doumith, Neil Woodford, Katie L Hopkins, Bettina Aasnæs, Bjørg Haldorsen, Arnfinn Sundsfjord
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway from 2007 to 2014 confirmed at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. All confirmed CPE isolates were characterized pheno- and genotypically, including by whole genome sequencing (WGS). Patient data were reviewed retrospectively. In total 59 CPE isolates were identified from 53 patients...
2017: PloS One
https://www.readbyqxmd.com/read/29141046/the-effect-of-observing-novice-and-expert-performance-on-acquisition-of-surgical-skills-on-a-robotic-platform
#8
David J Harris, Samuel J Vine, Mark R Wilson, John S McGrath, Marie-Eve LeBel, Gavin Buckingham
BACKGROUND: Observational learning plays an important role in surgical skills training, following the traditional model of learning from expertise. Recent findings have, however, highlighted the benefit of observing not only expert performance but also error-strewn performance. The aim of this study was to determine which model (novice vs. expert) would lead to the greatest benefits when learning robotically assisted surgical skills. METHODS: 120 medical students with no prior experience of robotically-assisted surgery completed a ring-carrying training task on three occasions; baseline, post-intervention and at one-week follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/29141028/developing-methods-for-assessing-abundance-and-distribution-of-european-oysters-ostrea-edulis-using-towed-video
#9
Linnea Thorngren, Thomas Dunér Holthuis, Susanne Lindegarth, Mats Lindegarth
Due to large-scale habitat losses and increasing pressures, benthic habitats in general, and perhaps oyster beds in particular, are commonly in decline and severely threatened on regional and global scales. Appropriate and cost-efficient methods for mapping and monitoring of the distribution, abundance and quality of remaining oyster populations are fundamental for sustainable management and conservation of these habitats and their associated values. Towed video has emerged as a promising method for surveying benthic communities in a both non-destructive and cost-efficient way...
2017: PloS One
https://www.readbyqxmd.com/read/29141010/multiple-effects-of-toxins-isolated-from-crotalus-durissus-terrificus-on-the-hepatitis-c-virus-life-cycle
#10
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient antivirals against HCV are needed. Compounds isolated from animal venoms have shown antiviral activity against some viruses such as Dengue virus, Yellow fever virus and Measles virus. In this study, we evaluated the effect of the complex crotoxin (CX) and its subunits crotapotin (CP) and phospholipase A2 (PLA2-CB) isolated from the venom of Crotalus durissus terrificus on HCV life cycle...
2017: PloS One
https://www.readbyqxmd.com/read/29140990/cultivar-architecture-modulates-spore-dispersal-by-rain-splash-a-new-perspective-to-reduce-disease-progression-in-cultivar-mixtures
#11
Tiphaine Vidal, Pauline Lusley, Marc Leconte, Claude de Vallavieille-Pope, Laurent Huber, Sébastien Saint-Jean
Cultivar mixtures can be used to improve the sustainability of disease management within farming systems by growing cultivars that differ in their disease resistance level in the same field. The impact of canopy aerial architecture on rain-splash dispersal could amplify disease reduction within mixtures. We designed a controlled conditions experiment to study single splash-dispersal events and their consequences for disease. We quantified this impact through the spore interception capacities of the component cultivars of a mixture...
2017: PloS One
https://www.readbyqxmd.com/read/29140984/an-observational-study-on-sport-induced-modulation-of-negative-attitude-towards-disability
#12
Giovanni Ottoboni, Melissa Milani, Annalisa Setti, Andrea Ceciliani, Rabih Chattat, Alessia Tessari
The present study investigates whether sport activities involving children with a disability can reduce negative attitudes towards disability in children without disability. We compared the effect of being schoolmate or member of the same football team whereby a child with disability was member of the class/team or not. This lead to four groups that were assessed both at the beginning and at the end of the school year. Two measures were collected: an ad-hoc questionnaire and an Implicit Association Test. The two assessments were designed to measure explicit and implicit attitudes towards children with disabilities...
2017: PloS One
https://www.readbyqxmd.com/read/29140980/prokaryotic-diversity-and-biogeochemical-characteristics-of-benthic-microbial-ecosystems-at-la-brava-a-hypersaline-lake-at-salar-de-atacama-chile
#13
Maria Eugenia Farias, Maria Cecilia Rasuk, Kimberley L Gallagher, Manuel Contreras, Daniel Kurth, Ana Beatriz Fernandez, Daniel Poiré, Fernando Novoa, Pieter T Visscher
Benthic microbial ecosystems of Laguna La Brava, Salar de Atacama, a high altitude hypersaline lake, were characterized in terms of bacterial and archaeal diversity, biogeochemistry, (including O2 and sulfide depth profiles and mineralogy), and physicochemical characteristics. La Brava is one of several lakes in the Salar de Atacama where microbial communities are growing in extreme conditions, including high salinity, high solar insolation, and high levels of metals such as lithium, arsenic, magnesium, and calcium...
2017: PloS One
https://www.readbyqxmd.com/read/29140970/clinical-impact-of-external-laryngeal-manipulation-during-laryngoscopy-on-tracheal-intubation-success-in-critically-ill-children
#14
Taiki Kojima, Elizabeth K Laverriere, Erin B Owen, Ilana Harwayne-Gidansky, Asha N Shenoi, Natalie Napolitano, Kyle J Rehder, Michelle A Adu-Darko, Sholeen T Nett, Debbie Spear, Keith Meyer, John S Giuliano, Keiko M Tarquinio, Ronald C Sanders, Jan Hau Lee, Dennis W Simon, Paula A Vanderford, Anthony Y Lee, Calvin A Brown, Peter W Skippen, Ryan K Breuer, Iris Toedt-Pingel, Simon J Parsons, Eleanor A Gradidge, Lily B Glater, Kathleen Culver, Simon Li, Lee A Polikoff, Joy D Howell, Gabrielle Nuthall, Gokul K Bysani, Ana L Graciano, Guillaume Emeriaud, Osamu Saito, Alberto Orioles, Karen Walson, Philipp Jung, Awni M Al-Subu, Takanari Ikeyama, Rakshay Shetty, Kathleen M Yoder, Vinay M Nadkarni, Akira Nishisaki
OBJECTIVES: External laryngeal manipulation is a commonly used maneuver to improve visualization of the glottis during tracheal intubation in children. However, the effectiveness to improve tracheal intubation attempt success rate in the nonanesthesia setting is not clear. The study objective was to evaluate the association between external laryngeal manipulation use and initial tracheal intubation attempt success in PICUs. DESIGN: A retrospective observational study using a multicenter emergency airway quality improvement registry...
November 14, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29140955/on-line-ratings-of-spine-surgeons-analysis-of-208-surgeons
#15
Jun Zhang, Adan Omar, Addisu Mesfin
STUDY DESIGN: Observational study OBJECTIVE.: To evaluate the online ratings of spine surgeons and variables that may affect online ratings. SUMMARY OF BACKGROUND DATA: Physician review websites (PRW) are rapidly growing for-profit businesses. Most Orthopaedic surgeons are rated on at least one PRW as are other surgical specialists. To date the online ratings of spine surgeons have not been evaluated. METHODS: Cervical Spine Research Society (CSRS) surgeon ratings on 5 physician rating websites were performed in April 2016: 'healthgrade...
November 14, 2017: Spine
https://www.readbyqxmd.com/read/29140934/response-of-symptomatic-persistent-chronic-disseminated-candidiasis-to-corticosteroid-therapy-in-immunosuppressed-pediatric-patients-case-study-and-review-of-the-literature
#16
Vered Shkalim-Zemer, Itzhak Levi, Salvador Fischer, Hannah Tamary, Joanne Yakobovich, Gali Avrahami, Gil Gilad, Sara Elitzur, Isaac Yaniv, Ronit Elhasid, Michal Manistersky, Itamar Shalit
BACKGROUND: Chronic disseminated candidiasis (CDC) is a severe invasive fungal infection principally observed during neutrophil recovery in patients with acute leukemia treated with intensive chemotherapy. Its pathophysiology remains unclear. We describe the management of six children with symptomatic CDC who did not respond to antifungal therapy. METHODS: The databases of the hematology-oncology departments of two tertiary pediatric medical centers were searched for all patients diagnosed with CDC from 2003 to 2015 who responded to corticosteroids after failing antifungal therapy...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140926/variability-in-negative-emotions-among-individuals-with-chronic-low-back-pain-relationships-with-pain-and-function
#17
James I Gerhart, John W Burns, Stephen Bruehl, David A Smith, Kristina M Post, Laura S Porter, Erik Schuster, Asokumar Buvanendran, Anne Marie Fras, Francis J Keefe
Chronic pain is associated with elevated negative emotions, and resources needed to adaptively regulate these emotions can be depleted during prolonged pain. Studies of links between pain, function and negative emotions in people with chronic pain, however, have focused almost exclusively on relationships among mean levels of these factors. Indexes that may reflect aspects of emotion regulation have typically not been analyzed. We propose that one index of emotion regulation is variability in emotion over time as opposed to average emotion over time...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140909/the-effects-of-load-on-peak-power-output-fatigue-during-the-bench-throw
#18
David Boffey, Bulent Sokmen, Kurt Sollanek, Wanda Boda, Steven Winter
The ability to create power is an important variable for athletic success. No study to date has compared peak power output (PPO) fatigue across multiple sets and with different loads with the bench throw. This study aimed to begin the process of establishing empirical upper body power training guidelines for moderately strong athletes by determining how load (30%, 45%, 60% 1RM) affects PPO (Watts) dropoff during 3 sets of 10 repetitions of the bench throw. 10 resistance-trained male volunteers ((mean ± SD): age 20...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140895/an-ex-vivo-comparison-of-2-cyanoacrylate-skin-protectants
#19
Daniel J Gibson
PURPOSE: The purpose of these experiments was to compare 2 commercially available skin protectants with different chemical compositions. DESIGN: Two materially different skin protectants were applied to ex vivo pig skin, subjected to stresses, and the resulting skin was observed and analyzed. METHODS: Using ex vivo pig skin, we sought to better understand the physical differences between a cyanoacrylate-based and a mixed cyanoacrylate/acrylic polymer-based skin protectant...
November 14, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29140887/inconsistencies-between-two-cross-cultural-adaptations-of-the-hospital-survey-on-patient-safety-culture-into-french
#20
Bastien Boussat, Patrice François, Gérald Gandon, Joris Giai, Arnaud Seigneurin, Thomas Perneger, José Labarère
OBJECTIVES: Two cross-cultural adaptations of the 12-dimension Hospital Survey on Patient Safety Culture (HSOPSC) into French coexist: the Occelli and Vlayen versions. The objective of this study was to assess the psychometric properties of the Occelli version in comparison with those reported for the Vlayen and the original US versions of this instrument. METHODS: Using the original data from a cross-sectional study of 5,064 employees at a single university hospital in France, we examined the acceptability, internal consistency, factorial structure, and construct validity of the Occelli version of the HSOPSC...
November 15, 2017: Journal of Patient Safety
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