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Gianluca Lista, Silvia Bianchi, Savina Mannarino, Federico Schena, Francesca Castoldi, Mauro Stronati, Fabio Mosca
OBJECTIVE: Early diagnosis of significant patent ductus arteriosus reduces the risk of clinical worsening in very low birth weight infants. Echocardiographic patent ductus arteriosus shunt flow pattern can be used to predict significant patent ductus arteriosus. Pulmonary venous flow, expressed as vein velocity time integral, is correlated to ductus arteriosus closure. The aim of this study is to investigate the relationship between significant reductions in vein velocity time integral and non-significant patent ductus arteriosus in the first week of life...
October 1, 2016: Clinics
Sergio Eduardo Alonso Araujo, Lucas de Araujo Horcel, Victor Edmond Seid, Alexandre Bruno Bertoncini, Sidney Klajner
Background: Stapled hemorrhoidopexy is associated with less postoperative pain and faster recovery. However, it may be associated with a greater risk of symptomatic recurrence. We hypothesized that undertaking a limited surgical excision of hemorrhoid disease after stapling may be a valid approach for selected patients. Aim: To compare long-term results after stapled hemorrhoidopexy with and without complementation with closed excisional technique. Method: In a retrospective uni-institutional cohort study, sixty-five (29 men) patients underwent stapled hemorrhoidopexy and 21 (13 men) underwent stapled hemorrhoidopexy with excision...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Alice Ricardo-Silva, Teresa Cristina Monte Gonçalves, José Francisco Luitgards-Moura, Catarina Macedo Lopes, Silvano Pedrosa da Silva, Amanda Queiroz Bastos, Nathalia Coelho Vargas, Maria-Rosa Goreti Freitas
During a medical entomology course in Boa Vista, Roraima, colonies of Triatoma maculata closely associated with pigeon nests were observed in concrete air-conditioner box located on the external plastered and cemented walls of a modern brick-built apartment block. In only one eight-hole ceramic brick, located inside one air-conditioner box, 127 specimens of T. maculata were collected. T. maculata is a recognised vector of Trypanosoma cruzi in the surrounding area and its domiciliation increases the risk of Chagas disease transmission...
October 13, 2016: Memórias do Instituto Oswaldo Cruz
Shaltiel Eloul, Richard G Compton
The diffusion of a particle from bulk solution is slowed as it moves close to an adsorbing surface. A general model is reported which is easily applied by theoreticians and experimentalists. Specifically, it is shown here that in general and regardless of the space size, the magnitude of the effect of hindered diffusion on the flux is a property of the diffusion layer thickness. We quantify and explain the effect. Predictions of concentration profiles show that a 'hindered diffusion layer' is formed near the adsorbing surface within the diffusion layer, observed even when the particle radius is just a 0...
October 19, 2016: Journal of Physical Chemistry Letters
Mohit Arora, Rekha S Patil
AIM AND OBJECTIVE: To study the cardiac manifestations of the dengue fever. METHODS: This one year descriptive study was undertaken at KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum under the Department of Medicine. A total of 120 patients with either dengue IgM or IgM and IgG were studied. The assessment of cardiac manifestations was done based on electrocardiogram, 2D echocardiography and cardiac enzymes. RESULTS: Of the 120 patients, 85 (70...
July 2016: Journal of the Association of Physicians of India
Hossein Rajabpour, Abdorreza Vaezihir
The North Tabriz Fault (NTF) is the predominant regional-scale tectonic structure in the northwest of Iran. In the east side of the city of Tabriz, a portion of the fault trend has been completely concealed by recent sediments and urbanization. In this paper, some hydrogeological methods are used to locate the concealed sector. As is clear from the pumping tests results, despite the fact that the northern observation wells were closer to the pumping wells than the southern ones, they have not been affected by pumping...
October 17, 2016: Ground Water
Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Yasushi Takahashi, Nobuyuki Ara, Tooru Shimosegawa
PURPOSE: Endoscopic diagnosis of gastric cancer (GC) that emerges after eradication of Helicobacter pylori may be affected by unique morphological changes. Using comprehensive endoscopic imaging, which can reveal biological alterations in gastric mucosa after eradication, previous studies demonstrated that Congo red chromoendoscopy (CRE) might clearly show an acid non-secretory area (ANA) with malignant potential, while autofluorescence imaging (AFI) without drug injection or dyeing may achieve early detection or prediction of GC...
September 2016: Journal of Gastric Cancer
Carmen Jiménez-Castells, Jorick Vanbeselaere, Sonja Kohlhuber, Bärbel Ruttkowski, Anja Joachim, Katharina Paschinger
BACKGROUND: The porcine nodule worm Oesophagostomum dentatum is a strongylid class V nematode rather closely related to the model organism Caenorhabditis elegans. However, in contrast to the non-parasitic C. elegans, the parasitic O. dentatum is an obligate sexual organism, which makes both a gender and developmental glycomic comparison possible. METHODS: Different enzymatic and chemical methods were used to release N-glycans from male and female O. dentatum as well as from L3 and L4 larvae...
October 14, 2016: Biochimica et Biophysica Acta
Jesus M Casida, Horng-Shiuann Wu, Martha Abshire, Bidisha Ghosh, James J Yang
BACKGROUND: There is no empirical study about the context and influence of self-management (SM) factors on quality of life (QOL) among adults with left ventricular assist device (LVADs). The purpose of this study was to close this knowledge gap by: (1) differentiating select SM factors (e.g., cognition) and overall QOL based on LVAD implant durations; (2) examining the relationships among SM factors and QOL variables; and (3) identifying which SM factors predict QOL. METHODS: An observational study was employed including 87 LVAD patients, ages 20 to 80 years, with mean implant durations of 18...
September 13, 2016: Journal of Heart and Lung Transplantation
Steffi Rocchi, Maxime Tisserant, Benoit Valot, Audrey Laboissière, Victor Frossard, Gabriel Reboux
Since 2010, the Loue River (Franche-Comté, East of France) has been suffering from massive fish kills infested by Saprolegnia parasitica. The river supplies inhabitants of the city of Besançon in drinking water, raising the question of a potential risk through both water consumption and use. We developed a real-time quantitative PCR (qPCR) to quantify S. parasitica in the Loue River as well as in the drinking water. A weak spatial trend is suggested with greater quantities of S. parasitica observed at the sampling station close to the main pumping station...
October 18, 2016: International Journal of Environmental Health Research
Clémentine Sarkozy, Sophie Kaltenbach, Pierre Faurie, Danielle Canioni, Françoise Berger, Alexandra Traverse-Glehen, Hervé Ghesquieres, Gilles Salles, Emmanuel Bachy, Marie-Alexandra Alyanakian, Olivier Hermine, Bénédicte Neven, Elizabeth Macintyre, Serge Romana, Thierry Jo Molina, Felipe Suarez, Vahid Asnafi, Julie Bruneau
Plasma-cell post-transplantation lymphoproliferative disorder (PC-PTLD) is a rare monomorphic PTLD entity divided into plasma cell myeloma (PCM) and plasmacytoma-like lesion (PLL) PTLD. To date, there are no exhaustive published cytogenetic data on PC-PTLD. We report array-based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL-PTLD. Patients had received kidney (n=6), heart (n=2), lung (n=1) or bone marrow (n=1) transplantation. There were six men and median age at time of PTLD was 56.5 years (3-74)...
October 17, 2016: Genes, Chromosomes & Cancer
Pravin Kesarwani, Paramita Chakraborty, Radhika Gudi, Shilpak Chatterjee, Gina Scurti, Kyle Toth, Patt Simms, Mahvash Husain, Kent Armeson, Shahid Husain, Elizabeth Garrett-Mayer, Chethamarakshan Vasu, Michael I Nishimura, Shikhar Mehrotra
Advancements in adoptive cell transfer therapy (ACT) has led to the use of T cells engineered with tumor specific T cell receptors, which after rapid expansion can be obtained in sufficient numbers for treating patients. However, due to massive proliferation these cells are close to replicative senescence, exhibit exhausted phenotype, and also display increased susceptibility to activation induced cell death. We have previously shown that tumor reactive T cells undergo caspase-independent cell death upon TCR restimulation with cognate antigen, which involves reactive oxygen species and c-jun N-terminal kinase...
October 14, 2016: Oncotarget
Jingyi Dong, Xiaoteng Lu, Chen Shao, Jie Huang, Khaled A S Al-Rasheid
The morphology and morphogenesis of a new saline soil hypotrich, Lamtostyla salina n. sp., collected from Longfeng Wetland in Daqing, north China, were studied based on live observations and protargol stained specimens. The new species is characterized as follows: body very flexible but not contractile, lanceolate with anterior end broadly rounded, widest at about 1/3 of body length, posterior end narrowly rounded; cortical granules colourless and scattered; amphisiellid median cirral row ends ahead of mid-body, composed of 5-13 cirri; 4-20 frontoventral cirri arranged in 2-4 rows; three frontal, one buccal and 2-6 transverse cirri; usually one left and one right marginal row, composed of 17-51 and 20-51 cirri respectively; usually two dorsal kineties; two macronuclear nodules and two micronuclei...
September 20, 2016: European Journal of Protistology
Minhua Cao, Jinwen Qin, Bing Liu
Tin anode materials have attracted much attention due to their high theoretical capacity, although a rapid capacity fade is commonly observed mainly due to structural degradation from volume expansion. Here, we report a versatile strategy based on basil seed-inspired design for constructing monodisperse core-shell Sn@C hybrid confined in a carbon matrix (Sn basil seeds). Analogous to the structure of basil seeds soaked in water, Sn basil seeds have been taken to tackle this volume expansion problem in lithium ion batteries (LIBs)...
October 17, 2016: Chemistry, An Asian Journal
Jérémie Barral, Alex D Reyes
The balance between excitation and inhibition (E-I balance) is maintained across brain regions though the network size, strength and number of synaptic connections, and connection architecture may vary substantially. We use a culture preparation to examine the homeostatic synaptic scaling rules that produce E-I balance and in vivo-like activity. We show that synaptic strength scales with the number of connections K as ∼ , close to the ideal theoretical value. Using optogenetic techniques, we delivered spatiotemporally patterned stimuli to neurons and confirmed key theoretical predictions: E-I balance is maintained, active decorrelation occurs and the spiking correlation increases with firing rate...
October 17, 2016: Nature Neuroscience
Antoine Ducuing, Stéphane Vincent
The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is specifically required for actin cable formation. Next, we used Zasp52 loss of function to dissect the mechanism of action of the cable. Surprisingly, closure dynamics are perfect in Zasp52 mutants: the cable is therefore dispensable for closure, even in the absence of the amnioserosa...
October 17, 2016: Nature Cell Biology
Aaron J Quyn, Michael J Solomon, Peter M Lee, Tim Badgery-Parker, Lindy M Masya, Jane M Young
BACKGROUND: Locally advanced pelvic malignancy can be associated with disabling symptoms and reduced quality of life. If resectable with clear margins, a pelvic exenteration can offer long-term survival and improved quality of life. Its role in the palliation of symptoms has been described; however, the clinical outcomes and surgical indication are poorly defined. OBJECTIVE: This study describes the clinical and quality-of-life outcomes after palliative pelvic exenteration for advanced pelvic malignancy...
November 2016: Diseases of the Colon and Rectum
Craig Waitt, Nashali M Ferrara, Henk Eshuis
The performance of the random phase approximation (RPA) is tested for ther- mochemistry and geometries of transition metal chemistry using various benchmarks obtained either computationally or experimentally. Comparison is made to popular (semi-)local, meta- and hybrid density functionals as well as to second-order Møller- Plesset perturbation theory (MP2) and its spin-component-scaled derivatives. The benchmarks sets include reaction energies, barrier heights and dissociation energies of prototype bond-activation reactions, dissociation energies for a set of large transition metal complexes, bond lengths and dissociation energies of metal hydride ions, and bond lengths and angles of a set of closed-shell first-row transition metal complexes...
October 17, 2016: Journal of Chemical Theory and Computation
Yasemin Saygili, Magnus Söderberg, Norman Pellet, Fabrizio Giordano, Yiming Cao, Ana B Munoz-Garcia, Shaik Mohammed Zakeeruddin, Nick Vlachopoulos, Michele Pavone, Gerrit Boschloo, Ladislav Kavan, Jacques-E Moser, Michael Grätzel, Anders Hagfeldt, Marina Freitag
Redox mediators play a major role determining the photocurrent and the photovoltage in dye-sensitized solar cells (DSCs). To maintain the photocurrent, the reduction of oxidized dye by the redox mediator should be significantly faster than the back electron transfer between TiO2 and the oxidized dye. The driving force for dye regeneration with the redox mediator should be sufficiently low to provide high photovoltages. With our introduction of new copper complexes as promising redox mediators in DSCs both criteria are satisfied to enhance power conversion efficiencies...
October 17, 2016: Journal of the American Chemical Society
L Tyler Mix, Julia Kirpich, Masato Kumauchi, Jie Ren, Mikas Vengris, Wouter D Hoff, Delmar S Larsen
We explored the photoisomerization mechanisms in novel homologs of Photoactive Yellow Protein (PYP) from Leptospira biflexa to identify conserved features and functional diversity in the primary photochemistry of this family of photoreceptors. In close agreement with the prototypical PYP from Halorhodospira halophila, we observe excited state absorbance near 375 nm and stimulated emission near 500 nm, with triphasic excited state decay. While the excited state decay for Lbif PYP is the slowest among known PYPs due to the redistribution of the amplitudes of the three decay components, the quantum yield for productive photocycle entry is very similar to that of Hhal PYP...
October 17, 2016: Biochemistry
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