keyword
MENU ▼
Read by QxMD icon Read
search

Antiretrovirals in childrens

keyword
https://www.readbyqxmd.com/read/27898736/long-term-antiretroviral-treatment-adherence-in-hiv-infected-adolescents-and-adults-in-uganda-a-qualitative-study
#1
Seth C Inzaule, Raph L Hamers, Cissy Kityo, Tobias F Rinke de Wit, Maria Roura
BACKGROUND: Long-term success of HIV antiretroviral therapy requires near-perfect adherence, maintained throughout one's lifetime. However, perceptions towards ART and patterns of adherence may change during the life course. We assessed challenges to long-term adherence in adolescents and adults in three regional HIV treatment centers in Uganda. METHODS: We conducted 24 in-depth interviews and 2 focus group discussions with a total of 33 health-care providers and expert clients (HIV patients on long-term ART who assist with adherence support of fellow patients)...
2016: PloS One
https://www.readbyqxmd.com/read/27898679/patient-reported-barriers-to-adherence-to-antiretroviral-therapy-a-systematic-review-and-meta-analysis
#2
Zara Shubber, Edward J Mills, Jean B Nachega, Rachel Vreeman, Marcelo Freitas, Peter Bock, Sabin Nsanzimana, Martina Penazzato, Tsitsi Appolo, Meg Doherty, Nathan Ford
BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the targeting of different interventions and future research priorities. METHODS AND FINDINGS: We searched MEDLINE via PubMed, Embase, Web of Science, and PsychINFO from 01 January 1997 to 31 March 2016 for studies reporting barriers to adherence to ART...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27898593/coinfection-with-hiv-and-hepatitis-c-virus-in-229-children-and-young-adults-living-in-europe
#3
(no author information available yet)
OBJECTIVE: To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment. DESIGN: Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts. METHODS: Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27894862/hiv-drug-resistance-testing-among-patients-failing-second-line-antiretroviral-therapy-comparison-of-in-house-and-commercial-sequencing
#4
Benjamin Chimukangara, Bhavini Varyani, Tinei Shamu, Junior Mutsvangwa, Justen Manasa, Elizabeth White, Cleophas Chimbetete, Ruedi Luethy, David Katzenstein
INTRODUCTION: HIV genotyping is often unavailable in low and middle-income countries due to infrastructure requirements and cost. We compared genotype resistance testing in patients with virologic failure, by amplification of HIV pol gene, followed by "in-house" sequencing and commercial sequencing. METHODS: Remnant plasma samples from adults and children failing second-line ART were amplified and sequenced using in-house and commercial di-deoxysequencing, and analyzed in Harare, Zimbabwe and at Stanford, U...
November 25, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27885058/association-between-human-immunodeficiency-virus-infection-and-arterial-stiffness-in-children
#5
Justin S Kuilder, Nikmah S Idris, Diederick E Grobbee, Michiel L Bots, Michael Mh Cheung, David Burgner, Nia Kurniati, Cuno Spm Uiterwaal
BACKGROUND: Human immunodeficiency virus infection (HIV) is associated with increased cardiovascular risk and adverse cardiovascular outcome in adults. Early recognition of changes in vascular properties might prove essential in cardiovascular prevention in HIV-infected patients. We investigated the relations between HIV infection and arterial stiffness in children. METHODS: This cross-sectional study included 51 HIV-infected and 52 healthy children (age 3.2-14...
November 24, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27882759/-management-of-care-of-hiv-positive-pregnant-women-in-the-period-1996-2014
#6
M Mojhová, I Mikysková, M Halaška, M Staňková, H Rozsypal, J Šrámek, J Záhumenský, M Malý
OBJECTIVE: The evaluation of multidisplinary care about HIV positive pregnant women in the Czech Republic. DESIGN: Review. SETTINGS: Gynekologicko-porodnická klinika 1. LF UK a Nemocnice na Bulovce, Praha. METHODS: The vertical transmission of HIV infection from mother to fetus occurs most often during birth, still 1-2% of HIV-positive pregnant women will transfer the virus transplacenta. Due to careful screening for HIV during pregnancy, counselling, combination antiretroviral (cART) therapy, childbirth planning and its performance by C-section there appears a significant decrease of the virus transmission to the fetus, its occurrence is around 2%...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27881690/acceptability-of-outpatient-ready-to-use-food-based-protocols-in-hiv-infected-senegalese-children-and-adolescents-within-the-maggsen-cohort-study
#7
Cecile Cames, Marie Varloteaux, Ndeye Ngone Have, Alhadji Bassine Diom, Philippe Msellati, Ngagne Mbaye, Helene Mbodj, Haby Sy Signate, Aminata Diack
OBJECTIVES: To assess the acceptability of ready-to-use food (RUF)-based outpatient protocols in HIV-infected children and adolescents with severe acute malnutrition (SAM) and moderate acute malnutrition (MAM). METHODS: Plumpy Nut and Plumpy Sup were supplied every 2 weeks and prescribed by weight to SAM and MAM children, respectively. Forty-three children, 24 MAM and 19 SAM, were enrolled. Organoleptic appreciation, feeding modalities, and perceptions surrounding RUF were recorded at week 2...
November 22, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27880749/early-diagnosis-of-hiv-infection-in-infants-one-caribbean-and-six-sub-saharan-african-countries-2011-2015
#8
Karidia Diallo, Andrea A Kim, Shirley Lecher, Dennis Ellenberger, R Suzanne Beard, Helen Dale, Mackenzie Hurlston, Molly Rivadeneira, Peter N Fonjungo, Laura N Broyles, Guoqing Zhang, Katrina Sleeman, Shon Nguyen, Steve Jadczak, Nadine Abiola, Raimi Ewetola, Jérémie Muwonga, Franck Fwamba, Christina Mwangi, Mary Naluguza, Charles Kiyaga, Isaac Ssewanyana, Deyde Varough, Domercant Wysler, David Lowrance, Frantz Jean Louis, Olbeg Desinor, Josiane Buteau, Francois Kesner, Vanessa Rouzier, Nat Segaren, Tessa Lewis, Abdoulaye Sarr, Geoffrey Chipungu, Sundeep Gupta, Daniel Singer, Reuben Mwenda, Hilary Kapoteza, Zawadi Chipeta, Nancy Knight, Sergio Carmona, William MacLeod, Gayle Sherman, Yogan Pillay, Clement B Ndongmo, Bridget Mugisa, Annie Mwila, James McAuley, Peter J Chipimo, Wezi Kaonga, Dailess Nsofwa, Davy Nsama, Fales Zulu Mwamba, Crispin Moyo, Clement Phiri, Marie-Yolande Borget, Leonard Ya-Kouadio, Abo Kouame, Christiane A Adje-Toure, John Nkengasong
Pediatric human immunodeficiency virus (HIV) infection remains an important public health issue in resource-limited settings. In 2015, 1.4 million children aged <15 years were estimated to be living with HIV (including 170,000 infants born in 2015), with the vast majority living in sub-Saharan Africa (1). In 2014, 150,000 children died from HIV-related causes worldwide (2). Access to timely HIV diagnosis and treatment for HIV-infected infants reduces HIV-associated mortality, which is approximately 50% by age 2 years without treatment (3)...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27879556/who-gets-severe-gynecomastia-among-hiv-infected-children-in-the-uk-and-ireland
#9
Julia Kenny, Katja Doerholt, Di M Gibb, Ali Judd
There are few data on gynecomastia in HIV-infected children. Within the UK/Ireland's national cohort, 56/1,873 (3%) HIV-infected children had gynecomastia, of which 10 (0.5%) were severe. All 10 had received antiretroviral therapy for a median of 27.5 [21,42] months; 4/10 had received efavirenz, 7/10 and 6/10 stavudine and/or didanosine respectively. Five were non-reversible, despite changing ART, and required breast reduction surgery.
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27875835/the-relevance-of-palliative-care-in-hiv-and-aging
#10
Jacqueline Shorthill, Rosanna F DeMarco
The connection between palliative care and HIV infection has deep and wide roots in the United States that go back to the time when many gay men in the early 1980s were dying from a disease we knew little about, and there was no way to help but to alleviate symptoms in hospice and end of life centers across the United States. More individuals (adults and children), families, and communities attribute the success of antiretroviral therapies and other therapeutic approaches to advancing quality of life and life itself today...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27846809/predictors-of-poor-retention-on-antiretroviral-therapy-as-a-major-hiv-drug-resistance-early-warning-indicator-in-cameroon-results-from-a-nationwide-systematic-random-sampling
#11
Serge Clotaire Billong, Joseph Fokam, Calixte Ida Penda, Salmon Amadou, David Same Kob, Edson-Joan Billong, Vittorio Colizzi, Alexis Ndjolo, Anne-Cecile Zoung-Kani Bisseck, Jean-Bosco Nfetam Elat
BACKGROUND: Retention on lifelong antiretroviral therapy (ART) is essential in sustaining treatment success while preventing HIV drug resistance (HIVDR), especially in resource-limited settings (RLS). In an era of rising numbers of patients on ART, mastering patients in care is becoming more strategic for programmatic interventions. Due to lapses and uncertainty with the current WHO sampling approach in Cameroon, we thus aimed to ascertain the national performance of, and determinants in, retention on ART at 12 months...
November 15, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27846070/implementation-and-operational-research-an-integrated-and-comprehensive-service-delivery-model-to-improve-pediatric-and-maternal-hiv-care-in-rural-africa
#12
Anna Gamell, Tracy R Glass, Lameck B Luwanda, Herry Mapesi, Leila Samson, Tom Mtoi, Angelo Nyamtema, Lukas Muri, Alex Ntamatungiro, Marcel Tanner, Christoph Hatz, Manuel Battegay, Emilio Letang
BACKGROUND: Strategies to improve HIV diagnosis and linkage into care, antiretroviral treatment coverage, and treatment outcomes of mothers and children are urgently needed in sub-Saharan Africa. METHODS: From December 2012, we implemented an intervention package to improve prevention of mother-to-child transmission (PMTCT) and pediatric HIV care in our rural Tanzanian clinic, consisting of: (1) creation of a PMTCT and pediatric unit integrated within the reproductive and child health clinic; (2) implementation of electronic medical records; (3) provider-initiated HIV testing and counseling in the hospital wards; and (4) early infant diagnosis test performed locally...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27842440/caregiver-reported-antiretroviral-therapy-non-adherence-during-the-first-week-and-after-a-month-of-treatment-initiation-among-children-diagnosed-with-hiv-in-ethiopia
#13
Mulatu Biru, Degu Jerene, Pia Lundqvist, Mitikie Molla, Workeabeba Abebe, Inger Hallström
To achieve optimal virologic suppression for children undergoing antiretroviral therapy (ART), adherence must be excellent. This is defined as taking more than 95% of their prescribed doses. To our knowledge, no study in Ethiopia has evaluated the level of treatment adherence at the beginning of the child's treatment. Our aim was therefore to evaluate caregiver-reported ART non-adherence among children and any predictors for this during the early course of treatment. We conducted a prospective cohort study of 306 children with HIV in eight health facilities in Ethiopia who were registered at ART clinics between 20 December 2014 and 20 April 2015...
November 14, 2016: AIDS Care
https://www.readbyqxmd.com/read/27837268/effect-of-high-dose-cholecalciferol-vitamin-d3-on-bone-and-body-composition-in-children-and-young-adults-with-hiv-infection-a-randomized-double-blind-placebo-controlled-trial
#14
A J Rovner, V A Stallings, R Rutstein, J I Schall, M B Leonard, B S Zemel
: It is unknown whether vitamin D supplementation positively impacts body composition and bone outcomes in children and young adults with HIV. This RCT found that despite increasing 25(OH)D concentrations, high dose vitamin D3 supplementation did not impact bone or body composition in children and young adults with HIV infection. INTRODUCTION: The objective of this paper was to determine the impact of high-dose daily cholecalciferol (vitamin D3) supplementation on body composition and bone density, structure, and strength in children and young adults with perinatally acquired (PHIV) or behaviorally acquired (BHIV) HIV infection...
November 11, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#15
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27828785/early-age-at-start-of-antiretroviral-therapy-associated-with-better-virologic-control-after-initial-suppression-in-hiv-infected-infants
#16
Stephanie Shiau, Renate Strehlau, Karl-Günter Technau, Faeezah Patel, Stephen M Arpadi, Ashraf Coovadia, Elaine J Abrams, Louise Kuhn
OBJECTIVE: The report of the 'Mississippi baby' who was initiated on antiretroviral therapy (ART) within 30 h of birth and maintained viral suppression off ART for 27 months has increased interest in the timing of ART initiation early in life. We examined associations between age at ART initiation and virologic outcomes in five cohorts of HIV-infected infants and young children who initiated ART before 2 years of age in Johannesburg, South Africa. METHODS: We compared those who initiated ART early (<6 months of age) and those who started ART late (6-24 months of age)...
November 8, 2016: AIDS
https://www.readbyqxmd.com/read/27825316/prevalence-and-effect-of-pre-treatment-drug-resistance-on-the-virological-response-to-antiretroviral-treatment-initiated-in-hiv-infected-children-a-eurocoord-chain-eppicc-joint-project
#17
Nicole Ngo-Giang-Huong, Linda Wittkop, Ali Judd, Peter Reiss, Tessa Goetghebuer, Dan Duiculescu, Antoni Noguera-Julian, Magdalena Marczynska, Carlo Giacquinto, Luminita Ene, Jose T Ramos, Cristina Cellerai, Thomas Klimkait, Benedicte Brichard, Niels Valerius, Caroline Sabin, Ramon Teira, Niels Obel, Christoph Stephan, Stéphane de Wit, Claire Thorne, Diana Gibb, Christine Schwimmer, Maria Athena Campbell, Deenan Pillay, Marc Lallemant
BACKGROUND: Few studies have evaluated the impact of pre-treatment drug resistance (PDR) on response to combination antiretroviral treatment (cART) in children. The objective of this joint EuroCoord-CHAIN-EPPICC/PENTA project was to assess the prevalence of PDR mutations and their association with virological outcome in the first year of cART in children. METHODS: HIV-infected children <18 years initiating cART between 1998 and 2008 were included if having at least one genotypic resistance test prior to cART initiation...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27824723/a-thirty-year-perspective-of-the-long-term-survival-cd4-percentage-and-social-achievements-of-perinatally-hiv-infected-children-as-a-function-of-their-birth-era
#18
Sharon Vuppula, Donna Tyungu, Aditya Kaul, Sulachni Chandwani, Mona Rigaud, William Borkowsky
BACKGROUND: Pediatric HIV has evolved from a pre-antiretroviral era (pre-1989 or Pre-ART) to an antiretroviral (ART) era (1989-1996) & to a highly active antiretroviral therapy (HAART) era (post-1996). As we have passed the 3rd decade following these individuals, we thought it useful to review clinical, laboratory, & social outcomes. METHODS: A retrospective, cross-sectional study of 399 children infected perinatally. They were divided into Pre-ART, ART & HAART groups...
November 7, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27821443/altered-plasmodium-falciparum-sensitivity-to-the-antiretroviral-protease-inhibitor-lopinavir-associated-with-polymorphisms-in-pfmdr1
#19
Ebere Sonoiki, Christian Nsanzabana, Jennifer Legac, Kirthana Mysore Vasudevarao Sindhe, Joseph DeRisi, Philip J Rosenthal
The HIV protease inhibitor lopinavir inhibits Plasmodium falciparum aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selected in vitro over ∼9 months, with ∼4-fold decreased sensitivity. Whole genome sequencing of resistant parasites showed a mutation and increased copy number in pfmdr1, a mutation in a protein of unknown function, but no polymorphisms in plasmepsin genes...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27812706/vitamin-d-deficiency-in-hiv-infected-children
#20
Ayesha Mirza, Saran Wells, Tabitha Gayton, Carmen Smotherman, Azeem Rathore, Dale Kraemer, Mobeen Rathore
OBJECTIVES: Improvement in life expectancy with the use of combination antiretroviral therapy has come with the recognition of the complications associated with chronic human immunodeficiency virus infection. Vitamin D has been of particular interest because of its effect on bone health and immune functions. The purpose of this study was to assess vitamin D status in children in relation to the duration and severity of their human immunodeficiency virus infection and nutritional status, as well as to determine whether there was any effect of seasonality...
November 2016: Southern Medical Journal
keyword
keyword
60419
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"