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https://www.readbyqxmd.com/read/28086969/multicenter-neonatal-databases-trends-in-research-uses
#1
Liza M Creel, Sean Gregory, Catherine J McNeal, Madhava R Beeram, David R Krauss
BACKGROUND: In the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight (LBW), and 1.5% are very low birth weight (VLBW). Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28078463/endoscopic-vacuum-therapy-for-various-defects-of-the-upper-gastrointestinal-tract
#2
Florian Kuehn, Gunnar Loske, Leif Schiffmann, Michael Gock, Ernst Klar
BACKGROUND: Postoperative, iatrogenic or spontaneous upper gastrointestinal defects result in significant morbidity and mortality of the patients. In the last few years, endoscopic vacuum therapy (EVT) has been recognized as a new promising method for repairing upper gastrointestinal defects of different etiology. However, probably due to insufficient data and no commercially available system for EVT of the upper gastrointestinal tract, until the end of 2014, covering of esophageal defects with self-expanding metal stents (SEMS) were still the mainstay of endoscopic therapy...
January 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28068233/multi-institutional-nomogram-predicting-survival-free-from-salvage-whole-brain-radiation-after-radiosurgery-in-patients-with-brain-metastases
#3
Daniel Gorovets, Diandra Ayala-Peacock, David J Tybor, Paul Rava, Daniel Ebner, Deus Cielo, Georg Norén, David E Wazer, Michael Chan, Jaroslaw T Hepel
PURPOSE: Optimal patient selection for stereotactic radiosurgery (SRS) as the initial treatment for brain metastases is complicated and controversial. This study aimed to develop a nomogram that predicts survival without salvage whole brain radiation therapy (WBRT) after upfront SRS. METHODS AND MATERIALS: Multi-institutional data were analyzed from 895 patients with 2095 lesions treated with SRS without prior or planned WBRT. Cox proportional hazards regression model was used to identify independent pre-SRS predictors of WBRT-free survival, which were integrated to build a nomogram that was subjected to bootstrap validation...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28063922/efficacy-and-safety-of-a-four-drug-fixed-dose-combination-regimen-versus-separate-drugs-for-treatment-of-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#4
REVIEW
Glaura C Lima, Emilia V Silva, Pérola de O Magalhães, Janeth S Naves
INTRODUCTION: Tuberculosis, particularly multi-drug-resistant tuberculosis, is a major cause of morbidity and mortality worldwide. To the best of our knowledge, however, no study to date has assessed the combined use of the four available drugs for tuberculosis treatment, which is an issue of great clinical relevance. OBJECTIVE: To determine whether the four-drug fixed-dose combination is safer or more effective than separate drugs for treatment of pulmonary tuberculosis...
December 23, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28063191/salvage-high-intensity-focused-ultrasound-hifu-for-locally-recurrent-prostate-cancer-after-failed-radiation-therapy-multi-institutional-analysis-of-418-patients
#5
Sebastien Crouzet, Andreas Blana, Francois J Murat, Gilles Pasticier, Stephen C W Brown, Giario N Conti, Roman Ganzer, Olivier Chapet, Albert Gelet, Christian G Chaussy, Cary N Robertson, Stefan Thuroff, John F Ward
OBJECTIVE: To report the oncological outcome of Salvage high-intensity focused ultrasound (S-HIFU) for locally recurrent prostate cancer (PCa) following External Beam Radiotherapy (EBRT) from a multicenter database. MATERIALS AND METHODS: This retrospective study comprises patients from 9 centers with local recurrent disease following EBRT treated with S-HIFU from 1995 to 2009. Biochemical free survival rates (BFSR) was based on the "Phoenix" definition (nadir+2)...
January 7, 2017: BJU International
https://www.readbyqxmd.com/read/28061873/prophylactic-melatonin-for-delirium-in-intensive-care-pro-medic-study-protocol-for-a-randomised-controlled-trial
#6
F Eduardo Martinez, Matthew Anstey, Andrew Ford, Brigit Roberts, Miranda Hardie, Robert Palmer, Lynn Choo, David Hillman, Michael Hensley, Erin Kelty, Kevin Murray, Bhajan Singh, Bradley Wibrow
BACKGROUND: Delirium is an acute state of brain dysfunction characterised by fluctuating inattention and cognitive disturbances, usually due to illness. It occurs commonly in the intensive care unit (ICU), and it is associated with greater morbidity and mortality. It is likely that disturbances of sleep and of the day-night cycle play a significant role. Melatonin is a naturally occurring, safe and cheap hormone that can be administered to improve sleep. The main aim of this trial will be to determine whether prophylactic melatonin administered to critically ill adults, when compared with placebo, decreases the rate of delirium...
January 6, 2017: Trials
https://www.readbyqxmd.com/read/28053211/optical-screening-for-rapid-antimicrobial-susceptibility-testing-and-for-observation-of-phenotypic-diversity-among-the-genetically-clonal-species-bacillus-anthracis
#7
Heather P McLaughlin, Amy S Gargis, Pierre Michel, David Sue, Linda M Weigel
: During high-impact events involving Bacillus anthracis, such as the Amerithrax incident of 2001 or the anthrax outbreaks in Russia and Sweden in 2016, critical decisions to reduce morbidity and mortality include rapid selection and distribution of effective antimicrobial agents for treatment and post-exposure prophylaxis. Detection of antimicrobial resistance currently relies on a conventional broth microdilution (BMD) method that requires a 16 - 20 hour incubation time for B. anthracis Advances in high-resolution optical screening offer a new technology to more rapidly evaluate antimicrobial susceptibility and to simultaneously assess growth characteristics of an isolate...
January 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28047881/we-ab-bra-07-operating-room-quality-assurance-orqa-for-spine-surgery-using-known-component-3d-2d-image-registration
#8
A Uneri, T De Silva, J Goerres, M Jacobson, M Ketcha, S Reaungamornrat, G Kleinszig, S Vogt, A Khanna, J Wolinsky, J Siewerdsen
PURPOSE: Intraoperative x-ray radiography/fluoroscopy is commonly used to qualitatively assess delivery of surgical devices (e.g., spine pedicle screws) but can fail to reliably detect suboptimal placement (e.g., breach of adjacent critical structures). We present a method wherein prior knowledge of the patient and surgical components is leveraged to match preoperative CT and intraoperative radiographs for quantitative assessment of 3D pose. The method presents a new means of operating room quantitative quality assurance (ORQA) that could improve quality and safety, and reduce the frequency of revision surgeries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044296/microfluidic-based-bacteria-isolation-from-whole-blood-for-diagnostics-of-blood-stream-infection
#9
Sergey Zelenin, Harisha Ramachandraiah, Asim Faridi, Aman Russom
Bacterial blood stream infection (BSI) potentially leads to life-threatening clinical conditions and medical emergencies such as severe sepsis, septic shock, and multi organ failure syndrome. Blood culturing is currently the gold standard for the identification of microorganisms and, although it has been automated over the decade, the process still requires 24-72 h to complete. This long turnaround time, especially for the identification of antimicrobial resistance, is driving the development of rapid molecular diagnostic methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28043019/immigration-policies-and-mental-health-morbidity-among-latinos-a-state-level-analysis
#10
Mark L Hatzenbuehler, Seth J Prins, Morgan Flake, Morgan Philbin, M Somjen Frazer, Daniel Hagen, Jennifer Hirsch
RATIONALE: Despite abundant state-level policy activity in the U.S. related to immigration, no research has examined the mental health impact of the overall policy climate for Latinos, taking into account both inclusionary and exclusionary legislation. OBJECTIVE: To examine associations between the state-level policy climate related to immigration and mental health outcomes among Latinos. METHODS: We created a multi-sectoral policy climate index that included 14 policies in four domains (immigration, race/ethnicity, language, and agricultural worker protections)...
November 30, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28042069/comprehensive-and-integrated-palliative-care-for-people-with-advanced-chronic-conditions-an-update-from-several-european-initiatives-and-recommendations-for-policy
#11
Xavier Gómez-Batiste, Scott Murray, Keri Thomas, Carles Blay, Kirsty Boyd, Sebastien Moine, Maxime Gignon, Bart Van den Eynden, Bert Leysen, Johan Wens, Yvonne Engels, Marianne Dees, Massimo Costantini
The number of people in their last years of life with advanced chronic conditions, palliative care needs and limited life prognosis due to different causes including multi-morbidity, organ failure, frailty, dementia, and cancer is rising. Such people represent more than 1% of the population. They are present in all care settings, cause around 75% of mortality, and may account for up to one third of total national health system spend. The response to their needs is usually late and largely based around institutional palliative care focused on cancer...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28039180/multimodality-treatment-for-esophageal-adenocaricnoma-multi-center-propensity-score-matched-study
#12
S R Markar, B J Noordman, H Mackenzie, J M Findlay, P R Boshier, M Ni, E W Steyerberg, A van der Gaast, M C C M Hulshof, N Maynard, M I van Berge Henegouwen, B P L Wijnhoven, J V Reynolds, J J B Van Lanschot, G B Hanna
BACKGROUND: The primary aim of this study was to compare survival from neoadjuvant chemoradiotherapy plus surgery (NCRS) versus neoadjuvant chemotherapy plus surgery (NCS) for the treatment of esophageal or junctional adenocarcinoma. The secondary aims were to compare pathological effects, short-term mortality and morbidity, and to evaluate the effect of lymph node harvest upon survival in both treatment groups. METHODS: Data were collected from 10 European centers from 2001 to 2012...
October 25, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28036311/etiological-profile-of-early-neonatal-bacterial-sepsis-by-multiplex-qpcr
#13
Walter P Silva-Junior, Almir S Martins, Paula C N Xavier, Kelly L A Appel, Silvio A Oliveira Junior, Durval B Palhares
INTRODUCTION: Given the major impact in terms of morbidity and mortality that episodes of early neonatal sepsis (ENS) have on both newborns and health systems, this study aimed to identify the etiological profile of early neonatal bacterial sepsis by a multiplex quantitative real-time polymerase chain reaction (qPCR). METHODOLOGY: Blood samples from newborns diagnosed with clinical ENS and hospitalized in neonatal intensive care units (NICUs) were collected and analyzed using the multiplex qPCR method to detect Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter sp...
December 30, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28030569/effect-of-an-education-programme-for-south-asians-with-asthma-and-their-clinicians-a-cluster-randomised-controlled-trial-oedipus
#14
Chris Griffiths, Stephen Bremner, Kamrul Islam, Ratna Sohanpal, Debi-Lee Vidal, Carolyn Dawson, Gillian Foster, Jean Ramsay, Gene Feder, Stephanie Taylor, Neil Barnes, Aklak Choudhury, Geoff Packe, Elizabeth Bayliss, Duncan Trathen, Philip Moss, Viv Cook, Anna Eleri Livingstone, Sandra Eldridge
BACKGROUND: People with asthma from ethnic minority groups experience significant morbidity. Culturally-specific interventions to reduce asthma morbidity are rare. We tested the hypothesis that a culturally-specific education programme, adapted from promising theory-based interventions developed in the USA, would reduce unscheduled care for South Asians with asthma in the UK. METHODS: A cluster randomised controlled trial, set in two east London boroughs. 105 of 107 eligible general practices were randomised to usual care or the education programme...
2016: PloS One
https://www.readbyqxmd.com/read/28028258/-exploration-of-the-factors-influencing-multi-drug-cancer-chemotherapy-in-the-elderly-a-retrospective-study
#15
Kentaro Ogata, Kazuo Tamura, Fumiaki Kiyomi, Yasushi Takamatsu, Hidetoshi Kamimura
Multi-drug administration is problematic in elderly patients, and the situation is further complicated in those with cancer, owing to a high possibility of side effects and augmentation due to interactions between concomitant or previous drugs the patients are receiving and the anti-cancer drugs administered. Analysis of the factors that influence the likelihood of cancer chemotherapy multi-drug administration in the elderly showed that age alone was a fundamental risk factor for multi-drug administration, comorbidities, and drug interactions...
December 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28024266/the-risk-of-being-depressed-is-significantly-higher-in-cancer-patients-than-in-the-general-population-prevalence-and-severity-of-depressive-symptoms-across-major-cancer-types
#16
T J Hartung, E Brähler, H Faller, M Härter, A Hinz, C Johansen, M Keller, U Koch, H Schulz, J Weis, A Mehnert
BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression. PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants...
December 23, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28009745/safety-and-feasibility-of-minimally-invasive-inguinal-lymph-node-dissection-in-patients-with-melanoma-safe-milnd-report-of-a-prospective-multi-institutional-trial
#17
James W Jakub, Alicia M Terando, Amod Sarnaik, Charlotte E Ariyan, Mark B Faries, Sabino Zani, Heather B Neuman, Nabil Wasif, Jeffrey M Farma, Bruce J Averbook, Karl Y Bilimoria, Travis E Grotz, Jacob B Jake Allred, Vera J Suman, Mary Sue Brady, Douglas Tyler, Jeffrey D Wayne, Heidi Nelson
BACKGROUND: Minimally invasive inguinal lymph node dissection (MILND) is a novel approach to inguinal lymphadenectomy. SAFE-MILND (NCT01500304) is a multicenter, phase I/II clinical trial evaluating the safety and feasibility of MILND for patients with melanoma in a group of surgeons newly adopting the procedure. METHODS: Twelve melanoma surgeons from 10 institutions without any previous MILND experience, enrolled patients into a prospective study after completing specialized training including didactic lectures, participating in a hands-on cadaveric laboratory, and being provided an instructional DVD of the procedure...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28004983/methicillin-resistant-staphylococcus-aureus-pneumonia-in-critically-ill-trauma-and-burn-patients-a-retrospective-cohort-study
#18
Kristen L Bunnell, Andrew R Zullo, Christine Collins, Charles A Adams
BACKGROUND: The timing and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in trauma patients are not well characterized. This information is critical for the selection of appropriate empiric antibiotics. The objective of this study was to determine the incidence of MRSA pneumonia in early-onset and late-onset pneumonia and to identify risk factors for MRSA in the trauma-burn intensive care unit (ICU). PATIENTS AND METHODS: We conducted a retrospective cohort study from January 2012 to March 2015 of patients in the trauma and burn ICU with clinical and microbiologic evidence of pneumonia...
December 22, 2016: Surgical Infections
https://www.readbyqxmd.com/read/28002548/absolute-rates-of-heart-failure-coronary-heart-disease-and-stroke-in-chronic-kidney-disease-an-analysis-of-3-community-based-cohort-studies
#19
Nisha Bansal, Ronit Katz, Cassianne Robinson-Cohen, Michelle C Odden, Lorien Dalrymple, Michael G Shlipak, Mark J Sarnak, David S Siscovick, Leila Zelnick, Bruce M Psaty, Bryan Kestenbaum, Adolfo Correa, Maryam Afkarian, Bessie Young, Ian H de Boer
Importance: Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Understanding the relative contributions of cardiovascular disease event types to the excess burden of cardiovascular disease is important for developing effective strategies to improve outcomes. Objective: To determine absolute rates and risk differences of incident heart failure (HF), coronary heart disease (CHD), and stroke in participants with vs without CKD...
December 21, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/28000656/portomesenteric-venous-thrombosis-a-rare-but-probably-under-reported-complication-of-laparoscopic-surgery-a-case-series
#20
Yan Mei Goh, Ajay Tokala, Tarek Hany, Kishore G Pursnani, Ravindra S Date
Portomesenteric venous thrombosis (PMVT) is a rare but well-reported complication following laparoscopic surgery. We present three cases of PMVT following laparoscopic surgery. Our first case is a 71-year-old morbidly obese woman admitted for elective laparoscopic giant hiatus hernia (LGHH) repair. Post-operatively, she developed multi-organ dysfunction and computed tomography scan revealed portal venous gas and extensive small bowel infarct. The second patient is a 51-year-old man with known previous deep venous thrombosis who also had elective LGHH repair...
December 21, 2016: Journal of Minimal Access Surgery
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