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https://www.readbyqxmd.com/read/29141032/a-qualitative-exploration-of-malaria-operational-research-situation-in-nigeria
#1
IkeOluwapo O Ajayi, Maduka D Ughasoro, Akintayo Ogunwale, Oluwaseun Odeyinka, Obafemi Babalola, Salami Sharafadeen, Al-Mukhtar Y Adamu, Olufemi Ajumobi, Taiwo Orimogunje, Patrick Nguku
BACKGROUND: Malaria, remains one of the leading causes of high morbidity and mortality in Nigeria despite implementation of several public health interventions for its control. Operational limitations and methodological gaps have been associated with malaria control interventions and research, and these have necessitated the need for a well-tailored Malaria Operational Research (MOR) agenda. However, there is paucity of evidence-based information on relevant stakeholders' experience, awareness, perceptions and use of MOR and suggestions on setting MOR agenda...
2017: PloS One
https://www.readbyqxmd.com/read/29135397/electrolytes-imbalance-caused-by-amikacin-in-patients-receiving-multi-drug-resistance-tuberculosis-treatment-at-hazara-region-kpk-pakistan
#2
Faheem Jan, Mukhtiar Hassan, Naveed Muhammad, Shahid Wali, Hafiz Sajid Akbar, Qazi Mashhood Atta, Farzana Gul
Introduction: Multi drug resistance-tuberculosis (MDR-TB) is considered amongst one of the fatal medical and public health issue. Greater frequency of adverse reactions has been observed using 2nd line antituberculosis drugs, which rises the rate of morbidity. Hypokalemia and hyponatremia are common in patients receiving MDR-TB treatment. Materials and Methods: This study was aimed to assess the effect of amikacin as multidrug resistance tuberculosis treatment on serum sodium and potassium level...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29134857/the-association-between-physical-activity-and-chronic-diseases-in-european-adults
#3
Adilson Marques, Teresa Santos, João Martins, Margarida Gaspar de Matos, Miguel González Valeiro
Chronic diseases are the leading cause of morbidity and mortality and are considered to be at epidemic levels worldwide. This is a cross-sectional multi-country study based on data from the European Social Survey round 7, 2014, comprising 30,826 participants (14,813 men) with mean age 50.4 ± 18.0. Physical activity and chronic diseases were self-reported. Men and women who practiced physical activity more often had lower odds of having heart problems, breathing problems, type 2 diabetes, and obesity. Engaged in physical activity 2-4 times/week and ≥5 times/week decrease the odds of having heart problems, high blood pressure, breathing problems, type 2 diabetes, and obesity, compared with men and women who engaged in physical activity 1 or less times per week...
November 14, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29133567/risk-factors-and-outcomes-associated-with-multidrug-resistant-acinetobacter-baumannii-upon-icu-admission
#4
Natalia Blanco, Anthony D Harris, Clare Rock, J Kristie Johnson, Lisa Pineles, Robert A Bonomo, Arjun Srinivasan, Melinda M Pettigrew, Kerri A Thom
Introduction: Multi-drug resistant (MDR) Acinetobacter baumannii, associated with broad-spectrum antibiotic use, is an important nosocomial pathogen associated with morbidity and mortality. This study aimed to investigate the prevalence of MDR A. baumannii perirectal colonization among adult patients at ICU admission over a 5-year period, and to identify risk factors and outcomes associated with colonization.Methods: A retrospective cohort analysis of patients admitted to the medical (MICU) and surgical intensive care units (SICU) at the University of Maryland Medical Center from May 2005 to September 2009 was performed using perirectal surveillance cultures on admission...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29132879/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-coronary-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#5
Stuart J Connolly, John W Eikelboom, Jackie Bosch, Gilles Dagenais, Leanne Dyal, Fernando Lanas, Kaj Metsarinne, Martin O'Donnell, Anthony L Dans, Jong-Won Ha, Alexandr N Parkhomenko, Alvaro A Avezum, Eva Lonn, Liu Lisheng, Christian Torp-Pedersen, Petr Widimsky, Aldo P Maggioni, Camilo Felix, Katalin Keltai, Masatsugu Hori, Khalid Yusoff, Tomasz J Guzik, Deepak L Bhatt, Kelley R H Branch, Nancy Cook Bruns, Scott D Berkowitz, Sonia S Anand, John D Varigos, Keith A A Fox, Salim Yusuf
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29132627/examining-health-disparities-by-gender-a-multimorbidity-network-analysis-of-electronic-medical-record
#6
Pankush Kalgotra, Ramesh Sharda, Julie M Croff
PROBLEM: Multimorbidity health disparities have not been well examined by gender. Co-occurring diseases may be mutually deleterious, co-occurring independently, or co-occurring from a common antecedent. Diseases linked by a common antecedent may be caused by biological, behavioral, social, or environmental factors. This paper aims to address the co-occurrences of diseases using network analysis. METHODS: In this study, we identify these multi-morbidities from a large electronic medical record (EMR) containing diagnoses, symptoms and treatment data on more than 22...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29131313/risk-score-to-predict-biliary-leakage-after-elective-liver-resection
#7
K Mohkam, O Farges, E Vibert, O Soubrane, R Adam, F-R Pruvot, J-M Regimbeau, M Adham, E Boleslawski, J-Y Mabrut
BACKGROUND: Biliary leakage remains a major cause of morbidity after liver resection. Previous prognostic studies of posthepatectomy biliary leakage (PHBL) lacked power, population homogeneity, and model validation. The present study aimed to develop a risk score for predicting severe PHBL. METHODS: In this multicentre observational study, patients who underwent liver resection without hepaticojejunostomy in one of nine tertiary centres between 2012 and 2015 were randomly assigned to a development or validation cohort in a 2 : 1 ratio...
November 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29129516/is-there-a-potential-link-between-vitamin-d-and-pulmonary-morbidities-in-preterm-infants
#8
Yang Yang, Yun Feng, Xu Chen, Xiao-Nan Mao, Jing-Han Zhang, Li Zhao, You-Yan Zhao, Rui Cheng
BACKGROUND: There hasn't been conclusive proof about the association between vitamin D and pulmonary morbidities of prematurity. METHODS: 106 preterm infants were retrospectively included into this study. Clinical data and blood samples of all the patients were collected within 24 h of admission. RESULTS: (1) Respiratory distress syndrome (RDS) patients were mainly concentrated in "≤30 weeks" stage when compared with other two gestational age groups...
November 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29127616/worm-infestation-diagnosis-treatment-and-prevention
#9
REVIEW
Bhavneet Bharti, Sahul Bharti, Sumeeta Khurana
Worm infections continue to be among the most common diseases affecting children from low and middle income countries. Major worm infections of public health importance include Ascariasis, Trichuriasis, Hookworm, and Enterobiasis, which are transmitted through contaminated soil. In India, combined prevalence rates of worm infestation as per pooled data of 127 surveys is over 20%. Although most helminthic infections are mild and are often asymptomatic, but moderate to heavy worm infestations are generally associated with growth faltering, nutritional compromise, anemia and suboptimal academic performance among children from endemic regions...
November 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29124346/live-surgery-highly-educational-or-harmful
#10
B Rocco, A A C Grasso, E De Lorenzis, J W Davis, C Abbou, A Breda, T Erdogru, R Gaston, I S Gill, E Liatsikos, B Oktay, J Palou, T Piéchaud, J U Stolzenburg, Y Sun, G Albo, H Villavicencio, X Zhang, V Disanto, P Emiliozzi, V Pansadoro
PURPOSE: Live surgery (LS) is considered a useful teaching opportunity. The benefits must be balanced with patient safety concerns. To evaluate the rate of complications of a series of urologic LS performed by experts during the Congress Challenge in Laparoscopy and Robotics (CILR). METHODS: We present a large, multi-institution, multi-surgeon database that derives from 12 CILR events, from 2004 to 2015 with a total of 224 cases. Radical prostatectomy (RP) was the most common procedure and a selection of complex cases was noted...
November 9, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29124025/efficacy-of-single-port-video-assisted-thoracoscopic-surgery-lobectomy-compared-with-triple-port-vats-by-propensity-score-matching
#11
Kyung Sub Song, Chang Kwon Park, Jae Bum Kim
Background: In recent years, single-port video-assisted thoracoscopic surgery (VATS) for lobectomy in non-small cell lung cancer (NSCLC) patients has become increasingly common. The objective of this study was to compare the feasibility and safety of single-port and triple-port VATS lobectomy. Methods: A total of 73 patients with NSCLC who underwent VATS lobectomy from December 2011 to August 2016 were retrospectively reviewed, including 47 in the triple-port group and 26 in the single-port group...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29123656/off-label-use-of-adipose-derived-stem-cells
#12
REVIEW
Francesco Simonacci, Nicolò Bertozzi, Edoardo Raposio
Background: Adipose-derived stem cells (ASCs) have a broad range of clinical applications. The ease of cell harvest and high yield with minimal donor-site morbidity makes adipose tissue an ideal source of stem cells. Further, the multi-lineage potential of these cells present significant opportunities within the field of tissue engineering, with studies successfully demonstrating their ability to produce a range of tissue types. Materials and methods: Literature review of publications on the use of ASCs, in the context of current European and US regulations...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29122528/safety-of-open-ventral-hernia-repair-in-high-risk-patients-with-metabolic-syndrome-a-multi-institutional-analysis-of-39-118-cases
#13
Dmitry Zavlin, Kevin T Jubbal, Jeffrey L Van Eps, Barbara L Bass, Warren A Ellsworth, Anthony Echo, Jeffrey D Friedman, Brian J Dunkin
BACKGROUND: Metabolic syndrome (MetS) entails the simultaneous presence of a constellation of dangerous risk factors including obesity, diabetes, hypertension, and dyslipidemia. The prevalence of MetS in Western society continues to rise and implies an elevated risk for surgical complications and/or poor surgical outcomes within the affected population. OBJECTIVE: To assess the risks and outcomes of multi-morbid patients with MetS undergoing open ventral hernia repair...
September 22, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29120311/alberta-s-provincial-take-home-naloxone-program-a-multi-sectoral-and-multi-jurisdictional-response-to-overdose
#14
Lisa K Freeman, Stacey Bourque, Nick Etches, Karin Goodison, Claire O'Gorman, Kay Rittenbach, Christopher A Sikora, Mark Yarema
SETTING: Alberta is a prairie province located in western Canada, with a population of approximately 4.3 million. In 2016, 363 Albertans died from apparent drug overdoses related to fentanyl, an opioid 50-100 times more toxic than morphine. This surpassed the number of deaths from motor vehicle collisions and homicides combined. INTERVENTION: Naloxone is a safe, effective, opioid antagonist that may quickly reverse an opioid overdose. In July 2015, a committee of community-based harm reduction programs in Alberta implemented a geographically restricted take-home naloxone (THN) program...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29119059/the-bacteriological-profile-of-the-burned-patients-in-the-center-of-burns-in-chu-mohamed-vi-marrakech-about-123-cases
#15
Yassine Benchamkha, Ouafaa Dhaidah, Adil Dahazze, Quaboul Meriem, Moulay Driss Elamrani, Salwa Ettalbi
The bacterial nosocomial infection is one of the leading causes of morbidity and mortality for burned patient; we conducted a retrospective study of 123 patients hospitalized in the burns center CHUMED VI of Marrakechover a period of 3 years, from January 1(st), 2013 to December 31(st), 2016. The criteria for nosocomial infection were those of the Center for Disease Control in Atlanta in 1988. Incidence rates were calculated. The bacterial ecology of the department was described as also antibiotype. The predominancy of the population was male...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29118676/host-responses-to-concurrent-combined-injuries-in-non-human-primates
#16
Matthew J Bradley, Diego A Vicente, Benjamin A Bograd, Erin M Sanders, Crystal L Leonhardt, Eric A Elster, Thomas A Davis
Background: Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a non-human primate soft tissue injury and closed abdomen hemorrhage and sepsis model developed to assess realistic injury patterns and induce MOF. Methods: Adult male Mauritan Cynomolgus Macaques underwent laparoscopy to create a cecal perforation and non-anatomic liver resection along with a full-thickness flank soft tissue injury...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/29118410/the-microbiological-characteristics-and-risk-factors-for-picc-related-bloodstream-infections-in-intensive-care-unit
#17
Shumin Zhang, Xiaofeng Sun, Yan Lei
The study was aimed to investigate the pathogens distribution and risk factors for PICC-related bloodstream infection in intensive care unit (ICU) patients. 402 patients placed with PICC in ICU were recruited in the study. The microbiological characteristics of PICC-related infection were investigated by Vitek 2 Compact automated microbial system. Antibiotics sensitivity was performed with disk diffusion and minimum inhibitory concentration (MIC) methods. Multivariate logistic and cox analyses were performed to identify the risk factors for PICC-related infection in ICU patients...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118115/computational-tools-for-clinical-support-a-multi-scale-compliant-model-for-haemodynamic-simulations-in-an-aortic-dissection-based-on-multi-modal-imaging-data
#18
Mirko Bonfanti, Stavroula Balabani, John P Greenwood, Sapna Puppala, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini
Aortic dissection (AD) is a vascular condition with high morbidity and mortality rates. Computational fluid dynamics (CFD) can provide insight into the progression of AD and aid clinical decisions; however, oversimplified modelling assumptions and high computational cost compromise the accuracy of the information and impede clinical translation. To overcome these limitations, a patient-specific CFD multi-scale approach coupled to Windkessel boundary conditions and accounting for wall compliance was developed and used to study a patient with AD...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29117876/the-role-of-gender-and-anxiety-in-the-association-between-somatic-diseases-and-depression-findings-from-three-combined-epidemiological-studies-in-primary-care
#19
E Asselmann, J Venz, L Pieper, H-U Wittchen, D Pittrow, K Beesdo-Baum
AIMS: Although associations between various somatic diseases and depression are well established, findings concerning the role of gender and anxiety disorders for these associations remain fragmented and partly inconsistent. Combining data from three large-scaled epidemiological studies in primary care, we aim to investigate interactions of somatic diseases with gender and anxiety disorders in the association with depression. METHODS: Self-reported depression according to the International Classification of Diseases, Tenth Edition (ICD-10) was assessed in n = 83 737 patients from three independent studies [DETECT (Diabetes Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment), Depression-2000 and Generalized Anxiety and Depression in Primary Care (GAD-P)] using the Depression Screening Questionnaire (DSQ)...
November 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29113880/-enhanced-system-for-maternal-mortality-surveillance-in-france-context-and-methods
#20
C Deneux-Tharaux, M Saucedo
Maternal mortality, despite its rarity in rich countries, remains a fundamental indicator of maternal health. It is considered as a "sentinel event", consequence of dysfunctions of the health care system, often cumulative. In addition to the classical epidemiological surveillance outcomes-number of deaths, maternal mortality ratio and identification of the subgroups of women at risk-its study allows an accurate analysis of each deceased woman's trajectory to identify opportunities for improvements in the content or organization of care; the correction of which will make it possible to prevent deaths but also upstream morbid events affected by the same dysfunctions...
November 4, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
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