keyword
MENU ▼
Read by QxMD icon Read
search

Lennox

keyword
https://www.readbyqxmd.com/read/29156220/the-epilepsy-phenotype-in-adult-patients-with-intellectual-disability-and-pathogenic-copy-number-variants
#1
Giuseppe d'Orsi, Tommaso Martino, Orazio Palumbo, Maria Grazia Pascarella, Pietro Palumbo, Maria Teresa Di Claudio, Carlo Avolio, Massimo Carella
PURPOSE: To characterize the electroclinical features of epilepsy associated with intellectual disability and pathogenic copy number variations (CNVs) METHODS: we prospectively investigated 61 adult patients with epilepsy and intellectual disability or other neurodevelopmental disorders. We performed high resolution SNP-Array analysis in order to detect clinical relevant chromosomal microdeletions and microduplications. An ordinal logistic regression model was fitted with 34 demographic, clinical and EEG-related variables in order to identify the epilepsy phenotype of patients with pathogenic CNVs...
November 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29154395/incidence-and-risk-factors-for-mortality-after-release-from-prison-in-australia-a-prospective-cohort-study
#2
Simon J Forsyth, Megan Carroll, Nicholas Lennox, Stuart A Kinner
AIMS: To estimate the incidence and identify risk factors for mortality in adults released from prisons in the state of Queensland, Australia. DESIGN: Prospective cohort study, linking baseline survey data with a national death register. SETTING: Selected prisons within Queensland, Australia. PARTICIPANTS: Adults (N=1320) recruited in Queensland prisons within 6 weeks of expected release, between August 2008 and July 2010, followed for up to 4...
November 20, 2017: Addiction
https://www.readbyqxmd.com/read/29150892/expanding-the-neurodevelopmental-phenotype-of-pura-syndrome
#3
Bo Hoon Lee, Margot R F Reijnders, Oluwatobi Abubakare, Emily Tuttle, Brynn Lape, Kelly Q Minks, Christopher Stodgell, Loisa Bennetto, Jennifer Kwon, Chin-To Fong, Karen W Gripp, Eric D Marsh, Wendy E Smith, Ahm M Huq, Stephanie A Coury, Wen-Hann Tan, Orestes Solis, Rupal I Mehta, Richard J Leventer, Diana Baralle, David Hunt, Alex R Paciorkowski
PURA syndrome is a recently described developmental encephalopathy presenting with neonatal hypotonia, feeding difficulties, global developmental delay, severe intellectual disability, and frequent apnea and epilepsy. We describe 18 new individuals with heterozygous sequence variations in PURA. A neuromotor disorder starting with neonatal hyptonia, but ultimately allowing delayed progression to walking, was present in nearly all individuals. Congenital apnea was present in 56% during infancy, but all cases in this cohort resolved during the first year of life...
November 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29130684/influence-of-proton-acceptors-on-the-proton-coupled-electron-transfer-reaction-kinetics-of-a-ruthenium-tyrosine-complex
#4
J Christian Lennox, Jillian L Dempsey
A polypyridyl ruthenium complex with fluorinated bipyridine ligands and a covalently bound tyrosine moiety was synthesized, and its photo-induced proton-coupled electron transfer (PCET) reactivity in acetonitrile was investigated with transient absorption spectroscopy. Using flash-quench methodology with methyl viologen as an oxidative quencher, a Ru(3+) species is generated that is capable of initiating the intramolecular PCET oxidation of the tyrosine moiety. Using a series of substituted pyridine bases, the reaction kinetics were found to vary as a function of proton acceptor concentration and identity, with no significant H/D kinetic isotope effect...
November 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29126048/lennox-gastaut-syndrome-in-adulthood-long-term-clinical-follow-up-of-38-patients-and-analysis-of-their-recorded-seizures
#5
Aglaia Vignoli, Gaia Oggioni, Giovanni De Maria, Angela Peron, Miriam Nella Savini, Elena Zambrelli, Valentina Chiesa, Francesca La Briola, Katherine Turner, Maria Paola Canevini
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with childhood onset that usually continues through adolescence and into adulthood. In the long term, patients with this condition still have intractable seizures, intellectual disability, behavioral problems, and physical comorbidities. The aim of this study was to describe the clinical and EEG characteristics of a group of adults with Lennox-Gastaut syndrome. We identified 38 (22 females, 16 males) patients with LGS older than age 18years at their last evaluation, with mean age of 43...
November 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29124439/lennox-gastaut-syndrome-a-comprehensive-review
#6
Ali A Asadi-Pooya
Lennox-Gastaut syndrome (LGS) is considered an epileptic encephalopathy and is defined by a triad of multiple drug-resistant seizure types, a specific EEG pattern showing bursts of slow spike-wave complexes or generalized paroxysmal fast activity, and intellectual disability. The prevalence of LGS is estimated between 1 and 2% of all patients with epilepsy. The etiology of LGS is often divided into two groups: identifiable (genetic-structural-metabolic) in 65 to 75% of the patients and LGS of unknown cause in others...
November 9, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29121573/rufinamide-crystal-structure-elucidation-and-solid-state-characterization
#7
Nita Salunke, Rajesh Thipparaboina, Rahul B Chavan, Anurag Lodagekar, Sudhir Mittapalli, Ashwini Nangia, Nalini R Shastri
Rufinamide (R) is a triazole derivative approved for the management of partial seizures and seizures associated with Lennox-Gastaut Syndrome, in November 2007. Crystal structure, solid state characterization, drug-excipient compatibility and solubility play a pivotal role in formulation development. This work deals with the crystal structure elucidation of R by single crystal X-ray diffraction and solid state characterization by thermal, spectroscopic and crystallographic techniques. Drug- excipient compatibility was assessed by differential scanning calorimetry (DSC)...
November 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29098688/thalamocortical-functional-connectivity-in-lennox-gastaut-syndrome-is-abnormally-enhanced-in-executive-control-and-default-mode-networks
#8
Aaron E L Warren, David F Abbott, Graeme D Jackson, John S Archer
OBJECTIVE: To identify abnormal thalamocortical circuits in the severe epilepsy of Lennox-Gastaut syndrome (LGS) that may explain the shared electroclinical phenotype and provide potential treatment targets. METHODS: Twenty patients with a diagnosis of LGS (mean age = 28.5 years) and 26 healthy controls (mean age = 27.6 years) were compared using task-free functional magnetic resonance imaging (MRI). The thalamus was parcellated according to functional connectivity with 10 cortical networks derived using group-level independent component analysis...
November 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29081329/treating-sleep-problems-in-young-people-at-ultra-high-risk-of-psychosis-a-feasibility-case-series
#9
Jonathan Bradley, Daniel Freeman, Eleanor Chadwick, Allison G Harvey, Bradley Mullins, Louise Johns, Bryony Sheaves, Belinda Lennox, Matthew Broome, Felicity Waite
BACKGROUND: Our view is that sleep disturbance may be a contributory causal factor in the development and maintenance of psychotic experiences. A recent series of randomized controlled intervention studies has shown that cognitive-behavioural approaches can improve sleep in people with psychotic experiences. However, the effects of psychological intervention for improving sleep have not been evaluated in young people at ultra-high risk of psychosis. Improving sleep might prevent later transition to a mental health disorder...
October 30, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29057354/l5-s1-anterior-lumbar-interbody-fusion-technique
#10
EDITORIAL
Ralph J Mobbs, Andrew Lennox, Yam-Ting Ho, Kevin Phan, Wen Jie Choy
No abstract text is available yet for this article.
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29057178/salmonella-infection-after-craniotomy
#11
Lennox Byer, Caleb Rutledge, Erika Wallender, Joseph A Osorio, Richard Jacobs, Philip V Theodosopoulos
Salmonella is an uncommon cause of meningitis, especially after neurosurgery. Here, we present a case of Salmonella meningitis after craniotomy, likely due to physical contact with a snake after surgery, with contiguous spread from the patient's hand to her wound. The purpose of this report is to serve as a reminder that patients undergoing neurosurgery should avoid contact with pets, including snakes and other reptiles, in the postoperative period and practice good hand hygiene.
August 15, 2017: Curēus
https://www.readbyqxmd.com/read/29053577/electrographic-changes-accompanying-recurrent-seizures-under-ketogenic-diet-treatment
#12
Chiara Lucchi, Maddalena Marchiò, Elisa Caramaschi, Carmela Giordano, Rocco Giordano, Azzurra Guerra, Giuseppe Biagini
The ketogenic diet (KD) is increasingly used to treat epilepsy refractory to antiepileptic drugs and other neurological disorders. In animal models, the KD was found to increase the threshold to seizures induced by different convulsive stimulations. However, in models in which suprathreshold stimuli were used, a paradoxical seizure worsening was consistently observed in KD-fed animals. To better define this phenomenon, we characterized the electrographic response to seizures induced in mice which were treated with the KD, and then corneally stimulated at 6-Hz in four different sessions...
October 20, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29033080/reconstitution-of-th17-tc17-and-treg-cells-after-paediatric-haematopoietic-stem-cell-transplantation-impact-of-interleukin-7
#13
Katrine Kielsen, Lars P Ryder, David Lennox-Hvenekilde, Monika Gad, Claus H Nielsen, Carsten Heilmann, Marianne Ifversen, Anders Elm Pedersen, Klaus Müller
Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disease (GVHD). IL-7 is essential for T-cell generation in the thymus and peripheral T-cell homeostasis. High IL-7 levels have been associated with impaired T-cell reconstitution, increased risk of acute GVHD and treatment-related mortality, but the underlying cellular mechanisms behind these associations have not been investigated previously...
October 9, 2017: Immunobiology
https://www.readbyqxmd.com/read/28992257/glomerular-function-in-relation-to-circulating-adhesion-molecules-and-inflammation-markers-in-a-general-population
#14
Ying-Mei Feng, Lutgarde Thijs, Zhen-Yu Zhang, Wen-Yi Yang, Qi-Fang Huang, Fang-Fei Wei, Tatiana Kuznetsova, Ann-Marie Jennings, Christian Delles, Rachael Lennox, Peter Verhamme, Anna Dominiczak, Jan A Staessen
Background: Inflammation is a hallmark of chronic kidney disease (CKD) and stimulates glomerular expression of vascular adhesion molecules (VCAMs). We investigated in a general population whether estimated glomerular filtration rate (eGFR) is associated with circulating adhesion molecules, inflammation markers or both. Methods: We measured serum levels of five adhesion molecules [VCAM-1, intracellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin and monocyte chemoattractant protein-1 (MCP-1)] and seven inflammation markers [C-reactive protein (CRP), neutrophil gelatinase-associated lipocalin (NGAL), tumour necrosis factor receptor 1 (TNF-R1), TNF-α, interleukin 6 (IL-6), IL-8 and vascular endothelial growth factor] in 1338 randomly recruited people (50...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28990447/psychotic-like-experiences-in-help-seeking-adolescents-dimensional-exploration-and-association-with-different-forms-of-bullying-victimization-a-developmental-social-psychiatry-perspective
#15
Gennaro Catone, Roberta Marotta, Simone Pisano, Belinda Lennox, Marco Carotenuto, Antonella Gritti, Antonio Pascotto, Matthew R Broome
BACKGROUND: Psychotic-like experiences (PLEs) are common in the general population and increase the risk of psychotic disorders. Adolescents are a high-risk group of this condition. Stressful events, such as bullying, have a role in the onset of PLEs. This study has several aims: (1) to assess PLEs in adolescents seeking help from a Child and Adolescent Mental Health Service, (2) to assess the association of PLEs with specific bullying victimization and (3) to assess difference in PLEs and victimizations by sex and age...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28987972/drop-out-during-a-randomized-trial-with-adolescents-with-intellectual-disability-was-associated-with-participant-burden-while-drop-out-at-study-exit-was-associated-with-carer-and-household-characteristics
#16
Robert S Ware, Lyn McPherson, Nicholas G Lennox
BACKGROUND: People with intellectual disability are difficult to retain in longitudinal studies. Research on determinants of study retention for individual-carer dyads, and their reasons for drop-out, are limited. AIMS: To investigate characteristics associated with drop-out, and to investigate whether characteristics varied by stage of drop-out. METHODS AND PROCEDURES: Data are from an Australian randomized trial with adolescents with intellectual disability living in the community...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28977483/does-becoming-a-volunteer-attenuate-loneliness-among-recently-widowed-older-adults
#17
Dawn C Carr, Ben Lennox Kail, Christina Matz-Costa, Yochai Z Shavit
Objectives: Loneliness is a significant public health concern, particularly for those who have lost a spouse through widowhood. This study examines whether becoming a volunteer at the time of widowhood is associated with reduction of these risks. Method: A pooled sample of 5,882 married adults age 51+, drawn from the 2006-2014 waves of the Health and Retirement Study, was used to estimate regression models of the relationship between becoming widowed (relative to staying continuously married) and loneliness, and whether the associated loneliness of having lost a spouse is moderated by starting to volunteer (<2 hr, 2+ hr/week)...
July 8, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28958764/making-midwifery-work-visible-the-multiple-purposes-of-documentation
#18
REVIEW
Bridget Kerkin, Susan Lennox, Jean Patterson
BACKGROUND: Midwives have a professional, ethical and legal obligation to effectively and thoroughly document the care provided to women and the decisions made within the partnership relationship. To appreciate the best approach to documenting midwifery care, it is important to first understand the purpose of midwifery documentation. AIM: The aim of this article is to explore the literature in relation to the purposes of midwifery documentation. METHOD: A literature search was performed using the CINAHL and Pubmed databases...
September 25, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28958062/the-relation-of-volunteering-and-subsequent-changes-in-physical-disability-in-older-adults
#19
Dawn C Carr, Ben Lennox Kail, John W Rowe
Objectives: To describe the association between initiating volunteering and changes in physical disability in older adults, and whether intensity and gender modify this relationship. Methods: Employing propensity score weighted regression adjustment, we calculate changes in disability using a sample of U.S. adults (n = 7,135) in the Health and Retirement Study (1996-2012) not volunteering at baseline but later initiating volunteering (1-99 hr/year or 100+ hours per year) or remaining a nonvolunteer...
July 28, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28947436/what-makes-a-sustainability-tool-valuable-practical-and-useful-in-real-world-healthcare-practice-a-mixed-methods-study-on-the-development-of-the-long-term-success-tool-in-northwest-london
#20
Laura Lennox, Cathal Doyle, Julie E Reed, Derek Bell
OBJECTIVES: Although improvement initiatives show benefits to patient care, they often fail to sustain. Models and frameworks exist to address this challenge, but issues with design, clarity and usability have been barriers to use in healthcare settings. This work aimed to collaborate with stakeholders to develop a sustainability tool relevant to people in healthcare settings and practical for use in improvement initiatives. DESIGN: Tool development was conducted in six stages...
September 24, 2017: BMJ Open
keyword
keyword
6041
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"