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https://www.readbyqxmd.com/read/27826325/enterovirus-71-infection-and-neurological-complications
#1
REVIEW
Kyung Yeon Lee
Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27818360/n-terminal-pro-b-type-natriuretic-peptide-for-the-prognostic-prediction-of-severe-enterovirus-71-associated-hand-foot-and-mouth-disease
#2
Jun Qiu, Xiulan Lu, Pingping Liu, Xinping Zhang, Chao Zuo, Zhenghui Xiao
OBJECTIVE: The aim of this study was to determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) can predict impending brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, cardiopulmonary failure, and death in children with severe enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD). METHODS: Plasma NT-proBNP levels of 282 children with severe EV71-associated HFMD were measured. RESULTS: NT-proBNP levels were significantly higher in patients with elevated blood glucose (>7...
November 3, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27801415/-comparative-evaluation-of-the-intensity-of-reparative-processes-in-the-lower-extremity-soft-tissues-of-diabetic-patients-receiving-local-negative-pressure-wound-treatment-and-standard-wound-care
#3
G R Galstyan, A Yu Tokmakova, E L Zaitseva, L P Doronina, I A Voronkova, R V Molchkov
AIM: To study the intensity of soft tissue repair in patients with diabetic foot syndrome (DFS) during local negative pressure wound treatment versus standard wound care. SUBJECTS AND METHODS: The investigators estimated the clinical (wound sizes, local tissue oxygenation), histological (light microscopy), and immunohistochemical (CD31, CD68, MMP-9, and TIMP-1) markers for reparative processes in patients with DFS during vacuum therapy versus standard wound care...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27770823/body-mass-index-and-extent-of-mri-detected-inflammation-opposite-effects-in-rheumatoid-arthritis-versus-other-arthritides-and-asymptomatic-persons
#4
Lukas Mangnus, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Tom W J Huizinga, Monique Reijnierse, Annette H M van der Helm-van Mil
BACKGROUND: In the population a high body mass index (BMI) has been associated with slightly increased inflammatory markers. Within rheumatoid arthritis (RA), however, a high BMI has been associated with less radiographic progression; this phenomenon is unexplained. We hypothesized that the phenomenon is caused by an inverse relationship between BMI and inflammation in hand and foot joints with RA. To explore this hypothesis, local inflammation was measured using magnetic resonance imaging (MRI) in early arthritis patients presenting with RA or other arthritides and in asymptomatic volunteers...
October 22, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27706779/clinical-significance-of-combined-liver-function-and-high-sensitivity-c-reactive-protein-measurement-in-children-with-hand-foot-mouth-disease
#5
F X Han, J H Gao, J H Gai
Hand-foot-mouth disease (HFMD) is a common pediatric disease responsible for the development of rashes or herpes on the hand, foot, and mouth. Severe complications of HFMD include myocarditis, pulmonary edema, aseptic meningoencephalitis, and even death. Therefore, early diagnosis of HFMD is of particular importance. In this study, we determined the clinical value of the combined detection of liver function and high-sensitivity C-reactive protein (hs-CRP) expression in children with HFMD. Three hundred children with HFMD were recruited to this study between July 2013 and July 2015 and divided into the mild and severe HFMD groups (N = 150 per group)...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27690011/aquaporin-4-a-potential-therapeutic-target-for-cerebral-edema
#6
Guanghui Tang, Guo-Yuan Yang
Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments suggests the function of aquaporin-4 in water transfer into and out of the brain parenchyma. Accumulating evidences have suggested that the dysregulation of aquaporin-4 relates to the brain edema resulting from a variety of neuro-disorders, such as ischemic or hemorrhagic stroke, trauma, etc...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27594952/intra-articular-osteoid-osteoma-of-the-calcaneus-a-case-report-and-review
#7
Tomo Hamada, Hidenori Matsubara, Hiroaki Kimura, Takao Aikawa, Yasuhisa Yoshida, Hiroyuki Tsuchiya
Osteoid osteoma of the calcaneus is rare and frequently misdiagnosed as arthritis because of similar symptoms. In addition, radiographic findings may be nonspecific, and magnetic resonance imaging (MRI) may show a bone marrow edema and changes in adjacent soft tissue. A 19-year-old man presented with a 6-month history of persistent pain and swelling in the left hind foot; diagnostic computed tomography and MRI analyses revealed lesions suggesting an intra-articular osteoid osteoma of the calcaneus. Initial MRI did not show specific findings...
September 2016: Radiology case reports
https://www.readbyqxmd.com/read/27594570/-skillful-care-for-chronic-vascular-wounds
#8
C Goullet de Rugy, I Lazareth, C You, A Stansal, P Priollet
In vascular medicine, wound care requires pluridisciplinary expertise and nursing skill. Care must be perfectly adapted to each individual patient, the specificities of each particular wound, and the underlying vascular disease. The goal is to achieve wound healing. Inappropriate care can retard healing or even aggravate the wound. The skin should be cleaned with water a non-allergic detergent and should concern the entire limb in addition to the wound itself. Fibrin or necrosis detersion is an important step that can be painful...
September 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27587374/bone-marrow-edema-syndrome-in-the-foot-and-ankle
#9
REVIEW
Seyed Alireza Mirghasemi, Elly Trepman, Mohammad Saleh Sadeghi, Narges Rahimi, Shervin Rashidinia
: Bone marrow edema syndrome (BMES) is an uncommon and self-limited syndrome characterized by extremity pain of unknown etiology. Symptoms may include sudden or gradual onset of swelling and pain at rest or during activity, usually at night. This syndrome mostly affects middle-aged men and younger women who have pain in the lower extremities. The most common sites involved with BMES, in decreasing order of frequency, are the bones about the hip, knee, ankle, and foot. The diagnosis of BMES is confirmed with magnetic resonance imaging to exclude other causes of bone marrow edema...
December 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27575610/abnormal-bone-marrow-signal-intensity-in-the-phalanges-of-the-foot-as-a-manifestation-of-raynaud-phenomenon-a-report-of-six-patients
#10
Edward Smitaman, Bruno P G Pereira, Brady K Huang, Mina M Zakhary, Evelyne Fliszar, Donald L Resnick
OBJECTIVE: The objectives of our study were to describe the MRI findings of pedal phalangeal bone marrow edema in patients with Raynaud phenomenon (RP) and discuss the clinical implications of these MRI findings. CONCLUSION: There is a progressive distal-to-proximal pattern of pedal phalangeal bone marrow edema on MRI in patients with RP. This knowledge may allow early diagnosis and treatment of rheumatologic disorders that are potentially associated with RP.
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27556777/nutrition-and-chronic-wounds-improving-clinical-outcomes
#11
Joseph A Molnar, Lucian G Vlad, Tuna Gumus
There is increasing awareness that chronic wound healing is very dependent on the patient's nutritional status, but there are no clearly established and accepted assessment protocols or interventions in clinical practice. Much of the data used as guidelines for chronic wound patients are extrapolated from acutely wounded trauma patients, but the 2 groups are very different patient populations. While most trauma patients are young, healthy, and well-nourished before injury, the chronic wound patient is usually old, with comorbidities and frequently malnourished...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27531950/cin85-deficiency-prevents-nephrin-endocytosis-and-proteinuria-in-diabetes
#12
Beina Teng, Patricia Schroder, Janina Müller-Deile, Heiko Schenk, Lynne Staggs, Irini Tossidou, Ivan Dikic, Hermann Haller, Mario Schiffer
Diabetic nephropathy (DN) is the major cause of end stage renal disease worldwide. Podocytes are important for glomerular filtration barrier function and maintenance of size selectivity in protein filtration in the kidney. Podocyte damage is the basis of many glomerular diseases characterized by loss of interdigitating foot processes and decreased expression of components of the slit diaphragm. Nephrin, a podocyte specific protein, is the main component of the slit diaphragm. Loss of nephrin is observed in human and rodent models of diabetic kidney disease...
August 16, 2016: Diabetes
https://www.readbyqxmd.com/read/27509583/from-man-to-fish-what-can-zebrafish-tell-us-about-apol1-nephropathy
#13
Opeyemi Olabisi, Khaldoun Al-Romaih, Joel Henderson, Ritu Tomar, Iain Drummond, Calum MacRae, Martin Pollak
BACKGROUND: Risk variant Apolipoprotein L1 (G1/G2) are strongly associated with a spectrum of kidney disease in people of recent African descent. The mechanism of ApoL1 nephropathy is unknown. Podocytes and/or endothelial cells are the presumed target kidney cells. Given the close homology in structure and function of zebrafish (ZF) pronephros and human nephron, we studied the effect of podocyte-specific or endothelium-specific expression of ApoL1 (G0, G1, or G2) on the structure and function of ZF pronephros...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27499235/a-new-animal-model-containing-human-scarb2-and-lacking-stat-1-is-highly-susceptible-to-ev71
#14
An-Ting Liou, Szu-Yao Wu, Chun-Che Liao, Ya-Shu Chang, Chih-Shin Chang, Chiaho Shih
Enterovirus 71 (EV71) is a major threat to children worldwide. Children infected with EV71 could develop subclinical infection and hand-foot-and -mouth disease (HFMD). In severe cases, patients could develop encephalitis, paralysis, pulmonary edema, and death. A more user-friendly and robust animal model is essential to investigating EV71 pathogenesis. Here, we established a hybrid (hSCARB2(+/+)/stat-1(-/-)) mouse strain from crossbreeding SCARB2 transgenic and stat-1 KO mice, and compared the susceptibilities to EV71 infection and pathogenesis between parental and hybrid mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27453454/magnetic-resonance-imaging-evidence-of-postoperative-cyst-formation-does-not-appear-to-affect-clinical-outcomes-after-autologous-osteochondral-transplantation-of-the-talus
#15
Ian Savage-Elliott, Niall A Smyth, Timothy W Deyer, Christopher D Murawski, Keir A Ross, Charles P Hannon, Huong T Do, John G Kennedy
PURPOSE: To identify potential cysts using magnetic resonance imaging (MRI) after autologous osteochondral transplantation (AOT) for osteochondral lesions of the talus (OLTs) as well as to determine the effect of cysts on short-term clinical outcomes. METHODS: Eighty-nine MRI scans of 37 patients who had AOT for an OLT were evaluated. Radiographic variables examined included cyst presence, cyst location, bone edema, and cartilage integrity. Patient clinical variables recorded and examined for association with the presence of a cyst included gender, age, preoperative lesion size, size and number of osteochondral graft used, symptoms reported, and pre- and postoperative Foot and Ankle Outcome Score (FAOS) and Short Form-12 (SF-12) scores measured at final follow-up...
September 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27448573/sunitinib-in-metastatic-renal-cell-carcinoma-mrcc-a-developing-country-experience-do-our-patients-behave-differently-than-the-western-patients
#16
Mohmad Hussain Mir, Khalid Hamid Changal, Shiekh Aejaz Aziz, Gull Mohammad Bhat, Abdul Rashid Lone
BACKGROUND: Metastatic renal cell carcinoma (mRCC) has historically been refractory to cytotoxic and hormonal agents. IL-2 and IFN-α provide response in a minority of patients. Small molecule tyrosine kinase inhibitors and monoclonal antibodies have established a role in the setting of mRCC. However, there is a lack of data from the Indian subcontinent. The aim of this study was to look whether our patients behave similarly as reported in the Western data to targeted agents, especially sunitinib...
November 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27446605/charcot-arthropathy-in-ultrasound-examination-a-case-report
#17
Mateusz Płaza, Anna Nowakowska-Płaza, Marta Walentowska-Janowicz, Marek Chojnowski, Iwona Sudoł-Szopińska
This article presents a patient with a long history of type 1 diabetes mellitus complicated with neuropathy and Charcot disease. The most common cause of neuropathic osteoarthropathy, called Charcot osteoarthropathy, is poorly controlled diabetes. The clinical picture is characterized by considerable edema, redness and increased skin temperature with relatively slight pain due to injury to nerve fibers responsible for pain sensation. The differential diagnosis should include bacterial or autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury...
June 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/27433040/purtscher-like-retinopathy-in-acute-alcoholic-pancreatitis
#18
Nitin Nema, Saba Ishrat, Abha Verma, Manoj Kela
A 23-year-old man with a history of alcoholism presented with vomiting, fever, and sharp epigastric pain radiating to the back and flanks. He was diagnosed as a case of acute alcoholic pancreatitis on the basis of clinical findings and investigations. On the next day of presentation, he developed sudden bilateral visual loss. His best-corrected visual acuity was finger counting at one-foot distance in both eyes. He had diffuse whitening in the circumpapillary area, haloes around the retinal vessels (Purtscher flecken) and intra-retinal hemorrhages on ophthalmoscopic examination...
May 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27427994/bilateral-central-foot-drop-in-a-pediatric-patient
#19
Semra Işık, Akın Akakın, Murat Şakir Ekşi, Baran Yılmaz, Tamer Aksoy, Murat Konakçı, Zafer Orkun Toktaş, Türker Kılıç
Foot drop is an inability to dorsiflex the ankle and toe. Primary causes of foot drop are compression or lesion of the 5th lumbar nerve and entrapment of the peroneal nerve at the head of the fibula. Rarely, some central nervous system lesions lead to foot drop. A 16-year-old boy was admitted with blunt head trauma that had happened in an assault. The muscle strength of the bilateral tibialis anterior, bilateral extensor digitorum longus and bilateral extensor digitorum brevis were Medical Research Council grade 1...
2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27417606/the-use-of-best-practice-in-the-treatment-of-a-complex-diabetic-foot-ulcer-a-case-report
#20
Melodie Blakely
BACKGROUND AND PURPOSE: Published guidelines for effective management of diabetic foot ulcers (DFU) include total contact casting (TCC). The purpose of this case study is to describe the application of best practice guidelines for the treatment of a diabetic foot ulcer (DFU) in a complex patient where TCC offloading could not be utilized. CASE DESCRIPTION: The patient was a 47 year-old female with a five-plus year history of a full-thickness DFU on the left plantar mid-foot...
March 4, 2016: Healthcare (Basel, Switzerland)
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