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https://www.readbyqxmd.com/read/29145274/diagnosis-of-fetal-megacystis-with-chromosomal-abnormality-by-2d-prenatal-ultrasound-a-case-report
#1
Fuman She, Shengwen Dong, Bibo Yuan, Xiaoli Gao
RATIONALE: The pathogenesis of fetal megacystis is divided into obstructive and nonobstructive. Megacystis combined with chromosomal abnormalities is rare and most of the cases are nonobstructive. PATIENT CONCERNS: The fetus showed posterior urethral obstructive megacystis with features of bladder enlargement, "keyhole" feature, and thick bladder wall. DIAGNOSES: Here, we present a case of fetal megacystis diagnosed by ultrasound at pregnancy week 15+2 and with multisystem abnormalities...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137027/morphobiochemical-diagnosis-of-acute-trabecular-microfractures-using-gamma-correction-tc-99m-hdp-pinhole-bone-scan-with-histopathological-verification
#2
Yong-Whee Bahk, Seok-Ha Hwang, U-Young Lee, Yong-An Chung, Joo-Young Jung, Hyeonseok S Jeong
We prospectively performed gamma correction pinhole bone scan (GCPBS) and histopathologic verification study to make simultaneous morphobiochemical diagnosis of trabecular microfractures (TMF) occurred in the femoral head as a part of femoral neck fracture.Materials consisted of surgical specimens of the femoral head in 6 consecutive patients. The specimens were imaged using Tc-99m hydroxymethylene diphosphonate (HDP) pinhole scan and processed by the gamma correction. After cleansing with 10% formalin solution, injured specimen surface was observed using a surgical microscope to record TMF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132544/histaminergic-receptors-modulate-spinal-cord-injury-induced-neuronal-nitric-oxide-synthase-upregulation-and-cord-pathology-new-roles-of-nanowired-drug-delivery-for-neuroprotection
#3
Hari S Sharma, Ranjana Patnaik, Dafin F Muresanu, José V Lafuente, Asya Ozkizilcik, Z Ryan Tian, Ala Nozari, Aruna Sharma
The possibility that histamine influences the spinal cord pathophysiology following trauma through specific receptor-mediated upregulation of neuronal nitric oxide synthase (nNOS) was examined in a rat model. A focal spinal cord injury (SCI) was inflicted by a longitudinal incision into the right dorsal horn of the T10-11 segments. The animals were allowed to survive 5h. The SCI significantly induced breakdown of the blood-spinal cord barrier to protein tracers, reduced the spinal cord blood flow at 5h, and increased the edema formation and massive upregulation of nNOS expression...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29113363/involvement-of-inducible-nitric-oxide-synthase-and-mitochondrial-dysfunction-in-the-pathogenesis-of-enterovirus-71-infection
#4
Dejian Dang, Chao Zhang, Rongguang Zhang, Weidong Wu, Shuaiyin Chen, Jingchao Ren, Peng Zhang, Guangyuan Zhou, Demin Feng, Tiantian Sun, Ying Li, Qiaoli Liu, Mengchen Li, Yuanlin Xi, Yuefei Jin, Guangcai Duan
Enterovirus71 (EV71) is recognized as the main causative agent of severe hand, foot and mouth disease (HFMD). However, the pathogenesis of EV71 infection has not been well characterized. Clinical evidence indicated that inducible nitric oxide synthase (iNOS) induction in the lung of HFMD patients contributes to the severe symptoms of pulmonary edema. In the present study, we recruited 142 subjects including HFMD patients and controls, and serum level of nitric oxide (NO) was determined. Next, cellular and animal model were used to further investigate the roles of iNOS and mitochondria damage during EV71 infection...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108321/association-study-of-inflammatory-cytokine-and-chemokine-expression-in-hand-foot-and-mouth-disease
#5
Wenzhong Shang, Suying Qian, Lijuan Fang, Yong Han, Cuiping Zheng
Objective: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand, foot and mouth disease (HFMD). Results: All cytokine/chemokine levels were higher in severe HFMD patients than in mild HFMD patients or controls (P < 0.01). RANTES, MCP-1, IL-4, IL-12 and IL-18 levels were higher in mild HFMD patients than in the controls (P < 0.05). In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (P < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29093386/the-impact-of-human-parvovirus-b19-infection-on-heart-failure-and-anemia-with-reference-to-iron-metabolism-markers-in-an-adult-woman
#6
Yuya Nakamura, Isao Ohsawa, Yoshikazu Goto, Hokuto Namba, Yusuke Dodo, Mayumi Tsuji, Yuji Kiuchi, Masahiro Inagaki, Hiromichi Gotoh
A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29083359/treatment-of-dorsal-fracture-dislocation-of-the-proximal-interphalangeal-joint-using-the-ligamentotaxor-device-clinical-and-radiographic-preliminary-results
#7
Francesco Kostoris, Gianluca Canton, Emiliano Longo, Francesco Romano, Luigi Murena
BACKGROUND AND AIM OF THE WORK: Fracture-dislocations of the proximal interphalangeal joint are complex injuries, often difficult to treat. Several treatment options have been described. Among them dynamic external fixation proved to be a safe technique leading to good results in many authors experience. The principles of this treatment are to avoid edema, prevent stiffness and tendon adhesions, promote joint remodelling and facilitate rehabilitation. The Ligamentotaxor® device is a simple and reproducible dynamic external fixation system that has been used in recent years to treat proximal interphalangeal joint fracture-dislocations, with favourable results...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29069705/-the-impact-of-multiple-intravitreal-anti-vegf-injections-on-intraocular-pressure
#8
Ioannis Lamprakis, Margarita Georgieva Todorova, Matthias Grüb, Torsten Schlote
Background To evaluate the possible effects of multiple intravitreal anti-vascular endothelial growth factor (VEGF) injections on intraocular pressure (IOP). Methods This study included 50 eyes of 50 patients who underwent multiple (≥ 10 injections) intravitreal anti-VEGF injections in one eye with age-related macular degeneration, diabetic macular edema or retinal vein occlusion. IOP was recorded after every injection on the first postoperative day. IOP > 21 mmHg was regarded as abnormal. For statistical analysis, the IOP was correlated with the number of injections...
October 25, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29066274/self-healing-juvenile-cutaneous-mucinosis-clinical-and-histopathologic-findings-of-nine-cases-the-relevance-of-long-term-follow-up
#9
Isabelle Luchsinger, Jérôme Coulombe, Franco Rongioletti, Marc Haspeslagh, Anne Dompmartin, Isabelle Melki, Rawane Dagher, Brigitte Bader-Meunier, Sylvie Fraitag, Christine Bodemer
BACKGROUND: Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder and the pathogenesis and long-term prognosis are unknown. OBJECTIVES: To elucidate the clinical and histopathologic characteristics, pathogenesis and outcome in patients with SHJCM. METHODS: Retrospective study of 9 patients with SHCJM. To complement initial findings, data collection forms were sent to the referring physicians. RESULTS: All patients had an acute onset of firm nodules...
October 21, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29060876/non-rigid-registration-of-fluorescein-angiography-and-optical-coherence-tomography-via-scanning-laser-ophthalmoscope-imaging
#10
Zeinab Ghasemi Kamasi, Marzieh Mokhtari, Hossein Rabbani
Fluorescein Angiography (FA) imaging is the gold standard technique for neurovascular imaging regarding assessing neurovascular diseases such as Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME). On the other hand, as FA imaging is invasive and does not provide any depth information, Optical Coherence Tomography (OCT) imaging technique is a good complementary for it in diagnosis process. To correlate the information of both FA and OCT images, an image alignment/registration process is needed. In absence of an automatic registration software, the clinician should do intuitive comparison to integrate these data which is a subjective and time consuming process...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056373/jte-852-a-novel-spleen-tyrosine-kinase-inhibitor-blocks-immunoglobulin-g-mediated-cellular-responses-and-autoimmune-reactions-in-vivo
#11
Toshinobu Kato, Takeshi Ohta, Hidenori Iwasaki, Hatsue Kobayashi, Akira Matsuo, Takahiro Hata, Mutsuyoshi Matsushita
AIMS: Immune and inflammatory responses mediated by immunoglobulin (Ig) G are largely responsible for the pathogenesis of autoimmune diseases. Spleen tyrosine kinase (Syk) plays a pivotal role in the IgG-mediated responses; therefore, Syk has emerged as a new therapeutic target for the treatment of autoimmune diseases. In this study, we investigated the inhibitory actions of JTE-852, a novel Syk inhibitor, on IgG-mediated cellular responses and autoimmune reactions in vivo. MAIN METHODS: We examined mediator secretion from human monocytes...
October 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/29049234/case-report-features-of-hand-foot-and-mouth-disease-in-neonates
#12
Wen-Wen Chen, Zhao-Bin Yang, Lian-Shu Lian, Li-Ping Xu
RATIONALE: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions. PATIENT CONCERNS: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Blood, oropharyngeal fluid, urine, and cerebrospinal fluid (CSF) samples were collected and detected for further diagnoses with the consent of the infants' parents. Some of them suffered aseptic meningitis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047014/a-callosal-catastrophe-toxic-leukoencephalopathy-associated-with-thermogenic-weight-loss-supplement-use
#13
Zakraus K Mahdavi, Ram Narayan, Shraddha Mainali, Benjamin M Greenberg, Venkatesh Aiyagari, David L McDonagh
BACKGROUND: The use of weight loss drugs and dietary supplements is common, but safety profiles for these drugs are largely unknown. Reports of toxicity have been published, and the use of these agents should be considered in clinical differential diagnoses. METHODS: We report the case of a patient with toxic leukoencephalopathy and hyponatremia associated with oral consumption of a thermogenic dietary supplement and essential oils. RESULTS: A 30-year-old woman presented after 2 days of headache, blurred vision, photophobia, vomiting, and hand spasms...
October 18, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29037114/home-based-hand-rehabilitation-with-a-robotic-glove-in-hemiplegic-patients-after-stroke-a-pilot-feasibility-study
#14
Palmira Bernocchi, Chiara Mulè, Fabio Vanoglio, Giovanni Taveggia, Alberto Luisa, Simonetta Scalvini
OBJECTIVE: To evaluate the feasibility and safety of home rehabilitation of the hand using a robotic glove, and, in addition, its effectiveness, in hemiplegic patients after stroke. METHODS: In this non-randomized pilot study, 21 hemiplegic stroke patients (Ashworth spasticity index ≤ 3) were prescribed, after in-hospital rehabilitation, a 2-month home-program of intensive hand training using the Gloreha Lite glove that provides computer-controlled passive mobilization of the fingers...
October 16, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29022962/retinal-necrosis-as-the-initial-presentation-of-primary-intraocular-lymphoma
#15
Parthopratim Dutta Majumder, Nirupama Raghothaman, Ranju Kharel, Nitin Kumar, Vikas Khetan
A 72 years old female presented with bilateral painless progressive loss of vision over one year. She was diagnosed as non-resolving bilateral panuveitis. Her visual acuity in right eye was hand movement close to face and left eye was perception of light with inaccurate projection of rays. Bilateral anterior chamber had 1+ cells and flares. Vitreous cells had 1+ cells and haze in right eye but the left eye had 3+ vitreous cells and haze. Right eye fundus had multiple, discrete sub retinal yellowish deposits with subretinal haemorrhage and macular edema with perivascular infiltrates...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29021443/phalangeal-microgeodic-syndrome-in-a-patient-with-systemic-lupus-erythematosus
#16
Shota Kurushima, Yoshiro Horai, Ayuko Takatani, Ayako Nishino, Shin-Ya Kawashiri, Kunihiro Ichinose, Hideki Nakamura, Atsushi Kawakami
We herein report a woman in her 50s with systemic lupus erythematosus (SLE) who developed swelling and pain in her fingers; the symptoms were more prominent in winter. Magnetic resonance imaging (MRI) revealed bone edema in the phalanges of both hands, which was compatible with phalangeal microgeodic syndrome (PMS). This is the first reported case of PMS in a patient with SLE and suggests that performing MRI should be considered for patients with SLE in order to assess the nature of finger symptoms and signs more precisely...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28970089/risk-factors-for-neurogenic-pulmonary-edema-in-patients-with-severe-hand-foot-and-mouth-disease-a-meta-analysis
#17
Lijun Peng, Ruping Luo, Zhisheng Jiang
OBJECTIVE: To investigate the risk factors for neurogenic pulmonary edema (NPE) in patients with severe hand, foot, and mouth disease (HFMD) and to provide evidence for the prevention and treatment of NPE. METHODS: Several databases were searched (from inception to 2017) to identify case-control studies on risk factors for NPE among patients with severe HFMD. Data were analyzed via meta-analysis. The combined odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed-effects and random-effects models, and a sensitivity analysis and evaluation of publication bias was also performed...
September 29, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28950851/the-ameliorative-effect-of-bloodletting-puncture-at-hand-twelve-jing-well-points-on-cerebral-edema-induced-by-permanent-middle-cerebral-ischemia-via-protecting-the-tight-junctions-of-the-blood-brain-barrier
#18
RANDOMIZED CONTROLLED TRIAL
Nannan Yu, Zhenguo Wang, Yucen Chen, Juntao Yang, Xuan Lu, Yi Guo, Zelin Chen, Zhifang Xu
BACKGROUND: Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demonstrated the fact that bloodletting puncture at hand twelve Jing-well points (HTWP) could alleviate cerebral edema, which mainly results from the disruption of blood-brain barrier (BBB). The study, therefore, was first designed to demonstrate whether BBB-protection serves an important role in the edema-relief effect of HTWP bloodletting, based on which to research the molecular mechanism underlying...
September 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28947243/hand-lesion-after-arthroscopic-rotator-cuff-repair-association-with-complex-regional-pain-syndrome
#19
Ryo Tanesue, Masafumi Gotoh, Yasuhiro Mitsui, Hidehiro Nakamura, Hirokazu Honda, Hiroki Ohzono, Hisao Shimokobe, Tsuyoshi Tokunaga, Takaki Imai, Takahiro Okawa, Naoto Shiba
BACKGROUND: It is known that complex regional pain syndrome (CRPS) occurs after arthroscopic rotator cuff repair (ARCR); however, few studies have investigated this complication. Therefore, the purpose of the present study was to evaluate CRPS after ARCR. METHODS: A total of 182 patients who underwent ARCR were enrolled in this study. The average age of patients was 62.8 ± 10.0 years, with an average follow-up period of 21.5 ± 38.1 months. CRPS criteria outlined by the Ministry of Health, Labor, and Welfare study team for CRPS in Japan (MHLWJ) and International Association for the Study of Pain (IASP 2005) were utilized for diagnosis...
September 22, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#20
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
December 1, 2017: Journal of Virology
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