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Ashraf Hassan Abadi, Marwa Saeed Hany, Shimaa Awadain Elsharif, Amal Abdel Haleem Eissa, Bernard Dewayne Gary, Heather Nicole Tinsley, Gary Anthony Piazza
Analogues with the scaffolds of 3-cyano-4-alkoxyphenyl-6-bromoaryl-2-pyridone and 2-amino-3-cyano-4-alkoxyphenyl-6-bromoarylpyridine were synthesized. Cyclization of the 2-amino derivatives with formic acid and formamide gave the corresponding pyrido[2,3-d]pyrimidin-4(3H)-one and the pyrido[2,3-d]-pyrimidin-4-amine derivatives, respectively. Active phosphodiesterase 3 (PDE3) inhibitors were identified from each of the four aforementioned scaffolds. This is the first report that pyrido[2,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4-amine derivatives can inhibit PDE3...
2013: Chemical & Pharmaceutical Bulletin
No abstract text is available yet for this article.
November 24, 1963: Minerva Pediatrica
No abstract text is available yet for this article.
1963: Marseille Médical
No abstract text is available yet for this article.
August 1962: Der Anaesthesist
N Kanzato, I Nakasone, O Sunagawa, Y Komine, K Fukiyama
A 69-year-old Japanese woman initially noticed difficulty in squatting in the last two years, followed by nasal voice, fatiguability in mastication, and blepharoptosis. On admission to our hospital, in addition to these neurological findings, we detected ectopic arrhythmia and Levine II systolic murmur at the apex region, without any subjective symptoms. The serum titer of anti-acetylcholine receptor antibody was elevated to 28 nmol/l (normal: < 0.2), and she responded to repetitive nerve stimulation at a frequency of 3 Hz showing 13% waning, she had positive test for edrophonium administration, and was diagnosed as having myasthenia gravis (MG)...
November 2001: Rinshō Shinkeigaku, Clinical Neurology
Y C Zhuang
Acute myocardial ischemia and reperfusion in 49 young pigs were produced by balloon occlusion of the left anterior descending coronary artery. Alternations of ST segment and T wave (STTA) were detected in 33 pigs during ischemia. They started at 30 seconds to 14 minutes (mean 5.4 +/- 4.1 minutes) after occlusion and maintained for 4.0 +/- 3.4 minutes. The start and end of STTA might be gradual or abrupt. Abrupt STTA provoked by ventricular premature beat (VPB), and might be reset by VPB and short run of non-sustained repetitive ventricular firing...
March 1993: Zhonghua Yi Xue za Zhi [Chinese medical journal]
R B Kleiman, D J Callans, B G Hook, F E Marchlinski
Previous generations of implantable cardioverter defibrillators (ICDs) required invasive electrophysiological testing to assess defibrillator function. Newer third-generation ICDs include the capability for performing noninvasive programmed stimulation (NIPS) and may reduce the need for invasive studies to assess tachycardia recognition and antitachycardia therapy algorithms. The effectiveness of ICD-based NIPS for the induction of ventricular arrhythmias has not, however, been formally assessed. Third-generation ICDs were implanted in 79 patients, who underwent a total of 166 postoperative defibrillator tests...
September 1994: Pacing and Clinical Electrophysiology: PACE
C Damase-Michel, J L Montastruc, P Montastruc
Several pharmacological and clinical studies have suggested that calcium channel antagonists (CCA) can exert central actions. The aim of the present study was to investigate their putative central cardiovascular properties in dogs. In normotensive pentobarbital-anesthetized dogs, intravenous (I.V.) nicardipine, -nifedipine -verapamil or diltiazem-induced a dose-dependent decrease in systolic and diastolic blood pressures followed by tachcardia due to baroreflex activation. By contrast, central (intracisternal: I...
1989: Fundamental & Clinical Pharmacology
M Shenasa, S Willems, X Chen, M Fromer, M Borggrefe
Transcatheter ablation techniques are emerging as an alternative therapeutical tool in the management of cardiac arrhythmias. Catheter ablation was initially introduced as the last resort to ablate the atrioventricular nodal conduction in patients with atrial fibrillation and uncontrolled ventricular response and in patients with drug refractory ventricular tachycardias. Direct current energy was used as the sole source of energy, but because of potential significant complications and early and late mortality, presumably mostly due to ventricular tachyarrhythmias, other sources of energy were sought...
June 1992: Herz
R D Gupta, P F Binnion
Thirty intact dogs were studied to determine digoxin concentration in various tissues after ventricular tachycardia had been induced by digoxin infusion. A control group was infused solely with digoxin. A second group was made acutely hypokalemic by glucose-insulin infusion before the digoxin infusion. A third group was infused with glucose and digoxin to determine the effect of increased blood glucose levels and osmalarity on the induction of ventricular tachycardia. Results were: (1) The amount of digoxin infused to produce ventricular tachycardia did not differ getween the normal and hypokalemic groups...
1976: Physiological Chemistry and Physics
A Castellanos, R J Sung, B Befeler, A Mayorga-Cortes, C Conde, S M Mallon, R J Myerburg
His bundle recordings were performed in 2 patients in whom AV nodal bypass tracts coexisted with intermittent AV conduction disturbances occurring below the site from which the His bundle deflection was recorded. Case 1 had: (a) tachycardia dependent right bundle-branch block, (b) persistent HV prolongation, and (c) bradycardia dependent AV block. Case 2 showed: (a) intra-atrial conduction delay, (b) tachcardia dependent left bundle-branch block with HV prolongation, (c) bradycardia dependent HV conduction disturbance, (d) tachycardia-bradycardia syndrome of an unusual type; the latter presumably resulted, during atrial flutter, from the alternation of rapid AH conduction through the bypass tract with intermittent (complete) distal His bundle block or bilateral bundle-branch block...
January 1977: British Heart Journal
R J Sung, A Castellanos
This report described initiation of A-V nodal reentrant tachyycardia in a patient with acute inferior myocardial infarction. The onset of tachycardia was preceded by an abortive A-V nodal Wenckebach periodicity. A-V nodal ischemia with or without vagotonia was implicated as the cause of induction of critical functional dissociation between the two A-V nodal conduction pathways. Since the tachycardia manifested its rate between 95-110 beats/min during the evolutionary phase of acute inferior myocardial infarction, it simulated, electrocardiographically, an accelerated A-V junctional rhythm...
November 1978: Chest
M Knippel, G Gibelli, G Bana, F De Alberti, C Ranzi
Three patterns of swallowing-induced supraventricular tachycardia in an asymptomatic young man are described. The patient had no esophageal disease. The electrophysiologic mechanism of arrhythmias remains speculative. Vagal stimulation produced by swallowing appears to cause tachcardias because atropine (1,5 mg iv) prevents their occurrrence.
1978: Giornale Italiano di Cardiologia
H S Karagueuzian, J J Fenoglio, M B Weiss, A L Wit
The effects of premature ventricular stimuli were studied in two groups of dogs with infarcts, one group subjected to permanent occlusion of the left anterior descending coronary artery and the other to temporary occlusion for 2 hours. In dogs with permanent occlusion, spontaneous ventricular arrhythmias occurred after 3-6 hours. In 13 dogs with temporary occlusion, ventricular arrhythmias occurred immediately after reperfusion and then persisted. In five dogs with temporary occlusion, ventricular arrhythmias did not occur spontaneously until 13-15 hours after occlusion...
June 1979: Circulation Research
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