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JOURNAL ARTICLE
Sungwoo Kang, Seun Jeon, Young-Gun Lee, Byoung Seok Ye
BACKGROUND: Association of medial temporal lobe (MTL) metabolism with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) has not been evaluated considering their mixed disease (MD). METHODS: 131 patients with AD, 133 with DLB, 122 with MD, and 28 normal controls (NCs) underwent neuropsychological tests, assessments for parkinsonism, cognitive fluctuation (CF), and visual hallucinations (VH), and 18 F-fluorodeoxyglucose PET to quantify MTL metabolism in the amygdala, hippocampus, and entorhinal cortex...
April 23, 2024: Alzheimer's Research & Therapy
#22
JOURNAL ARTICLE
K Baudin, A Sundström, H Lindner
BACKGROUND: Digital assistive technology (DAT) may support time management in people with dementia or mild cognitive impairment (MCI), but research on DAT for time management is limited. We aimed to explore how everyday could be supported by DAT for time management in persons with dementia or MCI from informal carers' perspectives. This study focused on a DAT device for time management called MEMOplanner (MMP). METHOD: Using a mixed-methods design, we utilized the Time-Proxy© questionnaire and a study-specific interview guide to investigate the perspectives of informal carers (n = 8) regarding the use of MMP by individuals with dementia or MCI...
April 23, 2024: BMC Geriatrics
#23
JOURNAL ARTICLE
Naomi Thompson, Ming-Hung Hsu, Helen Odell-Miller, Benjamin R Underwood, Emma Wolverson
BACKGROUND: The National Institute for Health and Care Excellence guidelines state that psychosocial interventions should be the first line of treatment for people with dementia who are experiencing distress behaviours, such as agitation and depression. However, little is known about the characteristics and outcomes of psychosocial interventions or the facilitators and barriers to implementation on inpatient mental health dementia wards which provide care for people with dementia who are often experiencing high levels of distress...
April 23, 2024: BMC Geriatrics
#24
JOURNAL ARTICLE
Chenxin Tian, Jennifer A Schrack, Yuri Agrawal, Yang An, Yurun Cai, Hang Wang, Alden L Gross, Qu Tian, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnick, Amal A Wanigatunga
Sensory impairment and brain atrophy is common among older adults, increasing the risk of dementia. Yet, the degree to which multiple co-occurring sensory impairments (MSI across vision, proprioception, vestibular function, olfactory, and hearing) are associated with brain morphometry remain unexplored. Data were from 208 cognitively unimpaired participants (mean age 72 ± 10 years; 59% women) enrolled in the Baltimore Longitudinal Study of Aging. Multiple linear regression models were used to estimate cross-sectional associations between MSI and regional brain imaging volumes...
April 23, 2024: Scientific Reports
#25
REVIEW
Madia Lozupone, Vittorio Dibello, Antonio Daniele, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panza
INTRODUCTION: Tauopathies are a spectrum of clinicopathological neurodegenerative disorders with increased aggregates included in glia and/or neurons of hyperphosphorylated insoluble tau protein, a microtubule-associated protein. Progressive supranuclear palsy (PSP) is an atypical dopaminergic-resistant parkinsonian syndrome, considered as a primary tauopathy with possible alteration of tau isoform ratio, and tau accumulations characterized by 4 R tau species as the main neuropathological lesions...
April 23, 2024: Expert Opinion on Pharmacotherapy
#26
JOURNAL ARTICLE
Insa Seeger, Andrea Diana Klausen, Ulf Günther, Jonas Bienzeisler, Helge Schnack, Johanna Sophie Lubasch
BACKGROUND: In order to evaluate whether the new rescue means "community emergency paramedics" (Gemeindenotfallsanitäter [G-NFS]) relieves the emergency medical service (EMS) in the care of low-priority emergencies, the perspective of general practitioners and patients was also surveyed in a written questionnaire as part of an innovation fund project. Recruitment for participation in the study proved to be difficult. The aim of this study is to evaluate why the G-NFS decided against providing information on study participation and what measures would be necessary to include more emergency patients in surveys in the future...
April 22, 2024: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
#27
JOURNAL ARTICLE
Tiantian Huang, Xiao-Kang Gong, Zheng Liang, Rong Yang, Liangwei Wu, Chaoqing Yang, Mengjuan Wu, Xiao-Chuan Wang, Xi-Ji Shu, Jian Bao
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive decline. Here, we investigated whether exercise-enriched blood plasm could yield a beneficial therapeutic effect on AD pathologies and cognitive decline in transgenic AD (P301S) mice. In this investigation, a cohort of 2-month-old C57BL/6 mice were granted continuous access to either a running wheel or a fixed wheel for 6 weeks. After that, their plasmas were extracted and subsequently injected intravenously into 4...
April 21, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#28
JOURNAL ARTICLE
Deng Wu, Jacquelyne Ka-Li Sun, Kim Hei-Man Chow
Increasing evidence indicates that terminally differentiated neurons in the brain may recommit to a cell cycle-like process during neuronal aging and under disease conditions. Because of the rare existence and random localization of these cells in the brain, their molecular profiles and disease-specific heterogeneities remain unclear. Through a bioinformatics approach that allows integrated analyses of multiple single-nucleus transcriptome datasets from human brain samples, these rare cell populations were identified and selected for further characterization...
April 2024: PLoS Biology
#29
JOURNAL ARTICLE
Siyang Liu, Heng Wan, Sheng Nie, Huanyi Cao, Lan Liu, Hua Liang, Hong Xu, Bicheng Liu, Chunbo Chen, Huafeng Liu, Qiongqiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Qijun Wan, Yan Zha, Ying Hu, Gang Xu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Aixin Guo, Jianping Weng, Hongjiang Wu, Fan Fan Hou, Jie Shen
BACKGROUND: Hypoglycemic pharmacotherapy interventions for alleviating the risk of dementia remains controversial, particularly about dipeptidyl peptidase 4 (DPP4) inhibitors versus metformin. Our objective was to investigate whether the initiation of DPP4 inhibitors, as opposed to metformin, was linked to a reduced risk of dementia. METHODS: We included individuals with type 2 diabetes over 40 years old who were new users of DPP4 inhibitors or metformin in the Chinese Renal Disease Data System (CRDS) database between 2009 and 2020...
April 23, 2024: Journal of Clinical Endocrinology and Metabolism
#30
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#31
JOURNAL ARTICLE
Constance Delaby, Sylvain Lehmann
The growing number of people suffering from Alzheimer's disease (AD) represents a major public health problem. The diagnosis of AD is multidisciplinary and involves the use of amyloid and tau biomarkers measured in cerebrospinal fluid. Recent advances in analytical techniques now allow us to measure these biomarkers in blood. Blood biomarkers offer particularly promising potential for early, minimally invasive detection of AD, as well as for differential diagnosis of dementia and patient follow-up. The aim of this review is to provide an overview of current and candidate blood biomarkers for AD, their informative value, and their potential to be integrated into clinical practice in the near future...
April 2024: Médecine Sciences: M/S
#32
JOURNAL ARTICLE
Liza L Behrens, Hannah L Anderson, Kaléi H Kowalchik, Jacqueline Mogle, Joanne Roman Jones, Kimberly Van Haitsma, Nancy Hodgson, Marie Boltz
BACKGROUND: Persons living with Alzheimer's disease and related dementia (ADRD) in nursing homes (NH) are often excluded from conversations about their health/safety. These omissions impinge on personhood and the rights to have care preferences heard and honored. While persons with ADRD maintain the ability to communicate their preferences long after their decision-making abilities are affected, little is known about how persons with ADRD understand the risks associated with their preferences...
April 23, 2024: Alzheimer Disease and Associated Disorders
#33
JOURNAL ARTICLE
Melmar Folloso, Steven Villaraza, Yi-Wen Lo, Pek-Lan Khong, Tomotaka Tanaka, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen
BACKGROUND: There are major challenges in determining the aetiology of vascular cognitive impairment (VCI) clinically, especially in the presence of mixed pathologies, such as vascular and amyloid. Most recently, two criteria (American Heart Association/American Stroke Association [AHA/ASA] and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-V]) have been proposed for the clinical diagnosis of VCI but have not as yet been validated using neuroimaging. AIMS: This study aims to determine whether the AHA/ASA and DSM-V criteria for VCI can distinguish between cases with predominantly vascular pathology and cases with mixed pathology...
April 23, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#34
JOURNAL ARTICLE
Peter T Serina, Megan Bounds, Hari Dandapani, T Chris Carnes, Sunny A Linnebur, Jonathan Gomez Picazo, Sarah E Keene, Elizabeth M Goldberg
No abstract text is available yet for this article.
April 23, 2024: Journal of the American Geriatrics Society
#35
REVIEW
Lina Feng, Jialun Guan, Ruonan Dong, Kai Zhao, Mingyu Zhang, Suhong Xia, Yu Zhang, Liping Chen, Fang Xiao, Jiazhi Liao
OBJECTIVE: This meta-analysis aimed to comprehensively explore the risk factors for inadequate bowel preparation (IBP). METHODS: We searched the Embase, PubMed, Web of Science, and The Cochrane Library databases up to August 24, 2023, to identify observational studies and randomized controlled trials (RCTs) that examined risk factors for IBP. A random effects model was used to pool the adjusted odds ratios and 95% confidence intervals. RESULTS: A total of 125 studies (91 observational studies, 34 RCTs) were included...
April 23, 2024: Journal of Evidence-based Medicine
#36
REVIEW
Francisco José Rodríguez-Alcázar, Raúl Juárez-Vela, Juan Luis Sánchez-González, Javier Martín-Vallejo
Introduction : Chronic non-communicable diseases, including diseases of mental origin such as Alzheimer's, affect all age groups and countries. These diseases have a major impact on the patient and their family environment. It is interesting that different questionnaires are measured in the same direction, given that different health questionnaires are used to measure caregiver burden. Objectives : To identify which type of intervention is the most appropriate to improve the health of the primary caregiver in patients with dementia...
April 15, 2024: Nursing Reports
#37
JOURNAL ARTICLE
Keith L Sanders, Astrid M Manuel, Andi Liu, Boyan Leng, Xiangning Chen, Zhongming Zhao
Alzheimer's Disease (AD) is a complex disease and the leading cause of dementia in older people. We aimed to uncover aspects of AD's pathogenesis that may contribute to drug repurposing efforts by integrating DNA methylation and genetic data. Implementing the network-based tool, a dense module search of genome-wide association studies (dmGWAS), we integrated a large-scale GWAS dataset with DNA methylation data to identify gene network modules associated with AD. Our analysis yielded 286 significant gene network modules...
April 1, 2024: Epigenomes
#38
JOURNAL ARTICLE
Sarah D Holmes, Barbara Resnick, Elizabeth Galik, Sorah Levy, Susan Scherr, Erin O'Brien
OBJECTIVES: The purpose of this study was to examine factors associated with engagement in meaningful activity among residents with dementia in assisted living. We hypothesized that greater functional independence, less pain, and lower behavioral and psychological symptom severity would be associated with higher engagement in meaningful activity after controlling for residents' age, gender, comorbidities, and cognition. Understanding factors associated with engagement in meaningful activity can help to inform strategies for optimizing engagement among residents with dementia in assisted living...
April 23, 2024: Aging & Mental Health
#39
JOURNAL ARTICLE
Hui Hong, Yutong Chen, Weiran Liu, Xiao Luo, Minming Zhang
INTRODUCTION: The distribution of voxel- and connection-based white matter hyperintensity (WMH) patterns in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), as well as factors associated with these patterns, remain unclear. METHOD: We analyzed the WMH distribution patterns in EOAD and LOAD at the voxel and connection levels, each compared with their age-matched cognitively unimpaired participants. Linear regression assessed the independent effects of amyloid and vascular risk factors on WMH distribution patterns in both groups...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#40
JOURNAL ARTICLE
Louise N Pivac, Belinda M Brown, Kelsey R Sewell, James D Doecke, Victor L Villemagne, Vincent Doré, Michael Weinborn, Hamid R Sohrabi, Samantha L Gardener, Romola S Bucks, Simon M Laws, Kevin Taddei, Paul Maruff, Colin L Masters, Christopher Rowe, Ralph N Martins, Stephanie R Rainey-Smith
INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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