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https://www.readbyqxmd.com/read/29471393/the-severe-impairment-profile-a-conceptual-shift
#1
Jordan S Robinson, Robert L Collins, Brian I Miller, Vitor H Pacheco, Nicholas M Wisdom
Objective: The current study sought to evaluate and replicate the severe impairment profile (SIP) of the Word Memory Test (WMT) in patients referred for dementia evaluations. Method: The sample consisted of 125 patients referred for a neuropsychological evaluation at a large Veterans Affairs Medical Center. Patients were assigned a Clinical Dementia Rating (CDR) by blind raters, and were classified according to their performance on performance validity testing. Subsequent chart reviews were conducted to help in more accurately determining the presence of severe memory impairment likely due to an underlying dementing process versus poor effort/task engagement...
March 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29471360/adverse-consequences-of-unmet-needs-for-care-in-high-need-high-cost-older-adults
#2
Scott R Beach, Richard Schulz, Esther M Friedman, Juleen Rodakowski, Grant Martsolf, Alton Everette James
Objectives: We explore adverse consequences of unmet needs for care among high-need/high-cost (HNHC) older adults. Method: Interviews with 4,024 community-dwelling older adults with ADL/IADL/mobility disabilities from the 2011 National Health and Aging Trends Study (NHATS). Reports of socio-demographics, disability compensatory strategies, and adverse consequences of unmet needs in the past month were obtained from older adults with multiple chronic conditions (MCC), probable dementia (DEM), and/or near end-of-life (EOL) and compared older adults not meeting these criteria...
February 17, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471080/subjective-age-and-risk-of-incident-dementia-evidence-from-the-national-health-and-aging-trends-survey
#3
Yannick Stephan, Angelina R Sutin, Martina Luchetti, Antonio Terracciano
The present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 2011 and cognitive status was again assessed in 2012, 2013, 2014 and 2015. Incident dementia was determined based on answers from self and proxy respondents. The analyses included 4262 participants without dementia at baseline...
February 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29471022/temporal-lobe-epilepsy-induced-neurodegeneration-and-cognitive-deficits-implications-for-aging
#4
REVIEW
Vrinda M, Arun S, Srikumar B N, Bindu M Kutty, Shankaranarayana Rao B S
Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit reorganization, and other structural and functional abnormalities. These elements ultimately lead to behavioural alterations such as anxiety, depression, and importantly cognitive impairment like learning disability and memory impairment. These factors can attribute to acceleration of aging and cognitive impairment in middle-aged people, which is otherwise evident in dementia and Alzheimer's disease among elderly people...
February 19, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29470861/mini-cog-for-the-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-within-a-primary-care-setting
#5
REVIEW
Dallas P Seitz, Calvin Ch Chan, Hailey T Newton, Sudeep S Gill, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Bruce A Fage
BACKGROUND: Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations. The majority of individuals with dementia will first present for care and assessment in primary care settings. There is a need for brief dementia screening instruments that can accurately diagnose dementia in primary care settings. The Mini-Cog is a brief, cognitive screening test that is frequently used to evaluate cognition in older adults in various settings...
February 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29470586/implications-of-the-care-act-for-latino-caregivers
#6
Billy A Caceres, Adriana Perez
The Caregiver Advise, Record, Enable (CARE) Act has the potential to make a positive impact in the lives of Latino older adults and their caregivers. As Latino individuals are the fastest growing older adult population, the number of Latino families and caregivers is also expected to grow, particularly among those providing care for someone with Alzheimer's disease or other dementias. Caregiving has been considered a culturally embedded value among Latino individuals. Although few studies have focused on caregiving in this population, those that exist suggest that Latino caregivers struggle to find bilingual and bicultural support and information and show higher levels of distress and health disparities...
March 1, 2018: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/29470096/the-psychometric-properties-sensitivity-and-specificity-of-the-geriatric-anxiety-inventory-hospital-anxiety-and-depression-scale-and-rating-anxiety-in-dementia-scale-in-aged-care-residents
#7
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVES: Limited research has been conducted into the identification of a valid and reliable screening measure for anxiety in aged care settings, despite it being one of the most common psychological conditions. This study aimed to determine an appropriate anxiety screening tool for aged care by comparing the reliability and validity of three commonly used measures and identifying specific cut-offs for the identification of generalized anxiety disorder (GAD). METHOD: One-hundred and eighty nursing home residents (M age = 85...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29469680/cognitive-impairment-and-social-security-s-representative-payee-program
#8
Anek Belbase, Geoffrey T Sanzenbacher, Sara Ellen King
Social Security's Representative Payee Program faces a difficult balance with respect to dementia: many dementia sufferers can conduct their finances without a payee if they have help from informal caregivers, but those without help are at risk. To date, it has been unclear what share of retirees with dementia use a payee, what share have help potentially available from another source, and what share have no observed means of assistance. This study finds that while fewer than 10% of retirees with dementia use a payee, only about 8% have no observed means of help...
February 22, 2018: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/29469590/association-of-physical-functioning-of-persons-with-dementia-with-caregiver-burden-and-depression-in-dementia-caregivers-an-integrative-data-analysis
#9
Nicole M Armstrong, Laura N Gitlin, Jeanine M Parisi, David L Roth, Alden L Gross
OBJECTIVES: To determine whether caregiver relationship and race modify associations between physical functioning of persons with dementia (PWD) and their caregiver's burden and general depressive symptoms. METHOD: We pooled data from four behavioral intervention trials (N = 1,211). Using latent growth modeling, we evaluated associations of PWD physical functioning with the level and rate of change in caregiver burden and caregivers' general depressive symptoms and stratified these associations by caregiver relationship and race...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29468984/vad-an-integrated-framework-for-cognitive-rehabilitation
#10
Dafin F Muresanu, Dana Slavoaca, Antox Alvarez, Volker Homberg, Ovidiu Bajenaru, Alla Guekht, Wolf-Dieter Heiss, Livia Popa, Johannes Vester, Ioana Muresanu, Codruta Birle, Maria Balea
Vascular dementia is the second most common cause of dementia, with clinical features that depend on neural substrates affected by the vascular lesions. Like most neurological disorders, it involves alterations that range from the molecular level to neuronal networks. Such alterations begin as compensatory mechanisms that reshape every subsystem involved in the brain's homeostasis. Although there have been recent huge advances in understanding the pathophysiology of cognitive dysfunction, a suitable therapeutic approach to vascular dementia remains elusive...
February 19, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29468898/paratonia-in-flemish-nursing-homes-current-state-of-practice
#11
Bieke Van Deun, Nele Van den Noortgate, Saucedo Cinthia, Anke Van Bladel, Cambier Dirk
BACKGROUND: Paratonia is a major underlying motor problem impeding functionality and locomotion in dementia. Despite its undeniable impact on patient's quality of life and daily care, there is a lack of evidence-based therapy on patients with this condition. METHODS: We surveyed physiotherapists working in nursing homes in Flanders (Belgium) concerning the use and perceived effect of therapeutic strategies and positioning methods/aids. RESULTS: Positioning and soft passive mobilization were the most applied and positively appraised therapeutic interventions...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29468887/managing-behavioral-and-psychological-symptoms-in-chinese-elderly-with-dementia-via-group-based-music-intervention-a-cluster-randomized-controlled-trial
#12
Rainbow Th Ho, Ted Ct Fong, C Y Sing, Pandora Ht Lee, Alice Bk Leung, Kitty Sm Chung, Janet Kl Kwok
The present study aimed to evaluate the effects of a group music intervention in managing behavioral and psychological symptoms in Chinese elderly with dementia. This cluster randomized trial recruited 73 elderly participants with moderate dementia from 10 elderly residential homes and assigned them to the intervention ( n = 40) and control ( n = 33) group. The intervention included 16 half-hour sessions of music intervention with multi-sensory components over eight weeks and control group received standard care...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29468724/a-roadmap-to-advance-dementia-research-in-prevention-diagnosis-intervention-and-care-by-2025
#13
James Pickett, Cathy Bird, Clive Ballard, Sube Banerjee, Carol Brayne, Katherine Cowan, Linda Clare, Adelina Comas-Herrera, Lynne Corner, Stephanie Daley, Martin Knapp, Louise Lafortune, Gill Livingston, Jill Manthorpe, Natalie Marchant, Jo Moriarty, Louise Robinson, Clare van Lynden, Gill Windle, Bob Woods, Katherine Gray, Clare Walton
OBJECTIVE: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. METHODS: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research...
February 22, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29468564/early-presymptomatic-changes-in-the-proteome-of-mitochondria-associated-membrane-in-the-app-ps1-mouse-model-of-alzheimer-s-disease
#14
Katalin Völgyi, Kata Badics, Fernando J Sialana, Péter Gulyássy, Edina Brigitta Udvari, Viktor Kis, László Drahos, Gert Lubec, Katalin Adrienna Kékesi, Gábor Juhász
Intracellular β-amyloid (Aβ) accumulation is an early event in Alzheimer's disease (AD) progression. Recently, it has been uncovered that presenilins (PSs), the key components of the amyloid precursor protein (APP) processing and the β-amyloid producing γ-secretase complex, are highly enriched in a special sub-compartment of the endoplasmic reticulum (ER) functionally connected to mitochondria, called mitochondria-associated ER membrane (MAM). A current hypothesis of pathogenesis of Alzheimer's diseases (AD) suggests that MAM is involved in the initial phase of AD...
February 22, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29468523/gender-differential-in-social-and-economic-predictors-of-incident-major-depressive-disorder-in-the-ibadan-study-of-ageing
#15
Akin Ojagbemi, Toyin Bello, Oye Gureje
PURPOSE: Working on the hypothesis that the social and economic factors associated with onset of late-life depression operate differently for men and women, we investigated the impact of current social relationships and lifetime occupational attainment on incident major depressive disorder (MDD) assessed in three follow-up waves over a period of 5 years. METHODS: Participants were part of a household multistage probability sample of 2149 Nigerians who were aged 65 years and above...
February 21, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29468161/big-data-and-dementia-charting-the-route-ahead-for-research-ethics-and-policy
#16
Marcello Ienca, Effy Vayena, Alessandro Blasimme
Emerging trends in pervasive computing and medical informatics are creating the possibility for large-scale collection, sharing, aggregation and analysis of unprecedented volumes of data, a phenomenon commonly known as big data. In this contribution, we review the existing scientific literature on big data approaches to dementia, as well as commercially available mobile-based applications in this domain. Our analysis suggests that big data approaches to dementia research and care hold promise for improving current preventive and predictive models, casting light on the etiology of the disease, enabling earlier diagnosis, optimizing resource allocation, and delivering more tailored treatments to patients with specific disease trajectories...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29468084/a-development-study-and-randomised-feasibility-trial-of-a-tailored-intervention-to-improve-activity-and-reduce-falls-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia
#17
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29467648/dissecting-endoplasmic-reticulum-unfolded-protein-response-upr-er-in-managing-clandestine-modus-operandi-of-alzheimer-s-disease
#18
REVIEW
Safikur Rahman, Ayyagari Archana, Arif Tasleem Jan, Rinki Minakshi
Alzheimer's disease (AD), a neurodegenerative disorder, is most common cause of dementia witnessed among aged people. The pathophysiology of AD develops as a consequence of neurofibrillary tangle formation which consists of hyperphosphorylated microtubule associated tau protein and senile plaques of amyloid-β (Aβ) peptide in specific brain regions that result in synaptic loss and neuronal death. The feeble buffering capacity of endoplasmic reticulum (ER) proteostasis in AD is evident through alteration in unfolded protein response (UPR), where UPR markers express invariably in AD patient's brain samples...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29467647/identification-of-a-novel-hemizygous-sqstm1-nonsense-mutation-in-atypical-behavioral-variant-frontotemporal-dementia
#19
Lin Sun, Zhouyi Rong, Wei Li, Honghua Zheng, Shifu Xiao, Xia Li
Frontotemporal dementia includes a large spectrum of neurodegenerative disorders. SQSTM1 , coding for p62 protein, plays a vital role in the pathogenesis of FTD. Here, we report a case of a female patient with SQSTM1 mutation S224X, who was 59 years old when she initially exhibited memory decline, mild personality changes, and subtle atrophy of frontal/temporal lobes in magnetic resonance imaging (MRI). Genetic testing revealed a nonsense mutation of the SQSTM1 gene (S224X), resulting in premature termination of protein synthesis and a predicted truncated protein 217 amino acids shorter than the normal protein...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29467644/use-of-peptides-for-the-management-of-alzheimer-s-disease-diagnosis-and-inhibition
#20
REVIEW
Mohammad H Baig, Khurshid Ahmad, Gulam Rabbani, Inho Choi
Alzheimer's disease (AD) is a form of dementia and the most common progressive neurodegenerative disease (ND). The targeting of amyloid-beta (Aβ) aggregation is one of the most widely used strategies to manage AD, and efforts are being made globally to develop peptide-based compounds for the early diagnosis and treatment of AD. Here, we briefly discuss the use of peptide-based compounds for the early diagnosis and treatment of AD and the use of peptide-based inhibitors targeting various Aβ aggregation checkpoints...
2018: Frontiers in Aging Neuroscience
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