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https://www.readbyqxmd.com/read/29913359/the-landscape-of-dementia-inclusivity
#1
Pauline Marsh, Helen Courtney-Pratt, Marina Campbell
A supported community gardening program became appealing and therapeutically beneficial to people living with the impacts of dementia and their carers, despite not targeting either cohort specifically. This paper discusses how this program provides insights into the landscape of dementia inclusivity. The gardens involved were spaces that allowed positive risk-taking opportunities, respectful intersubjectivity and active citizenship. Our research findings indicate that a meaningful response to the rising incidence of dementia may be to build upon social and geographical attributes of community gardens...
June 15, 2018: Health & Place
https://www.readbyqxmd.com/read/29912719/systematic-assessment-of-the-rehabilitation-needs-in-early-stage-dementia-for-home-dwelling-people-a-scoping-review-protocol
#2
Fritze Kristensen, Jette Thuesen, Sasja Jul Håkonsen
The objective of this scoping review is to examine and map assessment tools and procedures that are used by health and social care professionals in dementia care for the systematic assessment of the need for rehabilitation in primary and/or secondary healthcare settings for home-dwelling people diagnosed with early stage dementia based on recognized diagnostic criteria.
June 15, 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29912031/canine-outreach-promoting-engagement-the-effect-of-meaningful-activities-on-students-attitudes-toward-cognitively-impaired-older-adults
#3
B Morgan Yordy, W Stuart Pope, Chih-Hsuan Wang
Animal-assisted activities (AAAs) show promise in providing emotional and social benefits to older adults and may be used as a tool to promote therapeutic communication between students and cognitively impaired older adults. The purpose was to develop a program incorporating AAAs to enhance social engagement of cognitively impaired older adults in a community respite program and in turn enhance student comfort when caring for this vulnerable population. The Dementia Attitudes Scale, a validated tool, was used to measure students' attitudes before and after AAA intervention...
June 14, 2018: Nurse Educator
https://www.readbyqxmd.com/read/29911758/force-feeding-and-resuscitation-of-patients-with-advanced-dementia-a-public-opinion-study
#4
Tamar Shalom, Avichai Shuv-Ami
BACKGROUND: The treatment of advanced dementia patients is very complex and presents a difficult dilemma for physicians, and especially for the patient's family. In many cases, when the advanced dementia patient has no decisional capacity, the family needs to decide about force-feeding and resuscitation for their relative. OBJECTIVES: To examine public opinion regarding force-feeding and resuscitation of patients with advanced dementia. METHODS: Data from 1002 people who accompanied a patient to a hospital emergency department in Israel were collected and analyzed...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911493/normative-data-for-the-digit-symbol-substitution-test-in-a-population-based-sample-aged-65-79-years-results-from-the-german-health-interview-and-examination-survey-for-adults-degs1
#5
Beate Gaertner, Michael Wagner, Tobias Luck, Amanda K Buttery, Judith Fuchs, Markus A Busch
OBJECTIVE: To provide normative data for the Digit Symbol Substitution Test (DSST) of the Wechsler Adult Intelligence Scale, 3rd edition (WAIS-III) in a population-based sample of community-dwelling older adults in Germany according to age, sex, and level of education. METHOD: The sample comprised 1385 participants aged 65-79 years from the nationwide representative 'German Health Interview and Examination Survey for Adults' (DEGS1, 2008-2011). Participants with known cognitive impairment or dementia, other medical conditions affecting cognition, or currently using psychotropic drugs were excluded...
June 17, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29911331/an-observational-study-of-antipsychotic-medication-use-among-long-stay-nursing-home-residents-without-qualifying-diagnoses
#6
Lorraine J Phillips, Nancy M Birtley, Gregory F Petroski, Carol Siem, Marilyn Rantz
INTRODUCTION: Antipsychotic use in nursing homes varies widely across the United States; inadequate staffing, skill mix, and geropsychiatric training impede sustained improvement. AIM: This study identified risk factors of antipsychotic use in long-stay residents lacking qualifying or potentially qualifying diagnoses. METHOD: This secondary analysis used 2015 Minimum Data Set and cost report data from 458 Missouri nursing homes. The full sample (N=29,679) was split into two subsamples: residents with (N=15,114) and without (N=14,565) a dementia diagnosis...
June 17, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29910709/a-complex-relationship-between-suicide-dementia-and-amyloid-a-narrative-review
#7
Ismael Conejero, Sophie Navucet, Jacques Keller, Emilie Olié, Philippe Courtet, Audrey Gabelle
Background: Suicide rates are high among older adults and many conditions have been related to suicide in this population: chronic illnesses, physical disabilities, cancer, social isolation, mental disorders and neurocognitive disorders. Objectives: Among neurocognitive disorders, analysis of the relationships between dementia and suicidal behaviors led to conflicting results and some questions are still without answer. Particularly, it is not known whether (i) Alzheimer's disease (AD) increases the risk of suicidal ideation and suicide attempts (SA) or the frequency of death by suicide; (ii) the presence of suicidal ideation or SA in people older than 65 years of age is an early dementia sign; and (iii) amyloid load in frontal areas facilitates SA by modifying the decision-making pathway...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29910632/clinimetric-properties-of-the-electronic-pain-assessment-tool-epat-for-aged-care-residents-with-moderate-to-severe-dementia
#8
Kreshnik Hoti, Mustafa Atee, Jeffery D Hughes
Purpose: Accurate pain assessment is critical to detect pain and facilitate effective pain management in dementia patients. The electronic Pain Assessment Tool (ePAT) is a point-of-care solution that uses automated facial analysis in conjunction with other clinical indicators to evaluate the presence and intensity of pain in patients with dementia. This study aimed to examine clini-metric properties (clinical utility and predictive validity) of the ePAT in this population group. Methods: Data were extracted from a prospective validation (observational) study of the ePAT in dementia patients who were ≥65 years of age, living in a facility for ≥3 months, and had Psychogeriatric Assessment Scales - cognitive scores ≥10...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29909188/late-diagnosed-phenylketonuria-mimicking-x-linked-adrenoleukodystrophy-with-heterozygous-mutations-of-the-pah-gene-a-case-report-and-literature-review
#9
REVIEW
Yinglu Liu, Zhao Dong, Shengyuan Yu
Phenylketonuria (PKU) is a prevalent inherited metabolic disorder caused by a phenylalanine hydroxylase (PAH) or tetrahydrobiopterin (BH4) deficiency, which leads to the accumulation of phenylalanine (PHE). High blood levels of PHE have a toxic effect on the brain and are associated with several neurological signs. Most cases of PKU are identified during infancy, and diagnosis of PKU in adult is rare. Here, we describe a 29-year-old patient with progressive dementia and muscular weakness mimicking X-linked adrenoleukodystrophy...
June 11, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29909180/parkinsonism-is-associated-with-altered-primary-motor-cortex-plasticity-in-frontotemporal-dementia-primary-progressive-aphasia-variant
#10
Flavio Di Stasio, Suppa Antonio, Fabbrini Andrea, Marsili Luca, Asci Francesco, Conte Antonella, Trebbastoni Alessandro, De Lena Carlo, Berardelli Alfredo
In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkinsonism. With the technique of transcranial magnetic stimulation, we investigated long-term potentiation- and long-term depression-like plasticity in the primary motor cortex of bv-FTD and nfv-PPA patients, with and without parkinsonism, by using the theta-burst stimulation (TBS) protocol...
May 29, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29909174/road-traffic-noise-air-pollution-and-risk-of-dementia-results-from-the-betula-project
#11
John Andersson, Anna Oudin, Anna Sundström, Bertil Forsberg, Rolf Adolfsson, Maria Nordin
BACKGROUND: There is growing evidence for a negative impact of traffic-related air pollution on risk of dementia. However, the contribution of noise exposure to this association has been rarely examined. OBJECTIVE: We aimed to investigate the individual and combined effect of noise and air pollution on risk of dementia. METHODS: Data on dementia incidence over a 15 year period was obtained from the Betula project, a longitudinal study on health and ageing...
June 14, 2018: Environmental Research
https://www.readbyqxmd.com/read/29909157/fullerenol-c-60-oh-36-at-relatively-high-concentrations-impairs-hippocampal-theta-oscillations-in-vivo-and-in-vitro-and-triggers-epilepsy-in-vitro-a-dose-response-study
#12
Paulina Kazmierska, Anna Kobrzycka, Renata Bocian, Tomasz Kowalczyk, Anita Krokosz, Jacek Grebowski
Since the first identification of fullerenes (C60 ) and their synthesis in 1985, those compounds have been extensively studied in the biomedical field. In particular, their water-soluble derivatives, fullerenols (C60 (OH)n, n = 2-48), have recently been the subject of numerous investigations concerning their antioxidant and prooxidant properties in biological systems. A small fraction of that research has focused on the possible use of C60 and C60 (OH)n in neuroscience and the therapy of pathologies such as dementia, amyloid-β (Aβ) formation, and Parkinson's disease...
June 14, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29908727/metabolic-syndrome-contributes-to-cognitive-impairment-in-patients-with-parkinson-s-disease
#13
Zeyan Peng, Shuyang Dong, Yong Tao, Yingchao Huo, Zhenhua Zhou, Wen Huang, Hongdang Qu, Juan Liu, Yang Chen, Zhiqiang Xu, Yanjiang Wang, Huadong Zhou
INTRODUCTION: Metabolic syndrome (MetS) increases the risk of cognitive impairment in normal aging but this has not been studied in Parkinson's Disease (PD). The purpose of this study was to investigate the impact of MetS on cognitive impairment in PD. METHODS: This study investigated subjects older than 60 years who were diagnosed with PD. They were enrolled into this study between January 2010 and December 2011, and followed for 5 years. The assessment of cognitive function in subjects with PD was based on the cognitive and neuropsychiatric tests, and MetS was diagnosed according to the National Cholesterol Education Program's Adult Treatment Panel III...
May 16, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29908079/targeted-brain-proteomics-uncover-multiple-pathways-to-alzheimer-s-dementia
#14
Lei Yu, Vladislav A Petyuk, Chris Gaiteri, Sara Mostafavi, Tracy Young-Pearse, Raj C Shah, Aron S Buchman, Julie A Schneider, Paul D Piehowski, Ryan L Sontag, Thomas L Fillmore, Tujin Shi, Richard D Smith, Philip L De Jager, David A Bennett
OBJECTIVE: Previous gene expression analysis identified a network of co-expressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets. METHODS: Data came from 834 community-based older persons who were followed annually, died and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies...
June 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29907977/melatonin-induces-mechanisms-of-brain-resilience-against-neurodegeneration
#15
Rubén Corpas, Christian Griñán-Ferré, Verónica Palomera-Ávalos, David Porquet, Pablo García de Frutos, Silvia M Franciscato Cozzolino, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu, Bárbara R Cardoso
Melatonin is an endogenous pleiotropic molecule which orchestrates regulatory functions and protective capacity against age-related ailments. The increase in circulating levels of melatonin through dietary supplements intensifies its health benefits. Investigations in animal models have shown that melatonin protects against Alzheimer's disease (AD)-like pathology, although clinical studies have not been conclusive. We hypothesized that melatonin induces changes in the brain that prevent or attenuate AD by increasing resilience...
June 15, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29907927/-1-h-mrs-spectroscopy-in-preclinical-autosomal-dominant-alzheimer-disease
#16
Elizabeth Joe, Luis D Medina, John M Ringman, Joseph O'Neill
1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29907754/nano-particle-mediated-inhibition-of-parkinson-s-disease-using-computational-biology-approach
#17
Aman Chandra Kaushik, Shiv Bharadwaj, Sanjay Kumar, Dong-Qing Wei
Parkinson's disease (PD) arises as neurodegenerative disorder and characterized by progressive deterioration of motor functions due to forfeiture of dopamine-releasing neurons. During PD, neurons at stake loss their functionality that results into cognition impairment and forgetfulness, commonly called as dementia. Recently, nanoparticles (NPs) have been reported for easy drug delivery through blood-brain barrier (BBB) into the central nervous system (CNS) against the conventional drug delivery systems. However, present study attempted to elucidate the α-synuclein activity, a major factor casing PD, in presence of its inhibitor cerium oxide (CeO2 ) nanoparticle via computational biology approach...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907577/dementia-and-advance-directives-some-empirical-and-normative-concerns
#18
Karin R Jongsma, Marijke C Kars, Johannes J M van Delden
The authors of the paper 'Advance euthanasia directives: a controversial case and its ethical implications' articulate concerns and reasons with regard to the conduct of euthanasia in persons with dementia based on advance directives. While we agree on the conclusion that there needs to be more attention for such directives in the preparation phase, we disagree with the reasons provided by the authors to support their conclusions. We will outline two concerns with their reasoning by drawing on empirical research and by providing reasons that contradict their assumptions about competence of people with dementia and the (un)importance of happiness in reasoning about advance directives of people with dementia...
June 15, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29907423/understanding-the-impact-of-sex-and-gender-in-alzheimer-s-disease-a-call-to-action
#19
Rebecca A Nebel, Neelum T Aggarwal, Lisa L Barnes, Aimee Gallagher, Jill M Goldstein, Kejal Kantarci, Monica P Mallampalli, Elizabeth C Mormino, Laura Scott, Wai Haung Yu, Pauline M Maki, Michelle M Mielke
INTRODUCTION: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches. METHODS: The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD...
May 31, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29906661/loss-of-trem2-in-microglia-leads-to-widespread-disruption-of-cell-coexpression-networks-in-mouse-brain
#20
Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W Ryder, Eva Wozniak, Kristie Wood, Charles A Mein, Richard J B Dobson, David A Collier, Michael J O'Neill, Angela K Hodges, Stephen J Newhouse
Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the loss of Trem2 in mouse brain to better understand its role in disease using differential expression and coexpression network analysis of Trem2 knockout and wild-type mice. We generated RNA-Seq data from cortex and hippocampus sampled at 4 and 8 months. Using brain cell-type markers and ontology enrichment, we found subnetworks with cell type and/or functional identity...
May 17, 2018: Neurobiology of Aging
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