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Non-alcoholic steatosis

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https://www.readbyqxmd.com/read/28933748/dietary-composition-independent-of-weight-loss-in-the-management-of-non-alcoholic-fatty-liver-disease
#1
REVIEW
Tannaz Eslamparast, Puneeta Tandon, Maitreyi Raman
Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrates, total and saturated fat, with reduced intake of dietary fiber and omega-3 rich foods. Although lifestyle modifications including weight loss and exercise remain the keystone of NAFLD management, modifying dietary composition with or without a calorie-restricted diet may also be a feasible and sustainable strategy for NAFLD treatment...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28931435/circulating-retinol-binding-protein-4-levels-in-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#2
REVIEW
Zhongwei Zhou, Hongmei Chen, Huixiang Ju, Mingzhong Sun
BACKGROUND: Retinol binding protein 4 (RBP4) is implicated in obesity, insulin resistance and type 2 diabetes mellitus that are closely associated with nonalcoholic fatty liver disease (NAFLD). However, recent investigations regarding circulating RBP4 levels in NAFLD are conflicting. This meta-analysis is to determine whether NAFLD, non-alcoholic steatohepatitis (NASH) and simple steatosis (SS) patients have altered RBP4 levels. METHODS: We performed a systematic search in PubMed, EMBASE and The Cochrane Library up until 18 March 2017, and 12 studies comprising a total of 4247 participants (2271 NAFLD patients and 1976 controls) were included in the meta-analysis...
September 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28930194/developmental-programming-of-obesity-and-liver-metabolism-by-maternal-perinatal-nutrition-involves-the-melanocortin-system
#3
Paul Cordero, Jiawei Li, Vi Nguyen, Joaquim Pombo, Nuria Maicas, Marco Novelli, Paul D Taylor, Anne-Maj Samuelsson, Manlio Vinciguerra, Jude A Oben
Maternal obesity predisposes offspring to metabolic dysfunction and Non-Alcoholic Fatty Liver Disease (NAFLD). Melanocortin-4 receptor (Mc4r)-deficient mouse models exhibit obesity during adulthood. Here, we aim to determine the influence of the Mc4r gene on the liver of mice subjected to perinatal diet-induced obesity. Female mice heterozygous for Mc4r fed an obesogenic or a control diet for 5 weeks were mated with heterozygous males, with the same diet continued throughout pregnancy and lactation, generating four offspring groups: control wild type (C_wt), control knockout (C_KO), obese wild type (Ob_wt), and obese knockout (Ob_KO)...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28928235/testosterone-protects-high-fat-low-carbohydrate-diet-induced-non-alcoholic-fatty-liver-disease-in-castrated-male-rats-mainly-via-modulating-er-stress
#4
Yue Jia, Jennifer Kuang Yee, Christina Wang, Liana Nikolaenko, Maruja Diaz-Arjonilla, Joshua N Cohen, Samuel W French, Peter Y Liu, YanHe Lue, Wai-Nang Paul Lee, Ronald S Swerdloff
We previously showed that testosterone (T) deficiency enhanced high-fat diet (HFD) induced hepatic steatosis in rats that was independent of insulin resistance, and that T replacement reduced hepatic macrovesicular fat accumulation and inflammation. The present report explores the mechanism of T-protective effects on HFD-induced steatohepatitis. Adult male rats were randomized into four treatment groups for 15 weeks (intact rats on regular chow diet or HFD, and castrated rats on HFD with/without T replacement)...
September 19, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28925934/can-diet-help-non-obese-individuals-with-non-alcoholic-fatty-liver-disease-nafld
#5
Hamid A Merchant
Subjects diagnosed with non-alcoholic fatty liver disease (NAFLD) or hepatic steatosis are usually obese or overweight. NAFLD has also been reported in many non-obese healthy subjects as an incidental finding during imaging. Subjects with early-stage NAFLD who are otherwise healthy are often left unmanaged in current clinical practice; it is not clear if an early intervention in those individuals would be of any benefit in preventing NAFLD progression to more serious conditions. Since many of these subjects are non-alcoholic and have a normal body mass index (BMI), an intensive lifestyle change program is not usually recommended...
September 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28924123/the-improvement-of-the-hepatic-histological-findings-in-a-patient-with-non-alcoholic-steatohepatitis-with-type-2-diabetes-after-the-administration-of-the-sodium-glucose-cotransporter-2-inhibitor-ipragliflozin
#6
Akihiko Takeda, Aya Irahara, Atsuko Nakano, Emi Takata, Yuko Koketsu, Kunie Kimata, Eri Senda, Hajime Yamada, Kazuhito Ichikawa, Takahiro Fujimori, Yoshio Sumida
The patient was a 67-year-old woman with type 2 diabetes and non-alcoholic steatohepatitis (NASH). The administration of the sodium-glucose cotransporter 2 (SGLT2) inhibitor, ipragliflozin improved her liver dysfunction clinically and histologically. The serum alanine aminotransferase (ALT) and ferritin levels decreased to normal limits after treatment for four months. Type IV collagen and hyaluronic acid, both of which were serum fibrotic markers, decreased after treatment. Ultrasonography and computed tomography showed a decrease in the fat deposits in her liver...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28923496/deficiency-of-the-mitochondrial-nad-kinase-causes-stress-induced-hepatic-steatosis-in-mice
#7
Kezhong Zhang, Hyunbae Kim, Zhiyao Fu, Yining Qiu, Zhao Yang, Jiemei Wang, Deqiang Zhang, Xin Tong, Lei Yin, Jing Li, Jianmei Wu, Nathan R Qi, Sander M Houten, Ren Zhang
BACKGROUND & AIMS: The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) catalyzes phosphorylation of NAD to yield NADP. Little is known about the functions of mitochondrial NADP and MNADK in liver physiology and pathology. We investigated the effects of reduced mitochondrial NADP by deleting MNADK in mice. METHODS: We generated MNADK-knockout (KO) mice on a C57BL/6NTac background; mice with a wild-type Mnadk gene were used as controls...
September 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28906444/short-term-intake-of-a-fructose-fat-and-cholesterol-rich-diet-causes-hepatic-steatosis-in-mice-effect-of-antibiotic-treatment
#8
Annette Brandt, Cheng Jun Jin, Katja Nolte, Cathrin Sellmann, Anna Janina Engstler, Ina Bergheim
Intestinal microbiota and barrier functions seem to play an important role in the development of non-alcoholic fatty liver disease (NAFLD). However, whether these changes are an early event in the development of NAFLD or are primarily associated with later stages of the disease, has not yet been clarified. Using a pair-feeding model, we determined the effects of a short-term intake of a fat-, fructose- and cholesterol-rich diet (FFC) on the development of early hepatic steatosis and markers of intestinal barrier function in mice treated with and without non-resorbable antibiotics (AB)...
September 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28902430/reduced-serum-igf-1-associated-with-hepatic-osteodystrophy-is-a-main-determinant-of-low-cortical-but-not-trabecular-bone-mass
#9
Zhongbo Liu, Tianzhen Han, Haim Werner, Clifford J Rosen, Mitchell B Schaffler, Shoshana Yakar
Hepatic osteodystrophy is multifactorial in its pathogenesis. Numerous studies have shown that impairments of the hepatic growth hormone/insulin-like growth factor-1 axis (GH/IGF-1) are common in patients with non-alcoholic fatty liver disease, chronic viral hepatitis, liver cirrhosis, and chronic cholestatic liver disease. Moreover these conditions are also associated with low bone mineral density (BMD) and greater fracture risk, particularly in cortical bone sites. Hence, we addressed whether disruptions in the GH/IGF-1 axis were causally related to the low bone mass in states of chronic liver disease using a mouse model of liver-specific GH-receptor (GHR) gene deletion (Li-GHRKO)...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28900817/spleen-dimensions-are-inversely-associated-with-lysosomal-acid-lipase-activity-in-patients-with-non-alcoholic-fatty-liver-disease
#10
Licia Polimeni, Daniele Pastori, Francesco Baratta, Giulia Tozzi, Marta Novo, Roberto Vicinanza, Giovanni Troisi, Gaetano Pannitteri, Fabrizio Ceci, Laura Scardella, Francesco Violi, Francesco Angelico, Maria Del Ben
Fatty liver and splenomegaly are typical features of genetic lysosomal acid lipase (LAL) deficiency. No data in adult patients with non-genetic reduction of LAL activity are available. We investigate the association between spleen dimensions and LAL activity in non-alcoholic fatty liver disease (NAFLD) patients, in whom a reduced LAL activity has been reported. We include 425 consecutive patients who underwent abdominal ultrasound to evaluate hepatic steatosis and spleen dimensions. LAL activity was measured with dried blood spot method (Lalistat2)...
September 12, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28900305/berberine-ameliorates-fatty-acid-induced-oxidative-stress-in-human-hepatoma-cells
#11
Yixuan Sun, Xinlu Yuan, Feifei Zhang, Yamei Han, Xinxia Chang, Xi Xu, Yu Li, Xin Gao
Oxidative stress is thought to be critical for the pathogenesis of hepatic steatosis and its progress to non-alcoholic steatohepatitis. Berberine (BBR) can improve hepatic steatosis. In this study, we investigated the role of BBR in ameliorating oxidative stress. Lipid accumulation was measured in the livers of C57BL/6 mice fed a high fat diet (HFD) or a normal diet for 8 weeks, then either received BBR or vehicle for the study duration. Nrf2 distribution was detected in male Sprague-Dawley rats' livers in vivo and in Huh7 cells in vitro...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899784/mir-181b-regulates-steatosis-in-nonalcoholic-fatty-liver-disease-via-targeting-sirt1
#12
Yunxia Wang, Kongxi Zhu, Weihua Yu, Hongjuan Wang, Lan Liu, Qiong Wu, Shuai Li, Jianqiang Guo
Non-alcoholic fatty liver diseases (NAFLD) is one of the leading cause of chronic liver diseases in the world. However, the pathogenesis of NAFLD is still unclear. Emerging studies have demonstrated that microRNAs (miRs) are profoundly involved in NAFLD and related metabolic diseases. Here, we investigated the mechanisms by which miR-181b influences NAFLD via direct targeting SIRT1. The expression of miR181b was up-regulated while SIRT1 was down-regulated in both human NAFLD patients and high fat diet (HFD) induced NAFDL mice model...
September 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28895929/effects-of-oral-administration-of-silymarin-in-a-juvenile-murine-model-of-non-alcoholic-steatohepatitis
#13
Veronica Marin, Silvia Gazzin, Sabrina E Gambaro, Matteo Dal Ben, Sonia Calligaris, Monica Anese, Alan Raseni, Claudio Avellini, Pablo J Giraudi, Claudio Tiribelli, Natalia Rosso
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only alternative. In this study, we assessed the protective effects of silymarin in a juvenile non-alcoholic steatohepatitis (NASH) model and the in vitro effects on fat-laden human hepatocytes. C57Bl/6 mice were exposed to HFHC diet immediately after weaning. After eight weeks, animals showed histological signs of NASH...
September 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28895242/hepatocellular-carcinoma-in-a-mouse-model-fed-a-choline-deficient-l-amino-acid-defined-high-fat-diet
#14
Ayae Ikawa-Yoshida, Saori Matsuo, Atsuhiko Kato, Yusuke Ohmori, Atsuko Higashida, Eiji Kaneko, Masahiko Matsumoto
Hepatocellular carcinoma (HCC) is a common cancer worldwide and represents the outcome of the natural history of chronic liver disease. The growing rates of HCC may be partially attributable to increased numbers of people with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, details of the liver-specific molecular mechanisms responsible for the NAFLD-NASH-HCC progression remain unclear, and mouse models that can be used to explore the exact factors that influence the progression of NAFLD/NASH to the more chronic stages of liver disease and subsequent HCC are not yet fully established...
September 12, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28894701/relationship-between-diet-and-non-alcoholic-fatty-liver-disease-a-review-article
#15
REVIEW
Parvin Mirmiran, Zeynab Amirhamidi, Hanieh-Sadat Ejtahed, Zahra Bahadoran, Fereidoun Azizi
BACKGROUND: Diet plays a key role in the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to review systematically observational studies available regarding the relationship between food intakes and NAFLD. METHODS: We searched Scopus, PubMed, and Cochrane Library databases to identify English observational studies on food groups, dietary patterns, and NAFLD. Cross-sectional, case-control and cohort studies were selected and then duplication, topic, type of study, study population, variables examined and quality of data reporting of the articles were evaluated...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28892924/comparison-of-pioglitazone-and-metformin-efficacy-against-glucocorticoid-induced-atherosclerosis-and-hepatic-steatosis-in-insulin-resistant-rats
#16
I M Nagendra Nayak, Koyagura Narendar, Patil Ashok M, M G Jamadar, V Hemanth Kumar
INTRODUCTION: Insulin Resistance is a major cause of Atherosclerosis (AS) and Non Alcoholic Fatty Liver Disease (NAFLD). These lipid alterations in blood vessels and liver may progress to cardiovascular abnormalities and cirrhosis respectively. Drugs like pioglitazone (PIO) and metformin (MET) are effective insulin sensitizers used in T2DM. But their efficacy and tolerability needs to be compared in IR associated abnormalities. AIM: To compare the efficacy of PIO and MET in glucocorticoid induced AS, Hepatic Steatosis (HS) and IR in albino rats...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892211/early-menarche-is-associated-with-non-alcoholic-fatty-liver-disease-in-adulthood
#17
Kyung Hee Yi, Jin Soon Hwang, Se Won Lim, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
BACKGROUND: The aim of this study was to examine the association between early menarche (<12 years) and non-alcoholic fatty liver disease (NAFLD) in premenopausal women and to explore whether it is mediated by adult obesity and insulin resistance. METHODS: We analyzed data of premenopausal women, aged 15 or older, from the Korea National Health and Nutrition Examination Survey (2007-2009). We divided the women into 3 groups: early menarche, reference (12.00-15...
September 11, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28883861/bioavailable-testosterone-is-independently-associated-with-fatty-liver-index-in-postmenopausal-women
#18
Aleksandra Klisic, Nebojsa Kavaric, Milovan Jovanovic, Ivan Soldatovic, Najdana Gligorovic-Barhanovic, Jelena Kotur-Stevuljevic
INTRODUCTION: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. MATERIAL AND METHODS: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28880885/markers-of-intestinal-permeability-are-already-altered-in-early-stages-of-non-alcoholic-fatty-liver-disease-studies-in-children
#19
Anika Nier, Anna Janina Engstler, Ina Barbara Maier, Ina Bergheim
BACKGROUND & AIMS: Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing disease or are already found in initial disease stages has not yet been clarified. METHODS: Twenty children with simple steatosis (grade 1) diagnosed by ultrasound and 29 normal weight healthy control children (age <10 years) were included in the study (mean age 7...
2017: PloS One
https://www.readbyqxmd.com/read/28878811/serum-metabolites-in-non-alcoholic-fatty-liver-disease-development-or-reversion-a-targeted-metabolomic-approach-within-the-predimed-trial
#20
Christopher Papandreou, Mònica Bullò, Francisco José Tinahones, Miguel Ángel Martínez-González, Dolores Corella, Georgios A Fragkiadakis, José López-Miranda, Ramon Estruch, Montserrat Fitó, Jordi Salas-Salvadó
BACKGROUND: Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in metabolites indicate predisposition to NAFLD development and to assess the effects of NAFLD reversion on metabolite profiles. METHODS: A targeted liquid-chromatography tandem mass-spectrometry metabolic profiling (n = 453 metabolites) approach was applied, using serum from 45 subjects of the PREDIMED study, at baseline and after a median 3...
2017: Nutrition & Metabolism
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